Reviewed, UniProtKB/Swiss-Prot Q3YUY8 (NUDC_SHISS)

Names and origin

Protein names

Recommended name:
    NADH pyrophosphatase
    EC=3.6.1.22

Gene names

Name:	nudC
Ordered Locus Names:	SSON_4169

Organism

Shigella sonnei (strain Ss046) [Complete proteome] [HAMAP]

Taxonomic identifier

300269 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	NAD+ + H2O = AMP + NMN. HAMAP MF_00297
Cofactor	Divalent ions. Manganese or magnesium By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the Nudix hydrolase family. NudC subfamily.

Ontologies

Keywords
Ligand	Magnesium Manganese NAD
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	NAD+ diphosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	NADH pyrophosphatase HAMAP MF_00297		PRO_0000232124
Regions
	Motif	159 – 180	22	Nudix box HAMAP MF_00297

Sequences

	Sequence		Length	Mass (Da)
	Q3YUY8-1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 368FAE0480AF4CB3	FASTA	257	29,689
	10 20 30 40 50 60 MDRIIEKLDH GWWVVSHEQK LWLPKGELPY GEAANFDLVG QRALQIGEWQ GEPVWLVQQQ 70 80 90 100 110 120 RRHDMGSVRQ VIDLDVGLFQ LAGRGVQLAE FYRSHKYCGY CGHEMYPSKT EWAMLCSHCR 130 140 150 160 170 180 ERYYPQIAPC IIVAIRRDDS ILLAQHTRHR NGVHTVLAGF VEVGETLEQA VAREVMEESG 190 200 210 220 230 240 IKVKNLRYVT SQPWPFPQSL MTAFMAEYDS GDIVIDPKEL LEANWYRYDD LPLLPPPGTV 250 ARRLIEDTVA MCRAEYE

References

[1]

"Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery." Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J., Xu J. , Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J., Jin Q. Nucleic Acids Res. 33:6445-6458(2005) [PubMed: 16275786] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000038 Genomic DNA. Translation: AAZ90674.1.
RefSeq	YP_312909.1.
3D structure databases
SMR	Q3YUY8. Positions 1-257.
ModBase	Search...
Genome annotation databases
GeneID	3669085.
GenomeReviews	Gene locus SSON_4169 in contig CP000038_GR.
KEGG	ssn:SSON_4169.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3YUY8.
OMA	Q3YUY8. SPCIIVA.
Enzyme and pathway databases
BioCyc	SSON300269:SSO_4169-MON.
Family and domain databases
HAMAP	MF_00297. [Tree]
InterPro	IPR015375. NADH_PPase-like_N. IPR000086. NUDIX_hydrolase_core. IPR015376. Znr_NADH_PPase. [Graphical view]
Gene3D	G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
Pfam	PF00293. NUDIX. 1 hit. PF09296. NUDIX-like. 1 hit. PF09297. zf-NADH-PPase. 1 hit. [Graphical view]
PROSITE	PS00893. NUDIX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUDC_SHISS

Accession

Primary (citable) accession number: Q3YUY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	September 27, 2005
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)