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Q3YSH6

- SYL_EHRCJ

UniProt

Q3YSH6 - SYL_EHRCJ

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ehrlichia canis (strain Jake)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei594 – 5941ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECAN269484:GI02-301-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Ecaj_0282
OrganismiEhrlichia canis (strain Jake)
Taxonomic identifieri269484 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
ProteomesiUP000000435: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 829829Leucine--tRNA ligasePRO_0000334752Add
BLAST

Proteomic databases

PRIDEiQ3YSH6.

Interactioni

Protein-protein interaction databases

STRINGi269484.Ecaj_0282.

Structurei

3D structure databases

ProteinModelPortaliQ3YSH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi34 – 4411"HIGH" regionAdd
BLAST
Motifi591 – 5955"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3YSH6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHYDFKKVEQ DIQKKWNFYT DVKKAQCYVL EMFPYPSGNI HMGHLRNYTI
60 70 80 90 100
GDVIARYKRA CGINVFHPIG WDAFGLPAEN AALSYNINPQ TWTKNNIDNM
110 120 130 140 150
RCQLKSIGLS YDWNKELATC DADYYKHEQA FFLDFLKCGL AYRKESLVNW
160 170 180 190 200
DPIDQTVLAN EQVIDGKGWR SGAVVEKRKL SQWFLKITDF AEELLNDLKV
210 220 230 240 250
LDKWPEKVKL MQERWIGRSE GVVVDFEILN INKTLQVFTT CPHTLFGASF
260 270 280 290 300
IAVSFDHPIL QCVSDSDIIQ QINDFDKNNL ITDASSTVEK FGINSGLVVK
310 320 330 340 350
HPFLCMNLPV YVVNFVLMDY ATGAVFGCPA HDQRDFEFAK KYNLQIKQVV
360 370 380 390 400
FPEIDIDLGK EAYVGSGTMK NSDFLDGMTV DEAKEAMIAK LQLLGIGDKM
410 420 430 440 450
TYYRIHDWGI SRQRYWGCPI PIIYCEKCGT VPVSRKDLPV TLPQDVDFTK
460 470 480 490 500
SGNPLDNHPT WKYVKCPSCG MDAERETDTF DTFFESSWYF AAFCGTSSGI
510 520 530 540 550
DKDTCNMLLP VDYYIGGIEH AVLHLLYSRF FCRALTKCGY FNVKEPFSSL
560 570 580 590 600
ITQGMVCHAT YSDAQGNYLF PEEARKMMEE GQHVNVGRAE KMSKSKKNVV
610 620 630 640 650
NLEYIIDKYG ADTARLFILS DTPPDRDIEW LDDGIEGASK YLSKLWRMIV
660 670 680 690 700
SYDQINLNFN VEDIPEDAIK YRRCVHKIVS DITSDLEFCR LNCAVAKFRE
710 720 730 740 750
LSNILSEMIR TSVNSDVVSE AICILIRVIE PFIPHIAEKL WENIGGKDML
760 770 780 790 800
WNQMWPKADT ELLIERNVNI AVQVNGKFIR TLTVANNIDN DQLKSMALEM
810 820
AKNKIGNSVV KNVYIIPKRA VNIVIEKLS
Length:829
Mass (Da):94,858
Last modified:September 27, 2005 - v1
Checksum:iB2A7FC52332711ED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000107 Genomic DNA. Translation: AAZ68329.1.
RefSeqiWP_011304407.1. NC_007354.1.
YP_302927.1. NC_007354.1.

Genome annotation databases

EnsemblBacteriaiAAZ68329; AAZ68329; Ecaj_0282.
GeneIDi3617667.
KEGGiecn:Ecaj_0282.
PATRICi20574082. VBIEhrCan118076_0304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000107 Genomic DNA. Translation: AAZ68329.1 .
RefSeqi WP_011304407.1. NC_007354.1.
YP_302927.1. NC_007354.1.

3D structure databases

ProteinModelPortali Q3YSH6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269484.Ecaj_0282.

Proteomic databases

PRIDEi Q3YSH6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ68329 ; AAZ68329 ; Ecaj_0282 .
GeneIDi 3617667.
KEGGi ecn:Ecaj_0282.
PATRICi 20574082. VBIEhrCan118076_0304.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ECAN269484:GI02-301-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the obligately intracellular bacterium Ehrlichia canis reveals themes of complex membrane structure and immune evasion strategies."
    Mavromatis K., Doyle C.K., Lykidis A., Ivanova N., Francino M.P., Chain P., Shin M., Malfatti S., Larimer F., Copeland A., Detter J.C., Land M., Richardson P.M., Yu X.J., Walker D.H., McBride J.W., Kyrpides N.C.
    J. Bacteriol. 188:4015-4023(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Jake.

Entry informationi

Entry nameiSYL_EHRCJ
AccessioniPrimary (citable) accession number: Q3YSH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 27, 2005
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3