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Q3YSH6

- SYL_EHRCJ

UniProt

Q3YSH6 - SYL_EHRCJ

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Protein
Leucine--tRNA ligase
Gene
leuS, Ecaj_0282
Organism
Ehrlichia canis (strain Jake)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei594 – 5941ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECAN269484:GI02-301-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Ecaj_0282
OrganismiEhrlichia canis (strain Jake)
Taxonomic identifieri269484 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
ProteomesiUP000000435: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 829829Leucine--tRNA ligaseUniRule annotation
PRO_0000334752Add
BLAST

Proteomic databases

PRIDEiQ3YSH6.

Interactioni

Protein-protein interaction databases

STRINGi269484.Ecaj_0282.

Structurei

3D structure databases

ProteinModelPortaliQ3YSH6.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi34 – 4411"HIGH" regionUniRule annotation
Add
BLAST
Motifi591 – 5955"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3YSH6-1 [UniParc]FASTAAdd to Basket

« Hide

MHYDFKKVEQ DIQKKWNFYT DVKKAQCYVL EMFPYPSGNI HMGHLRNYTI    50
GDVIARYKRA CGINVFHPIG WDAFGLPAEN AALSYNINPQ TWTKNNIDNM 100
RCQLKSIGLS YDWNKELATC DADYYKHEQA FFLDFLKCGL AYRKESLVNW 150
DPIDQTVLAN EQVIDGKGWR SGAVVEKRKL SQWFLKITDF AEELLNDLKV 200
LDKWPEKVKL MQERWIGRSE GVVVDFEILN INKTLQVFTT CPHTLFGASF 250
IAVSFDHPIL QCVSDSDIIQ QINDFDKNNL ITDASSTVEK FGINSGLVVK 300
HPFLCMNLPV YVVNFVLMDY ATGAVFGCPA HDQRDFEFAK KYNLQIKQVV 350
FPEIDIDLGK EAYVGSGTMK NSDFLDGMTV DEAKEAMIAK LQLLGIGDKM 400
TYYRIHDWGI SRQRYWGCPI PIIYCEKCGT VPVSRKDLPV TLPQDVDFTK 450
SGNPLDNHPT WKYVKCPSCG MDAERETDTF DTFFESSWYF AAFCGTSSGI 500
DKDTCNMLLP VDYYIGGIEH AVLHLLYSRF FCRALTKCGY FNVKEPFSSL 550
ITQGMVCHAT YSDAQGNYLF PEEARKMMEE GQHVNVGRAE KMSKSKKNVV 600
NLEYIIDKYG ADTARLFILS DTPPDRDIEW LDDGIEGASK YLSKLWRMIV 650
SYDQINLNFN VEDIPEDAIK YRRCVHKIVS DITSDLEFCR LNCAVAKFRE 700
LSNILSEMIR TSVNSDVVSE AICILIRVIE PFIPHIAEKL WENIGGKDML 750
WNQMWPKADT ELLIERNVNI AVQVNGKFIR TLTVANNIDN DQLKSMALEM 800
AKNKIGNSVV KNVYIIPKRA VNIVIEKLS 829
Length:829
Mass (Da):94,858
Last modified:September 27, 2005 - v1
Checksum:iB2A7FC52332711ED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000107 Genomic DNA. Translation: AAZ68329.1.
RefSeqiYP_302927.1. NC_007354.1.

Genome annotation databases

EnsemblBacteriaiAAZ68329; AAZ68329; Ecaj_0282.
GeneIDi3617667.
KEGGiecn:Ecaj_0282.
PATRICi20574082. VBIEhrCan118076_0304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000107 Genomic DNA. Translation: AAZ68329.1 .
RefSeqi YP_302927.1. NC_007354.1.

3D structure databases

ProteinModelPortali Q3YSH6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269484.Ecaj_0282.

Proteomic databases

PRIDEi Q3YSH6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ68329 ; AAZ68329 ; Ecaj_0282 .
GeneIDi 3617667.
KEGGi ecn:Ecaj_0282.
PATRICi 20574082. VBIEhrCan118076_0304.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ECAN269484:GI02-301-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the obligately intracellular bacterium Ehrlichia canis reveals themes of complex membrane structure and immune evasion strategies."
    Mavromatis K., Doyle C.K., Lykidis A., Ivanova N., Francino M.P., Chain P., Shin M., Malfatti S., Larimer F., Copeland A., Detter J.C., Land M., Richardson P.M., Yu X.J., Walker D.H., McBride J.W., Kyrpides N.C.
    J. Bacteriol. 188:4015-4023(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Jake.

Entry informationi

Entry nameiSYL_EHRCJ
AccessioniPrimary (citable) accession number: Q3YSH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 27, 2005
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi