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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ehrlichia canis (strain Jake)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei594ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECAN269484:G1G4X-303-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Ecaj_0282
OrganismiEhrlichia canis (strain Jake)
Taxonomic identifieri269484 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
Proteomesi
  • UP000000435 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347521 – 829Leucine--tRNA ligaseAdd BLAST829

Proteomic databases

PRIDEiQ3YSH6

Interactioni

Protein-protein interaction databases

STRINGi269484.Ecaj_0282

Structurei

3D structure databases

ProteinModelPortaliQ3YSH6
SMRiQ3YSH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi34 – 44"HIGH" regionAdd BLAST11
Motifi591 – 595"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q3YSH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHYDFKKVEQ DIQKKWNFYT DVKKAQCYVL EMFPYPSGNI HMGHLRNYTI
60 70 80 90 100
GDVIARYKRA CGINVFHPIG WDAFGLPAEN AALSYNINPQ TWTKNNIDNM
110 120 130 140 150
RCQLKSIGLS YDWNKELATC DADYYKHEQA FFLDFLKCGL AYRKESLVNW
160 170 180 190 200
DPIDQTVLAN EQVIDGKGWR SGAVVEKRKL SQWFLKITDF AEELLNDLKV
210 220 230 240 250
LDKWPEKVKL MQERWIGRSE GVVVDFEILN INKTLQVFTT CPHTLFGASF
260 270 280 290 300
IAVSFDHPIL QCVSDSDIIQ QINDFDKNNL ITDASSTVEK FGINSGLVVK
310 320 330 340 350
HPFLCMNLPV YVVNFVLMDY ATGAVFGCPA HDQRDFEFAK KYNLQIKQVV
360 370 380 390 400
FPEIDIDLGK EAYVGSGTMK NSDFLDGMTV DEAKEAMIAK LQLLGIGDKM
410 420 430 440 450
TYYRIHDWGI SRQRYWGCPI PIIYCEKCGT VPVSRKDLPV TLPQDVDFTK
460 470 480 490 500
SGNPLDNHPT WKYVKCPSCG MDAERETDTF DTFFESSWYF AAFCGTSSGI
510 520 530 540 550
DKDTCNMLLP VDYYIGGIEH AVLHLLYSRF FCRALTKCGY FNVKEPFSSL
560 570 580 590 600
ITQGMVCHAT YSDAQGNYLF PEEARKMMEE GQHVNVGRAE KMSKSKKNVV
610 620 630 640 650
NLEYIIDKYG ADTARLFILS DTPPDRDIEW LDDGIEGASK YLSKLWRMIV
660 670 680 690 700
SYDQINLNFN VEDIPEDAIK YRRCVHKIVS DITSDLEFCR LNCAVAKFRE
710 720 730 740 750
LSNILSEMIR TSVNSDVVSE AICILIRVIE PFIPHIAEKL WENIGGKDML
760 770 780 790 800
WNQMWPKADT ELLIERNVNI AVQVNGKFIR TLTVANNIDN DQLKSMALEM
810 820
AKNKIGNSVV KNVYIIPKRA VNIVIEKLS
Length:829
Mass (Da):94,858
Last modified:September 27, 2005 - v1
Checksum:iB2A7FC52332711ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000107 Genomic DNA Translation: AAZ68329.1
RefSeqiWP_011304407.1, NC_007354.1

Genome annotation databases

EnsemblBacteriaiAAZ68329; AAZ68329; Ecaj_0282
KEGGiecn:Ecaj_0282

Similar proteinsi

Entry informationi

Entry nameiSYL_EHRCJ
AccessioniPrimary (citable) accession number: Q3YSH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 27, 2005
Last modified: April 25, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health