Q3YSH3 (SURE_EHRCJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	Ecaj_0285

Organism

Ehrlichia canis (strain Jake) [Complete proteome] [HAMAP]

Taxonomic identifier

269484 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Ehrlichia

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	5'-nucleotidase surE HAMAP MF_00060		PRO_0000235613
Sites
	Metal binding	8	1	Divalent metal cation By similarity
	Metal binding	9	1	Divalent metal cation By similarity
	Metal binding	42	1	Divalent metal cation By similarity
	Metal binding	94	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3YSH3 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 7CE7A8CD3A7EED22	FASTA	256	27,714
	10 20 30 40 50 60 MKVLLTNDDG FHATGIKVLK EIIIESGIAS EVWIAAPASN CSGYGRSIGV KTATDVYQIG 70 80 90 100 110 120 DTEFIVNSTP STSAFLGLRE ITGKKPDLVL SGINSGINVG NDIGYSGTIG AAAEGAMMNI 130 140 150 160 170 180 PSIAISQEYD GKHGEINWIN PQKFLKKIIN MLLEVPFWNK STIMNVNFPL VPAKGIKFTS 190 200 210 220 230 240 QGEYIPSNKI EKKRNVSGSI SYTVHRIAPD KGNRGYSDDS IKAIDDGYIT ITPLKLDMTD 250 FDALESLIAL YKDCTI

References

[1]

"The genome of the obligately intracellular bacterium Ehrlichia canis reveals themes of complex membrane structure and immune evasion strategies." Mavromatis K., Doyle C.K., Lykidis A., Ivanova N., Francino M.P., Chain P., Shin M., Malfatti S., Larimer F., Copeland A., Detter J.C., Land M., Richardson P.M., Yu X.J., Walker D.H., McBride J.W., Kyrpides N.C. J. Bacteriol. 188:4015-4023(2006) [PubMed: 16707693] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Jake.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000107 Genomic DNA. Translation: AAZ68332.1.
RefSeq	YP_302930.1. NC_007354.1.
3D structure databases
ProteinModelPortal	Q3YSH3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3YSH3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3617670.
GenomeReviews	Gene locus Ecaj_0285 in contig CP000107_GR.
KEGG	ecn:Ecaj_0285.
PATRIC	20574088. VBIEhrCan118076_0307.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0496.
HOGENOM	HBG600532.
OMA	GHEIWHS.
PhylomeDB	Q3YSH3.
ProtClustDB	CLSK749108.
Enzyme and pathway databases
BioCyc	ECAN269484:ECAJ_0285-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_EHRCJ

Accession

Primary (citable) accession number: Q3YSH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	September 27, 2005
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program