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Q3YS95

- ASSY_EHRCJ

UniProt

Q3YS95 - ASSY_EHRCJ

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Protein

Argininosuccinate synthase

Gene
argG, Ecaj_0367
Organism
Ehrlichia canis (strain Jake)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei85 – 851Citrulline By similarity
Binding sitei90 – 901Citrulline By similarity
Binding sitei115 – 1151ATP; via amide nitrogen By similarity
Binding sitei117 – 1171Aspartate By similarity
Binding sitei121 – 1211Aspartate By similarity
Binding sitei121 – 1211Citrulline By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei125 – 1251Citrulline By similarity
Binding sitei176 – 1761Citrulline By similarity
Binding sitei185 – 1851Citrulline By similarity
Binding sitei261 – 2611Citrulline By similarity
Binding sitei273 – 2731Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 159ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECAN269484:GI02-391-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Ecaj_0367
OrganismiEhrlichia canis (strain Jake)
Taxonomic identifieri269484 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
ProteomesiUP000000435: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Argininosuccinate synthaseUniRule annotationPRO_0000263923Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi269484.Ecaj_0367.

Structurei

3D structure databases

ProteinModelPortaliQ3YS95.
SMRiQ3YS95. Positions 3-392.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3YS95-1 [UniParc]FASTAAdd to Basket

« Hide

MKKIVLAYSG GLDTSVILKW LQENYNCEVV VFTADLGQDD DMSVIRQKAT    50
ALNVKEIFIE DLKEEFVKDF VFPMFRANTV YEGYYLLGTS IARPLIAKRQ 100
IEIAKLTGAD TVAHGATGKG NDQIRFEFGY YCCNPNIKVI APWRQWKLTS 150
RNSLIEYAKK HGINVPLDKS SEPPYSIDAN LLHTSYEGKS LEDPYVEPDY 200
TILSKSVTPE LASDTPEYIE ISFEKGDPCA INNIPLSPAN LLKQLNTIGG 250
KHGIGIIDIV ENRYVGIKSR GIYETPGGTI LLHAHRAIES ITLDREAAHL 300
KDEIMPKYAK LIYNGYWWTT ERKMLQALID RSQEKVNGVV RLKLYKGSVI 350
VVGRKSENSL YSHNLASFDL SEDYNHTDAE GFIKINSLRL RNC 393
Length:393
Mass (Da):44,353
Last modified:September 27, 2005 - v1
Checksum:i4444B569FA3174C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000107 Genomic DNA. Translation: AAZ68410.1.
RefSeqiYP_303008.1. NC_007354.1.

Genome annotation databases

EnsemblBacteriaiAAZ68410; AAZ68410; Ecaj_0367.
GeneIDi3617804.
KEGGiecn:Ecaj_0367.
PATRICi20574274. VBIEhrCan118076_0396.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000107 Genomic DNA. Translation: AAZ68410.1 .
RefSeqi YP_303008.1. NC_007354.1.

3D structure databases

ProteinModelPortali Q3YS95.
SMRi Q3YS95. Positions 3-392.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269484.Ecaj_0367.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ68410 ; AAZ68410 ; Ecaj_0367 .
GeneIDi 3617804.
KEGGi ecn:Ecaj_0367.
PATRICi 20574274. VBIEhrCan118076_0396.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci ECAN269484:GI02-391-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the obligately intracellular bacterium Ehrlichia canis reveals themes of complex membrane structure and immune evasion strategies."
    Mavromatis K., Doyle C.K., Lykidis A., Ivanova N., Francino M.P., Chain P., Shin M., Malfatti S., Larimer F., Copeland A., Detter J.C., Land M., Richardson P.M., Yu X.J., Walker D.H., McBride J.W., Kyrpides N.C.
    J. Bacteriol. 188:4015-4023(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Jake.

Entry informationi

Entry nameiASSY_EHRCJ
AccessioniPrimary (citable) accession number: Q3YS95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 27, 2005
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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