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Q3YS64

- MDH_EHRCJ

UniProt

Q3YS64 - MDH_EHRCJ

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Ehrlichia canis (strain Jake)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351NADUniRule annotation
Binding sitei84 – 841SubstrateUniRule annotation
Binding sitei90 – 901SubstrateUniRule annotation
Binding sitei97 – 971NADUniRule annotation
Binding sitei122 – 1221SubstrateUniRule annotation
Binding sitei153 – 1531SubstrateUniRule annotation
Active sitei177 – 1771Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NADUniRule annotation
Nucleotide bindingi120 – 1223NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciECAN269484:GI02-425-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Ecaj_0398
OrganismiEhrlichia canis (strain Jake)
Taxonomic identifieri269484 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
ProteomesiUP000000435: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Malate dehydrogenasePRO_0000241947Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269484.Ecaj_0398.

Structurei

3D structure databases

ProteinModelPortaliQ3YS64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiFVINVAN.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3YS64-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKRKKIALI GAGNIGGMIA YLIRLKNLGD VVLLDVNDGI AKGKALDMAE
60 70 80 90 100
SSPVGKYNGE ILGTNNYADI EGADAIVVTA GITRKPGMSR EDLINTNVNI
110 120 130 140 150
IKEVADNIGK YAPNAFVVVV TNPLDVMVFA MHKYSKLSSN MVVGMAGILD
160 170 180 190 200
SARFSYFIAK ELNVSVDNVN SLVLGGHGDL MLPLVKYSSV AGISIADLIK
210 220 230 240 250
IDLITQDKVD AIIERTRKGG EEIVSLLKIG SAYYAPAESA LLMIDSYLND
260 270 280 290 300
RRLILPCSVY LKGEYGVSNL FVGVPVIIGR NGVEKIIELE LTEQEKNIFD
310
NSVKLIKNLV SNV
Length:313
Mass (Da):33,762
Last modified:September 27, 2005 - v1
Checksum:i8CF3E7B4C1836F23
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000107 Genomic DNA. Translation: AAZ68441.1.
RefSeqiWP_011304519.1. NC_007354.1.
YP_303039.1. NC_007354.1.

Genome annotation databases

EnsemblBacteriaiAAZ68441; AAZ68441; Ecaj_0398.
GeneIDi3617612.
KEGGiecn:Ecaj_0398.
PATRICi20574342. VBIEhrCan118076_0427.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000107 Genomic DNA. Translation: AAZ68441.1 .
RefSeqi WP_011304519.1. NC_007354.1.
YP_303039.1. NC_007354.1.

3D structure databases

ProteinModelPortali Q3YS64.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269484.Ecaj_0398.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ68441 ; AAZ68441 ; Ecaj_0398 .
GeneIDi 3617612.
KEGGi ecn:Ecaj_0398.
PATRICi 20574342. VBIEhrCan118076_0427.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi FVINVAN.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci ECAN269484:GI02-425-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the obligately intracellular bacterium Ehrlichia canis reveals themes of complex membrane structure and immune evasion strategies."
    Mavromatis K., Doyle C.K., Lykidis A., Ivanova N., Francino M.P., Chain P., Shin M., Malfatti S., Larimer F., Copeland A., Detter J.C., Land M., Richardson P.M., Yu X.J., Walker D.H., McBride J.W., Kyrpides N.C.
    J. Bacteriol. 188:4015-4023(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Jake.

Entry informationi

Entry nameiMDH_EHRCJ
AccessioniPrimary (citable) accession number: Q3YS64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: September 27, 2005
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3