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Q3YS64

- MDH_EHRCJ

UniProt

Q3YS64 - MDH_EHRCJ

Protein

Malate dehydrogenase

Gene

mdh

Organism
Ehrlichia canis (strain Jake)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351NADUniRule annotation
    Binding sitei84 – 841SubstrateUniRule annotation
    Binding sitei90 – 901SubstrateUniRule annotation
    Binding sitei97 – 971NADUniRule annotation
    Binding sitei122 – 1221SubstrateUniRule annotation
    Binding sitei153 – 1531SubstrateUniRule annotation
    Active sitei177 – 1771Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166NADUniRule annotation
    Nucleotide bindingi120 – 1223NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciECAN269484:GI02-425-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:Ecaj_0398
    OrganismiEhrlichia canis (strain Jake)
    Taxonomic identifieri269484 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
    ProteomesiUP000000435: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Malate dehydrogenasePRO_0000241947Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi269484.Ecaj_0398.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3YS64.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiFVINVAN.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3YS64-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKRKKIALI GAGNIGGMIA YLIRLKNLGD VVLLDVNDGI AKGKALDMAE    50
    SSPVGKYNGE ILGTNNYADI EGADAIVVTA GITRKPGMSR EDLINTNVNI 100
    IKEVADNIGK YAPNAFVVVV TNPLDVMVFA MHKYSKLSSN MVVGMAGILD 150
    SARFSYFIAK ELNVSVDNVN SLVLGGHGDL MLPLVKYSSV AGISIADLIK 200
    IDLITQDKVD AIIERTRKGG EEIVSLLKIG SAYYAPAESA LLMIDSYLND 250
    RRLILPCSVY LKGEYGVSNL FVGVPVIIGR NGVEKIIELE LTEQEKNIFD 300
    NSVKLIKNLV SNV 313
    Length:313
    Mass (Da):33,762
    Last modified:September 27, 2005 - v1
    Checksum:i8CF3E7B4C1836F23
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000107 Genomic DNA. Translation: AAZ68441.1.
    RefSeqiYP_303039.1. NC_007354.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ68441; AAZ68441; Ecaj_0398.
    GeneIDi3617612.
    KEGGiecn:Ecaj_0398.
    PATRICi20574342. VBIEhrCan118076_0427.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000107 Genomic DNA. Translation: AAZ68441.1 .
    RefSeqi YP_303039.1. NC_007354.1.

    3D structure databases

    ProteinModelPortali Q3YS64.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269484.Ecaj_0398.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ68441 ; AAZ68441 ; Ecaj_0398 .
    GeneIDi 3617612.
    KEGGi ecn:Ecaj_0398.
    PATRICi 20574342. VBIEhrCan118076_0427.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi FVINVAN.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci ECAN269484:GI02-425-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the obligately intracellular bacterium Ehrlichia canis reveals themes of complex membrane structure and immune evasion strategies."
      Mavromatis K., Doyle C.K., Lykidis A., Ivanova N., Francino M.P., Chain P., Shin M., Malfatti S., Larimer F., Copeland A., Detter J.C., Land M., Richardson P.M., Yu X.J., Walker D.H., McBride J.W., Kyrpides N.C.
      J. Bacteriol. 188:4015-4023(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Jake.

    Entry informationi

    Entry nameiMDH_EHRCJ
    AccessioniPrimary (citable) accession number: Q3YS64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3