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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Ehrlichia canis (strain Jake)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei241ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECAN269484:G1G4X-458-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:Ecaj_0432
OrganismiEhrlichia canis (strain Jake)
Taxonomic identifieri269484 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
Proteomesi
  • UP000000435 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002373601 – 469Glutamate--tRNA ligase 1Add BLAST469

Proteomic databases

PRIDEiQ3YS31

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi269484.Ecaj_0432

Structurei

3D structure databases

ProteinModelPortaliQ3YS31
SMRiQ3YS31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 21"HIGH" regionUniRule annotationAdd BLAST11
Motifi238 – 242"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q3YS31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHDVITRFA PSPTGHLHLG GARTALFNWL YAKHNNGKFL LRIEDTDKKR
60 70 80 90 100
SSQELIDSII NAMSWLKIHY DGKAVLQSEN ISRHVEIANQ LMLNNKAYYC
110 120 130 140 150
YCSEEEINKE KEESAKKGLY YKHNCIWKNK SAPNSNITRV VRLKSPTDGV
160 170 180 190 200
TSFDDEVYGN ITVNNSQLDD MILLRSDNTP TYLLSVVVDD HDMNISHIIR
210 220 230 240 250
GTDHLTNTAR QLLIYNALEW DPPKFAHIPL IHDENGNKLS KRHQAIGIHE
260 270 280 290 300
YKNSGILPEA IFNYLLRMGW SHENDEVITI DQAIRWFSIE GIGQSPSRLD
310 320 330 340 350
SKKLEFLNNH YINITDNETI LNMIIPIIEE KTGHIITDVK KGYLLKGLSE
360 370 380 390 400
LKKRTKNLVN LAKESLFYVE DIPISIDQES ITVIKDYKHI FSILYDNLSK
410 420 430 440 450
ISEKDWNHNI LMSIIKDISC NLEVKISIVY HCLRASITGR MNAPSIIEIM
460
INLQHKECLQ RIKYALDVI
Length:469
Mass (Da):53,980
Last modified:September 27, 2005 - v1
Checksum:iF265F659A7DB3D4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000107 Genomic DNA Translation: AAZ68474.1
RefSeqiWP_011304552.1, NC_007354.1

Genome annotation databases

EnsemblBacteriaiAAZ68474; AAZ68474; Ecaj_0432
KEGGiecn:Ecaj_0432

Similar proteinsi

Entry informationi

Entry nameiSYE1_EHRCJ
AccessioniPrimary (citable) accession number: Q3YS31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: September 27, 2005
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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