Q3YS21 (ARGB_EHRCJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	Ecaj_0444

Organism

Ehrlichia canis (strain Jake) [Complete proteome] [HAMAP]

Taxonomic identifier

269484 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Ehrlichia

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Acetylglutamate kinase HAMAP MF_00082_B		PRO_0000264702
Regions
	Region	90 – 91	2	Substrate binding By similarity
Sites
	Binding site	112	1	Substrate By similarity
	Binding site	218	1	Substrate By similarity
	Site	55	1	Transition state stabilizer By similarity
	Site	278	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3YS21 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 4C3E072F93C74D20	FASTA	323	34,787
	10 20 30 40 50 60 MKLHNVLKNN NNNKEDVGPS IEQFGGNAEW FNTTKVLSEC LPYIQQFSGE TFVIKYGGAA 70 80 90 100 110 120 MTDRKLAESF AHDIVLLKQL GINPIVVHGG GNKINSFLEK INKKSTFING LRVTDAETLE 130 140 150 160 170 180 VVEMVLCGLV NKDITQLINK AGGNAIGLCG KDANLIEAKK VCYTYKENQS NNVEKILDMG 190 200 210 220 230 240 FVGEPHEVNT DLLFFIEESD FIPVIAPVCS GENNITYNVN ADLVAGALAN ALAAAKLIIL 250 260 270 280 290 300 TNVSGVTDAN GNLLSEISVS DAENLIEQGV ANSGMIPKLQ TCIKVVKEGY GSAHIIDGRI 310 320 PHVLLLELFT VHGTGTMVLG NDI

References

[1]

"The genome of the obligately intracellular bacterium Ehrlichia canis reveals themes of complex membrane structure and immune evasion strategies." Mavromatis K., Doyle C.K., Lykidis A., Ivanova N., Francino M.P., Chain P., Shin M., Malfatti S., Larimer F., Copeland A., Detter J.C., Land M., Richardson P.M., Yu X.J., Walker D.H., McBride J.W., Kyrpides N.C. J. Bacteriol. 188:4015-4023(2006) [PubMed: 16707693] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Jake.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000107 Genomic DNA. Translation: AAZ68484.1.
RefSeq	YP_303082.1. NC_007354.1.
3D structure databases
HSSP	HSSP built from PDB template 2BUF based on UniProtKB Q9HTN2.
ProteinModelPortal	Q3YS21.
SMR	Q3YS21. Positions 33-321.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3YS21.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3618049.
GenomeReviews	Gene locus Ecaj_0444 in contig CP000107_GR.
KEGG	ecn:Ecaj_0444.
PATRIC	20574448. VBIEhrCan118076_0479.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HBG497643.
OMA	GGNAMID.
PhylomeDB	Q3YS21.
ProtClustDB	PRK00942.
Enzyme and pathway databases
BioCyc	ECAN269484:ECAJ_0444-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_EHRCJ

Accession

Primary (citable) accession number: Q3YS21

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	September 27, 2005
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program