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Q3YRJ8 (Q3YRJ8_EHRCJ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase HAMAP MF_00323 RuleBase RU000607
EC=4.99.1.1 HAMAP MF_00323 RuleBase RU000607
Alternative name(s):
Heme synthase HAMAP MF_00323
Protoheme ferro-lyase HAMAP MF_00323
Gene names
Name:hemH HAMAP MF_00323
Ordered Locus Names:Ecaj_0623
OrganismEhrlichia canis (strain Jake) [Complete proteome] [HAMAP]
Taxonomic identifier269484 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Ehrlichia

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family. HAMAP MF_00323 RuleBase RU004185

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding1941Iron By similarity HAMAP MF_00323
Metal binding2741Iron By similarity HAMAP MF_00323

Sequences

Sequence LengthMass (Da)Tools
Q3YRJ8 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: EF99797950B53413

FASTA33739,035
        10         20         30         40         50         60 
MSKIAVVLFN LGGPQSLSEV RSFLFNLFYD KNIINLANPL RFILATLISF FRKKKAIGIY 

        70         80         90        100        110        120 
KHLNGQSPIL KETKIQASSL ENILNDNNDN QYQVFIFMRY SQPSAKDTVE SVCQYNPDKI 

       130        140        150        160        170        180 
ILLPLYPHYS TTTTLSAIQH WNYYMNKSNL QFSTSTVCCY YNNTNYIKAQ CQLIIEKYQE 

       190        200        210        220        230        240 
AQKYGLPRVL FSAHSLPISI MQQGDPYQHQ IEKNVLLITK FLNIPELDYK ICYQSKVGPV 

       250        260        270        280        290        300 
KWLEPSTISE IKQAKQDNVP IVLVPISFVS ENSETLVELD IDYKAIISKE NMFFRVPTLS 

       310        320        330 
NNGYYIKCLK EICMQDHKNT CPTKCKMCFR YLTNSYL

« Hide

References

[1]"The genome of the obligately intracellular bacterium Ehrlichia canis reveals themes of complex membrane structure and immune evasion strategies."
Mavromatis K., Doyle C.K., Lykidis A., Ivanova N., Francino M.P., Chain P., Shin M., Malfatti S., Larimer F., Copeland A., Detter J.C., Land M., Richardson P.M., Yu X.J., Walker D.H., McBride J.W., Kyrpides N.C.
J. Bacteriol. 188:4015-4023(2006) [PubMed: 16707693] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000107 Genomic DNA. Translation: AAZ68657.1.
RefSeqYP_303255.1. NC_007354.1.

3D structure databases

ProteinModelPortalQ3YRJ8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3YRJ8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3618166.
GenomeReviewsGene locus Ecaj_0623 in contig CP000107_GR.
KEGGecn:Ecaj_0623.
PATRIC20574846. VBIEhrCan118076_0671.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMASWYDEPK.
PhylomeDBQ3YRJ8.
ProtClustDBPRK00035.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ3YRJ8_EHRCJ
AccessionPrimary (citable) accession number: Q3YRJ8
Entry history
Integrated into UniProtKB/TrEMBL: September 27, 2005
Last sequence update: September 27, 2005
Last modified: December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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