Q3YEC7 (RABL6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rab-like protein 6

Alternative name(s):
GTP-binding protein Parf
Partner of ARF
Rab-like protein 1
Short name=RBEL1

Gene names

Name:	RABL6
Synonyms:	C9orf86, PARF

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	729 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. Ref.1
Subcellular location	Isoform 1: Cytoplasm. Note: Predominantly cytoplasmic. Ref.1 Ref.2 Ref.3 Isoform 3: Nucleus. Note: Predominantly nuclear. Ref.1 Ref.2 Ref.3
Post-translational modification	Isoform 1 is O-glycosylated, while other isoforms are not. Ref.2
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.
Sequence caution	The sequence AAH02945.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH21095.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH35786.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB14408.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB55213.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	GTP-binding Nucleotide-binding
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	centrosome Inferred from direct assay. Source: HPA cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MDFI	Q99750	2	EBI-742029,EBI-724076
SPINK7	P58062	3	EBI-742029,EBI-1182445

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q3YEC7-1)

Also known as: RBEL1A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Predominant isoform. Overexpressed in about 67% of primary breast tumors.

Isoform 2 (identifier: Q3YEC7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     199-199: D → DS

Isoform 3 (identifier: Q3YEC7-3)

Also known as: RBEL1B;

The sequence of this isoform differs from the canonical sequence as follows:
     361-729: LFGTSPATEA...HPGGGDYEEL → PPPWGWRLRG...AYGSASGREP

Note: No experimental confirmation available.

Isoform 4 (identifier: Q3YEC7-4)

Also known as: RBEL1D;

The sequence of this isoform differs from the canonical sequence as follows:
     236-264: RETLLRQLETNQLDMDATLEELSVQQETE → VSTHHVGWSGCWSLTSFQVSPV
     265-729: Missing.

Isoform 5 (identifier: Q3YEC7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     199-199: D → DS
     236-264: RETLLRQLETNQLDMDATLEELSVQQETE → VSTHHVGWSGCWSLTSFQVSPV
     265-729: Missing.

Isoform 6 (identifier: Q3YEC7-6)

Also known as: RBEL1C;

The sequence of this isoform differs from the canonical sequence as follows:
     236-302: RETLLRQLET...PSPGSQSPVV → KDVRLAQERG...SSPLLSCSIP
     303-729: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 729	729	Rab-like protein 6		PRO_0000274223
Regions
	Nucleotide binding	50 – 57	8	GTP Potential
	Nucleotide binding	100 – 104	5	GTP Potential
	Nucleotide binding	177 – 179	3	GTP Potential
	Region	39 – 279	241	Small GTPase-like
	Region	655 – 693	39	Interaction with CDKN2A
	Compositional bias	293 – 384	92	Pro-rich
	Compositional bias	645 – 685	41	Lys-rich
Amino acid modifications
	Modified residue	356	1	Phosphoserine Ref.12
	Modified residue	402	1	Phosphoserine Ref.10
	Modified residue	425	1	Phosphoserine Ref.11 Ref.12 Ref.14
	Modified residue	427	1	Phosphoserine Ref.11 Ref.12 Ref.14
	Modified residue	470	1	Phosphoserine By similarity
	Modified residue	471	1	Phosphoserine By similarity
	Modified residue	577	1	Phosphoserine Ref.9
	Modified residue	596	1	Phosphoserine Ref.9 Ref.12 Ref.14
	Modified residue	599	1	Phosphothreonine Ref.9 Ref.12 Ref.14
Natural variations
	Alternative sequence	199	1	D → DS in isoform 2 and isoform 5.		VSP_022646
	Alternative sequence	236 – 302	67	RETLL…QSPVV → KDVRLAQERGCAVVLVSEEV RMPAGWDCCWGRLGWKEGGS QTCPVPALLGRPLLPAEPSP HHWVDYSLESSPLLSCSIP in isoform 6.		VSP_042559
	Alternative sequence	236 – 264	29	RETLL…QQETE → VSTHHVGWSGCWSLTSFQVS PV in isoform 4 and isoform 5.		VSP_022647
	Alternative sequence	265 – 729	465	Missing in isoform 4 and isoform 5.		VSP_022648
	Alternative sequence	303 – 729	427	Missing in isoform 6.		VSP_042560
	Alternative sequence	361 – 729	369	LFGTS…DYEEL → PPPWGWRLRGALGRRGQWPP WGGGRACHCLGRHLPLYHRL CRCPVAAVCASELEEAGHWW SPGWALQVLGLQAQCEPALQ EGRGQLASARLGGHPGPLGA EPPVFLRDVTEAQEGPVRVC LQRLGRGRLAVGCALPRHLL ALRAHLGPQHAYGSASGREP in isoform 3.		VSP_022649
	Natural variant	382	1	E → Q. Ref.1 Ref.5 Ref.6 Ref.7 Corresponds to variant rs2811741 [ dbSNP | Ensembl ].		VAR_030210
Experimental info
	Sequence conflict	137	1	Y → C in BAB14408. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (RBEL1A) [UniParc]. Last modified February 6, 2007. Version 2. Checksum: 6C3FDB38C7FD7D59	FASTA	729	79,549
	10 20 30 40 50 60 MFSALKKLVG SDQAPGRDKN IPAGLQSMNQ ALQRRFAKGV QYNMKIVIRG DRNTGKTALW 70 80 90 100 110 120 HRLQGRPFVE EYIPTQEIQV TSIHWSYKTT DDIVKVEVWD VVDKGKCKKR GDGLKMENDP 130 140 150 160 170 180 QEAESEMALD AEFLDVYKNC NGVVMMFDIT KQWTFNYILR ELPKVPTHVP VCVLGNYRDM 190 200 210 220 230 240 GEHRVILPDD VRDFIDNLDR PPGSSYFRYA ESSMKNSFGL KYLHKFFNIP FLQLQRETLL 250 260 270 280 290 300 RQLETNQLDM DATLEELSVQ QETEDQNYGI FLEMMEARSR GHASPLAANG QSPSPGSQSP 310 320 330 340 350 360 VVPAGAVSTG SSSPGTPQPA PQLPLNAAPP SSVPPVPPSE ALPPPACPSA PAPRRSIISR 370 380 390 400 410 420 LFGTSPATEA APPPPEPVPA AEGPATVQSV EDFVPDDRLD RSFLEDTTPA RDEKKVGAKA 430 440 450 460 470 480 AQQDSDSDGE ALGGNPMVAG FQDDVDLEDQ PRGSPPLPAG PVPSQDITLS SEEEAEVAAP 490 500 510 520 530 540 TKGPAPAPQQ CSEPETKWSS IPASKPRRGT APTRTAAPPW PGGVSVRTGP EKRSSTRPPA 550 560 570 580 590 600 EMEPGKGEQA SSSESDPEGP IAAQMLSFVM DDPDFESEGS DTQRRADDFP VRDDPSDVTD 610 620 630 640 650 660 EDEGPAEPPP PPKLPLPAFR LKNDSDLFGL GLEEAGPKES SEEGKEGKTP SKEKKKKKKK 670 680 690 700 710 720 GKEEEEKAAK KKSKHKKSKD KEEGKEERRR RQQRPPRSRE RTAADELEAF LGGGAPGGRH PGGGDYEEL
	Isoform 2 [UniParc]. Checksum: 76CED43E38D6167F	FASTA	730	79,636
	10 20 30 40 50 60 MFSALKKLVG SDQAPGRDKN IPAGLQSMNQ ALQRRFAKGV QYNMKIVIRG DRNTGKTALW 70 80 90 100 110 120 HRLQGRPFVE EYIPTQEIQV TSIHWSYKTT DDIVKVEVWD VVDKGKCKKR GDGLKMENDP 130 140 150 160 170 180 QEAESEMALD AEFLDVYKNC NGVVMMFDIT KQWTFNYILR ELPKVPTHVP VCVLGNYRDM 190 200 210 220 230 240 GEHRVILPDD VRDFIDNLDS RPPGSSYFRY AESSMKNSFG LKYLHKFFNI PFLQLQRETL 250 260 270 280 290 300 LRQLETNQLD MDATLEELSV QQETEDQNYG IFLEMMEARS RGHASPLAAN GQSPSPGSQS 310 320 330 340 350 360 PVVPAGAVST GSSSPGTPQP APQLPLNAAP PSSVPPVPPS EALPPPACPS APAPRRSIIS 370 380 390 400 410 420 RLFGTSPATE AAPPPPEPVP AAEGPATVQS VEDFVPDDRL DRSFLEDTTP ARDEKKVGAK 430 440 450 460 470 480 AAQQDSDSDG EALGGNPMVA GFQDDVDLED QPRGSPPLPA GPVPSQDITL SSEEEAEVAA 490 500 510 520 530 540 PTKGPAPAPQ QCSEPETKWS SIPASKPRRG TAPTRTAAPP WPGGVSVRTG PEKRSSTRPP 550 560 570 580 590 600 AEMEPGKGEQ ASSSESDPEG PIAAQMLSFV MDDPDFESEG SDTQRRADDF PVRDDPSDVT 610 620 630 640 650 660 DEDEGPAEPP PPPKLPLPAF RLKNDSDLFG LGLEEAGPKE SSEEGKEGKT PSKEKKKKKK 670 680 690 700 710 720 KGKEEEEKAA KKKSKHKKSK DKEEGKEERR RRQQRPPRSR ERTAADELEA FLGGGAPGGR 730 HPGGGDYEEL
	Isoform 3 (RBEL1B) [UniParc]. Checksum: ABB2BD2287F358BF	FASTA	520	57,397
	10 20 30 40 50 60 MFSALKKLVG SDQAPGRDKN IPAGLQSMNQ ALQRRFAKGV QYNMKIVIRG DRNTGKTALW 70 80 90 100 110 120 HRLQGRPFVE EYIPTQEIQV TSIHWSYKTT DDIVKVEVWD VVDKGKCKKR GDGLKMENDP 130 140 150 160 170 180 QEAESEMALD AEFLDVYKNC NGVVMMFDIT KQWTFNYILR ELPKVPTHVP VCVLGNYRDM 190 200 210 220 230 240 GEHRVILPDD VRDFIDNLDR PPGSSYFRYA ESSMKNSFGL KYLHKFFNIP FLQLQRETLL 250 260 270 280 290 300 RQLETNQLDM DATLEELSVQ QETEDQNYGI FLEMMEARSR GHASPLAANG QSPSPGSQSP 310 320 330 340 350 360 VVPAGAVSTG SSSPGTPQPA PQLPLNAAPP SSVPPVPPSE ALPPPACPSA PAPRRSIISR 370 380 390 400 410 420 PPPWGWRLRG ALGRRGQWPP WGGGRACHCL GRHLPLYHRL CRCPVAAVCA SELEEAGHWW 430 440 450 460 470 480 SPGWALQVLG LQAQCEPALQ EGRGQLASAR LGGHPGPLGA EPPVFLRDVT EAQEGPVRVC 490 500 510 520 LQRLGRGRLA VGCALPRHLL ALRAHLGPQH AYGSASGREP
	Isoform 4 (RBEL1D) [UniParc]. Checksum: B086094A0AA8FCB0	FASTA	257	29,585
	10 20 30 40 50 60 MFSALKKLVG SDQAPGRDKN IPAGLQSMNQ ALQRRFAKGV QYNMKIVIRG DRNTGKTALW 70 80 90 100 110 120 HRLQGRPFVE EYIPTQEIQV TSIHWSYKTT DDIVKVEVWD VVDKGKCKKR GDGLKMENDP 130 140 150 160 170 180 QEAESEMALD AEFLDVYKNC NGVVMMFDIT KQWTFNYILR ELPKVPTHVP VCVLGNYRDM 190 200 210 220 230 240 GEHRVILPDD VRDFIDNLDR PPGSSYFRYA ESSMKNSFGL KYLHKFFNIP FLQLQVSTHH 250 VGWSGCWSLT SFQVSPV
	Isoform 5 [UniParc]. Checksum: 99980CF4224BDA2F	FASTA	258	29,672
	10 20 30 40 50 60 MFSALKKLVG SDQAPGRDKN IPAGLQSMNQ ALQRRFAKGV QYNMKIVIRG DRNTGKTALW 70 80 90 100 110 120 HRLQGRPFVE EYIPTQEIQV TSIHWSYKTT DDIVKVEVWD VVDKGKCKKR GDGLKMENDP 130 140 150 160 170 180 QEAESEMALD AEFLDVYKNC NGVVMMFDIT KQWTFNYILR ELPKVPTHVP VCVLGNYRDM 190 200 210 220 230 240 GEHRVILPDD VRDFIDNLDS RPPGSSYFRY AESSMKNSFG LKYLHKFFNI PFLQLQVSTH 250 HVGWSGCWSL TSFQVSPV
	Isoform 6 (RBEL1C) [UniParc]. Checksum: 64FCC800FAB9C14E	FASTA	314	35,809
	10 20 30 40 50 60 MFSALKKLVG SDQAPGRDKN IPAGLQSMNQ ALQRRFAKGV QYNMKIVIRG DRNTGKTALW 70 80 90 100 110 120 HRLQGRPFVE EYIPTQEIQV TSIHWSYKTT DDIVKVEVWD VVDKGKCKKR GDGLKMENDP 130 140 150 160 170 180 QEAESEMALD AEFLDVYKNC NGVVMMFDIT KQWTFNYILR ELPKVPTHVP VCVLGNYRDM 190 200 210 220 230 240 GEHRVILPDD VRDFIDNLDR PPGSSYFRYA ESSMKNSFGL KYLHKFFNIP FLQLQKDVRL 250 260 270 280 290 300 AQERGCAVVL VSEEVRMPAG WDCCWGRLGW KEGGSQTCPV PALLGRPLLP AEPSPHHWVD 310 YSLESSPLLS CSIP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of novel ARF binding proteins by two-hybrid screening." Tompkins V., Hagen J., Zediak V.P., Quelle D.E. Cell Cycle 5:641-646(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLN-382, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CDKN2A.
[2]	"RBEL1 is a novel gene that encodes a nucleocytoplasmic Ras superfamily GTP-binding protein and is overexpressed in breast cancer." Montalbano J., Jin W., Sheikh M.S., Huang Y. J. Biol. Chem. 282:37640-37649(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), ALTERNATIVE SPLICING, GLYCOSYLATION, SUBCELLULAR LOCATION.
[3]	"Identification and characterization of RBEL1 subfamily of GTPases in the Ras superfamily involved in cell growth regulation." Montalbano J., Lui K., Sheikh M.S., Huang Y. J. Biol. Chem. 284:18129-18142(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 6), SUBCELLULAR LOCATION.
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Lin L., Nong W., Li H., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Wen S., Zhou G., Yang S. Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-382.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT GLN-382. Tissue: Brain and Kidney.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-729 (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-729 (ISOFORM 1), VARIANT GLN-382.
[8]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 251-719. Tissue: Brain.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-577; SER-596 AND THR-599, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425 AND SER-427, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356; SER-425; SER-427; SER-596 AND THR-599, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425; SER-427; SER-596 AND THR-599, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ141240 mRNA. Translation: AAZ73768.1. EF156752 mRNA. Translation: ABO84837.1. EF156753 mRNA. Translation: ABO84838.1. GQ169126 mRNA. Translation: ACS45171.1. GQ169127 mRNA. Translation: ACS45172.1. AL355987 Genomic DNA. Translation: CAI12685.1. AL355987 Genomic DNA. Translation: CAI12686.1. DQ099383 mRNA. Translation: AAZ13759.1. BC002945 mRNA. Translation: AAH02945.2. Different initiation. BC021095 mRNA. Translation: AAH21095.2. Different initiation. BC035786 mRNA. Translation: AAH35786.1. Different initiation. AK023107 mRNA. Translation: BAB14408.1. Different initiation. AK027586 mRNA. Translation: BAB55213.1. Different initiation. AL713707 mRNA. Translation: CAD28504.1.
IPI	IPI00186586. IPI00514888. IPI00827825. IPI00827874. IPI00827967. IPI00827972.
RefSeq	NP_001167459.1. NM_001173988.1. NP_001167460.1. NM_001173989.2. NP_078994.3. NM_024718.4.
UniGene	Hs.370555.
3D structure databases
ProteinModelPortal	Q3YEC7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q3YEC7. 5 interactions.
PTM databases
PhosphoSite	Q3YEC7.
Polymorphism databases
DMDM	125957950.
Proteomic databases
PaxDb	Q3YEC7.
PRIDE	Q3YEC7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000311502; ENSP00000311134; ENSG00000196642. ENST00000357466; ENSP00000350056; ENSG00000196642. ENST00000371663; ENSP00000360727; ENSG00000196642. ENST00000371671; ENSP00000360736; ENSG00000196642.
GeneID	55684.
KEGG	hsa:55684.
UCSC	uc004cji.1. human. uc004cjj.1. human.
Organism-specific databases
CTD	55684.
GeneCards	GC09P139695.
HGNC	HGNC:24703. RABL6.
HPA	HPA044037.
MIM	610615. gene.
neXtProt	NX_Q3YEC7.
PharmGKB	PA134868176.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG138310.
HOGENOM	HOG000015428.
HOVERGEN	HBG080325.
InParanoid	Q3YEC7.
OrthoDB	EOG4K6G4S.
PhylomeDB	Q3YEC7.
Gene expression databases
ArrayExpress	Q3YEC7.
Bgee	Q3YEC7.
Genevestigator	Q3YEC7.
Family and domain databases
InterPro	IPR013684. MIRO-like. IPR001806. Small_GTPase. [Graphical view]
Pfam	PF08477. Miro. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	C9orf86. human.
GenomeRNAi	55684.
NextBio	60481.
SOURCE	Search...

Entry information

Entry name

RABL6_HUMAN

Accession

Primary (citable) accession number: Q3YEC7
Secondary accession number(s): A8QVZ7 , A8QVZ8, C6K8I4, C6K8I5, Q4F968, Q5T5R7, Q8IWK1, Q8TCL4, Q8WU94, Q96SR8, Q9BU21, Q9H935

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	May 1, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.