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Q3YEC7

- RABL6_HUMAN

UniProt

Q3YEC7 - RABL6_HUMAN

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Protein

Rab-like protein 6

Gene
RABL6, C9orf86, PARF
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi50 – 578GTP Reviewed prediction
Nucleotide bindingi100 – 1045GTP Reviewed prediction
Nucleotide bindingi177 – 1793GTP Reviewed prediction

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. protein binding Source: IntAct

GO - Biological processi

  1. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rab-like protein 6
Alternative name(s):
GTP-binding protein Parf
Partner of ARF
Rab-like protein 1
Short name:
RBEL1
Gene namesi
Name:RABL6
Synonyms:C9orf86, PARF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:24703. RABL6.

Subcellular locationi

Isoform 1 : Cytoplasm
Note: Predominantly cytoplasmic.3 Publications
Isoform 3 : Nucleus
Note: Predominantly nuclear.3 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134868176.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Rab-like protein 6PRO_0000274223Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei402 – 4021Phosphoserine1 Publication
Modified residuei425 – 4251Phosphoserine3 Publications
Modified residuei427 – 4271Phosphoserine3 Publications
Modified residuei470 – 4701Phosphoserine By similarity
Modified residuei471 – 4711Phosphoserine By similarity
Modified residuei577 – 5771Phosphoserine1 Publication
Modified residuei596 – 5961Phosphoserine3 Publications
Modified residuei599 – 5991Phosphothreonine3 Publications

Post-translational modificationi

Isoform 1 is O-glycosylated, while other isoforms are not.1 Publication

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ3YEC7.
PaxDbiQ3YEC7.
PRIDEiQ3YEC7.

PTM databases

PhosphoSiteiQ3YEC7.

Expressioni

Gene expression databases

ArrayExpressiQ3YEC7.
BgeeiQ3YEC7.
GenevestigatoriQ3YEC7.

Organism-specific databases

HPAiHPA044037.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MDFIQ997502EBI-742029,EBI-724076
SPINK7P580623EBI-742029,EBI-1182445

Protein-protein interaction databases

BioGridi120812. 20 interactions.
IntActiQ3YEC7. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ3YEC7.
SMRiQ3YEC7. Positions 41-239.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni39 – 279241Small GTPase-likeAdd
BLAST
Regioni655 – 69339Interaction with CDKN2AAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi293 – 38492Pro-richAdd
BLAST
Compositional biasi645 – 68541Lys-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG138310.
HOGENOMiHOG000015428.
HOVERGENiHBG080325.
InParanoidiQ3YEC7.
OMAiGRACHCL.
PhylomeDBiQ3YEC7.
TreeFamiTF313974.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF08477. Miro. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3YEC7-1) [UniParc]FASTAAdd to Basket

Also known as: RBEL1A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFSALKKLVG SDQAPGRDKN IPAGLQSMNQ ALQRRFAKGV QYNMKIVIRG    50
DRNTGKTALW HRLQGRPFVE EYIPTQEIQV TSIHWSYKTT DDIVKVEVWD 100
VVDKGKCKKR GDGLKMENDP QEAESEMALD AEFLDVYKNC NGVVMMFDIT 150
KQWTFNYILR ELPKVPTHVP VCVLGNYRDM GEHRVILPDD VRDFIDNLDR 200
PPGSSYFRYA ESSMKNSFGL KYLHKFFNIP FLQLQRETLL RQLETNQLDM 250
DATLEELSVQ QETEDQNYGI FLEMMEARSR GHASPLAANG QSPSPGSQSP 300
VVPAGAVSTG SSSPGTPQPA PQLPLNAAPP SSVPPVPPSE ALPPPACPSA 350
PAPRRSIISR LFGTSPATEA APPPPEPVPA AEGPATVQSV EDFVPDDRLD 400
RSFLEDTTPA RDEKKVGAKA AQQDSDSDGE ALGGNPMVAG FQDDVDLEDQ 450
PRGSPPLPAG PVPSQDITLS SEEEAEVAAP TKGPAPAPQQ CSEPETKWSS 500
IPASKPRRGT APTRTAAPPW PGGVSVRTGP EKRSSTRPPA EMEPGKGEQA 550
SSSESDPEGP IAAQMLSFVM DDPDFESEGS DTQRRADDFP VRDDPSDVTD 600
EDEGPAEPPP PPKLPLPAFR LKNDSDLFGL GLEEAGPKES SEEGKEGKTP 650
SKEKKKKKKK GKEEEEKAAK KKSKHKKSKD KEEGKEERRR RQQRPPRSRE 700
RTAADELEAF LGGGAPGGRH PGGGDYEEL 729

Note: Predominant isoform. Overexpressed in about 67% of primary breast tumors.

Length:729
Mass (Da):79,549
Last modified:February 6, 2007 - v2
Checksum:i6C3FDB38C7FD7D59
GO
Isoform 2 (identifier: Q3YEC7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     199-199: D → DS

Show »
Length:730
Mass (Da):79,636
Checksum:i76CED43E38D6167F
GO
Isoform 3 (identifier: Q3YEC7-3) [UniParc]FASTAAdd to Basket

Also known as: RBEL1B

The sequence of this isoform differs from the canonical sequence as follows:
     361-729: LFGTSPATEA...HPGGGDYEEL → PPPWGWRLRG...AYGSASGREP

Note: No experimental confirmation available.

Show »
Length:520
Mass (Da):57,397
Checksum:iABB2BD2287F358BF
GO
Isoform 4 (identifier: Q3YEC7-4) [UniParc]FASTAAdd to Basket

Also known as: RBEL1D

The sequence of this isoform differs from the canonical sequence as follows:
     236-264: RETLLRQLETNQLDMDATLEELSVQQETE → VSTHHVGWSGCWSLTSFQVSPV
     265-729: Missing.

Show »
Length:257
Mass (Da):29,585
Checksum:iB086094A0AA8FCB0
GO
Isoform 5 (identifier: Q3YEC7-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     199-199: D → DS
     236-264: RETLLRQLETNQLDMDATLEELSVQQETE → VSTHHVGWSGCWSLTSFQVSPV
     265-729: Missing.

Show »
Length:258
Mass (Da):29,672
Checksum:i99980CF4224BDA2F
GO
Isoform 6 (identifier: Q3YEC7-6) [UniParc]FASTAAdd to Basket

Also known as: RBEL1C

The sequence of this isoform differs from the canonical sequence as follows:
     236-302: RETLLRQLET...PSPGSQSPVV → KDVRLAQERG...SSPLLSCSIP
     303-729: Missing.

Show »
Length:314
Mass (Da):35,809
Checksum:i64FCC800FAB9C14E
GO

Sequence cautioni

The sequence AAH02945.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAH21095.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAH35786.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB14408.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB55213.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti382 – 3821E → Q.4 Publications
Corresponds to variant rs2811741 [ dbSNP | Ensembl ].
VAR_030210

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei199 – 1991D → DS in isoform 2 and isoform 5. VSP_022646
Alternative sequencei236 – 30267RETLL…QSPVV → KDVRLAQERGCAVVLVSEEV RMPAGWDCCWGRLGWKEGGS QTCPVPALLGRPLLPAEPSP HHWVDYSLESSPLLSCSIP in isoform 6. VSP_042559Add
BLAST
Alternative sequencei236 – 26429RETLL…QQETE → VSTHHVGWSGCWSLTSFQVS PV in isoform 4 and isoform 5. VSP_022647Add
BLAST
Alternative sequencei265 – 729465Missing in isoform 4 and isoform 5. VSP_022648Add
BLAST
Alternative sequencei303 – 729427Missing in isoform 6. VSP_042560Add
BLAST
Alternative sequencei361 – 729369LFGTS…DYEEL → PPPWGWRLRGALGRRGQWPP WGGGRACHCLGRHLPLYHRL CRCPVAAVCASELEEAGHWW SPGWALQVLGLQAQCEPALQ EGRGQLASARLGGHPGPLGA EPPVFLRDVTEAQEGPVRVC LQRLGRGRLAVGCALPRHLL ALRAHLGPQHAYGSASGREP in isoform 3. VSP_022649Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371Y → C in BAB14408. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ141240 mRNA. Translation: AAZ73768.1.
EF156752 mRNA. Translation: ABO84837.1.
EF156753 mRNA. Translation: ABO84838.1.
GQ169126 mRNA. Translation: ACS45171.1.
GQ169127 mRNA. Translation: ACS45172.1.
AL355987 Genomic DNA. Translation: CAI12685.1.
AL355987 Genomic DNA. Translation: CAI12686.1.
DQ099383 mRNA. Translation: AAZ13759.1.
BC002945 mRNA. Translation: AAH02945.2. Different initiation.
BC021095 mRNA. Translation: AAH21095.2. Different initiation.
BC035786 mRNA. Translation: AAH35786.1. Different initiation.
AK023107 mRNA. Translation: BAB14408.1. Different initiation.
AK027586 mRNA. Translation: BAB55213.1. Different initiation.
AL713707 mRNA. Translation: CAD28504.1.
CCDSiCCDS48058.1. [Q3YEC7-1]
CCDS55352.1. [Q3YEC7-2]
CCDS55353.1. [Q3YEC7-6]
RefSeqiNP_001167459.1. NM_001173988.1. [Q3YEC7-2]
NP_001167460.1. NM_001173989.2. [Q3YEC7-6]
NP_078994.3. NM_024718.4. [Q3YEC7-1]
UniGeneiHs.370555.

Genome annotation databases

EnsembliENST00000311502; ENSP00000311134; ENSG00000196642. [Q3YEC7-1]
ENST00000357466; ENSP00000350056; ENSG00000196642. [Q3YEC7-3]
ENST00000371663; ENSP00000360727; ENSG00000196642. [Q3YEC7-2]
ENST00000371671; ENSP00000360736; ENSG00000196642. [Q3YEC7-6]
GeneIDi55684.
KEGGihsa:55684.
UCSCiuc004cjh.3. human. [Q3YEC7-6]
uc004cji.1. human. [Q3YEC7-1]
uc004cjj.1. human. [Q3YEC7-2]
uc004cjm.2. human. [Q3YEC7-4]

Polymorphism databases

DMDMi125957950.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ141240 mRNA. Translation: AAZ73768.1 .
EF156752 mRNA. Translation: ABO84837.1 .
EF156753 mRNA. Translation: ABO84838.1 .
GQ169126 mRNA. Translation: ACS45171.1 .
GQ169127 mRNA. Translation: ACS45172.1 .
AL355987 Genomic DNA. Translation: CAI12685.1 .
AL355987 Genomic DNA. Translation: CAI12686.1 .
DQ099383 mRNA. Translation: AAZ13759.1 .
BC002945 mRNA. Translation: AAH02945.2 . Different initiation.
BC021095 mRNA. Translation: AAH21095.2 . Different initiation.
BC035786 mRNA. Translation: AAH35786.1 . Different initiation.
AK023107 mRNA. Translation: BAB14408.1 . Different initiation.
AK027586 mRNA. Translation: BAB55213.1 . Different initiation.
AL713707 mRNA. Translation: CAD28504.1 .
CCDSi CCDS48058.1. [Q3YEC7-1 ]
CCDS55352.1. [Q3YEC7-2 ]
CCDS55353.1. [Q3YEC7-6 ]
RefSeqi NP_001167459.1. NM_001173988.1. [Q3YEC7-2 ]
NP_001167460.1. NM_001173989.2. [Q3YEC7-6 ]
NP_078994.3. NM_024718.4. [Q3YEC7-1 ]
UniGenei Hs.370555.

3D structure databases

ProteinModelPortali Q3YEC7.
SMRi Q3YEC7. Positions 41-239.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120812. 20 interactions.
IntActi Q3YEC7. 5 interactions.

PTM databases

PhosphoSitei Q3YEC7.

Polymorphism databases

DMDMi 125957950.

Proteomic databases

MaxQBi Q3YEC7.
PaxDbi Q3YEC7.
PRIDEi Q3YEC7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311502 ; ENSP00000311134 ; ENSG00000196642 . [Q3YEC7-1 ]
ENST00000357466 ; ENSP00000350056 ; ENSG00000196642 . [Q3YEC7-3 ]
ENST00000371663 ; ENSP00000360727 ; ENSG00000196642 . [Q3YEC7-2 ]
ENST00000371671 ; ENSP00000360736 ; ENSG00000196642 . [Q3YEC7-6 ]
GeneIDi 55684.
KEGGi hsa:55684.
UCSCi uc004cjh.3. human. [Q3YEC7-6 ]
uc004cji.1. human. [Q3YEC7-1 ]
uc004cjj.1. human. [Q3YEC7-2 ]
uc004cjm.2. human. [Q3YEC7-4 ]

Organism-specific databases

CTDi 55684.
GeneCardsi GC09P139702.
HGNCi HGNC:24703. RABL6.
HPAi HPA044037.
MIMi 610615. gene.
neXtProti NX_Q3YEC7.
PharmGKBi PA134868176.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG138310.
HOGENOMi HOG000015428.
HOVERGENi HBG080325.
InParanoidi Q3YEC7.
OMAi GRACHCL.
PhylomeDBi Q3YEC7.
TreeFami TF313974.

Miscellaneous databases

ChiTaRSi C9orf86. human.
GeneWikii C9orf86.
GenomeRNAii 55684.
NextBioi 60481.
PROi Q3YEC7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q3YEC7.
Bgeei Q3YEC7.
Genevestigatori Q3YEC7.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view ]
Pfami PF08477. Miro. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel ARF binding proteins by two-hybrid screening."
    Tompkins V., Hagen J., Zediak V.P., Quelle D.E.
    Cell Cycle 5:641-646(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLN-382, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CDKN2A.
  2. "RBEL1 is a novel gene that encodes a nucleocytoplasmic Ras superfamily GTP-binding protein and is overexpressed in breast cancer."
    Montalbano J., Jin W., Sheikh M.S., Huang Y.
    J. Biol. Chem. 282:37640-37649(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), ALTERNATIVE SPLICING, GLYCOSYLATION, SUBCELLULAR LOCATION.
  3. "Identification and characterization of RBEL1 subfamily of GTPases in the Ras superfamily involved in cell growth regulation."
    Montalbano J., Lui K., Sheikh M.S., Huang Y.
    J. Biol. Chem. 284:18129-18142(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 6), SUBCELLULAR LOCATION.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Lin L., Nong W., Li H., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Wen S., Zhou G., Yang S.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-382.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT GLN-382.
    Tissue: Brain and Kidney.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-729 (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-729 (ISOFORM 1), VARIANT GLN-382.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 251-719.
    Tissue: Brain.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-577; SER-596 AND THR-599, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425 AND SER-427, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425; SER-427; SER-596 AND THR-599, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425; SER-427; SER-596 AND THR-599, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRABL6_HUMAN
AccessioniPrimary (citable) accession number: Q3YEC7
Secondary accession number(s): A8QVZ7
, A8QVZ8, C6K8I4, C6K8I5, Q4F968, Q5T5R7, Q8IWK1, Q8TCL4, Q8WU94, Q96SR8, Q9BU21, Q9H935
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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