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Q3YEC7

- RABL6_HUMAN

UniProt

Q3YEC7 - RABL6_HUMAN

Protein

Rab-like protein 6

Gene

RABL6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi50 – 578GTPSequence Analysis
    Nucleotide bindingi100 – 1045GTPSequence Analysis
    Nucleotide bindingi177 – 1793GTPSequence Analysis

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rab-like protein 6
    Alternative name(s):
    GTP-binding protein Parf
    Partner of ARF
    Rab-like protein 1
    Short name:
    RBEL1
    Gene namesi
    Name:RABL6
    Synonyms:C9orf86, PARF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:24703. RABL6.

    Subcellular locationi

    Isoform 1 : Cytoplasm
    Note: Predominantly cytoplasmic.
    Isoform 3 : Nucleus
    Note: Predominantly nuclear.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134868176.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 729729Rab-like protein 6PRO_0000274223Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei402 – 4021Phosphoserine1 Publication
    Modified residuei425 – 4251Phosphoserine3 Publications
    Modified residuei427 – 4271Phosphoserine3 Publications
    Modified residuei470 – 4701PhosphoserineBy similarity
    Modified residuei471 – 4711PhosphoserineBy similarity
    Modified residuei577 – 5771Phosphoserine1 Publication
    Modified residuei596 – 5961Phosphoserine3 Publications
    Modified residuei599 – 5991Phosphothreonine3 Publications

    Post-translational modificationi

    Isoform 1 is O-glycosylated, while other isoforms are not.1 Publication

    Keywords - PTMi

    Acetylation, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ3YEC7.
    PaxDbiQ3YEC7.
    PRIDEiQ3YEC7.

    PTM databases

    PhosphoSiteiQ3YEC7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3YEC7.
    BgeeiQ3YEC7.
    GenevestigatoriQ3YEC7.

    Organism-specific databases

    HPAiHPA044037.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MDFIQ997502EBI-742029,EBI-724076
    SPINK7P580623EBI-742029,EBI-1182445

    Protein-protein interaction databases

    BioGridi120812. 21 interactions.
    IntActiQ3YEC7. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3YEC7.
    SMRiQ3YEC7. Positions 41-239.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni39 – 279241Small GTPase-likeAdd
    BLAST
    Regioni655 – 69339Interaction with CDKN2AAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi293 – 38492Pro-richAdd
    BLAST
    Compositional biasi645 – 68541Lys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiNOG138310.
    HOGENOMiHOG000015428.
    HOVERGENiHBG080325.
    InParanoidiQ3YEC7.
    OMAiGRACHCL.
    PhylomeDBiQ3YEC7.
    TreeFamiTF313974.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR013684. MIRO-like.
    IPR027417. P-loop_NTPase.
    IPR001806. Small_GTPase.
    [Graphical view]
    PfamiPF08477. Miro. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3YEC7-1) [UniParc]FASTAAdd to Basket

    Also known as: RBEL1A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFSALKKLVG SDQAPGRDKN IPAGLQSMNQ ALQRRFAKGV QYNMKIVIRG    50
    DRNTGKTALW HRLQGRPFVE EYIPTQEIQV TSIHWSYKTT DDIVKVEVWD 100
    VVDKGKCKKR GDGLKMENDP QEAESEMALD AEFLDVYKNC NGVVMMFDIT 150
    KQWTFNYILR ELPKVPTHVP VCVLGNYRDM GEHRVILPDD VRDFIDNLDR 200
    PPGSSYFRYA ESSMKNSFGL KYLHKFFNIP FLQLQRETLL RQLETNQLDM 250
    DATLEELSVQ QETEDQNYGI FLEMMEARSR GHASPLAANG QSPSPGSQSP 300
    VVPAGAVSTG SSSPGTPQPA PQLPLNAAPP SSVPPVPPSE ALPPPACPSA 350
    PAPRRSIISR LFGTSPATEA APPPPEPVPA AEGPATVQSV EDFVPDDRLD 400
    RSFLEDTTPA RDEKKVGAKA AQQDSDSDGE ALGGNPMVAG FQDDVDLEDQ 450
    PRGSPPLPAG PVPSQDITLS SEEEAEVAAP TKGPAPAPQQ CSEPETKWSS 500
    IPASKPRRGT APTRTAAPPW PGGVSVRTGP EKRSSTRPPA EMEPGKGEQA 550
    SSSESDPEGP IAAQMLSFVM DDPDFESEGS DTQRRADDFP VRDDPSDVTD 600
    EDEGPAEPPP PPKLPLPAFR LKNDSDLFGL GLEEAGPKES SEEGKEGKTP 650
    SKEKKKKKKK GKEEEEKAAK KKSKHKKSKD KEEGKEERRR RQQRPPRSRE 700
    RTAADELEAF LGGGAPGGRH PGGGDYEEL 729

    Note: Predominant isoform. Overexpressed in about 67% of primary breast tumors.

    Length:729
    Mass (Da):79,549
    Last modified:February 6, 2007 - v2
    Checksum:i6C3FDB38C7FD7D59
    GO
    Isoform 2 (identifier: Q3YEC7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         199-199: D → DS

    Show »
    Length:730
    Mass (Da):79,636
    Checksum:i76CED43E38D6167F
    GO
    Isoform 3 (identifier: Q3YEC7-3) [UniParc]FASTAAdd to Basket

    Also known as: RBEL1B

    The sequence of this isoform differs from the canonical sequence as follows:
         361-729: LFGTSPATEA...HPGGGDYEEL → PPPWGWRLRG...AYGSASGREP

    Note: No experimental confirmation available.

    Show »
    Length:520
    Mass (Da):57,397
    Checksum:iABB2BD2287F358BF
    GO
    Isoform 4 (identifier: Q3YEC7-4) [UniParc]FASTAAdd to Basket

    Also known as: RBEL1D

    The sequence of this isoform differs from the canonical sequence as follows:
         236-264: RETLLRQLETNQLDMDATLEELSVQQETE → VSTHHVGWSGCWSLTSFQVSPV
         265-729: Missing.

    Show »
    Length:257
    Mass (Da):29,585
    Checksum:iB086094A0AA8FCB0
    GO
    Isoform 5 (identifier: Q3YEC7-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         199-199: D → DS
         236-264: RETLLRQLETNQLDMDATLEELSVQQETE → VSTHHVGWSGCWSLTSFQVSPV
         265-729: Missing.

    Show »
    Length:258
    Mass (Da):29,672
    Checksum:i99980CF4224BDA2F
    GO
    Isoform 6 (identifier: Q3YEC7-6) [UniParc]FASTAAdd to Basket

    Also known as: RBEL1C

    The sequence of this isoform differs from the canonical sequence as follows:
         236-302: RETLLRQLET...PSPGSQSPVV → KDVRLAQERG...SSPLLSCSIP
         303-729: Missing.

    Show »
    Length:314
    Mass (Da):35,809
    Checksum:i64FCC800FAB9C14E
    GO

    Sequence cautioni

    The sequence AAH02945.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH21095.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH35786.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB14408.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB55213.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti137 – 1371Y → C in BAB14408. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti382 – 3821E → Q.4 Publications
    Corresponds to variant rs2811741 [ dbSNP | Ensembl ].
    VAR_030210

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei199 – 1991D → DS in isoform 2 and isoform 5. 2 PublicationsVSP_022646
    Alternative sequencei236 – 30267RETLL…QSPVV → KDVRLAQERGCAVVLVSEEV RMPAGWDCCWGRLGWKEGGS QTCPVPALLGRPLLPAEPSP HHWVDYSLESSPLLSCSIP in isoform 6. 1 PublicationVSP_042559Add
    BLAST
    Alternative sequencei236 – 26429RETLL…QQETE → VSTHHVGWSGCWSLTSFQVS PV in isoform 4 and isoform 5. 2 PublicationsVSP_022647Add
    BLAST
    Alternative sequencei265 – 729465Missing in isoform 4 and isoform 5. 2 PublicationsVSP_022648Add
    BLAST
    Alternative sequencei303 – 729427Missing in isoform 6. 1 PublicationVSP_042560Add
    BLAST
    Alternative sequencei361 – 729369LFGTS…DYEEL → PPPWGWRLRGALGRRGQWPP WGGGRACHCLGRHLPLYHRL CRCPVAAVCASELEEAGHWW SPGWALQVLGLQAQCEPALQ EGRGQLASARLGGHPGPLGA EPPVFLRDVTEAQEGPVRVC LQRLGRGRLAVGCALPRHLL ALRAHLGPQHAYGSASGREP in isoform 3. 2 PublicationsVSP_022649Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ141240 mRNA. Translation: AAZ73768.1.
    EF156752 mRNA. Translation: ABO84837.1.
    EF156753 mRNA. Translation: ABO84838.1.
    GQ169126 mRNA. Translation: ACS45171.1.
    GQ169127 mRNA. Translation: ACS45172.1.
    AL355987 Genomic DNA. Translation: CAI12685.1.
    AL355987 Genomic DNA. Translation: CAI12686.1.
    DQ099383 mRNA. Translation: AAZ13759.1.
    BC002945 mRNA. Translation: AAH02945.2. Different initiation.
    BC021095 mRNA. Translation: AAH21095.2. Different initiation.
    BC035786 mRNA. Translation: AAH35786.1. Different initiation.
    AK023107 mRNA. Translation: BAB14408.1. Different initiation.
    AK027586 mRNA. Translation: BAB55213.1. Different initiation.
    AL713707 mRNA. Translation: CAD28504.1.
    CCDSiCCDS48058.1. [Q3YEC7-1]
    CCDS55352.1. [Q3YEC7-2]
    CCDS55353.1. [Q3YEC7-6]
    RefSeqiNP_001167459.1. NM_001173988.1. [Q3YEC7-2]
    NP_001167460.1. NM_001173989.2. [Q3YEC7-6]
    NP_078994.3. NM_024718.4. [Q3YEC7-1]
    UniGeneiHs.370555.

    Genome annotation databases

    EnsembliENST00000311502; ENSP00000311134; ENSG00000196642. [Q3YEC7-1]
    ENST00000357466; ENSP00000350056; ENSG00000196642. [Q3YEC7-3]
    ENST00000371663; ENSP00000360727; ENSG00000196642. [Q3YEC7-2]
    ENST00000371671; ENSP00000360736; ENSG00000196642. [Q3YEC7-6]
    GeneIDi55684.
    KEGGihsa:55684.
    UCSCiuc004cjh.3. human. [Q3YEC7-6]
    uc004cji.1. human. [Q3YEC7-1]
    uc004cjj.1. human. [Q3YEC7-2]
    uc004cjm.2. human. [Q3YEC7-4]

    Polymorphism databases

    DMDMi125957950.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ141240 mRNA. Translation: AAZ73768.1 .
    EF156752 mRNA. Translation: ABO84837.1 .
    EF156753 mRNA. Translation: ABO84838.1 .
    GQ169126 mRNA. Translation: ACS45171.1 .
    GQ169127 mRNA. Translation: ACS45172.1 .
    AL355987 Genomic DNA. Translation: CAI12685.1 .
    AL355987 Genomic DNA. Translation: CAI12686.1 .
    DQ099383 mRNA. Translation: AAZ13759.1 .
    BC002945 mRNA. Translation: AAH02945.2 . Different initiation.
    BC021095 mRNA. Translation: AAH21095.2 . Different initiation.
    BC035786 mRNA. Translation: AAH35786.1 . Different initiation.
    AK023107 mRNA. Translation: BAB14408.1 . Different initiation.
    AK027586 mRNA. Translation: BAB55213.1 . Different initiation.
    AL713707 mRNA. Translation: CAD28504.1 .
    CCDSi CCDS48058.1. [Q3YEC7-1 ]
    CCDS55352.1. [Q3YEC7-2 ]
    CCDS55353.1. [Q3YEC7-6 ]
    RefSeqi NP_001167459.1. NM_001173988.1. [Q3YEC7-2 ]
    NP_001167460.1. NM_001173989.2. [Q3YEC7-6 ]
    NP_078994.3. NM_024718.4. [Q3YEC7-1 ]
    UniGenei Hs.370555.

    3D structure databases

    ProteinModelPortali Q3YEC7.
    SMRi Q3YEC7. Positions 41-239.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120812. 21 interactions.
    IntActi Q3YEC7. 5 interactions.

    PTM databases

    PhosphoSitei Q3YEC7.

    Polymorphism databases

    DMDMi 125957950.

    Proteomic databases

    MaxQBi Q3YEC7.
    PaxDbi Q3YEC7.
    PRIDEi Q3YEC7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311502 ; ENSP00000311134 ; ENSG00000196642 . [Q3YEC7-1 ]
    ENST00000357466 ; ENSP00000350056 ; ENSG00000196642 . [Q3YEC7-3 ]
    ENST00000371663 ; ENSP00000360727 ; ENSG00000196642 . [Q3YEC7-2 ]
    ENST00000371671 ; ENSP00000360736 ; ENSG00000196642 . [Q3YEC7-6 ]
    GeneIDi 55684.
    KEGGi hsa:55684.
    UCSCi uc004cjh.3. human. [Q3YEC7-6 ]
    uc004cji.1. human. [Q3YEC7-1 ]
    uc004cjj.1. human. [Q3YEC7-2 ]
    uc004cjm.2. human. [Q3YEC7-4 ]

    Organism-specific databases

    CTDi 55684.
    GeneCardsi GC09P139702.
    HGNCi HGNC:24703. RABL6.
    HPAi HPA044037.
    MIMi 610615. gene.
    neXtProti NX_Q3YEC7.
    PharmGKBi PA134868176.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG138310.
    HOGENOMi HOG000015428.
    HOVERGENi HBG080325.
    InParanoidi Q3YEC7.
    OMAi GRACHCL.
    PhylomeDBi Q3YEC7.
    TreeFami TF313974.

    Miscellaneous databases

    ChiTaRSi C9orf86. human.
    GeneWikii C9orf86.
    GenomeRNAii 55684.
    NextBioi 60481.
    PROi Q3YEC7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3YEC7.
    Bgeei Q3YEC7.
    Genevestigatori Q3YEC7.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR013684. MIRO-like.
    IPR027417. P-loop_NTPase.
    IPR001806. Small_GTPase.
    [Graphical view ]
    Pfami PF08477. Miro. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel ARF binding proteins by two-hybrid screening."
      Tompkins V., Hagen J., Zediak V.P., Quelle D.E.
      Cell Cycle 5:641-646(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLN-382, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CDKN2A.
    2. "RBEL1 is a novel gene that encodes a nucleocytoplasmic Ras superfamily GTP-binding protein and is overexpressed in breast cancer."
      Montalbano J., Jin W., Sheikh M.S., Huang Y.
      J. Biol. Chem. 282:37640-37649(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), ALTERNATIVE SPLICING, GLYCOSYLATION, SUBCELLULAR LOCATION.
    3. "Identification and characterization of RBEL1 subfamily of GTPases in the Ras superfamily involved in cell growth regulation."
      Montalbano J., Lui K., Sheikh M.S., Huang Y.
      J. Biol. Chem. 284:18129-18142(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 6), SUBCELLULAR LOCATION.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Lin L., Nong W., Li H., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Wen S., Zhou G., Yang S.
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-382.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT GLN-382.
      Tissue: Brain and Kidney.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-729 (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-729 (ISOFORM 1), VARIANT GLN-382.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 251-719.
      Tissue: Brain.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-577; SER-596 AND THR-599, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425 AND SER-427, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425; SER-427; SER-596 AND THR-599, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425; SER-427; SER-596 AND THR-599, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRABL6_HUMAN
    AccessioniPrimary (citable) accession number: Q3YEC7
    Secondary accession number(s): A8QVZ7
    , A8QVZ8, C6K8I4, C6K8I5, Q4F968, Q5T5R7, Q8IWK1, Q8TCL4, Q8WU94, Q96SR8, Q9BU21, Q9H935
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3