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Protein

Transforming growth factor beta regulator 1

Gene

TBRG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.1 Publication

GO - Biological processi

  • cell cycle arrest Source: HGNC
  • DNA replication Source: HGNC
  • negative regulation of cell proliferation Source: HGNC
  • protein localization to nucleoplasm Source: HGNC
  • protein stabilization Source: HGNC

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor beta regulator 1
Alternative name(s):
Nuclear interactor of ARF and Mdm2
Gene namesi
Name:TBRG1
Synonyms:NIAM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000154144.12
HGNCiHGNC:29551 TBRG1
MIMi610614 gene
neXtProtiNX_Q3YBR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi84897
OpenTargetsiENSG00000154144
PharmGKBiPA134926528

Polymorphism and mutation databases

BioMutaiTBRG1
DMDMi121943045

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002742182 – 411Transforming growth factor beta regulator 1Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei10PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ3YBR2
MaxQBiQ3YBR2
PaxDbiQ3YBR2
PeptideAtlasiQ3YBR2
PRIDEiQ3YBR2
ProteomicsDBi61892
61893 [Q3YBR2-2]
61894 [Q3YBR2-3]

PTM databases

iPTMnetiQ3YBR2
PhosphoSitePlusiQ3YBR2

Expressioni

Tissue specificityi

Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma.1 Publication

Gene expression databases

BgeeiENSG00000154144
CleanExiHS_TBRG1
ExpressionAtlasiQ3YBR2 baseline and differential
GenevisibleiQ3YBR2 HS

Organism-specific databases

HPAiHPA055645
HPA068022

Interactioni

Subunit structurei

Interacts with CDKN2A and MDM2.2 Publications

Protein-protein interaction databases

BioGridi124337, 15 interactors
IntActiQ3YBR2, 15 interactors
STRINGi9606.ENSP00000409016

Structurei

Secondary structure

1411
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi185 – 187Combined sources3
Beta strandi190 – 197Combined sources8
Helixi203 – 205Combined sources3
Beta strandi214 – 223Combined sources10
Beta strandi230 – 240Combined sources11
Beta strandi242 – 251Combined sources10
Helixi255 – 257Combined sources3
Beta strandi259 – 263Combined sources5
Helixi264 – 279Combined sources16
Helixi290 – 294Combined sources5
Helixi299 – 305Combined sources7
Helixi311 – 313Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WZOX-ray1.60A179-324[»]
ProteinModelPortaliQ3YBR2
SMRiQ3YBR2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3YBR2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 241FYR N-terminalPROSITE-ProRule annotationAdd BLAST60
Domaini242 – 321FYR C-terminalPROSITE-ProRule annotationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi134 – 161Lys-richAdd BLAST28

Sequence similaritiesi

Belongs to the TBRG1 family.Curated

Phylogenomic databases

eggNOGiENOG410ITPM Eukaryota
ENOG410XTBM LUCA
GeneTreeiENSGT00390000013374
HOVERGENiHBG094027
InParanoidiQ3YBR2
OMAiGARKCIN
OrthoDBiEOG091G0WMG
PhylomeDBiQ3YBR2
TreeFamiTF324736

Family and domain databases

InterProiView protein in InterPro
IPR003889 FYrich_C
IPR003888 FYrich_N
PfamiView protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
SMARTiView protein in SMART
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
PROSITEiView protein in PROSITE
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3YBR2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLLDGLASS PRAPLQSSKA RMKKLPKKSQ NEKYRLKYLR LRKAAKATVF
60 70 80 90 100
ENAAICDEIA RLEEKFLKAK EERRYLLKKL LQLQALTEGE VQAAAPSHSS
110 120 130 140 150
SLPLTYGVAS SVGTIQGAGP ISGPSTGAEE PFGKKTKKEK KEKGKENNKL
160 170 180 190 200
EVLKKTCKKK KMAGGARKLV QPIALDPSGR PVFPIGLGGL TVYSLGEIIT
210 220 230 240 250
DRPGFHDESA IYPVGYCSTR IYASMKCPDQ KCLYTCQIKD GGVQPQFEIV
260 270 280 290 300
PEDDPQNAIV SSSADACHAE LLRTISTTMG KLMPNLLPAG ADFFGFSHPA
310 320 330 340 350
IHNLIQSCPG ARKCINYQWV KFDVCKPGDG QLPEGLPEND AAMSFEAFQR
360 370 380 390 400
QIFDEDQNDP LLPGSLDLPE LQPAAFVSSY QPMYLTHEPL VDTHLQHLKS
410
PSQGSPIQSS D
Length:411
Mass (Da):44,946
Last modified:September 27, 2005 - v1
Checksum:iC6FDE7D7961E78C4
GO
Isoform 2 (identifier: Q3YBR2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-197: MSLLDGLASS...GGLTVYSLGE → MVWPALWELY...KKAKRTTNWK

Show »
Length:260
Mass (Da):29,157
Checksum:i8F7E21F0ACF41A68
GO
Isoform 3 (identifier: Q3YBR2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-224: Missing.

Show »
Length:187
Mass (Da):20,558
Checksum:iDAF7DAC71DF246C1
GO

Sequence cautioni

The sequence BAB84966 differs from that shown. Reason: Frameshift at position 229.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti406P → S in BAD96656 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0226441 – 224Missing in isoform 3. 1 PublicationAdd BLAST224
Alternative sequenceiVSP_0226451 – 197MSLLD…YSLGE → MVWPALWELYRELGLFQGPA LGLRNHLGRKLRRRKKKKAK RTTNWK in isoform 2. 3 PublicationsAdd BLAST197

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ144542 mRNA Translation: AAZ76016.1
AK027527 mRNA Translation: BAB55177.1
AK074140 mRNA Translation: BAB84966.1 Frameshift.
AY696294 mRNA Translation: AAU10523.1
AK222936 mRNA Translation: BAD96656.1
BC109269 mRNA Translation: AAI09270.1
AL713631 mRNA Translation: CAD28450.1
AL831881 mRNA Translation: CAH10595.1
CCDSiCCDS8448.2 [Q3YBR2-1]
RefSeqiNP_116200.2, NM_032811.2 [Q3YBR2-1]
XP_016873931.1, XM_017018442.1 [Q3YBR2-2]
UniGeneiHs.436410

Genome annotation databases

EnsembliENST00000441174; ENSP00000409016; ENSG00000154144 [Q3YBR2-1]
GeneIDi84897
KEGGihsa:84897
UCSCiuc001qak.5 human [Q3YBR2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTBRG1_HUMAN
AccessioniPrimary (citable) accession number: Q3YBR2
Secondary accession number(s): Q53GJ5
, Q66ZJ6, Q69YS7, Q8TCS4, Q8TEI4, Q96SV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: September 27, 2005
Last modified: June 20, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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