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Protein

Transmembrane protein 176B

Gene

TMEM176B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity).By similarity

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • negative regulation of dendritic cell differentiation Source: Ensembl
  • organ morphogenesis Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 176B
Alternative name(s):
Protein LR8
Gene namesi
Name:TMEM176B
Synonyms:LR8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:29596. TMEM176B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei65 – 8521HelicalSequence analysisAdd
BLAST
Transmembranei95 – 11521HelicalSequence analysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence analysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405966.

Polymorphism and mutation databases

BioMutaiTMEM176B.
DMDMi313104018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Transmembrane protein 176BPRO_0000279875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei236 – 2361PhosphoserineCombined sources
Modified residuei245 – 2451PhosphoserineCombined sources
Modified residuei254 – 2541PhosphoserineBy similarity
Modified residuei258 – 2581PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3YBM2.
PRIDEiQ3YBM2.

PTM databases

iPTMnetiQ3YBM2.
PhosphoSiteiQ3YBM2.

Expressioni

Tissue specificityi

Expressed in lung and dermal fibroblasts.1 Publication

Inductioni

Up-regulated in fibrotic lung. Down-regulated in activated dendritic cells.2 Publications

Gene expression databases

BgeeiQ3YBM2.
CleanExiHS_TMEM176B.
ExpressionAtlasiQ3YBM2. baseline and differential.
GenevisibleiQ3YBM2. HS.

Organism-specific databases

HPAiHPA047509.

Interactioni

Protein-protein interaction databases

IntActiQ3YBM2. 1 interaction.
STRINGi9606.ENSP00000318409.

Structurei

3D structure databases

ProteinModelPortaliQ3YBM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM176 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXII. Eukaryota.
ENOG410ZDNZ. LUCA.
GeneTreeiENSGT00530000064074.
HOGENOMiHOG000290691.
HOVERGENiHBG094020.
InParanoidiQ3YBM2.
OMAiRASGCAF.
OrthoDBiEOG7H4DVP.
PhylomeDBiQ3YBM2.
TreeFamiTF335389.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR009281. TMEM176A/TMEM176B.
[Graphical view]
PANTHERiPTHR15756. PTHR15756. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3YBM2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTQNTVIVNG VAMASRPSQP THVNVHIHQE SALTQLLKAG GSLKKFLFHP
60 70 80 90 100
GDTVPSTARI GYEQLALGVT QILLGVVSCV LGVCLSLGPW TVLSASGCAF
110 120 130 140 150
WAGSVVIAAG AGAIVHEKHP GKLAGYISSL LTLAGFATAM AAVVLCVNSF
160 170 180 190 200
IWQTEPFLYI DTVCDRSDPV FPTTGYRWMR RSQENQWQKE ECRAYMQMLR
210 220 230 240 250
KLFTAIRALF LAVCVLKVIV SLVSLGVGLR NLCGQSSQPL NEEGSEKRLL
260 270
GENSVPPSPS REQTSTAIVL
Length:270
Mass (Da):29,056
Last modified:November 30, 2010 - v2
Checksum:i6D27B2A384709FDD
GO
Isoform 2 (identifier: Q3YBM2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-105: Missing.

Note: No experimental confirmation available.
Show »
Length:233
Mass (Da):25,379
Checksum:iD6B82DA53CCE8D08
GO

Sequence cautioni

The sequence AAH91471.1 differs from that shown. Reason: Erroneous termination at position 30. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 182PS → HA in AAD23440 (PubMed:9922225).Curated
Sequence conflicti237 – 2371S → P in AK129525 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401G → E.
Corresponds to variant rs10240587 [ dbSNP | Ensembl ].
VAR_057766
Natural varianti55 – 551P → S.1 Publication
Corresponds to variant rs11546671 [ dbSNP | Ensembl ].
VAR_031035
Natural varianti70 – 701T → A.
Corresponds to variant rs28434777 [ dbSNP | Ensembl ].
VAR_031036
Natural varianti94 – 941S → R.3 Publications
Corresponds to variant rs3173833 [ dbSNP | Ensembl ].
VAR_031037
Natural varianti134 – 1341A → T.1 Publication
Corresponds to variant rs2072443 [ dbSNP | Ensembl ].
VAR_031038
Natural varianti180 – 1801R → W.
Corresponds to variant rs17256042 [ dbSNP | Ensembl ].
VAR_031039

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei69 – 10537Missing in isoform 2. 1 PublicationVSP_046283Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115384 mRNA. Translation: AAD23440.1.
DQ144974 mRNA. Translation: AAZ75648.1.
AK129525 mRNA. No translation available.
AK315575 mRNA. Translation: BAG37949.1.
AC006479 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW54077.1.
CH471173 Genomic DNA. Translation: EAW54078.1.
CH471173 Genomic DNA. Translation: EAW54079.1.
CH471173 Genomic DNA. Translation: EAW54080.1.
BC004358 mRNA. Translation: AAH04358.1.
BC014586 mRNA. Translation: AAH14586.1.
BC091471 mRNA. Translation: AAH91471.1. Sequence problems.
CCDSiCCDS47746.1. [Q3YBM2-2]
CCDS5908.1. [Q3YBM2-1]
RefSeqiNP_001094781.1. NM_001101311.1. [Q3YBM2-1]
NP_001094782.1. NM_001101312.1. [Q3YBM2-1]
NP_001094784.1. NM_001101314.1. [Q3YBM2-2]
NP_054739.3. NM_014020.3. [Q3YBM2-1]
XP_006715996.2. XM_006715933.2. [Q3YBM2-2]
UniGeneiHs.647090.
Hs.709505.

Genome annotation databases

EnsembliENST00000326442; ENSP00000318409; ENSG00000106565. [Q3YBM2-1]
ENST00000429904; ENSP00000397810; ENSG00000106565. [Q3YBM2-1]
ENST00000434545; ENSP00000413531; ENSG00000106565. [Q3YBM2-1]
ENST00000447204; ENSP00000410269; ENSG00000106565. [Q3YBM2-1]
ENST00000450753; ENSP00000404831; ENSG00000106565. [Q3YBM2-2]
ENST00000492607; ENSP00000419258; ENSG00000106565. [Q3YBM2-1]
GeneIDi28959.
KEGGihsa:28959.
UCSCiuc003whu.5. human. [Q3YBM2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115384 mRNA. Translation: AAD23440.1.
DQ144974 mRNA. Translation: AAZ75648.1.
AK129525 mRNA. No translation available.
AK315575 mRNA. Translation: BAG37949.1.
AC006479 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW54077.1.
CH471173 Genomic DNA. Translation: EAW54078.1.
CH471173 Genomic DNA. Translation: EAW54079.1.
CH471173 Genomic DNA. Translation: EAW54080.1.
BC004358 mRNA. Translation: AAH04358.1.
BC014586 mRNA. Translation: AAH14586.1.
BC091471 mRNA. Translation: AAH91471.1. Sequence problems.
CCDSiCCDS47746.1. [Q3YBM2-2]
CCDS5908.1. [Q3YBM2-1]
RefSeqiNP_001094781.1. NM_001101311.1. [Q3YBM2-1]
NP_001094782.1. NM_001101312.1. [Q3YBM2-1]
NP_001094784.1. NM_001101314.1. [Q3YBM2-2]
NP_054739.3. NM_014020.3. [Q3YBM2-1]
XP_006715996.2. XM_006715933.2. [Q3YBM2-2]
UniGeneiHs.647090.
Hs.709505.

3D structure databases

ProteinModelPortaliQ3YBM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3YBM2. 1 interaction.
STRINGi9606.ENSP00000318409.

PTM databases

iPTMnetiQ3YBM2.
PhosphoSiteiQ3YBM2.

Polymorphism and mutation databases

BioMutaiTMEM176B.
DMDMi313104018.

Proteomic databases

PaxDbiQ3YBM2.
PRIDEiQ3YBM2.

Protocols and materials databases

DNASUi28959.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326442; ENSP00000318409; ENSG00000106565. [Q3YBM2-1]
ENST00000429904; ENSP00000397810; ENSG00000106565. [Q3YBM2-1]
ENST00000434545; ENSP00000413531; ENSG00000106565. [Q3YBM2-1]
ENST00000447204; ENSP00000410269; ENSG00000106565. [Q3YBM2-1]
ENST00000450753; ENSP00000404831; ENSG00000106565. [Q3YBM2-2]
ENST00000492607; ENSP00000419258; ENSG00000106565. [Q3YBM2-1]
GeneIDi28959.
KEGGihsa:28959.
UCSCiuc003whu.5. human. [Q3YBM2-1]

Organism-specific databases

CTDi28959.
GeneCardsiTMEM176B.
HGNCiHGNC:29596. TMEM176B.
HPAiHPA047509.
MIMi610385. gene.
neXtProtiNX_Q3YBM2.
PharmGKBiPA162405966.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXII. Eukaryota.
ENOG410ZDNZ. LUCA.
GeneTreeiENSGT00530000064074.
HOGENOMiHOG000290691.
HOVERGENiHBG094020.
InParanoidiQ3YBM2.
OMAiRASGCAF.
OrthoDBiEOG7H4DVP.
PhylomeDBiQ3YBM2.
TreeFamiTF335389.

Miscellaneous databases

ChiTaRSiTMEM176B. human.
GenomeRNAii28959.
PROiQ3YBM2.
SOURCEiSearch...

Gene expression databases

BgeeiQ3YBM2.
CleanExiHS_TMEM176B.
ExpressionAtlasiQ3YBM2. baseline and differential.
GenevisibleiQ3YBM2. HS.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR009281. TMEM176A/TMEM176B.
[Graphical view]
PANTHERiPTHR15756. PTHR15756. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a gene product expressed by a subpopulation of human lung fibroblasts by differential display."
    Lurton J., Rose T.M., Raghu G., Narayanan A.S.
    Am. J. Respir. Cell Mol. Biol. 20:327-331(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION, VARIANTS SER-55 AND ARG-94.
    Tissue: Lung.
  2. "Cloning of a full-length Homo sapiens mRNA coding for a tetraspanin-like LR8 protein."
    Anton B., Matus M., Canseco J., Calva J.C., Flores A., Gonzaga R., Salazar A., Arreola R., Leff P.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-94.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Macrophage and Placenta.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-94 AND THR-134.
    Tissue: Lung and Placenta.
  7. "Identification of a new member of the CD20/FcepsilonRIbeta family overexpressed in tolerated allografts."
    Louvet C., Chiffoleau E., Heslan M., Tesson L., Heslan J.-M., Brion R., Beriou G., Guillonneau C., Khalife J., Anegon I., Cuturi M.-C.
    Am. J. Transplant. 5:2143-2153(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236; SER-245 AND SER-258, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiT176B_HUMAN
AccessioniPrimary (citable) accession number: Q3YBM2
Secondary accession number(s): B2RDK2
, D3DWZ7, E9PAV4, Q5BJI2, Q9BT42, Q9Y609
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: November 30, 2010
Last modified: June 8, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.