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Protein

Interleukin-15

Gene

IL15

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-15
Short name:
IL-15
Gene namesi
Name:IL15
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 15

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000004339330 – 48Sequence analysisAdd BLAST19
ChainiPRO_000004339449 – 162Interleukin-15Add BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 133By similarity
Disulfide bondi90 ↔ 136By similarity
Glycosylationi108N-linked (GlcNAc...)Sequence analysis1
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Glycosylationi143N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed in many tissues including heart, spleen, lung, liver, muscle and kidney (at mRNA level). Expressed in many tissues including heart, spleen, lung, liver, muscle and kidney (at protein level).1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007620.

Structurei

3D structure databases

ProteinModelPortaliQ3Y5G8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-15/IL-21 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ5D. Eukaryota.
ENOG41119SX. LUCA.
GeneTreeiENSGT00390000016264.
HOVERGENiHBG006142.
InParanoidiQ3Y5G8.
KOiK05433.
OMAiRSTSIQC.
OrthoDBiEOG091G0VGG.
TreeFamiTF336199.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR020439. IL-15.
IPR003443. IL-15/IL-21_fam.
IPR020466. IL-15_mml.
[Graphical view]
PfamiPF02372. IL15. 1 hit.
[Graphical view]
PRINTSiPR01947. INTLKN15MAML.
PR01930. INTRLEUKIN15.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3Y5G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRISKPYLRS TSIQCYLCLL LNSHFLAEAG IHVFIFGCIS AGLPKTEANW
60 70 80 90 100
HDVISDLKRI EDLIKSIHID ATLYTESDAH PNCKVTAMKC FLLELRVISH
110 120 130 140 150
ESRNMDINET VQNLIILANT SLSSKGNVTE SGCKECEELE EKNITEFLQS
160
FIHIVQMFIN SP
Length:162
Mass (Da):18,330
Last modified:September 27, 2005 - v1
Checksum:i6F9C7CC129FB64B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ157452 mRNA. Translation: AAZ82803.1.
RefSeqiNP_001075685.1. NM_001082216.2.
XP_017202736.1. XM_017347247.1.
UniGeneiOcu.1795.

Genome annotation databases

EnsembliENSOCUT00000008824; ENSOCUP00000007620; ENSOCUG00000008827.
GeneIDi100009017.
KEGGiocu:100009017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ157452 mRNA. Translation: AAZ82803.1.
RefSeqiNP_001075685.1. NM_001082216.2.
XP_017202736.1. XM_017347247.1.
UniGeneiOcu.1795.

3D structure databases

ProteinModelPortaliQ3Y5G8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007620.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000008824; ENSOCUP00000007620; ENSOCUG00000008827.
GeneIDi100009017.
KEGGiocu:100009017.

Organism-specific databases

CTDi3600.

Phylogenomic databases

eggNOGiENOG410IZ5D. Eukaryota.
ENOG41119SX. LUCA.
GeneTreeiENSGT00390000016264.
HOVERGENiHBG006142.
InParanoidiQ3Y5G8.
KOiK05433.
OMAiRSTSIQC.
OrthoDBiEOG091G0VGG.
TreeFamiTF336199.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR020439. IL-15.
IPR003443. IL-15/IL-21_fam.
IPR020466. IL-15_mml.
[Graphical view]
PfamiPF02372. IL15. 1 hit.
[Graphical view]
PRINTSiPR01947. INTLKN15MAML.
PR01930. INTRLEUKIN15.
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIL15_RABIT
AccessioniPrimary (citable) accession number: Q3Y5G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: September 27, 2005
Last modified: October 5, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.