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Q3Y4F4 (CFI_CANGE) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chalcone--flavonone isomerase

Short name=Chalcone isomerase
EC=5.5.1.6
Gene names
Name:CHI
OrganismCanna generalis (Canna lily) (Canna glauca x Canna indica)
Taxonomic identifier341692 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaZingiberalesCannaceaeCanna

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones. Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin By similarity.

Catalytic activity

A chalcone = a flavanone.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Miscellaneous

Part of the biosynthetic pathway for all classes of flavonoids, a large class of secondary plant metabolites, many of which are brightly colored.

Sequence similarities

Belongs to the chalcone isomerase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 226226Chalcone--flavonone isomerase
PRO_0000314570

Sites

Binding site511Substrate By similarity
Binding site1161Substrate By similarity
Binding site1941Substrate By similarity
Site1091Important for catalytic activity By similarity

Experimental info

Sequence conflict661G → A in AAZ80911. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q3Y4F4 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: F954066B1C11D07B

FASTA22624,228
        10         20         30         40         50         60 
MAQAGVSLPK LVIGEVTFPP AAAPPGSSSS LFLAGAGERG LEIDRQFVVF TAIGVYLEDL 

        70         80         90        100        110        120 
AVSTLGPKWK GKTADDLAGN SDFFRDIFTG PFEKFTRITM VKPLSGQQYS EKVEENCVAH 

       130        140        150        160        170        180 
WKAAGTYTEA EAAAVEKFKE ACKNETFPPG TSILFTHQVS PASLTITFWR EGSMPETGNT 

       190        200        210        220 
VIESKALSEA ILESIIGKHG VSPGAKRSVA QRLSEILEEV KLEGSK 

« Hide

References

[1]"Isolation and characterization of a Canna generalis gene encoding chalcone flavonone isomerase."
Li J., Li M.R., Li H.Q.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ160231 Genomic DNA. Translation: AAZ80910.1.
DQ160232 mRNA. Translation: AAZ80911.1.

3D structure databases

ProteinModelPortalQ3Y4F4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR016087. Chalcone_isomerase.
IPR016088. Chalcone_isomerase_3-sand.
IPR003466. Chalcone_isomerase_subgr.
[Graphical view]
Gene3DG3DSA:3.50.70.10. Chalcone. 1 hit.
PfamPF02431. Chalcone. 1 hit.
[Graphical view]
SUPFAMSSF54626. Chalcone. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCFI_CANGE
AccessionPrimary (citable) accession number: Q3Y4F4
Secondary accession number(s): Q3Y4F3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 27, 2005
Last modified: September 21, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families