Q3Y4F4 (CFI_CANGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chalcone--flavonone isomerase
Short name=Chalcone isomerase
EC=5.5.1.6

Gene names

Name:

CHI

Organism

Canna generalis (Canna lily) (Canna glauca x Canna indica)

Taxonomic identifier

341692 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Zingiberales › Cannaceae › Canna

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones. Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin By similarity.
Catalytic activity	A chalcone = a flavanone.
Pathway	Secondary metabolite biosynthesis; flavonoid biosynthesis.
Miscellaneous	Part of the biosynthetic pathway for all classes of flavonoids, a large class of secondary plant metabolites, many of which are brightly colored.
Sequence similarities	Belongs to the chalcone isomerase family.

Ontologies

Keywords
Biological process	Flavonoid biosynthesis
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	cellular modified amino acid biosynthetic process Inferred from electronic annotation. Source: InterPro flavonoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chalcone isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	Chalcone--flavonone isomerase		PRO_0000314570
Sites
	Binding site	51	1	Substrate By similarity
	Binding site	116	1	Substrate By similarity
	Binding site	194	1	Substrate By similarity
	Site	109	1	Important for catalytic activity By similarity
Experimental info
	Sequence conflict	66	1	G → A in AAZ80911. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q3Y4F4 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: F954066B1C11D07B	FASTA	226	24,228
	10 20 30 40 50 60 MAQAGVSLPK LVIGEVTFPP AAAPPGSSSS LFLAGAGERG LEIDRQFVVF TAIGVYLEDL 70 80 90 100 110 120 AVSTLGPKWK GKTADDLAGN SDFFRDIFTG PFEKFTRITM VKPLSGQQYS EKVEENCVAH 130 140 150 160 170 180 WKAAGTYTEA EAAAVEKFKE ACKNETFPPG TSILFTHQVS PASLTITFWR EGSMPETGNT 190 200 210 220 VIESKALSEA ILESIIGKHG VSPGAKRSVA QRLSEILEEV KLEGSK

References

[1]	"Isolation and characterization of a Canna generalis gene encoding chalcone flavonone isomerase." Li J., Li M.R., Li H.Q. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ160231 Genomic DNA. Translation: AAZ80910.1. DQ160232 mRNA. Translation: AAZ80911.1.
3D structure databases
ProteinModelPortal	Q3Y4F4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR016087. Chalcone_isomerase. IPR016088. Chalcone_isomerase_3-sand. IPR003466. Chalcone_isomerase_subgr. [Graphical view]
Gene3D	G3DSA:3.50.70.10. Chalcone. 1 hit.
Pfam	PF02431. Chalcone. 1 hit. [Graphical view]
SUPFAM	SSF54626. Chalcone. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CFI_CANGE

Accession

Primary (citable) accession number: Q3Y4F4
Secondary accession number(s): Q3Y4F3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 27, 2005
Last modified:	September 21, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program