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Protein

Glutamate decarboxylase

Gene

gadB

Organism
Enterococcus faecium DO
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciEFAE333849:GLCV-261-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadBImported
ORF Names:HMPREF0351_10261Imported
OrganismiEnterococcus faecium DOImported
Taxonomic identifieri333849 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000005269 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

KOiK01580.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3Y080-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYGKDNQEE KNYLEPIFGS ASEDVDLPKY KLNKESIEPR IAYQLVQDEM
60 70 80 90 100
LDEGNARLNL ATFCQTYMEP EAVKLMTQTL EKNAIDKSEY PRTTEIENRC
110 120 130 140 150
VNMIADLWHA PNNEKFMGTS TIGSSEACML GGMAMKFAWR KRAEKLGLDI
160 170 180 190 200
QAKKPNLVIS SGYQVCWEKF CVYWDVELRE VPMDEKHMSI NLDTVMDYVD
210 220 230 240 250
EYTIGIVGIM GITYTGRYDD IKGLNDLVEA HNKQTDYKVY IHVDAASGGF
260 270 280 290 300
YAPFTEPDLV WDFQLKNVIS INSSGHKYGL VYPGVGWVLW RDQQYLPEEL
310 320 330 340 350
VFKVSYLGGE MPTMAINFSH SAAQLIGQYY NFVRYGFDGY RDIHQRTHDV
360 370 380 390 400
AVYLAKEIEK TGIFEIINDG SELPVVCYKL KEDPNREWTL YDLSDRLLMK
410 420 430 440 450
GWQVPAYPLP KDLDQLIIQR LVVRADFGMN MAGDYVQDMN QAIEELNKAH
460
IVYHKKQDVK TYGFTH
Length:466
Mass (Da):53,715
Last modified:October 11, 2005 - v1
Checksum:iE7D3C84E398A0624
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003583 Genomic DNA. Translation: AFK57885.1.
RefSeqiYP_006374867.1. NC_017960.1.

Genome annotation databases

EnsemblBacteriaiAFK57885; AFK57885; HMPREF0351_10261.
EAN09880; EAN09880; EfaeDRAFT_1317.
GeneIDi12998920.
KEGGiefu:HMPREF0351_10261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003583 Genomic DNA. Translation: AFK57885.1.
RefSeqiYP_006374867.1. NC_017960.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFK57885; AFK57885; HMPREF0351_10261.
EAN09880; EAN09880; EfaeDRAFT_1317.
GeneIDi12998920.
KEGGiefu:HMPREF0351_10261.

Phylogenomic databases

KOiK01580.

Enzyme and pathway databases

BioCyciEFAE333849:GLCV-261-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DOImported.

Entry informationi

Entry nameiQ3Y080_ENTFC
AccessioniPrimary (citable) accession number: Q3Y080
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 29, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.