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Q3XXK8

- Q3XXK8_ENTFC

UniProt

Q3XXK8 - Q3XXK8_ENTFC

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Protein

D-alanine--D-alanine ligase

Gene
ddlA, ddl, EfaeDRAFT_0577, HMPREF0351_10178
Organism
Enterococcus faecium DO
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi295 – 2951Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi308 – 3081Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi308 – 3081Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi310 – 3101Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi169 – 22456ATP By similarityUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciEFAE333849:GLCV-178-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlAImported
Synonyms:ddlUniRule annotation
ORF Names:EfaeDRAFT_0577Imported, HMPREF0351_10178Imported
OrganismiEnterococcus faecium DOImported
Taxonomic identifieri333849 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000005269: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini136 – 341206ATP-grasp By similarityUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

KOiK01921.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3XXK8-1 [UniParc]FASTAAdd to Basket

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MKITLLYGGR SAEHEVSILS AFSVLNAIYY NYYQVQLVFI TKEGQWVKGP    50
LLTEKPASKD VLHLSWDPSG QTEEGFTGKV INPGEIKEEG AIVFPVLHGP 100
NGEDGTIQGF LETLNMPYVG AGVLTSACAM DKIMTKYILQ AAGVPQVPYV 150
PVLKNQWKEN PKKVFDQCEG SLLYPMFVKP ANMGSSVGIT KAENREELQN 200
ALATAYQYDS RAIVEQGIEA REIEVAVLGN EDVRTTLPGE VVKDVAFYDY 250
EAKYINNKIE MQIPAEVPEE VYQKAQEYAK LAYTMLGGSG LSRCDFFLTN 300
KNELFLNELN SMPGFTEFSM YPLLWENMGL KYGDLIEELI QLGMNRYHQR 350
QSFFEKNE 358
Length:358
Mass (Da):40,247
Last modified:October 11, 2005 - v1
Checksum:i0801F31DB1FA9FEC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003583 Genomic DNA. Translation: AFK57802.1.
AAAK03000077 Genomic DNA. Translation: EAN08955.1.
RefSeqiYP_006374784.1. NC_017960.1.

Genome annotation databases

EnsemblBacteriaiAFK57802; AFK57802; HMPREF0351_10178.
EAN08955; EAN08955; EfaeDRAFT_0577.
GeneIDi12998837.
KEGGiefu:HMPREF0351_10178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003583 Genomic DNA. Translation: AFK57802.1 .
AAAK03000077 Genomic DNA. Translation: EAN08955.1 .
RefSeqi YP_006374784.1. NC_017960.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFK57802 ; AFK57802 ; HMPREF0351_10178 .
EAN08955 ; EAN08955 ; EfaeDRAFT_0577 .
GeneIDi 12998837.
KEGGi efu:HMPREF0351_10178.

Phylogenomic databases

KOi K01921.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci EFAE333849:GLCV-178-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. DOE Joint Genome Institute
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DOImported.
  2. "Annotation of the draft genome assembly of Enterococcus faecium DO."
    US DOE Joint Genome Institute (JGI-ORNL)
    Larimer F., Land M.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DOImported.
  3. "Sequencing of the draft genome and assembly of Enterococcus faecium DO."
    US DOE Joint Genome Institute (JGI-PGF)
    Copeland A., Lucas S., Lapidus A., Barry K., Detter C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DOImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DOImported.

Entry informationi

Entry nameiQ3XXK8_ENTFC
AccessioniPrimary (citable) accession number: Q3XXK8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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