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Q3V8A3

- PDXA_METCA

UniProt

Q3V8A3 - PDXA_METCA

Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

    Catalytic activityi

    4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

    Cofactori

    Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei134 – 1341SubstrateUniRule annotation
    Binding sitei135 – 1351SubstrateUniRule annotation
    Metal bindingi163 – 1631Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi208 – 2081Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi263 – 2631Divalent metal cation; shared with dimeric partnerUniRule annotation
    Binding sitei271 – 2711SubstrateUniRule annotation
    Binding sitei280 – 2801SubstrateUniRule annotation
    Binding sitei289 – 2891SubstrateUniRule annotation

    GO - Molecular functioni

    1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. cobalt ion binding Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. NAD binding Source: InterPro
    5. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Keywords - Ligandi

    Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00244; UER00312.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
    Alternative name(s):
    4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
    Gene namesi
    Name:pdxAUniRule annotation
    Ordered Locus Names:MCA0603
    OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
    Taxonomic identifieri243233 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
    ProteomesiUP000006821: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3303304-hydroxythreonine-4-phosphate dehydrogenasePRO_1000081868Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243233.MCA0603.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3V8A3.
    SMRiQ3V8A3. Positions 1-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PdxA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1995.
    HOGENOMiHOG000221592.
    KOiK00097.
    OMAiEQNSAYV.
    OrthoDBiEOG6GN6ZC.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    HAMAPiMF_00536. PdxA.
    InterProiIPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view]
    PfamiPF04166. PdxA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00557. pdxA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3V8A3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPRLLLTSG EPAGIGPDLC VLLSRRPFPC GITVLGDPDL LESRARLLGV    50
    PIELRRVVSG DVVPPHEPGV LHVLPTRRQP GTAPGKLDPA NAAYVLETIA 100
    DGARACLAGH YDALVTAPVQ KSVINEAGIA FTGHTEFIAG ITGGSPVMML 150
    AAEGFRVALA TTHLPLAEVS RAITVERLTG VLGVLHEDLV RRFGFSRPRI 200
    LVCGLNPHAG EGGHLGGEEI TVIEPVLARL RQDGMDLTGP LPADTLFLPH 250
    NLDRADAVLA MYHDQGLPVL KYAGFSRAVN ITLGLPIIRT SVDHGTALDR 300
    AGTGQIDTGS LEEAVRVAME MATGRPAESP 330
    Length:330
    Mass (Da):34,736
    Last modified:October 11, 2005 - v1
    Checksum:i76C8BA8F1A44BD44
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017282 Genomic DNA. Translation: AAU93126.1.
    RefSeqiYP_113119.1. NC_002977.6.

    Genome annotation databases

    EnsemblBacteriaiAAU93126; AAU93126; MCA0603.
    GeneIDi3103080.
    KEGGimca:MCA0603.
    PATRICi22604976. VBIMetCap22254_0620.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017282 Genomic DNA. Translation: AAU93126.1 .
    RefSeqi YP_113119.1. NC_002977.6.

    3D structure databases

    ProteinModelPortali Q3V8A3.
    SMRi Q3V8A3. Positions 1-325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243233.MCA0603.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU93126 ; AAU93126 ; MCA0603 .
    GeneIDi 3103080.
    KEGGi mca:MCA0603.
    PATRICi 22604976. VBIMetCap22254_0620.

    Phylogenomic databases

    eggNOGi COG1995.
    HOGENOMi HOG000221592.
    KOi K00097.
    OMAi EQNSAYV.
    OrthoDBi EOG6GN6ZC.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00312 .

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    HAMAPi MF_00536. PdxA.
    InterProi IPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view ]
    Pfami PF04166. PdxA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00557. pdxA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33009 / NCIMB 11132 / Bath.

    Entry informationi

    Entry nameiPDXA_METCA
    AccessioniPrimary (citable) accession number: Q3V8A3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The active site is located at the dimer interface.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3