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Q3V818

- PDXA_SYMTH

UniProt

Q3V818 - PDXA_SYMTH

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Protein
4-hydroxythreonine-4-phosphate dehydrogenase
Gene
pdxA, STH2300
Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei140 – 1401Substrate By similarity
Binding sitei141 – 1411Substrate By similarity
Metal bindingi170 – 1701Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi214 – 2141Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi269 – 2691Divalent metal cation; shared with dimeric partner By similarity
Binding sitei277 – 2771Substrate By similarity
Binding sitei295 – 2951Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, NADP

Enzyme and pathway databases

BioCyciSTHE292459:GJMM-2375-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene namesi
Name:pdxA
Ordered Locus Names:STH2300
OrganismiSymbiobacterium thermophilum (strain T / IAM 14863)
Taxonomic identifieri292459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVIII. Incertae SedisSymbiobacterium
ProteomesiUP000000417: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3353354-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation
PRO_1000211916Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi292459.STH2300.

Structurei

3D structure databases

ProteinModelPortaliQ3V818.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221593.
KOiK00097.
OMAiAIPMGDP.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3V818-1 [UniParc]FASTAAdd to Basket

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MDTRPLIGIT MGDPASIGPE IAAKALANPE IYALCRPLLI GDSRVMARAF    50
ETTGVKLNLN PVATPAEGKY AHGTVDLIDL PVVDMGTLQW GQVQAQAGAA 100
AFAYIKRSIE LALEGAVDAV TTGPINKEAL KAARIDFIGH TEIFGELTGS 150
HDPLTMFETK GLRIFFLTRH VSLAQACRMI TRDRVLDYIR RCTAALEQLG 200
LVRPKLAVAG LNPHCGEHGL FGDEEVREIE PAVQQAQAEG YNVSGPHPAD 250
SVFWHAAQGR FDAVLSLYHD QGHIAAKMYD FERTVSITAG LPFLRSSVDH 300
GTAFDIAGTG RASAVSLEEA IRVGAKYAAA FRRTR 335
Length:335
Mass (Da):36,102
Last modified:October 11, 2005 - v1
Checksum:iC6B4D45E97B0DEDE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006840 Genomic DNA. Translation: BAD41285.1.
RefSeqiYP_076129.1. NC_006177.1.

Genome annotation databases

EnsemblBacteriaiBAD41285; BAD41285; STH2300.
GeneIDi2979467.
KEGGisth:STH2300.
PATRICi23782778. VBISymThe116959_2303.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006840 Genomic DNA. Translation: BAD41285.1 .
RefSeqi YP_076129.1. NC_006177.1.

3D structure databases

ProteinModelPortali Q3V818.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 292459.STH2300.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD41285 ; BAD41285 ; STH2300 .
GeneIDi 2979467.
KEGGi sth:STH2300.
PATRICi 23782778. VBISymThe116959_2303.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221593.
KOi K00097.
OMAi AIPMGDP.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci STHE292459:GJMM-2375-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
    Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
    Nucleic Acids Res. 32:4937-4944(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T / IAM 14863.

Entry informationi

Entry nameiPDXA_SYMTH
AccessioniPrimary (citable) accession number: Q3V818
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: October 11, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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