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Protein

Putative D-threonate 4-phosphate dehydrogenase

Gene

STH2300

Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP).By similarity

Catalytic activityi

D-threonate 4-phosphate + NAD+ = dihydroxyacetone phosphate + CO2 + NADH.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 1 divalent metal cation per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140SubstrateBy similarity1
Binding sitei141SubstrateBy similarity1
Metal bindingi170Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi214Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi269Divalent metal cation; shared with dimeric partnerBy similarity1
Binding sitei277SubstrateBy similarity1
Binding sitei295SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism
LigandMetal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative D-threonate 4-phosphate dehydrogenaseBy similarity (EC:1.1.1.-By similarity)
Gene namesi
Ordered Locus Names:STH2300
OrganismiSymbiobacterium thermophilum (strain T / IAM 14863)
Taxonomic identifieri292459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSymbiobacteriaceaeSymbiobacterium
Proteomesi
  • UP000000417 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002119161 – 335Putative D-threonate 4-phosphate dehydrogenaseAdd BLAST335

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi292459.STH2300.

Structurei

3D structure databases

ProteinModelPortaliQ3V818.
SMRiQ3V818.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family. PdxA2 subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CEZ. Bacteria.
COG1995. LUCA.
HOGENOMiHOG000221593.
KOiK00097.
OMAiAPVHKGV.
OrthoDBiPOG091H03XD.

Family and domain databases

InterProiView protein in InterPro
IPR005255. PdxA.
PANTHERiPTHR30004. PTHR30004. 1 hit.
PfamiView protein in Pfam
PF04166. PdxA. 1 hit.
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3V818-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTRPLIGIT MGDPASIGPE IAAKALANPE IYALCRPLLI GDSRVMARAF
60 70 80 90 100
ETTGVKLNLN PVATPAEGKY AHGTVDLIDL PVVDMGTLQW GQVQAQAGAA
110 120 130 140 150
AFAYIKRSIE LALEGAVDAV TTGPINKEAL KAARIDFIGH TEIFGELTGS
160 170 180 190 200
HDPLTMFETK GLRIFFLTRH VSLAQACRMI TRDRVLDYIR RCTAALEQLG
210 220 230 240 250
LVRPKLAVAG LNPHCGEHGL FGDEEVREIE PAVQQAQAEG YNVSGPHPAD
260 270 280 290 300
SVFWHAAQGR FDAVLSLYHD QGHIAAKMYD FERTVSITAG LPFLRSSVDH
310 320 330
GTAFDIAGTG RASAVSLEEA IRVGAKYAAA FRRTR
Length:335
Mass (Da):36,102
Last modified:October 11, 2005 - v1
Checksum:iC6B4D45E97B0DEDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006840 Genomic DNA. Translation: BAD41285.1.
RefSeqiWP_011196423.1. NC_006177.1.

Genome annotation databases

EnsemblBacteriaiBAD41285; BAD41285; STH2300.
KEGGisth:STH2300.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPDXA2_SYMTH
AccessioniPrimary (citable) accession number: Q3V818
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: October 11, 2005
Last modified: June 7, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families