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Q3V6T2

- GRDN_HUMAN

UniProt

Q3V6T2 - GRDN_HUMAN

Protein

Girdin

Gene

CCDC88A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (15 May 2007)
      Previous versions | rss
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    Functioni

    Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation By similarity. Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.By similarity2 Publications

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. microtubule binding Source: UniProtKB
    3. phosphatidylinositol binding Source: UniProtKB
    4. protein homodimerization activity Source: UniProtKB
    5. protein kinase B binding Source: UniProtKB

    GO - Biological processi

    1. activation of protein kinase B activity Source: UniProtKB
    2. cell migration Source: UniProtKB
    3. DNA replication Source: UniProtKB-KW
    4. lamellipodium assembly Source: UniProtKB
    5. membrane organization Source: UniProtKB
    6. regulation of actin cytoskeleton organization Source: UniProtKB
    7. regulation of cell proliferation Source: UniProtKB
    8. regulation of DNA replication Source: UniProtKB
    9. regulation of neuron projection development Source: UniProtKB
    10. regulation of protein phosphorylation Source: UniProtKB
    11. TOR signaling Source: UniProtKB

    Keywords - Biological processi

    DNA replication, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Girdin
    Alternative name(s):
    Akt phosphorylation enhancer
    Short name:
    APE
    Coiled-coil domain-containing protein 88A
    G alpha-interacting vesicle-associated protein
    Short name:
    GIV
    Girders of actin filament
    Hook-related protein 1
    Short name:
    HkRP1
    Gene namesi
    Name:CCDC88A
    Synonyms:APEImported, GRDN, KIAA1212Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:25523. CCDC88A.

    Subcellular locationi

    Membrane 2 Publications. Cell membrane 2 Publications. Cytoplasmcytosol. Cytoplasmic vesicle 2 Publications. Cell projectionlamellipodium
    Note: Localizes to the cell membrane through interaction with phosphoinositides.2 Publications

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    2. cytoplasmic vesicle Source: UniProtKB
    3. cytosol Source: UniProtKB
    4. endoplasmic reticulum Source: UniProtKB
    5. Golgi apparatus Source: UniProtKB
    6. lamellipodium Source: UniProtKB
    7. membrane Source: UniProtKB
    8. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1417 – 14171S → A: Disrupts actin organization, cell migration and lamellipodia formation. 1 Publication

    Organism-specific databases

    PharmGKBiPA162381751.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18711871GirdinPRO_0000287429Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1387 – 13871Phosphoserine1 Publication
    Modified residuei1417 – 14171Phosphoserine; by PKB/AKT11 Publication
    Modified residuei1673 – 16731Phosphothreonine1 Publication
    Modified residuei1675 – 16751PhosphoserineBy similarity
    Modified residuei1837 – 18371Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation is induced by epidermal growth factor (EGF) in a phosphoinositide 3-kinase (PI3K)-dependent manner. Phosphorylation by AKT1/PKB is necessary for the delocalization from the cell membrane and for cell migration.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ3V6T2.
    PaxDbiQ3V6T2.
    PRIDEiQ3V6T2.

    PTM databases

    PhosphoSiteiQ3V6T2.

    Expressioni

    Tissue specificityi

    Expressed ubiquitously.1 Publication

    Gene expression databases

    ArrayExpressiQ3V6T2.
    BgeeiQ3V6T2.
    CleanExiHS_CCDC88A.
    GenevestigatoriQ3V6T2.

    Organism-specific databases

    HPAiHPA038101.

    Interactioni

    Subunit structurei

    Interacts (via C-terminus) with DISC1; the interaction is direct. Interacts with AKT proteins; the interaction is inhibited in presence of DISC1 By similarity. Homodimer. The non-phosphorylated form interacts with phosphatidylinositol 4-phosphate [PI4P] and weakly with phosphatidylinositol 3-phosphate [PI3P]. Interacts with microtubules. Interacts with actin through its C-terminal domain. Interacts with the C-terminus of AKT1/PKB.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi120829. 15 interactions.
    IntActiQ3V6T2. 8 interactions.
    STRINGi9606.ENSP00000338728.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3V6T2.
    SMRiQ3V6T2. Positions 14-163.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1390 – 140819Phosphoinositide-binding1 PublicationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili196 – 425230Sequence AnalysisAdd
    BLAST
    Coiled coili458 – 1385928Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCDC88 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG12793.
    HOVERGENiHBG057867.
    InParanoidiQ3V6T2.
    OMAiCIRLKEL.
    OrthoDBiEOG7N0C3V.
    PhylomeDBiQ3V6T2.
    TreeFamiTF320231.

    Family and domain databases

    InterProiIPR027717. Girdin.
    IPR008636. Hook-related_fam.
    [Graphical view]
    PANTHERiPTHR18947. PTHR18947. 1 hit.
    PTHR18947:SF30. PTHR18947:SF30. 1 hit.
    PfamiPF05622. HOOK. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q3V6T2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MENEIFTPLL EQFMTSPLVT WVKTFGPLAA GNGTNLDEYV ALVDGVFLNQ     50
    VMLQINPKLE SQRVNKKVNN DASLRMHNLS ILVRQIKFYY QETLQQLIMM 100
    SLPNVLIIGK NPFSEQGTEE VKKLLLLLLG CAVQCQKKEE FIERIQGLDF 150
    DTKAAVAAHI QEVTHNQENV FDLQWMEVTD MSQEDIEPLL KNMALHLKRL 200
    IDERDEHSET IIELSEERDG LHFLPHASSS AQSPCGSPGM KRTESRQHLS 250
    VELADAKAKI RRLRQELEEK TEQLLDCKQE LEQMEIELKR LQQENMNLLS 300
    DARSARMYRD ELDALREKAV RVDKLESEVS RYKERLHDIE FYKARVEELK 350
    EDNQVLLETK TMLEDQLEGT RARSDKLHEL EKENLQLKAK LHDMEMERDM 400
    DRKKIEELME ENMTLEMAQK QSMDESLHLG WELEQISRTS ELSEAPQKSL 450
    GHEVNELTSS RLLKLEMENQ SLTKTVEELR TTVDSVEGNA SKILKMEKEN 500
    QRLSKKVEIL ENEIVQEKQS LQNCQNLSKD LMKEKAQLEK TIETLRENSE 550
    RQIKILEQEN EHLNQTVSSL RQRSQISAEA RVKDIEKENK ILHESIKETS 600
    SKLSKIEFEK RQIKKELEHY KEKGERAEEL ENELHHLEKE NELLQKKITN 650
    LKITCEKIEA LEQENSELER ENRKLKKTLD SFKNLTFQLE SLEKENSQLD 700
    EENLELRRNV ESLKCASMKM AQLQLENKEL ESEKEQLKKG LELLKASFKK 750
    TERLEVSYQG LDIENQRLQK TLENSNKKIQ QLESELQDLE MENQTLQKNL 800
    EELKISSKRL EQLEKENKSL EQETSQLEKD KKQLEKENKR LRQQAEIKDT 850
    TLEENNVKIG NLEKENKTLS KEIGIYKESC VRLKELEKEN KELVKRATID 900
    IKTLVTLRED LVSEKLKTQQ MNNDLEKLTH ELEKIGLNKE RLLHDEQSTD 950
    DSRYKLLESK LESTLKKSLE IKEEKIAALE ARLEESTNYN QQLRQELKTV 1000
    KKNYEALKQR QDEERMVQSS PPISGEDNKW ERESQETTRE LLKVKDRLIE 1050
    VERNNATLQA EKQALKTQLK QLETQNNNLQ AQILALQRQT VSLQEQNTTL 1100
    QTQNAKLQVE NSTLNSQSTS LMNQNAQLLI QQSSLENENE SVIKEREDLK 1150
    SLYDSLIKDH EKLELLHERQ ASEYESLISK HGTLKSAHKN LEVEHRDLED 1200
    RYNQLLKQKG QLEDLEKMLK VEQEKMLLEN KNHETVAAEY KKLCGENDRL 1250
    NHTYSQLLKE TEVLQTDHKN LKSLLNNSKL EQTRLEAEFS KLKEQYQQLD 1300
    ITSTKLNNQC ELLSQLKGNL EEENRHLLDQ IQTLMLQNRT LLEQNMESKD 1350
    LFHVEQRQYI DKLNELRRQK EKLEEKIMDQ YKFYDPSPPR RRGNWITLKM 1400
    RKLIKSKKDI NRERQKSLTL TPTRSDSSEG FLQLPHQDSQ DSSSVGSNSL 1450
    EDGQTLGTKK SSMVALKRLP FLRNRPKDKD KMKACYRRSM SMNDLVQSMV 1500
    LAGQWTGSTE NLEVPDDIST GKRRKELGAM AFSTTAINFS TVNSSAGFRS 1550
    KQLVNNKDTT SFEDISPQGV SDDSSTGSRV HASRPASLDS GRTSTSNSNN 1600
    NASLHEVKAG AVNNQSRPQS HSSGEFSLLH DHEAWSSSGS SPIQYLKRQT 1650
    RSSPVLQHKI SETLESRHHK IKTGSPGSEV VTLQQFLEES NKLTSVQIKS 1700
    SSQENLLDEV MKSLSVSSDF LGKDKPVSCG LARSVSGKTP GDFYDRRTTK 1750
    PEFLRPGPRK TEDTYFISSA GKPTPGTQGK IKLVKESSLS RQSKDSNPYA 1800
    TLPRASSVIS TAEGTTRRTS IHDFLTKDSR LPISVDSPPA AADSNTTAAS 1850
    NVDKVQESRN SKSRSREQQS S 1871
    Length:1,871
    Mass (Da):216,042
    Last modified:May 15, 2007 - v2
    Checksum:i9DD2E06F2A235AA5
    GO
    Isoform 22 Publications (identifier: Q3V6T2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1463-1491: MVALKRLPFLRNRPKDKDKMKACYRRSMS → T

    Show »
    Length:1,843
    Mass (Da):212,620
    Checksum:i32BCF709F5ADEDC0
    GO
    Isoform 3 (identifier: Q3V6T2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         952-952: Missing.

    Show »
    Length:1,870
    Mass (Da):215,954
    Checksum:i259F771ECE3DDCFD
    GO
    Isoform 4 (identifier: Q3V6T2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         952-952: Missing.
         1463-1491: MVALKRLPFLRNRPKDKDKMKACYRRSMS → T

    Show »
    Length:1,842
    Mass (Da):212,533
    Checksum:i48C4D509CC7EEE68
    GO
    Isoform 5 (identifier: Q3V6T2-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         952-952: Missing.
         1733-1806: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,796
    Mass (Da):207,797
    Checksum:iDE7B152EACCC2422
    GO

    Sequence cautioni

    The sequence CAD97945.1 differs from that shown. Reason: Intron retention at the C-terminus.
    The sequence AAY14932.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAI46020.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1066 – 10661K → E in CAI46020. (PubMed:17974005)Curated
    Sequence conflicti1081 – 10811A → T in CAD97945. (PubMed:17974005)Curated
    Sequence conflicti1661 – 16611S → P in CAD97945. (PubMed:17974005)Curated
    Sequence conflicti1710 – 17101V → I in CAI46020. (PubMed:17974005)Curated
    Sequence conflicti1799 – 17991Y → H in CAD98038. (PubMed:17974005)Curated
    Sequence conflicti1836 – 18361D → G in CAI46020. (PubMed:17974005)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei952 – 9521Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsVSP_040129
    Alternative sequencei1463 – 149129MVALK…RRSMS → T in isoform 2 and isoform 4. 4 PublicationsVSP_052409Add
    BLAST
    Alternative sequencei1733 – 180674Missing in isoform 5. 1 PublicationVSP_044943Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB201172 mRNA. Translation: BAE44387.1.
    AB125644 mRNA. Translation: BAF44475.1.
    AC019198 Genomic DNA. Translation: AAY14932.1. Different initiation.
    AC092176 Genomic DNA. Translation: AAX82029.1.
    AC012358 Genomic DNA. No translation available.
    BC132736 mRNA. Translation: AAI32737.1.
    BC144320 mRNA. Translation: AAI44321.1.
    BX537985 mRNA. Translation: CAD97945.1. Sequence problems.
    BX538154 mRNA. Translation: CAD98038.1.
    BX648138 mRNA. Translation: CAI46020.1. Different initiation.
    CCDSiCCDS33203.1. [Q3V6T2-2]
    CCDS46288.1. [Q3V6T2-3]
    CCDS58710.1. [Q3V6T2-5]
    RefSeqiNP_001129069.1. NM_001135597.1. [Q3V6T2-3]
    NP_001241872.1. NM_001254943.1. [Q3V6T2-5]
    NP_060554.3. NM_018084.4. [Q3V6T2-2]
    XP_005264480.1. XM_005264423.1. [Q3V6T2-4]
    UniGeneiHs.292925.

    Genome annotation databases

    EnsembliENST00000263630; ENSP00000263630; ENSG00000115355. [Q3V6T2-2]
    ENST00000336838; ENSP00000338728; ENSG00000115355. [Q3V6T2-3]
    ENST00000413716; ENSP00000404431; ENSG00000115355. [Q3V6T2-5]
    ENST00000436346; ENSP00000410608; ENSG00000115355. [Q3V6T2-1]
    GeneIDi55704.
    KEGGihsa:55704.
    UCSCiuc002ryu.2. human. [Q3V6T2-4]
    uc002ryv.2. human. [Q3V6T2-3]
    uc010yoz.1. human. [Q3V6T2-2]
    uc010ypa.1. human.

    Polymorphism databases

    DMDMi147644956.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB201172 mRNA. Translation: BAE44387.1 .
    AB125644 mRNA. Translation: BAF44475.1 .
    AC019198 Genomic DNA. Translation: AAY14932.1 . Different initiation.
    AC092176 Genomic DNA. Translation: AAX82029.1 .
    AC012358 Genomic DNA. No translation available.
    BC132736 mRNA. Translation: AAI32737.1 .
    BC144320 mRNA. Translation: AAI44321.1 .
    BX537985 mRNA. Translation: CAD97945.1 . Sequence problems.
    BX538154 mRNA. Translation: CAD98038.1 .
    BX648138 mRNA. Translation: CAI46020.1 . Different initiation.
    CCDSi CCDS33203.1. [Q3V6T2-2 ]
    CCDS46288.1. [Q3V6T2-3 ]
    CCDS58710.1. [Q3V6T2-5 ]
    RefSeqi NP_001129069.1. NM_001135597.1. [Q3V6T2-3 ]
    NP_001241872.1. NM_001254943.1. [Q3V6T2-5 ]
    NP_060554.3. NM_018084.4. [Q3V6T2-2 ]
    XP_005264480.1. XM_005264423.1. [Q3V6T2-4 ]
    UniGenei Hs.292925.

    3D structure databases

    ProteinModelPortali Q3V6T2.
    SMRi Q3V6T2. Positions 14-163.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120829. 15 interactions.
    IntActi Q3V6T2. 8 interactions.
    STRINGi 9606.ENSP00000338728.

    PTM databases

    PhosphoSitei Q3V6T2.

    Polymorphism databases

    DMDMi 147644956.

    Proteomic databases

    MaxQBi Q3V6T2.
    PaxDbi Q3V6T2.
    PRIDEi Q3V6T2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263630 ; ENSP00000263630 ; ENSG00000115355 . [Q3V6T2-2 ]
    ENST00000336838 ; ENSP00000338728 ; ENSG00000115355 . [Q3V6T2-3 ]
    ENST00000413716 ; ENSP00000404431 ; ENSG00000115355 . [Q3V6T2-5 ]
    ENST00000436346 ; ENSP00000410608 ; ENSG00000115355 . [Q3V6T2-1 ]
    GeneIDi 55704.
    KEGGi hsa:55704.
    UCSCi uc002ryu.2. human. [Q3V6T2-4 ]
    uc002ryv.2. human. [Q3V6T2-3 ]
    uc010yoz.1. human. [Q3V6T2-2 ]
    uc010ypa.1. human.

    Organism-specific databases

    CTDi 55704.
    GeneCardsi GC02M055514.
    HGNCi HGNC:25523. CCDC88A.
    HPAi HPA038101.
    MIMi 609736. gene.
    neXtProti NX_Q3V6T2.
    PharmGKBi PA162381751.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOVERGENi HBG057867.
    InParanoidi Q3V6T2.
    OMAi CIRLKEL.
    OrthoDBi EOG7N0C3V.
    PhylomeDBi Q3V6T2.
    TreeFami TF320231.

    Miscellaneous databases

    ChiTaRSi CCDC88A. human.
    GeneWikii CCDC88A.
    GenomeRNAii 55704.
    NextBioi 60553.
    PROi Q3V6T2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3V6T2.
    Bgeei Q3V6T2.
    CleanExi HS_CCDC88A.
    Genevestigatori Q3V6T2.

    Family and domain databases

    InterProi IPR027717. Girdin.
    IPR008636. Hook-related_fam.
    [Graphical view ]
    PANTHERi PTHR18947. PTHR18947. 1 hit.
    PTHR18947:SF30. PTHR18947:SF30. 1 hit.
    Pfami PF05622. HOOK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, INTERACTION WITH AKT1, INTERACTION WITH PHOSPHOINOSITIDES, HOMOOLIGOMERIZATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION AT SER-1417 BY AKT1, MUTAGENESIS OF SER-1417.
      Tissue: Fetal brain1 Publication.
    2. "A novel hook-related protein family and the characterization of hook-related protein 1."
      Simpson F., Martin S., Evans T.M., Kerr M., James D.E., Parton R.G., Teasdale R.D., Wicking C.
      Traffic 6:442-458(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
      Tissue: Fetal brain1 Publication.
    3. Anai M.
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5).
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 811-1871 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 826-1850 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 851-1871 (ISOFORM 4).
      Tissue: Amygdala and Testis.
    7. "Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles."
      Le-Niculescu H., Niesman I., Fischer T., DeVries L., Farquhar M.G.
      J. Biol. Chem. 280:22012-22020(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, SUBCELLULAR LOCATION.
    8. "Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways."
      Enomoto A., Ping J., Takahashi M.
      Ann. N. Y. Acad. Sci. 1086:169-184(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1387; THR-1673 AND SER-1837, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGRDN_HUMAN
    AccessioniPrimary (citable) accession number: Q3V6T2
    Secondary accession number(s): A1IGE7
    , B7ZM78, C9JG83, Q53SF1, Q581G3, Q5HYD0, Q7Z339, Q7Z3C5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3