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Protein

Homeobox protein Hox-D3

Gene

hoxd3a

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi160 – 21960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D3
Gene namesi
Name:hoxd3a
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
ProteomesiUP000001038 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Homeobox protein Hox-D3PRO_0000363947Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi8090.ENSORLP00000021951.

Structurei

3D structure databases

ProteinModelPortaliQ3V5Z9.
SMRiQ3V5Z9. Positions 160-219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi128 – 1336Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG284589.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiQ3V5Z9.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3V5Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKATYYDNS GLFGGYSYPK PDSYSYGPAH QSYPTANIES DYQGPVCPIQ
60 70 80 90 100
TPAVRPPALK DTDLNGDCMR QSSSQSSNSG TQAGSISEQQ APPLSASPPS
110 120 130 140 150
SNSSASQKKK SPSGGASGAA TPALTKQIFP WMKETRQNSK QKSNNCGEVS
160 170 180 190 200
DEKSPPGPAS KRVRTAYTSA QLVELEKEFH FNRYLCRPRR VEMANLLNLT
210 220 230 240 250
ERQIKIWFQN RRMKYKKDQK SKGLAHSPLG HSPDRSPPLS GPNHVGYSGQ
260 270 280 290 300
LQNVNSLSYD APSPPSFAKP QQNMYGLAAY TAPLGGCIPQ QKRYPGSEYE
310 320 330 340 350
HHGMQSNGGF ANANLQGSPV YVGGNFVDSM PASGPMFNLG HLPHPSSTSV
360 370 380 390
DYSCAAQIPG NHHHGPCDPH PTYTDLTSHQ ASQGRIQEAP KLTHL
Length:395
Mass (Da):42,794
Last modified:October 11, 2005 - v1
Checksum:iA7E44CE171E912A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208013 Genomic DNA. Translation: BAE44287.1.
AB232923 Genomic DNA. Translation: BAE53501.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208013 Genomic DNA. Translation: BAE44287.1.
AB232923 Genomic DNA. Translation: BAE53501.1.

3D structure databases

ProteinModelPortaliQ3V5Z9.
SMRiQ3V5Z9. Positions 160-219.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8090.ENSORLP00000021951.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG284589.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiQ3V5Z9.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Organization and structure of hox gene loci in medaka genome and comparison with those of pufferfish and zebrafish genomes."
    Kurosawa G., Takamatsu N., Takahashi M., Sumitomo M., Sanaka E., Yamada K., Nishii K., Matsuda M., Asakawa S., Ishiguro H., Miura K., Kurosawa Y., Shimizu N., Kohara Y., Hori H.
    Gene 370:75-82(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Hd-rR.

Entry informationi

Entry nameiHXD3_ORYLA
AccessioniPrimary (citable) accession number: Q3V5Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: October 11, 2005
Last modified: June 24, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.