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Q3V5Z9

- HXD3_ORYLA

UniProt

Q3V5Z9 - HXD3_ORYLA

Protein

Homeobox protein Hox-D3

Gene

hoxd3a

Organism
Oryzias latipes (Medaka fish) (Japanese ricefish)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi160 – 21960HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-D3
    Gene namesi
    Name:hoxd3a
    OrganismiOryzias latipes (Medaka fish) (Japanese ricefish)
    Taxonomic identifieri8090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
    ProteomesiUP000001038: Unplaced

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 395395Homeobox protein Hox-D3PRO_0000363947Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ3V5Z9.
    SMRiQ3V5Z9. Positions 160-219.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi128 – 1336Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG284589.
    HOGENOMiHOG000252944.
    HOVERGENiHBG107984.
    InParanoidiQ3V5Z9.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR025281. DUF4074.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF13293. DUF4074. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3V5Z9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKATYYDNS GLFGGYSYPK PDSYSYGPAH QSYPTANIES DYQGPVCPIQ    50
    TPAVRPPALK DTDLNGDCMR QSSSQSSNSG TQAGSISEQQ APPLSASPPS 100
    SNSSASQKKK SPSGGASGAA TPALTKQIFP WMKETRQNSK QKSNNCGEVS 150
    DEKSPPGPAS KRVRTAYTSA QLVELEKEFH FNRYLCRPRR VEMANLLNLT 200
    ERQIKIWFQN RRMKYKKDQK SKGLAHSPLG HSPDRSPPLS GPNHVGYSGQ 250
    LQNVNSLSYD APSPPSFAKP QQNMYGLAAY TAPLGGCIPQ QKRYPGSEYE 300
    HHGMQSNGGF ANANLQGSPV YVGGNFVDSM PASGPMFNLG HLPHPSSTSV 350
    DYSCAAQIPG NHHHGPCDPH PTYTDLTSHQ ASQGRIQEAP KLTHL 395
    Length:395
    Mass (Da):42,794
    Last modified:October 11, 2005 - v1
    Checksum:iA7E44CE171E912A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB208013 Genomic DNA. Translation: BAE44287.1.
    AB232923 Genomic DNA. Translation: BAE53501.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB208013 Genomic DNA. Translation: BAE44287.1 .
    AB232923 Genomic DNA. Translation: BAE53501.1 .

    3D structure databases

    ProteinModelPortali Q3V5Z9.
    SMRi Q3V5Z9. Positions 160-219.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG284589.
    HOGENOMi HOG000252944.
    HOVERGENi HBG107984.
    InParanoidi Q3V5Z9.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR025281. DUF4074.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF13293. DUF4074. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Organization and structure of hox gene loci in medaka genome and comparison with those of pufferfish and zebrafish genomes."
      Kurosawa G., Takamatsu N., Takahashi M., Sumitomo M., Sanaka E., Yamada K., Nishii K., Matsuda M., Asakawa S., Ishiguro H., Miura K., Kurosawa Y., Shimizu N., Kohara Y., Hori H.
      Gene 370:75-82(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Hd-rR.

    Entry informationi

    Entry nameiHXD3_ORYLA
    AccessioniPrimary (citable) accession number: Q3V5Z9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3