Q3V5Z9 (HXD3_ORYLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-D3

Gene names

Name:

hoxd3a

Organism

Oryzias latipes (Medaka fish) (Japanese ricefish) [Reference proteome]

Taxonomic identifier

8090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Euteleostei › Neognathi › Neoteleostei › Eurypterygii › Ctenosquamata › Acanthomorpha › Euacanthomorpha › Holacanthopterygii › Acanthopterygii › Euacanthopterygii › Percomorpha › Smegmamorpha › Atherinomorpha › Beloniformes › Adrianichthyoidei › Adrianichthyidae › Oryziinae › Oryzias

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Homeobox protein Hox-D3		PRO_0000363947
Regions
	DNA binding	160 – 219	60	Homeobox
	Motif	128 – 133	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	Q3V5Z9 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: A7E44CE171E912A5	FASTA	395	42,794
	10 20 30 40 50 60 MQKATYYDNS GLFGGYSYPK PDSYSYGPAH QSYPTANIES DYQGPVCPIQ TPAVRPPALK 70 80 90 100 110 120 DTDLNGDCMR QSSSQSSNSG TQAGSISEQQ APPLSASPPS SNSSASQKKK SPSGGASGAA 130 140 150 160 170 180 TPALTKQIFP WMKETRQNSK QKSNNCGEVS DEKSPPGPAS KRVRTAYTSA QLVELEKEFH 190 200 210 220 230 240 FNRYLCRPRR VEMANLLNLT ERQIKIWFQN RRMKYKKDQK SKGLAHSPLG HSPDRSPPLS 250 260 270 280 290 300 GPNHVGYSGQ LQNVNSLSYD APSPPSFAKP QQNMYGLAAY TAPLGGCIPQ QKRYPGSEYE 310 320 330 340 350 360 HHGMQSNGGF ANANLQGSPV YVGGNFVDSM PASGPMFNLG HLPHPSSTSV DYSCAAQIPG 370 380 390 NHHHGPCDPH PTYTDLTSHQ ASQGRIQEAP KLTHL

References

[1]

"Organization and structure of hox gene loci in medaka genome and comparison with those of pufferfish and zebrafish genomes." Kurosawa G., Takamatsu N., Takahashi M., Sumitomo M., Sanaka E., Yamada K., Nishii K., Matsuda M., Asakawa S., Ishiguro H., Miura K., Kurosawa Y., Shimizu N., Kohara Y., Hori H. Gene 370:75-82(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Hd-rR.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB208013 Genomic DNA. Translation: BAE44287.1. AB232923 Genomic DNA. Translation: BAE53501.1.
3D structure databases
ProteinModelPortal	Q3V5Z9.
SMR	Q3V5Z9. Positions 160-219.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG284589.
HOGENOM	HOG000252944.
HOVERGEN	HBG107984.
InParanoid	Q3V5Z9.
OrthoDB	EOG4S4PH1.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR025281. DUF4074. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF13293. DUF4074. 1 hit. PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXD3_ORYLA

Accession

Primary (citable) accession number: Q3V5Z9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	October 11, 2005
Last modified:	May 29, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program