UniProtKB - Q3V5X8 (Q3V5X8_RAT)
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Protein
Submitted name:
Endonuclease G
Gene
Endog
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- deoxyribonuclease activity Source: RGD
- endonuclease activity Source: UniProtKB-KW
- metal ion binding Source: InterPro
- nucleic acid binding Source: InterPro
GO - Biological processi
- aging Source: RGD
- apoptotic DNA fragmentation Source: RGD
- cellular response to calcium ion Source: RGD
- cellular response to glucose stimulus Source: RGD
- cellular response to hypoxia Source: RGD
- cellular response to oxidative stress Source: RGD
- in utero embryonic development Source: RGD
- neuron death in response to oxidative stress Source: RGD
- positive regulation of apoptotic DNA fragmentation Source: RGD
- positive regulation of apoptotic process Source: RGD
- positive regulation of hydrogen peroxide-mediated programmed cell death Source: RGD
- response to antibiotic Source: RGD
- response to estradiol Source: RGD
- response to mechanical stimulus Source: RGD
- response to tumor necrosis factor Source: RGD
Keywordsi
Molecular function | EndonucleaseImported, Hydrolase, Nuclease |
Names & Taxonomyi
Protein namesi | Submitted name: Endonuclease GImported |
Gene namesi | ORF Names:rCG_45387Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1310763. Endog. |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_5014104721 | 20 – 294 | Sequence analysisAdd BLAST | 275 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 74 – 282 | Endonuclease_NSInterPro annotationAdd BLAST | 209 | |
Domaini | 75 – 282 | NUCInterPro annotationAdd BLAST | 208 |
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
eggNOGi | KOG3721. Eukaryota. COG1864. LUCA. |
GeneTreei | ENSGT00530000063772. |
HOGENOMi | HOG000214172. |
HOVERGENi | HBG002851. |
KOi | K01173. |
OMAi | VPHWVFE. |
OrthoDBi | EOG091G0BHG. |
TreeFami | TF105386. |
Family and domain databases
InterProi | View protein in InterPro IPR018524. DNA/RNA_endonuclease_AS. IPR001604. DNA/RNA_non-sp_Endonuclease. IPR020821. Extracellular_endonuc_su_A. |
Pfami | View protein in Pfam PF01223. Endonuclease_NS. 1 hit. |
SMARTi | View protein in SMART SM00892. Endonuclease_NS. 1 hit. SM00477. NUC. 1 hit. |
PROSITEi | View protein in PROSITE PS01070. NUCLEASE_NON_SPEC. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q3V5X8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRALRAGLTL ALGAGLGAAA EHWRRREGKG PGLLGRVPVL PVVAADLPAL
60 70 80 90 100
PGGPAGSTGE LAKYGLPGVA QLRSRESYVL SYDPRTRGAL WVLEQLRPER
110 120 130 140 150
LRGDGDRRAC DFHEDDSVHA YHRATNADYR GSGFDRGHLA AAANHRWSQR
160 170 180 190 200
AMDDTFYLSN VAPQVPHLNQ HAWNNLEKYS RSLTRTYQNV YVCTGPLFLP
210 220 230 240 250
RTEADGKSYV KYQVIGKNHV AVPTHFFKVL ILEAASGQIE LRSYVMPNAP
260 270 280 290
VDETLPLERF LVPIESIERA SGLLFVPNIL ARAGNLKAIT AGSK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07051398 Genomic DNA. No translation available. AABR07072849 Genomic DNA. No translation available. AABR07072850 Genomic DNA. No translation available. AB221075 mRNA. Translation: BAE44115.1. CH474001 Genomic DNA. Translation: EDL93340.1. |
RefSeqi | NP_001030110.1. NM_001034938.1. |
UniGenei | Rn.3807. |
Genome annotation databases
Ensembli | ENSRNOT00000021531; ENSRNOP00000021531; ENSRNOG00000016033. |
GeneIDi | 362100. |
KEGGi | rno:362100. |
UCSCi | RGD:1310763. rat. |
Similar proteinsi
Entry informationi
Entry namei | Q3V5X8_RAT | |
Accessioni | Q3V5X8Primary (citable) accession number: Q3V5X8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | March 28, 2018 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |