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Protein
Submitted name:

Endonuclease G

Gene

Endog

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • apoptotic DNA fragmentation Source: Ensembl
  • cellular response to calcium ion Source: RGD
  • cellular response to glucose stimulus Source: RGD
  • cellular response to hypoxia Source: RGD
  • cellular response to oxidative stress Source: RGD
  • in utero embryonic development Source: Ensembl
  • neuron death in response to oxidative stress Source: RGD
  • positive regulation of apoptotic DNA fragmentation Source: RGD
  • positive regulation of hydrogen peroxide-mediated programmed cell death Source: RGD
  • response to antibiotic Source: Ensembl
  • response to estradiol Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to tumor necrosis factor Source: Ensembl

Keywordsi

Molecular functionEndonucleaseImported, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Submitted name:
Endonuclease GImported
Gene namesi
Name:EndogImported
Synonyms:endogImported
ORF Names:rCG_45387Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1310763 Endog

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501410472120 – 294Sequence analysisAdd BLAST275

Proteomic databases

PRIDEiQ3V5X8

Expressioni

Gene expression databases

BgeeiENSRNOG00000016033

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021531

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 282Endonuclease_NSInterPro annotationAdd BLAST209
Domaini75 – 282NUCInterPro annotationAdd BLAST208

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3721 Eukaryota
COG1864 LUCA
GeneTreeiENSGT00530000063772
HOGENOMiHOG000214172
HOVERGENiHBG002851
KOiK01173
OMAiVPHWVFE
OrthoDBiEOG091G0BHG
TreeFamiTF105386

Family and domain databases

InterProiView protein in InterPro
IPR018524 DNA/RNA_endonuclease_AS
IPR001604 DNA/RNA_non-sp_Endonuclease
IPR020821 Extracellular_endonuc_su_A
PfamiView protein in Pfam
PF01223 Endonuclease_NS, 1 hit
SMARTiView protein in SMART
SM00892 Endonuclease_NS, 1 hit
SM00477 NUC, 1 hit
PROSITEiView protein in PROSITE
PS01070 NUCLEASE_NON_SPEC, 1 hit

Sequencei

Sequence statusi: Complete.

Q3V5X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALRAGLTL ALGAGLGAAA EHWRRREGKG PGLLGRVPVL PVVAADLPAL
60 70 80 90 100
PGGPAGSTGE LAKYGLPGVA QLRSRESYVL SYDPRTRGAL WVLEQLRPER
110 120 130 140 150
LRGDGDRRAC DFHEDDSVHA YHRATNADYR GSGFDRGHLA AAANHRWSQR
160 170 180 190 200
AMDDTFYLSN VAPQVPHLNQ HAWNNLEKYS RSLTRTYQNV YVCTGPLFLP
210 220 230 240 250
RTEADGKSYV KYQVIGKNHV AVPTHFFKVL ILEAASGQIE LRSYVMPNAP
260 270 280 290
VDETLPLERF LVPIESIERA SGLLFVPNIL ARAGNLKAIT AGSK
Length:294
Mass (Da):32,268
Last modified:October 11, 2005 - v1
Checksum:iBE47E0D9D537C06C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07051398 Genomic DNA No translation available.
AABR07072849 Genomic DNA No translation available.
AABR07072850 Genomic DNA No translation available.
AB221075 mRNA Translation: BAE44115.1
CH474001 Genomic DNA Translation: EDL93340.1
RefSeqiNP_001030110.1, NM_001034938.1
UniGeneiRn.3807

Genome annotation databases

EnsembliENSRNOT00000021531; ENSRNOP00000021531; ENSRNOG00000016033
GeneIDi362100
KEGGirno:362100
UCSCiRGD:1310763 rat

Similar proteinsi

Entry informationi

Entry nameiQ3V5X8_RAT
AccessioniPrimary (citable) accession number: Q3V5X8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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