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Protein
Submitted name:

Endonuclease G

Gene

Endog

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • apoptotic DNA fragmentation Source: Ensembl
  • cellular response to calcium ion Source: RGD
  • cellular response to glucose stimulus Source: RGD
  • cellular response to hypoxia Source: RGD
  • cellular response to oxidative stress Source: RGD
  • in utero embryonic development Source: Ensembl
  • neuron death in response to oxidative stress Source: RGD
  • positive regulation of apoptotic DNA fragmentation Source: RGD
  • positive regulation of hydrogen peroxide-mediated programmed cell death Source: RGD
  • response to antibiotic Source: Ensembl
  • response to estradiol Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to tumor necrosis factor Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseImported, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Submitted name:
Endonuclease GImported
Submitted name:
Protein EndogImported
Gene namesi
Name:EndogImported
Synonyms:endogImported
ORF Names:rCG_45387Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1310763. Endog.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • mitochondrion Source: RGD
  • nucleus Source: RGD
  • perikaryon Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 294275Sequence analysisPRO_5007209151Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021531.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 282209Endonuclease_NSInterPro annotationAdd
BLAST
Domaini75 – 282208NUCInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3721. Eukaryota.
COG1864. LUCA.
GeneTreeiENSGT00530000063772.
HOGENOMiHOG000214172.
HOVERGENiHBG002851.
KOiK01173.
OMAiHVFHRAT.
OrthoDBiEOG7VB2FZ.
PhylomeDBiQ3V5X8.
TreeFamiTF105386.

Family and domain databases

Gene3Di3.40.570.10. 1 hit.
InterProiIPR018524. DNA/RNA_endonuclease_AS.
IPR001604. DNA/RNA_non-sp_Endonuclease.
IPR020821. Extracellular_endonuc_su_A.
[Graphical view]
PfamiPF01223. Endonuclease_NS. 1 hit.
[Graphical view]
SMARTiSM00892. Endonuclease_NS. 1 hit.
SM00477. NUC. 1 hit.
[Graphical view]
PROSITEiPS01070. NUCLEASE_NON_SPEC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3V5X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALRAGLTL ALGAGLGAAA EHWRRREGKG PGLLGRVPVL PVVAADLPAL
60 70 80 90 100
PGGPAGSTGE LAKYGLPGVA QLRSRESYVL SYDPRTRGAL WVLEQLRPER
110 120 130 140 150
LRGDGDRRAC DFHEDDSVHA YHRATNADYR GSGFDRGHLA AAANHRWSQR
160 170 180 190 200
AMDDTFYLSN VAPQVPHLNQ HAWNNLEKYS RSLTRTYQNV YVCTGPLFLP
210 220 230 240 250
RTEADGKSYV KYQVIGKNHV AVPTHFFKVL ILEAASGQIE LRSYVMPNAP
260 270 280 290
VDETLPLERF LVPIESIERA SGLLFVPNIL ARAGNLKAIT AGSK
Length:294
Mass (Da):32,268
Last modified:October 11, 2005 - v1
Checksum:iBE47E0D9D537C06C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07051398 Genomic DNA. No translation available.
AABR07072849 Genomic DNA. No translation available.
AABR07072850 Genomic DNA. No translation available.
AB221075 mRNA. Translation: BAE44115.1.
CH474001 Genomic DNA. Translation: EDL93340.1.
RefSeqiNP_001030110.1. NM_001034938.1.
UniGeneiRn.3807.

Genome annotation databases

EnsembliENSRNOT00000021531; ENSRNOP00000021531; ENSRNOG00000016033.
GeneIDi362100.
KEGGirno:362100.
UCSCiRGD:1310763. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07051398 Genomic DNA. No translation available.
AABR07072849 Genomic DNA. No translation available.
AABR07072850 Genomic DNA. No translation available.
AB221075 mRNA. Translation: BAE44115.1.
CH474001 Genomic DNA. Translation: EDL93340.1.
RefSeqiNP_001030110.1. NM_001034938.1.
UniGeneiRn.3807.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021531.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021531; ENSRNOP00000021531; ENSRNOG00000016033.
GeneIDi362100.
KEGGirno:362100.
UCSCiRGD:1310763. rat.

Organism-specific databases

CTDi2021.
RGDi1310763. Endog.

Phylogenomic databases

eggNOGiKOG3721. Eukaryota.
COG1864. LUCA.
GeneTreeiENSGT00530000063772.
HOGENOMiHOG000214172.
HOVERGENiHBG002851.
KOiK01173.
OMAiHVFHRAT.
OrthoDBiEOG7VB2FZ.
PhylomeDBiQ3V5X8.
TreeFamiTF105386.

Family and domain databases

Gene3Di3.40.570.10. 1 hit.
InterProiIPR018524. DNA/RNA_endonuclease_AS.
IPR001604. DNA/RNA_non-sp_Endonuclease.
IPR020821. Extracellular_endonuc_su_A.
[Graphical view]
PfamiPF01223. Endonuclease_NS. 1 hit.
[Graphical view]
SMARTiSM00892. Endonuclease_NS. 1 hit.
SM00477. NUC. 1 hit.
[Graphical view]
PROSITEiPS01070. NUCLEASE_NON_SPEC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. "Involvement of endonuclease G in nucleosomal DNA fragmentation under sustained endogenous oxidative stress."
    Ishihara Y., Shimamoto N.
    J. Biol. Chem. 281:6726-6733(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: LiverImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ3V5X8_RAT
AccessioniPrimary (citable) accession number: Q3V5X8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.