Endog

Functionⁱ

GO - Molecular functionⁱ

deoxyribonuclease activity
Source: RGD
Inferred from direct assayⁱ
- 16407272
endonuclease activity Source: UniProtKB-KW
metal ion binding Source: InterPro
nucleic acid binding Source: InterPro

GO - Biological processⁱ

aging
Source: RGD
Inferred from expression patternⁱ
- 15650125
apoptotic DNA fragmentation Source: Ensembl
cellular response to calcium ion
Source: RGD
Inferred from expression patternⁱ
- 12582256
cellular response to glucose stimulus
Source: RGD
Inferred from expression patternⁱ
- 23192364
cellular response to hypoxia
Source: RGD
Inferred from expression patternⁱ
- 17379825
cellular response to oxidative stress
Source: RGD
Inferred from expression patternⁱ
- 16407272
in utero embryonic development Source: Ensembl
neuron death in response to oxidative stress
Source: RGD
Inferred from expression patternⁱ
- 23006905
positive regulation of apoptotic DNA fragmentation
Source: RGD
Inferred from mutant phenotypeⁱ
- 16407272
positive regulation of hydrogen peroxide-mediated programmed cell death
Source: RGD
Inferred from mutant phenotypeⁱ
- 20594982
response to antibiotic Source: Ensembl
response to estradiol
Source: RGD
Inferred from expression patternⁱ
- 24121025
response to mechanical stimulus
Source: RGD
Inferred from expression patternⁱ
- 21540338
response to tumor necrosis factor Source: Ensembl

Complete GO annotation...

Keywords - Molecular functionⁱ

EndonucleaseImported, Hydrolase, Nuclease

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Endonuclease GImported Automatic assertion inferred from database entriesⁱ EMBL:BAE44115.1 Submitted name: Protein EndogImported Automatic assertion inferred from database entriesⁱ Ensembl:ENSRNOP00000021531
Gene namesⁱ	Name:EndogImported Automatic assertion inferred from database entriesⁱ EMBL:EDL93340.1 Ensembl:ENSRNOP00000021531 RGD:1310763 Synonyms:endogImported Automatic assertion inferred from database entriesⁱ EMBL:BAE44115.1 ORF Names:rCG_45387Imported Automatic assertion inferred from database entriesⁱ EMBL:EDL93340.1
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 3

Organism-specific databases

RGDⁱ	1310763. Endog.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytosol
Source: RGD
Inferred from direct assayⁱ
- 16407272
mitochondrion
Source: RGD
Inferred from direct assayⁱ
- 16407272
nucleus
Source: RGD
Inferred from direct assayⁱ
- 16407272
perikaryon
Source: RGD
Inferred from direct assayⁱ
- 16689664

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Signal peptideⁱ	1 – 19	19	Sequence analysis Automatic assertion according to rulesⁱ SAM:SignalP			Add BLAST
Chainⁱ	20 – 294	275	Sequence analysis Automatic assertion according to rulesⁱ SAM:SignalP		PRO_5007923730	Add BLAST

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000016033.

Bgeeⁱ

ENSRNOG00000016033.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000021531.

STRINGⁱ

10116.ENSRNOP00000021531.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Domainⁱ	74 – 282	209	Endonuclease_NSInterPro annotation Automatic assertion inferred from signature matchⁱ SMART:SM00892			Add BLAST
Domainⁱ	75 – 282	208	NUCInterPro annotation Automatic assertion inferred from signature matchⁱ SMART:SM00477			Add BLAST

Keywords - Domainⁱ

SignalSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3721. Eukaryota. COG1864. LUCA.
GeneTreeⁱ	ENSGT00530000063772.
HOGENOMⁱ	HOG000214172.
HOVERGENⁱ	HBG002851.
KOⁱ	K01173.
OMAⁱ	VRYQVIG.
OrthoDBⁱ	EOG091G0BHG.
TreeFamⁱ	TF105386.

Family and domain databases

Gene3Dⁱ	3.40.570.10. 1 hit.
InterProⁱ	IPR018524. DNA/RNA_endonuclease_AS. IPR001604. DNA/RNA_non-sp_Endonuclease. IPR020821. Extracellular_endonuc_su_A. [Graphical view]
Pfamⁱ	PF01223. Endonuclease_NS. 1 hit. [Graphical view]
SMARTⁱ	SM00892. Endonuclease_NS. 1 hit. SM00477. NUC. 1 hit. [Graphical view]
PROSITEⁱ	PS01070. NUCLEASE_NON_SPEC. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3V5X8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRALRAGLTL ALGAGLGAAA EHWRRREGKG PGLLGRVPVL PVVAADLPAL 
        60         70         80         90        100
PGGPAGSTGE LAKYGLPGVA QLRSRESYVL SYDPRTRGAL WVLEQLRPER 
       110        120        130        140        150
LRGDGDRRAC DFHEDDSVHA YHRATNADYR GSGFDRGHLA AAANHRWSQR 
       160        170        180        190        200
AMDDTFYLSN VAPQVPHLNQ HAWNNLEKYS RSLTRTYQNV YVCTGPLFLP 
       210        220        230        240        250
RTEADGKSYV KYQVIGKNHV AVPTHFFKVL ILEAASGQIE LRSYVMPNAP 
       260        270        280        290 
VDETLPLERF LVPIESIERA SGLLFVPNIL ARAGNLKAIT AGSK

Length:294

Mass (Da):32,268

Last modified:October 11, 2005 - v1

Checksum:ⁱBE47E0D9D537C06C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07051398 Genomic DNA. No translation available. AABR07072849 Genomic DNA. No translation available. AABR07072850 Genomic DNA. No translation available. AB221075 mRNA. Translation: BAE44115.1. CH474001 Genomic DNA. Translation: EDL93340.1.
RefSeqⁱ	NP_001030110.1. NM_001034938.1.
UniGeneⁱ	Rn.3807.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000021531; ENSRNOP00000021531; ENSRNOG00000016033.
GeneIDⁱ	362100.
KEGGⁱ	rno:362100.
UCSCⁱ	RGD:1310763. rat.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07051398 Genomic DNA. No translation available. AABR07072849 Genomic DNA. No translation available. AABR07072850 Genomic DNA. No translation available. AB221075 mRNA. Translation: BAE44115.1. CH474001 Genomic DNA. Translation: EDL93340.1.
RefSeqⁱ	NP_001030110.1. NM_001034938.1.
UniGeneⁱ	Rn.3807.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000021531.

STRINGⁱ

10116.ENSRNOP00000021531.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000021531; ENSRNOP00000021531; ENSRNOG00000016033.
GeneIDⁱ	362100.
KEGGⁱ	rno:362100.
UCSCⁱ	RGD:1310763. rat.

Organism-specific databases

CTDⁱ	2021.
RGDⁱ	1310763. Endog.

Phylogenomic databases

eggNOGⁱ	KOG3721. Eukaryota. COG1864. LUCA.
GeneTreeⁱ	ENSGT00530000063772.
HOGENOMⁱ	HOG000214172.
HOVERGENⁱ	HBG002851.
KOⁱ	K01173.
OMAⁱ	VRYQVIG.
OrthoDBⁱ	EOG091G0BHG.
TreeFamⁱ	TF105386.

Gene expression databases

Bgeeⁱ	ENSRNOG00000016033.

Bgeeⁱ

ENSRNOG00000016033.

Family and domain databases

Gene3Dⁱ	3.40.570.10. 1 hit.
InterProⁱ	IPR018524. DNA/RNA_endonuclease_AS. IPR001604. DNA/RNA_non-sp_Endonuclease. IPR020821. Extracellular_endonuc_su_A. [Graphical view]
Pfamⁱ	PF01223. Endonuclease_NS. 1 hit. [Graphical view]
SMARTⁱ	SM00892. Endonuclease_NS. 1 hit. SM00477. NUC. 1 hit. [Graphical view]
PROSITEⁱ	PS01070. NUCLEASE_NON_SPEC. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

Q3V5X8_RAT

Accessionⁱ

Primary (citable) accession number: Q3V5X8

Entry historyⁱ

Integrated into UniProtKB/TrEMBL:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3V5X8 (Q3V5X8_RAT)

UniProt

Q3V5X8 - Q3V5X8_RAT

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Endonuclease G

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ