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Protein

Adhesion G-protein coupled receptor G5

Gene

Adgrg5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiP02.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G-protein coupled receptor G5
Alternative name(s):
G-protein coupled receptor 114
G-protein coupled receptor PGR27
Gene namesi
Name:Adgrg5
Synonyms:Gm1109, Gpr114, Pgr27
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2685955. Adgrg5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 245222ExtracellularCuratedAdd
BLAST
Transmembranei246 – 26621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini267 – 28317CytoplasmicCuratedAdd
BLAST
Transmembranei284 – 30421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini305 – 31814ExtracellularCuratedAdd
BLAST
Transmembranei319 – 33921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini340 – 35011CytoplasmicCuratedAdd
BLAST
Transmembranei351 – 37121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini372 – 41241ExtracellularCuratedAdd
BLAST
Transmembranei413 – 43321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini434 – 45219CytoplasmicCuratedAdd
BLAST
Transmembranei453 – 47523Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini476 – 4794ExtracellularCurated
Transmembranei480 – 49920Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini500 – 52324CytoplasmicCuratedAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 523500Adhesion G-protein coupled receptor G5PRO_0000288638Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence analysis
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence analysis
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence analysis
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence analysis
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence analysis
Glycosylationi389 – 3891N-linked (GlcNAc...)Sequence analysis
Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3V3Z3.
PRIDEiQ3V3Z3.

PTM databases

PhosphoSiteiQ3V3Z3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000061577.
CleanExiMM_GPR114.
ExpressionAtlasiQ3V3Z3. baseline and differential.
GenevisibleiQ3V3Z3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000132628.

Structurei

3D structure databases

ProteinModelPortaliQ3V3Z3.
SMRiQ3V3Z3. Positions 203-499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini182 – 23453GPSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOVERGENiHBG107961.
InParanoidiQ3V3Z3.
KOiK08459.
TreeFamiTF321769.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR003910. GPR1/GPR3/GPR5.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01422. GPR56ORPHANR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3V3Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPHGALFFY LCLLAAQVVL VETLSDLLVL MKRLEQPVGR GLSSRARHIH
60 70 80 90 100
SLEQKLLNAS FGGHNLTLQT NSIQSLVFKL SCDFPGLSLS STTLTNVSQV
110 120 130 140 150
RAPHAMQFPA ELTKGACVTS RPAELRLICI YFFTAHLFQD DRNSSLLNNY
160 170 180 190 200
VLGAQLDHRP VNNLQKPVNI SFWHNRSLEG YTVSCVFWKE GASKSSWGAW
210 220 230 240 250
SPEGCYTEQP SATQVLCHCN HLTYFAVLML SGDPVPAELQ VPLEYISFVG
260 270 280 290 300
CSISIVASLL TILLYAQSRK QSDSTTRIHM NLNGSVLLLN VTFLLSSQMT
310 320 330 340 350
LPTMPRPVCK VLAAVLHYAL LSSLTWMAIE GFNLYLFLGR VYNAYIRRYL
360 370 380 390 400
LKLCMLGWGF PALLVLLLLM IKSSVYGPCV TSLSKSQENG TGFQNVSMCW
410 420 430 440 450
IRSPMVHSIL VMGYGGFTSL FNLVVLAWAL WILCRLRARE KALSPWAYRD
460 470 480 490 500
TAMVLGLTVL LGTTWTLAFF SFGVFLLPQL FLFTIFNSLY GFFLFLWFCS
510 520
QKRYSDAEAK AEMEAVSSSQ MTH
Length:523
Mass (Da):58,547
Last modified:October 3, 2012 - v2
Checksum:i330D435A94E0894C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791K → N in BAE20445 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028878 mRNA. Translation: BAE20445.1.
AC129606 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11153.1.
CCDSiCCDS22552.1.
RefSeqiNP_001028640.2. NM_001033468.3.
NP_001139444.1. NM_001145972.1.
XP_011246724.1. XM_011248422.1.
UniGeneiMm.334726.

Genome annotation databases

EnsembliENSMUST00000074570; ENSMUSP00000074155; ENSMUSG00000061577.
GeneIDi382045.
KEGGimmu:382045.
UCSCiuc009mxi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028878 mRNA. Translation: BAE20445.1.
AC129606 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11153.1.
CCDSiCCDS22552.1.
RefSeqiNP_001028640.2. NM_001033468.3.
NP_001139444.1. NM_001145972.1.
XP_011246724.1. XM_011248422.1.
UniGeneiMm.334726.

3D structure databases

ProteinModelPortaliQ3V3Z3.
SMRiQ3V3Z3. Positions 203-499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000132628.

Protein family/group databases

MEROPSiP02.016.
GPCRDBiSearch...

PTM databases

PhosphoSiteiQ3V3Z3.

Proteomic databases

PaxDbiQ3V3Z3.
PRIDEiQ3V3Z3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074570; ENSMUSP00000074155; ENSMUSG00000061577.
GeneIDi382045.
KEGGimmu:382045.
UCSCiuc009mxi.2. mouse.

Organism-specific databases

CTDi221188.
MGIiMGI:2685955. Adgrg5.

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOVERGENiHBG107961.
InParanoidiQ3V3Z3.
KOiK08459.
TreeFamiTF321769.

Miscellaneous databases

PROiQ3V3Z3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061577.
CleanExiMM_GPR114.
ExpressionAtlasiQ3V3Z3. baseline and differential.
GenevisibleiQ3V3Z3. MM.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR003910. GPR1/GPR3/GPR5.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01422. GPR56ORPHANR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRG5_MOUSE
AccessioniPrimary (citable) accession number: Q3V3Z3
Secondary accession number(s): G5E8G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.