Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Integrin alpha-1

Gene

Itga1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi497 – 5059Sequence analysis
Calcium bindingi579 – 5879Sequence analysis
Calcium bindingi641 – 6499Sequence analysis

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: Ensembl
  • cell adhesion Source: MGI
  • cell-matrix adhesion Source: MGI
  • cellular extravasation Source: MGI
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
  • neuron projection morphogenesis Source: Ensembl
  • neutrophil chemotaxis Source: MGI
  • positive regulation of neuron apoptotic process Source: Ensembl
  • positive regulation of phosphoprotein phosphatase activity Source: UniProtKB
  • vasodilation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-216083. Integrin cell surface interactions.
R-MMU-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-1
Alternative name(s):
CD49 antigen-like family member A
Laminin and collagen receptor
VLA-1
CD_antigen: CD49a
Gene namesi
Name:Itga1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:96599. Itga1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 11411113ExtracellularSequence analysisAdd
BLAST
Transmembranei1142 – 116423HelicalSequence analysisAdd
BLAST
Topological domaini1165 – 117915CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • acrosomal vesicle Source: Ensembl
  • basal part of cell Source: MGI
  • cell surface Source: UniProtKB
  • external side of plasma membrane Source: MGI
  • extracellular exosome Source: MGI
  • focal adhesion Source: MGI
  • integrin alpha1-beta1 complex Source: MGI
  • membrane Source: MGI
  • membrane raft Source: Ensembl
  • neuron projection Source: Ensembl
  • perikaryon Source: Ensembl
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828By similarityAdd
BLAST
Chaini29 – 11791151Integrin alpha-1By similarityPRO_0000273722Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi82 ↔ 92By similarity
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence analysis
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence analysis
Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence analysis
Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence analysis
Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence analysis
Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence analysis
Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence analysis
Glycosylationi459 – 4591N-linked (GlcNAc...)Sequence analysis
Glycosylationi531 – 5311N-linked (GlcNAc...)Sequence analysis
Disulfide bondi687 ↔ 696By similarity
Glycosylationi698 – 6981N-linked (GlcNAc...)Sequence analysis
Disulfide bondi702 ↔ 755By similarity
Glycosylationi747 – 7471N-linked (GlcNAc...)Sequence analysis
Glycosylationi779 – 7791N-linked (GlcNAc...)Sequence analysis
Disulfide bondi807 ↔ 813By similarity
Glycosylationi839 – 8391N-linked (GlcNAc...)Sequence analysis
Disulfide bondi877 ↔ 885By similarity
Glycosylationi882 – 8821N-linked (GlcNAc...)Sequence analysis
Glycosylationi907 – 9071N-linked (GlcNAc...)Sequence analysis
Glycosylationi938 – 9381N-linked (GlcNAc...)Sequence analysis
Glycosylationi965 – 9651N-linked (GlcNAc...)Sequence analysis
Glycosylationi973 – 9731N-linked (GlcNAc...)Sequence analysis
Glycosylationi1007 – 10071N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1029 ↔ 1062By similarity
Disulfide bondi1065 ↔ 1072By similarity
Glycosylationi1083 – 10831N-linked (GlcNAc...)Sequence analysis
Glycosylationi1102 – 11021N-linked (GlcNAc...)Sequence analysis
Glycosylationi1113 – 11131N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ3V3R4.
PaxDbiQ3V3R4.
PRIDEiQ3V3R4.

PTM databases

PhosphoSiteiQ3V3R4.
SwissPalmiQ3V3R4.

Expressioni

Gene expression databases

CleanExiMM_ITGA1.
GenevisibleiQ3V3R4. MM.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1 (By similarity). Interacts with RAB21 (By similarity). Interacts (via cytoplasmic domain) with PTPN2; activates PTPN2 phosphatase activity towards EGFR and negatively regulates EGF signaling (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077132.

Structurei

3D structure databases

ProteinModelPortaliQ3V3R4.
SMRiQ3V3R4. Positions 29-362, 379-656, 1135-1179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati30 – 9162FG-GAP 1Add
BLAST
Repeati101 – 16060FG-GAP 2Add
BLAST
Domaini175 – 364190VWFAPROSITE-ProRule annotationAdd
BLAST
Repeati365 – 41753FG-GAP 3Add
BLAST
Repeati422 – 47453FG-GAP 4Add
BLAST
Repeati475 – 53763FG-GAP 5Add
BLAST
Repeati556 – 61459FG-GAP 6Add
BLAST
Repeati618 – 67861FG-GAP 7Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1167 – 11715GFFKR motif

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPB7. Eukaryota.
ENOG410YEM8. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiQ3V3R4.
KOiK06480.
OMAiQRFSIAI.
OrthoDBiEOG7GBFW6.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3V3R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPRRPASLE VTVACIWLLT VILGVCISFN VDVKNSMSFS GPVEDMFGYT
60 70 80 90 100
VQQYENEEGK WVLIGSPLVG QPKARTGDVY KCPVGRERSM PCVKLDLPVN
110 120 130 140 150
TSIPNVTEIK ENMTFGSTLV TNPKGGFLAC GPLYAYRCGH LHYTTGICSD
160 170 180 190 200
VSPTFQVVNS FAPVQECSTQ LDIVIVLDGS NSIYPWESVT AFLNDLLKRM
210 220 230 240 250
DIGPKQTQVG IVQYGANVTH EFNLNKYSST EEVLVAANKI GRRGGLQTMT
260 270 280 290 300
ALGIDTARKE AFTEARGARR GVKKVMVIVT DGESHDNYRL KQVIQDCEDE
310 320 330 340 350
NIQRFSIAIL GHYNRGNLST EKFVEEIKSI ASEPTEKHFF NVSDELALVT
360 370 380 390 400
IVKALGERIF ALEATADQSA ASFEMEMSQT GFSAHYSQDW VMLGAVGAYD
410 420 430 440 450
WNGTVVMQKA NQIVIPHNTT FQTEPTKMNE PLASYLGYTV NSATIPGDVL
460 470 480 490 500
YIAGQPRYNH TGQVVIYKME DGDVNILQTL SGEQIGSYFG SVLTTIDIDK
510 520 530 540 550
DSYTDLLLVG APMYMGTEKE EQGKVYVYAV NQTRFEYQMS LEPIKQTCCS
560 570 580 590 600
SLKDNSCTKE NKNEPCGARF GTAVAAVKDL NVDGFNDVVI GAPLEDDHAG
610 620 630 640 650
AVYIYHGSGK TIRKEYAQRI PSGGDGKTLK FFGQSIHGEM DLNGDGLTDV
660 670 680 690 700
TIGGLGGAAL FWARDVAVVK VTMNFEPNKV NIQKKNCRVE GKETVCINAT
710 720 730 740 750
MCFHVKLKSK EDSVYEADLQ YRVTLDSLRQ ISRSFFSGTQ ERRIQRNLTV
760 770 780 790 800
RESECIRHSF YMLDKHDFQD SVRVTLDFNL TDPENGPVLD DALPNSVHGH
810 820 830 840 850
IPFAKDCGNK ERCVSDLTLD VSTTEKNLLI VRSQNDKFNV SLTVKNKGDS
860 870 880 890 900
AYNTRTVVQY SPNLIFSGIE EIQKDSCESN QNITCRVGYP FLRTGDVVNF
910 920 930 940 950
KIIFQFNTSH LSENAIIHLS ATSDSEEPLE SLYDNEVNIS IPVKYEVGLQ
960 970 980 990 1000
FYSSASEHHI SVAANETVPE LINSTKDIGD EINVFYTIRK RGHFPMPELR
1010 1020 1030 1040 1050
LAISFPNLTS DGYPVLYPTG WSSSDNVNCR PRSLEDPLGI NSGKKMTISK
1060 1070 1080 1090 1100
SEVLKRGTIQ DCSTCKIATI TCHLLPSDVS QVNVSLILWK PTFIKAHFSS
1110 1120 1130 1140 1150
LNLTIRGELQ SENSSLTLSS SNRKRELAIQ ISKDGLPGRV PLWVILLSAF
1160 1170
AGLLLLMLLI LALWKIGFFK RPLKKKMEK
Length:1,179
Mass (Da):130,810
Last modified:October 3, 2012 - v2
Checksum:iD158F297AFA8119F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti782 – 7821D → N in BAE20498 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035870 mRNA. Translation: BAE20498.1.
AC175538 Genomic DNA. No translation available.
CT025598 Genomic DNA. No translation available.
CCDSiCCDS36788.1.
RefSeqiNP_001028400.2. NM_001033228.3.
UniGeneiMm.317280.

Genome annotation databases

EnsembliENSMUST00000061673; ENSMUSP00000077132; ENSMUSG00000042284.
GeneIDi109700.
KEGGimmu:109700.
UCSCiuc007rxx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035870 mRNA. Translation: BAE20498.1.
AC175538 Genomic DNA. No translation available.
CT025598 Genomic DNA. No translation available.
CCDSiCCDS36788.1.
RefSeqiNP_001028400.2. NM_001033228.3.
UniGeneiMm.317280.

3D structure databases

ProteinModelPortaliQ3V3R4.
SMRiQ3V3R4. Positions 29-362, 379-656, 1135-1179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077132.

PTM databases

PhosphoSiteiQ3V3R4.
SwissPalmiQ3V3R4.

Proteomic databases

MaxQBiQ3V3R4.
PaxDbiQ3V3R4.
PRIDEiQ3V3R4.

Protocols and materials databases

DNASUi109700.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061673; ENSMUSP00000077132; ENSMUSG00000042284.
GeneIDi109700.
KEGGimmu:109700.
UCSCiuc007rxx.1. mouse.

Organism-specific databases

CTDi3672.
MGIiMGI:96599. Itga1.

Phylogenomic databases

eggNOGiENOG410IPB7. Eukaryota.
ENOG410YEM8. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiQ3V3R4.
KOiK06480.
OMAiQRFSIAI.
OrthoDBiEOG7GBFW6.
TreeFamiTF105391.

Enzyme and pathway databases

ReactomeiR-MMU-216083. Integrin cell surface interactions.
R-MMU-445355. Smooth Muscle Contraction.

Miscellaneous databases

ChiTaRSiItga1. mouse.
NextBioi362605.
PROiQ3V3R4.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ITGA1.
GenevisibleiQ3V3R4. MM.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP."
    Mattila E., Pellinen T., Nevo J., Vuoriluoto K., Arjonen A., Ivaska J.
    Nat. Cell Biol. 7:78-85(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN EGFR SIGNALING.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiITA1_MOUSE
AccessioniPrimary (citable) accession number: Q3V3R4
Secondary accession number(s): F8VQN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 3, 2012
Last modified: May 11, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.