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Protein

Integrin alpha-1

Gene

Itga1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi497 – 505Sequence analysis9
Calcium bindingi579 – 587Sequence analysis9
Calcium bindingi641 – 649Sequence analysis9

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: Ensembl
  • cell adhesion Source: MGI
  • cell-matrix adhesion Source: MGI
  • cellular extravasation Source: MGI
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
  • neuron projection morphogenesis Source: Ensembl
  • neutrophil chemotaxis Source: MGI
  • positive regulation of neuron apoptotic process Source: Ensembl
  • positive regulation of phosphoprotein phosphatase activity Source: UniProtKB
  • vasodilation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-216083. Integrin cell surface interactions.
R-MMU-416700. Other semaphorin interactions.
R-MMU-445355. Smooth Muscle Contraction.
R-MMU-447041. CHL1 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-1
Alternative name(s):
CD49 antigen-like family member A
Laminin and collagen receptor
VLA-1
CD_antigen: CD49a
Gene namesi
Name:Itga1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:96599. Itga1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 1141ExtracellularSequence analysisAdd BLAST1113
Transmembranei1142 – 1164HelicalSequence analysisAdd BLAST23
Topological domaini1165 – 1179CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

  • acrosomal vesicle Source: Ensembl
  • basal part of cell Source: MGI
  • cell surface Source: UniProtKB
  • external side of plasma membrane Source: MGI
  • extracellular exosome Source: MGI
  • focal adhesion Source: MGI
  • integrin alpha1-beta1 complex Source: MGI
  • membrane Source: MGI
  • membrane raft Source: Ensembl
  • neuron projection Source: Ensembl
  • perikaryon Source: Ensembl
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28By similarityAdd BLAST28
ChainiPRO_000027372229 – 1179Integrin alpha-1By similarityAdd BLAST1151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi82 ↔ 92By similarity
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1
Glycosylationi105N-linked (GlcNAc...)Sequence analysis1
Glycosylationi112N-linked (GlcNAc...)Sequence analysis1
Glycosylationi217N-linked (GlcNAc...)Sequence analysis1
Glycosylationi317N-linked (GlcNAc...)Sequence analysis1
Glycosylationi341N-linked (GlcNAc...)Sequence analysis1
Glycosylationi402N-linked (GlcNAc...)Sequence analysis1
Glycosylationi418N-linked (GlcNAc...)Sequence analysis1
Glycosylationi459N-linked (GlcNAc...)Sequence analysis1
Glycosylationi531N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi687 ↔ 696By similarity
Glycosylationi698N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi702 ↔ 755By similarity
Glycosylationi747N-linked (GlcNAc...)Sequence analysis1
Glycosylationi779N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi807 ↔ 813By similarity
Glycosylationi839N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi877 ↔ 885By similarity
Glycosylationi882N-linked (GlcNAc...)Sequence analysis1
Glycosylationi907N-linked (GlcNAc...)Sequence analysis1
Glycosylationi938N-linked (GlcNAc...)Sequence analysis1
Glycosylationi965N-linked (GlcNAc...)Sequence analysis1
Glycosylationi973N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1007N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1029 ↔ 1062By similarity
Disulfide bondi1065 ↔ 1072By similarity
Glycosylationi1083N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1102N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1113N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ3V3R4.
PaxDbiQ3V3R4.
PeptideAtlasiQ3V3R4.
PRIDEiQ3V3R4.

PTM databases

iPTMnetiQ3V3R4.
PhosphoSitePlusiQ3V3R4.
SwissPalmiQ3V3R4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042284.
CleanExiMM_ITGA1.
GenevisibleiQ3V3R4. MM.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1 (By similarity). Interacts with RAB21 (By similarity). Interacts (via cytoplasmic domain) with PTPN2; activates PTPN2 phosphatase activity towards EGFR and negatively regulates EGF signaling (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077132.

Structurei

3D structure databases

ProteinModelPortaliQ3V3R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati30 – 91FG-GAP 1PROSITE-ProRule annotationAdd BLAST62
Repeati101 – 160FG-GAP 2PROSITE-ProRule annotationAdd BLAST60
Domaini175 – 364VWFAPROSITE-ProRule annotationAdd BLAST190
Repeati365 – 417FG-GAP 3PROSITE-ProRule annotationAdd BLAST53
Repeati422 – 474FG-GAP 4PROSITE-ProRule annotationAdd BLAST53
Repeati475 – 537FG-GAP 5PROSITE-ProRule annotationAdd BLAST63
Repeati556 – 614FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati618 – 678FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1167 – 1171GFFKR motif5

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPB7. Eukaryota.
ENOG410YEM8. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiQ3V3R4.
KOiK06480.
OMAiQRFSIAI.
OrthoDBiEOG091G00TK.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3V3R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPRRPASLE VTVACIWLLT VILGVCISFN VDVKNSMSFS GPVEDMFGYT
60 70 80 90 100
VQQYENEEGK WVLIGSPLVG QPKARTGDVY KCPVGRERSM PCVKLDLPVN
110 120 130 140 150
TSIPNVTEIK ENMTFGSTLV TNPKGGFLAC GPLYAYRCGH LHYTTGICSD
160 170 180 190 200
VSPTFQVVNS FAPVQECSTQ LDIVIVLDGS NSIYPWESVT AFLNDLLKRM
210 220 230 240 250
DIGPKQTQVG IVQYGANVTH EFNLNKYSST EEVLVAANKI GRRGGLQTMT
260 270 280 290 300
ALGIDTARKE AFTEARGARR GVKKVMVIVT DGESHDNYRL KQVIQDCEDE
310 320 330 340 350
NIQRFSIAIL GHYNRGNLST EKFVEEIKSI ASEPTEKHFF NVSDELALVT
360 370 380 390 400
IVKALGERIF ALEATADQSA ASFEMEMSQT GFSAHYSQDW VMLGAVGAYD
410 420 430 440 450
WNGTVVMQKA NQIVIPHNTT FQTEPTKMNE PLASYLGYTV NSATIPGDVL
460 470 480 490 500
YIAGQPRYNH TGQVVIYKME DGDVNILQTL SGEQIGSYFG SVLTTIDIDK
510 520 530 540 550
DSYTDLLLVG APMYMGTEKE EQGKVYVYAV NQTRFEYQMS LEPIKQTCCS
560 570 580 590 600
SLKDNSCTKE NKNEPCGARF GTAVAAVKDL NVDGFNDVVI GAPLEDDHAG
610 620 630 640 650
AVYIYHGSGK TIRKEYAQRI PSGGDGKTLK FFGQSIHGEM DLNGDGLTDV
660 670 680 690 700
TIGGLGGAAL FWARDVAVVK VTMNFEPNKV NIQKKNCRVE GKETVCINAT
710 720 730 740 750
MCFHVKLKSK EDSVYEADLQ YRVTLDSLRQ ISRSFFSGTQ ERRIQRNLTV
760 770 780 790 800
RESECIRHSF YMLDKHDFQD SVRVTLDFNL TDPENGPVLD DALPNSVHGH
810 820 830 840 850
IPFAKDCGNK ERCVSDLTLD VSTTEKNLLI VRSQNDKFNV SLTVKNKGDS
860 870 880 890 900
AYNTRTVVQY SPNLIFSGIE EIQKDSCESN QNITCRVGYP FLRTGDVVNF
910 920 930 940 950
KIIFQFNTSH LSENAIIHLS ATSDSEEPLE SLYDNEVNIS IPVKYEVGLQ
960 970 980 990 1000
FYSSASEHHI SVAANETVPE LINSTKDIGD EINVFYTIRK RGHFPMPELR
1010 1020 1030 1040 1050
LAISFPNLTS DGYPVLYPTG WSSSDNVNCR PRSLEDPLGI NSGKKMTISK
1060 1070 1080 1090 1100
SEVLKRGTIQ DCSTCKIATI TCHLLPSDVS QVNVSLILWK PTFIKAHFSS
1110 1120 1130 1140 1150
LNLTIRGELQ SENSSLTLSS SNRKRELAIQ ISKDGLPGRV PLWVILLSAF
1160 1170
AGLLLLMLLI LALWKIGFFK RPLKKKMEK
Length:1,179
Mass (Da):130,810
Last modified:October 3, 2012 - v2
Checksum:iD158F297AFA8119F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti782D → N in BAE20498 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035870 mRNA. Translation: BAE20498.1.
AC175538 Genomic DNA. No translation available.
CT025598 Genomic DNA. No translation available.
CCDSiCCDS36788.1.
RefSeqiNP_001028400.2. NM_001033228.3.
UniGeneiMm.317280.

Genome annotation databases

EnsembliENSMUST00000061673; ENSMUSP00000077132; ENSMUSG00000042284.
GeneIDi109700.
KEGGimmu:109700.
UCSCiuc007rxx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035870 mRNA. Translation: BAE20498.1.
AC175538 Genomic DNA. No translation available.
CT025598 Genomic DNA. No translation available.
CCDSiCCDS36788.1.
RefSeqiNP_001028400.2. NM_001033228.3.
UniGeneiMm.317280.

3D structure databases

ProteinModelPortaliQ3V3R4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077132.

PTM databases

iPTMnetiQ3V3R4.
PhosphoSitePlusiQ3V3R4.
SwissPalmiQ3V3R4.

Proteomic databases

MaxQBiQ3V3R4.
PaxDbiQ3V3R4.
PeptideAtlasiQ3V3R4.
PRIDEiQ3V3R4.

Protocols and materials databases

DNASUi109700.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061673; ENSMUSP00000077132; ENSMUSG00000042284.
GeneIDi109700.
KEGGimmu:109700.
UCSCiuc007rxx.1. mouse.

Organism-specific databases

CTDi3672.
MGIiMGI:96599. Itga1.

Phylogenomic databases

eggNOGiENOG410IPB7. Eukaryota.
ENOG410YEM8. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiQ3V3R4.
KOiK06480.
OMAiQRFSIAI.
OrthoDBiEOG091G00TK.
TreeFamiTF105391.

Enzyme and pathway databases

ReactomeiR-MMU-216083. Integrin cell surface interactions.
R-MMU-416700. Other semaphorin interactions.
R-MMU-445355. Smooth Muscle Contraction.
R-MMU-447041. CHL1 interactions.

Miscellaneous databases

ChiTaRSiItga1. mouse.
PROiQ3V3R4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042284.
CleanExiMM_ITGA1.
GenevisibleiQ3V3R4. MM.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITA1_MOUSE
AccessioniPrimary (citable) accession number: Q3V3R4
Secondary accession number(s): F8VQN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.