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Q3V3Q7

- PACS2_MOUSE

UniProt

Q3V3Q7 - PACS2_MOUSE

Protein

Phosphofurin acidic cluster sorting protein 2

Gene

Pacs2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also involved in ion channel trafficking, directing acidic cluster-containing ion channels to distict subcellular compartments By similarity.By similarity

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphofurin acidic cluster sorting protein 2
    Short name:
    PACS-2
    Alternative name(s):
    PACS1-like protein
    Gene namesi
    Name:Pacs2
    Synonyms:Kiaa0602, Pacs1l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1924399. Pacs2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    2. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 862862Phosphofurin acidic cluster sorting protein 2PRO_0000259512Add
    BLAST

    Proteomic databases

    PaxDbiQ3V3Q7.
    PRIDEiQ3V3Q7.

    PTM databases

    PhosphoSiteiQ3V3Q7.

    Expressioni

    Gene expression databases

    CleanExiMM_PACS2.
    GenevestigatoriQ3V3Q7.

    Interactioni

    Subunit structurei

    Interacts with BID and PKD2.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ3V3Q7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi274 – 2796Poly-Asp
    Compositional biasi658 – 71053Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PACS family.Curated

    Phylogenomic databases

    eggNOGiNOG279176.
    HOGENOMiHOG000047329.
    HOVERGENiHBG053488.

    Family and domain databases

    InterProiIPR019381. Phosphofurin_acidic_CS-1.
    [Graphical view]
    PfamiPF10254. Pacs-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3V3Q7-1 [UniParc]FASTAAdd to Basket

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    MAERGRLGLP GAPGALNTPV PMNLFATWEV DGSSPSCVPR LCSLTLKKLA    50
    VLRELEKELL SVVIAVKMQY PHFLKREGNK LQIMLQRRKR YKNRTILGYK 100
    TLAAGSINMA EVMQHPSEGG QVLSLCSSIK EASVKVAEIW IVSLSSQPID 150
    HEDSAMQAGP KTKSTDNYSE EEYESFSSEQ EASDDAVQGQ DLDEDDFDVG 200
    KPKKQRRSIV RTTSMTRQQN FKQKVVALLR RFKVSEEVLD SEQDPAEHVP 250
    EVEEDLDLLY DTLDVENPSD SGPDMDDDDS VLSTPKPKLR PYFEGLSHSS 300
    SQTEIGSIHS ARSHREPPSP ADVPEKTRSL GGKQQLSDSV SDTVALSAAV 350
    PREPSGQPED SPEAETSTLD VFTEKLPPSG RIIKTESLVI PSTRSESKPA 400
    GRRGRSTSLK ERQPARPQNE RANSLDNERC PDTRSQLQIP RKTVYDQLNH 450
    ILISDDQLPE NIILVNTSDW QGQFLSDVLQ KHTLPVVCTC SAADVQAAFS 500
    TIVSRIQRYC NCNSQPPTPV KIAVAGAQHY LSAILRLFVE QLSHKTPDWL 550
    GYMRFLIIPL GSHPVARYLG SVDYRYNNFF QDLAWRDLFN KLEAQSSVQD 600
    TPDIVSRITQ YISGANCAHQ LPIAEAMLTY KQKSPDEESS QRFIPFVGVV 650
    KVGIVEPSSA TSGDSDDAAP SSSSILSSTP PSASTSPAAK EASPTPPSSP 700
    SVSGGLSSPS QGVGAELMGL QVDYWTAAQP ADRKRDAEKK DMPTTKNTLK 750
    CTFRSLQVSR LPSSGEAAAT PTMSMTVVTK EKNKKVMFLP KKTKDKEVES 800
    KSQCIEGISR LICTAKHQQN MLRVLIDGVE CSDVKFFQLA AQWSSHVKHF 850
    PICIFGHSKA TF 862
    Length:862
    Mass (Da):94,932
    Last modified:July 27, 2011 - v2
    Checksum:iC3702C5537A03B38
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti56 – 6813EKELL…IAVKM → GQVETDLALTFSL in BAC65608. (PubMed:12693553)CuratedAdd
    BLAST
    Sequence conflicti122 – 1221V → L in BAE20504. (PubMed:16141072)Curated
    Sequence conflicti250 – 2501P → S in BAE20504. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036581 mRNA. Translation: BAE20504.1.
    AC073562 Genomic DNA. No translation available.
    AK122326 mRNA. Translation: BAC65608.1.
    BC043302 mRNA. Translation: AAH43302.1.
    RefSeqiNP_001278374.1. NM_001291445.1.
    UniGeneiMm.35754.

    Genome annotation databases

    GeneIDi217893.
    UCSCiuc007pfq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036581 mRNA. Translation: BAE20504.1 .
    AC073562 Genomic DNA. No translation available.
    AK122326 mRNA. Translation: BAC65608.1 .
    BC043302 mRNA. Translation: AAH43302.1 .
    RefSeqi NP_001278374.1. NM_001291445.1.
    UniGenei Mm.35754.

    3D structure databases

    ProteinModelPortali Q3V3Q7.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q3V3Q7.

    Proteomic databases

    PaxDbi Q3V3Q7.
    PRIDEi Q3V3Q7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 217893.
    UCSCi uc007pfq.1. mouse.

    Organism-specific databases

    MGIi MGI:1924399. Pacs2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG279176.
    HOGENOMi HOG000047329.
    HOVERGENi HBG053488.

    Miscellaneous databases

    PROi Q3V3Q7.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_PACS2.
    Genevestigatori Q3V3Q7.

    Family and domain databases

    InterProi IPR019381. Phosphofurin_acidic_CS-1.
    [Graphical view ]
    Pfami PF10254. Pacs-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 56-862.
      Tissue: Brain.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 647-862.
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiPACS2_MOUSE
    AccessioniPrimary (citable) accession number: Q3V3Q7
    Secondary accession number(s): E9QKL3, Q80TW2, Q80VG3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 58 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3