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Protein

Phosphofurin acidic cluster sorting protein 2

Gene

Pacs2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also involved in ion channel trafficking, directing acidic cluster-containing ion channels to distict subcellular compartments (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphofurin acidic cluster sorting protein 2
Short name:
PACS-2
Alternative name(s):
PACS1-like protein
Gene namesi
Name:Pacs2
Synonyms:Kiaa0602, Pacs1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1924399. Pacs2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Phosphofurin acidic cluster sorting protein 2PRO_0000259512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei387 – 3871PhosphoserineBy similarity
Modified residuei424 – 4241PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3V3Q7.
PaxDbiQ3V3Q7.
PRIDEiQ3V3Q7.

PTM databases

PhosphoSiteiQ3V3Q7.

Expressioni

Gene expression databases

CleanExiMM_PACS2.

Interactioni

Subunit structurei

Interacts with BID and PKD2.By similarity

Protein-protein interaction databases

BioGridi229978. 1 interaction.
STRINGi10090.ENSMUSP00000081953.

Structurei

3D structure databases

ProteinModelPortaliQ3V3Q7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi274 – 2796Poly-Asp
Compositional biasi658 – 71053Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the PACS family.Curated

Phylogenomic databases

eggNOGiNOG279176.
HOGENOMiHOG000047329.
HOVERGENiHBG053488.
InParanoidiQ3V3Q7.

Family and domain databases

InterProiIPR019381. Phosphofurin_acidic_CS-1.
[Graphical view]
PfamiPF10254. Pacs-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3V3Q7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERGRLGLP GAPGALNTPV PMNLFATWEV DGSSPSCVPR LCSLTLKKLA
60 70 80 90 100
VLRELEKELL SVVIAVKMQY PHFLKREGNK LQIMLQRRKR YKNRTILGYK
110 120 130 140 150
TLAAGSINMA EVMQHPSEGG QVLSLCSSIK EASVKVAEIW IVSLSSQPID
160 170 180 190 200
HEDSAMQAGP KTKSTDNYSE EEYESFSSEQ EASDDAVQGQ DLDEDDFDVG
210 220 230 240 250
KPKKQRRSIV RTTSMTRQQN FKQKVVALLR RFKVSEEVLD SEQDPAEHVP
260 270 280 290 300
EVEEDLDLLY DTLDVENPSD SGPDMDDDDS VLSTPKPKLR PYFEGLSHSS
310 320 330 340 350
SQTEIGSIHS ARSHREPPSP ADVPEKTRSL GGKQQLSDSV SDTVALSAAV
360 370 380 390 400
PREPSGQPED SPEAETSTLD VFTEKLPPSG RIIKTESLVI PSTRSESKPA
410 420 430 440 450
GRRGRSTSLK ERQPARPQNE RANSLDNERC PDTRSQLQIP RKTVYDQLNH
460 470 480 490 500
ILISDDQLPE NIILVNTSDW QGQFLSDVLQ KHTLPVVCTC SAADVQAAFS
510 520 530 540 550
TIVSRIQRYC NCNSQPPTPV KIAVAGAQHY LSAILRLFVE QLSHKTPDWL
560 570 580 590 600
GYMRFLIIPL GSHPVARYLG SVDYRYNNFF QDLAWRDLFN KLEAQSSVQD
610 620 630 640 650
TPDIVSRITQ YISGANCAHQ LPIAEAMLTY KQKSPDEESS QRFIPFVGVV
660 670 680 690 700
KVGIVEPSSA TSGDSDDAAP SSSSILSSTP PSASTSPAAK EASPTPPSSP
710 720 730 740 750
SVSGGLSSPS QGVGAELMGL QVDYWTAAQP ADRKRDAEKK DMPTTKNTLK
760 770 780 790 800
CTFRSLQVSR LPSSGEAAAT PTMSMTVVTK EKNKKVMFLP KKTKDKEVES
810 820 830 840 850
KSQCIEGISR LICTAKHQQN MLRVLIDGVE CSDVKFFQLA AQWSSHVKHF
860
PICIFGHSKA TF
Length:862
Mass (Da):94,932
Last modified:July 27, 2011 - v2
Checksum:iC3702C5537A03B38
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 6813EKELL…IAVKM → GQVETDLALTFSL in BAC65608 (PubMed:12693553).CuratedAdd
BLAST
Sequence conflicti122 – 1221V → L in BAE20504 (PubMed:16141072).Curated
Sequence conflicti250 – 2501P → S in BAE20504 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036581 mRNA. Translation: BAE20504.1.
AC073562 Genomic DNA. No translation available.
AK122326 mRNA. Translation: BAC65608.1.
BC043302 mRNA. Translation: AAH43302.1.
RefSeqiNP_001278374.1. NM_001291445.1.
UniGeneiMm.35754.

Genome annotation databases

GeneIDi217893.
UCSCiuc007pfq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036581 mRNA. Translation: BAE20504.1.
AC073562 Genomic DNA. No translation available.
AK122326 mRNA. Translation: BAC65608.1.
BC043302 mRNA. Translation: AAH43302.1.
RefSeqiNP_001278374.1. NM_001291445.1.
UniGeneiMm.35754.

3D structure databases

ProteinModelPortaliQ3V3Q7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229978. 1 interaction.
STRINGi10090.ENSMUSP00000081953.

PTM databases

PhosphoSiteiQ3V3Q7.

Proteomic databases

MaxQBiQ3V3Q7.
PaxDbiQ3V3Q7.
PRIDEiQ3V3Q7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi217893.
UCSCiuc007pfq.2. mouse.

Organism-specific databases

CTDi23241.
MGIiMGI:1924399. Pacs2.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG279176.
HOGENOMiHOG000047329.
HOVERGENiHBG053488.
InParanoidiQ3V3Q7.

Miscellaneous databases

PROiQ3V3Q7.
SOURCEiSearch...

Gene expression databases

CleanExiMM_PACS2.

Family and domain databases

InterProiIPR019381. Phosphofurin_acidic_CS-1.
[Graphical view]
PfamiPF10254. Pacs-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 56-862.
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 647-862.
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiPACS2_MOUSE
AccessioniPrimary (citable) accession number: Q3V3Q7
Secondary accession number(s): E9QKL3, Q80TW2, Q80VG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 27, 2011
Last modified: July 22, 2015
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.