SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q3V3Q7

- PACS2_MOUSE

UniProt

Q3V3Q7 - PACS2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phosphofurin acidic cluster sorting protein 2

Gene
Pacs2, Kiaa0602, Pacs1l
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also involved in ion channel trafficking, directing acidic cluster-containing ion channels to distict subcellular compartments By similarity.

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphofurin acidic cluster sorting protein 2
Short name:
PACS-2
Alternative name(s):
PACS1-like protein
Gene namesi
Name:Pacs2
Synonyms:Kiaa0602, Pacs1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1924399. Pacs2.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  2. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Phosphofurin acidic cluster sorting protein 2PRO_0000259512Add
BLAST

Proteomic databases

PaxDbiQ3V3Q7.
PRIDEiQ3V3Q7.

PTM databases

PhosphoSiteiQ3V3Q7.

Expressioni

Gene expression databases

CleanExiMM_PACS2.
GenevestigatoriQ3V3Q7.

Interactioni

Subunit structurei

Interacts with BID and PKD2 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ3V3Q7.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi274 – 2796Poly-Asp
Compositional biasi658 – 71053Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the PACS family.

Phylogenomic databases

eggNOGiNOG279176.
HOGENOMiHOG000047329.
HOVERGENiHBG053488.

Family and domain databases

InterProiIPR019381. Phosphofurin_acidic_CS-1.
[Graphical view]
PfamiPF10254. Pacs-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3V3Q7-1 [UniParc]FASTAAdd to Basket

« Hide

MAERGRLGLP GAPGALNTPV PMNLFATWEV DGSSPSCVPR LCSLTLKKLA    50
VLRELEKELL SVVIAVKMQY PHFLKREGNK LQIMLQRRKR YKNRTILGYK 100
TLAAGSINMA EVMQHPSEGG QVLSLCSSIK EASVKVAEIW IVSLSSQPID 150
HEDSAMQAGP KTKSTDNYSE EEYESFSSEQ EASDDAVQGQ DLDEDDFDVG 200
KPKKQRRSIV RTTSMTRQQN FKQKVVALLR RFKVSEEVLD SEQDPAEHVP 250
EVEEDLDLLY DTLDVENPSD SGPDMDDDDS VLSTPKPKLR PYFEGLSHSS 300
SQTEIGSIHS ARSHREPPSP ADVPEKTRSL GGKQQLSDSV SDTVALSAAV 350
PREPSGQPED SPEAETSTLD VFTEKLPPSG RIIKTESLVI PSTRSESKPA 400
GRRGRSTSLK ERQPARPQNE RANSLDNERC PDTRSQLQIP RKTVYDQLNH 450
ILISDDQLPE NIILVNTSDW QGQFLSDVLQ KHTLPVVCTC SAADVQAAFS 500
TIVSRIQRYC NCNSQPPTPV KIAVAGAQHY LSAILRLFVE QLSHKTPDWL 550
GYMRFLIIPL GSHPVARYLG SVDYRYNNFF QDLAWRDLFN KLEAQSSVQD 600
TPDIVSRITQ YISGANCAHQ LPIAEAMLTY KQKSPDEESS QRFIPFVGVV 650
KVGIVEPSSA TSGDSDDAAP SSSSILSSTP PSASTSPAAK EASPTPPSSP 700
SVSGGLSSPS QGVGAELMGL QVDYWTAAQP ADRKRDAEKK DMPTTKNTLK 750
CTFRSLQVSR LPSSGEAAAT PTMSMTVVTK EKNKKVMFLP KKTKDKEVES 800
KSQCIEGISR LICTAKHQQN MLRVLIDGVE CSDVKFFQLA AQWSSHVKHF 850
PICIFGHSKA TF 862
Length:862
Mass (Da):94,932
Last modified:July 27, 2011 - v2
Checksum:iC3702C5537A03B38
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 6813EKELL…IAVKM → GQVETDLALTFSL in BAC65608. 1 PublicationAdd
BLAST
Sequence conflicti122 – 1221V → L in BAE20504. 1 Publication
Sequence conflicti250 – 2501P → S in BAE20504. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK036581 mRNA. Translation: BAE20504.1.
AC073562 Genomic DNA. No translation available.
AK122326 mRNA. Translation: BAC65608.1.
BC043302 mRNA. Translation: AAH43302.1.
RefSeqiNP_001278374.1. NM_001291445.1.
UniGeneiMm.35754.

Genome annotation databases

GeneIDi217893.
UCSCiuc007pfq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK036581 mRNA. Translation: BAE20504.1 .
AC073562 Genomic DNA. No translation available.
AK122326 mRNA. Translation: BAC65608.1 .
BC043302 mRNA. Translation: AAH43302.1 .
RefSeqi NP_001278374.1. NM_001291445.1.
UniGenei Mm.35754.

3D structure databases

ProteinModelPortali Q3V3Q7.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q3V3Q7.

Proteomic databases

PaxDbi Q3V3Q7.
PRIDEi Q3V3Q7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 217893.
UCSCi uc007pfq.1. mouse.

Organism-specific databases

MGIi MGI:1924399. Pacs2.
Rougei Search...

Phylogenomic databases

eggNOGi NOG279176.
HOGENOMi HOG000047329.
HOVERGENi HBG053488.

Miscellaneous databases

PROi Q3V3Q7.
SOURCEi Search...

Gene expression databases

CleanExi MM_PACS2.
Genevestigatori Q3V3Q7.

Family and domain databases

InterProi IPR019381. Phosphofurin_acidic_CS-1.
[Graphical view ]
Pfami PF10254. Pacs-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 56-862.
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 647-862.
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiPACS2_MOUSE
AccessioniPrimary (citable) accession number: Q3V3Q7
Secondary accession number(s): E9QKL3, Q80TW2, Q80VG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi