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Unreviewed, UniProtKB/TrEMBL Q3V3E0 (Q3V3E0_MOUSE)

Last modified January 19, 2010. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    Putative uncharacterized protein EMBL BAE20601.1
Gene names
Name: Smad3 MGI 1201674
OrganismMus musculus (Mouse) EMBL BAE20601.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length371 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level.

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Ontologies

Keywords
   Biological processTranscription
Transcription regulation Spearmint SPM003619
   Cellular componentNucleus Spearmint SPM003619
Gene Ontology (GO)
   Biological processSMAD protein complex assembly

Inferred from electronic annotation. Source: Compara

activation of caspase activity

Inferred from electronic annotation. Source: Compara

activation of pro-apoptotic gene products

Inferred from electronic annotation. Source: Compara

cell cycle arrest

Inferred from electronic annotation. Source: Compara

cell-cell junction organization

Inferred from electronic annotation. Source: Compara

developmental growth

Inferred from genetic interaction. Source: MGI

embryonic cranial skeleton morphogenesis

Inferred from genetic interaction. Source: MGI

embryonic foregut morphogenesis

Inferred from genetic interaction. Source: MGI

embryonic pattern specification

Inferred from genetic interaction. Source: MGI

endoderm development

Inferred from genetic interaction. Source: MGI

evasion of host defenses by virus

Inferred from electronic annotation. Source: Compara

heart looping

Inferred from genetic interaction. Source: MGI

immune system development

Inferred from genetic interaction. Source: MGI

in utero embryonic development

Inferred from genetic interaction. Source: MGI

induction of apoptosis

Inferred from electronic annotation. Source: Compara

lens fiber cell differentiation

Inferred from mutant phenotype. Source: MGI

liver development

Inferred from genetic interaction. Source: MGI

mesoderm formation

Inferred from mutant phenotype. Source: MGI

negative regulation of apoptosis

Inferred from electronic annotation. Source: Compara

negative regulation of cell growth

Inferred from electronic annotation. Source: Compara

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Compara

negative regulation of gene-specific transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Compara

negative regulation of mitotic cell cycle

Inferred from electronic annotation. Source: Compara

negative regulation of osteoblast differentiation

Inferred from genetic interaction. Source: MGI

osteoblast development

Inferred from genetic interaction. Source: MGI

paraxial mesoderm morphogenesis

Inferred from mutant phenotype. Source: MGI

pericardium development

Inferred from genetic interaction. Source: MGI

positive regulation of alkaline phosphatase activity

Inferred from electronic annotation. Source: Compara

positive regulation of bone mineralization

Inferred from electronic annotation. Source: Compara

positive regulation of cell migration

Inferred from electronic annotation. Source: Compara

positive regulation of epithelial to mesenchymal transition

Inferred from electronic annotation. Source: Compara

positive regulation of focal adhesion assembly

Inferred from electronic annotation. Source: Compara

positive regulation of gene-specific transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Compara

positive regulation of interleukin-1 beta production

Inferred from electronic annotation. Source: Compara

positive regulation of positive chemotaxis

Inferred from electronic annotation. Source: Compara

positive regulation of stress fiber assembly

Inferred from electronic annotation. Source: Compara

positive regulation of transcription factor import into nucleus

Inferred from electronic annotation. Source: Compara

positive regulation of transforming growth factor-beta3 production

Inferred from electronic annotation. Source: Compara

regulation of binding

Inferred from direct assay. Source: MGI

regulation of epithelial cell proliferation

Inferred from mutant phenotype. Source: MGI

regulation of striated muscle tissue development

Inferred from direct assay. Source: MGI

regulation of transforming growth factor beta receptor signaling pathway

Inferred from direct assay. Source: MGI

regulation of transforming growth factor-beta2 production

Inferred from electronic annotation. Source: Compara

release of cytochrome c from mitochondria

Inferred from electronic annotation. Source: Compara

response to hypoxia

Inferred from electronic annotation. Source: Compara

somitogenesis

Inferred from mutant phenotype. Source: MGI

thyroid gland development

Inferred from genetic interaction. Source: MGI

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

transdifferentiation

Inferred from electronic annotation. Source: Compara

transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

transport

Inferred from electronic annotation. Source: Compara

   Cellular componentplasma membrane

Inferred from direct assay. Source: MGI

receptor complex

Inferred from electronic annotation. Source: Compara

transcription factor complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionR-SMAD binding

Inferred from electronic annotation. Source: Compara

co-SMAD binding

Inferred from electronic annotation. Source: Compara

collagen binding

Inferred from physical interaction. Source: MGI

double-stranded DNA binding

Inferred from direct assay. Source: MGI

ligand-regulated transcription factor activity

Inferred from electronic annotation. Source: Compara

promoter binding

Inferred from electronic annotation. Source: Compara

protein homodimerization activity

Inferred from electronic annotation. Source: Compara

specific transcriptional repressor activity

Inferred from electronic annotation. Source: Compara

transcription activator activity

Inferred from direct assay. Source: MGI

transcription factor activity

Inferred from direct assay. Source: MGI

transcription factor binding

Inferred from physical interaction. Source: MGI

transforming growth factor beta receptor binding

Inferred from electronic annotation. Source: Compara

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

Inferred from electronic annotation. Source: Compara

ubiquitin protein ligase binding

Inferred from electronic annotation. Source: Compara

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL BAE20601.1

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Sequences

Sequence LengthMass (Da)Tools
Q3V3E0-1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: BFDB5CCCE440FB1E

FASTA37141,931
        10         20         30         40         50         60 
ITTQNVNTKC ITIPRSLDGR LQVSHRKGLP HVIYCRLWRW PDLHSHHELR AMELCEFAFN 

        70         80         90        100        110        120 
MKKDEVCVNP YHYQRVETPV LPPVLVPRHT EIPAEFPPLD DYSHSIPENT NFPAGIEPQS 

       130        140        150        160        170        180 
NIPETPPPGY LSEDGETSDH QMNHSMDAGS PNLSPNPMSP AHNNLDLQPV TYCEPAFWCS 

       190        200        210        220        230        240 
ISYYELNQRV GETFHASQPS MTVDGFTDPS NSERFCLGLL SNVNRNAAVE LTRRHIGRGV 

       250        260        270        280        290        300 
RLYYIGGEVF AECLSDSAIF VQSPNCNQRY GWHPATVCKI PPGCNLKIFN NQEFAALLAQ 

       310        320        330        340        350        360 
SVNQGFEAVY QLTRMCTIRM SFVKGWGAEY RRQTVTSTPC WIELHLNGPL QWLDKVLTQM 

       370 
GSPSIRCSSV S

« Hide

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References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J EMBL BAE20601.1.
Tissue: Thymus EMBL BAE20601.1.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK041743 mRNA. Translation: BAE20601.1.
IPIIPI00314870.
UniGeneMm.7320

3D structure databases

SMRQ3V3E0. Positions 1-78, 166-362.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3V3E0.

Genome annotation databases

EnsemblENSMUST00000034973; ENSMUSP00000034973; ENSMUSG00000032402; Mus musculus. [Genome view]
ENSMUST00000113931; ENSMUSP00000109564; ENSMUSG00000032402; Mus musculus. [Genome view]

Organism-specific databases

MGIMGI:1201674. Smad3.

Phylogenomic databases

HOVERGENQ3V3E0.
InParanoidQ3V3E0.

Gene expression databases

ArrayExpressQ3V3E0.
BgeeQ3V3E0.
GenevestigatorQ3V3E0.

Family and domain databases

InterProIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
[Graphical view]
Gene3DG3DSA:3.90.520.10. MAD_MH1. 1 hit.
G3DSA:2.60.200.10. MH2_Dwarfin-type. 1 hit.
PANTHERPTHR13703. Dwarfin. 1 hit.
PfamPF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view]
SMARTSM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view]
PROSITEPS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameQ3V3E0_MOUSE
AccessionPrimary (citable) accession number: Q3V3E0
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: January 19, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information