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Protein

Mothers against decapentaplegic homolog

Gene

Smad3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
  • activin receptor signaling pathway Source: MGI
  • cell-cell junction organization Source: MGI
  • cell cycle arrest Source: MGI
  • developmental growth Source: MGI
  • embryonic cranial skeleton morphogenesis Source: MGI
  • embryonic foregut morphogenesis Source: MGI
  • embryonic pattern specification Source: MGI
  • endoderm development Source: MGI
  • evasion or tolerance of host defenses by virus Source: MGI
  • extrinsic apoptotic signaling pathway Source: MGI
  • gastrulation Source: MGI
  • heart looping Source: MGI
  • immune response Source: MGI
  • immune system development Source: MGI
  • intracellular signal transduction Source: MGI
  • in utero embryonic development Source: MGI
  • lens fiber cell differentiation Source: MGI
  • liver development Source: MGI
  • mesoderm formation Source: MGI
  • negative regulation of apoptotic process Source: Ensembl
  • negative regulation of cell growth Source: MGI
  • negative regulation of cell proliferation Source: Ensembl
  • negative regulation of mitotic cell cycle Source: MGI
  • negative regulation of osteoblast differentiation Source: MGI
  • negative regulation of protein catabolic process Source: MGI
  • negative regulation of protein phosphorylation Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • nodal signaling pathway Source: MGI
  • osteoblast development Source: MGI
  • paraxial mesoderm morphogenesis Source: MGI
  • pericardium development Source: MGI
  • positive regulation of alkaline phosphatase activity Source: Ensembl
  • positive regulation of bone mineralization Source: Ensembl
  • positive regulation of canonical Wnt signaling pathway Source: MGI
  • positive regulation of catenin import into nucleus Source: MGI
  • positive regulation of cell migration Source: Ensembl
  • positive regulation of epithelial to mesenchymal transition Source: MGI
  • positive regulation of extracellular matrix assembly Source: MGI
  • positive regulation of focal adhesion assembly Source: Ensembl
  • positive regulation of gene expression Source: MGI
  • positive regulation of interleukin-1 beta production Source: Ensembl
  • positive regulation of positive chemotaxis Source: Ensembl
  • positive regulation of stress fiber assembly Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription factor import into nucleus Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of transforming growth factor beta3 production Source: Ensembl
  • protein stabilization Source: MGI
  • regulation of binding Source: MGI
  • regulation of epithelial cell proliferation Source: MGI
  • regulation of striated muscle tissue development Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of transforming growth factor beta2 production Source: MGI
  • regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  • response to hypoxia Source: MGI
  • signal transduction involved in regulation of gene expression Source: Ensembl
  • skeletal system development Source: MGI
  • SMAD protein complex assembly Source: MGI
  • SMAD protein signal transduction Source: MGI
  • somitogenesis Source: MGI
  • thyroid gland development Source: MGI
  • transcription from RNA polymerase II promoter Source: GOC
  • transdifferentiation Source: Ensembl
  • transforming growth factor beta receptor signaling pathway Source: MGI
  • transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mothers against decapentaplegic homologUniRule annotation
Short name:
MAD homologUniRule annotation
Short name:
Mothers against DPP homologUniRule annotation
Alternative name(s):
SMAD family memberUniRule annotation
Gene namesi
Name:Smad3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1201674. Smad3.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiQ3V3E0.
ExpressionAtlasiQ3V3E0. baseline and differential.
GenevestigatoriQ3V3E0.

Interactioni

Family & Domainsi

Sequence similaritiesi

Belongs to the dwarfin/SMAD family.UniRule annotation
Contains 1 MH1 (MAD homology 1) domain.UniRule annotation
Contains 1 MH2 (MAD homology 2) domain.UniRule annotation

Phylogenomic databases

HOVERGENiHBG053353.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
3.90.520.10. 1 hit.
InterProiIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiPF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF56366. SSF56366. 1 hit.
PROSITEiPS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3V3E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ITTQNVNTKC ITIPRSLDGR LQVSHRKGLP HVIYCRLWRW PDLHSHHELR
60 70 80 90 100
AMELCEFAFN MKKDEVCVNP YHYQRVETPV LPPVLVPRHT EIPAEFPPLD
110 120 130 140 150
DYSHSIPENT NFPAGIEPQS NIPETPPPGY LSEDGETSDH QMNHSMDAGS
160 170 180 190 200
PNLSPNPMSP AHNNLDLQPV TYCEPAFWCS ISYYELNQRV GETFHASQPS
210 220 230 240 250
MTVDGFTDPS NSERFCLGLL SNVNRNAAVE LTRRHIGRGV RLYYIGGEVF
260 270 280 290 300
AECLSDSAIF VQSPNCNQRY GWHPATVCKI PPGCNLKIFN NQEFAALLAQ
310 320 330 340 350
SVNQGFEAVY QLTRMCTIRM SFVKGWGAEY RRQTVTSTPC WIELHLNGPL
360 370
QWLDKVLTQM GSPSIRCSSV S
Length:371
Mass (Da):41,931
Last modified:October 11, 2005 - v1
Checksum:iBFDB5CCCE440FB1E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041743 mRNA. Translation: BAE20601.1.
UniGeneiMm.7320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041743 mRNA. Translation: BAE20601.1.
UniGeneiMm.7320.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ3V3E0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1201674. Smad3.

Phylogenomic databases

HOVERGENiHBG053353.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ3V3E0.
ExpressionAtlasiQ3V3E0. baseline and differential.
GenevestigatoriQ3V3E0.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
3.90.520.10. 1 hit.
InterProiIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiPF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF56366. SSF56366. 1 hit.
PROSITEiPS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.

Entry informationi

Entry nameiQ3V3E0_MOUSE
AccessioniPrimary (citable) accession number: Q3V3E0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 1, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.