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Protein

Mothers against decapentaplegic homolog

Gene

Smad3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. beta-catenin binding Source: MGI
  2. bHLH transcription factor binding Source: MGI
  3. chromatin binding Source: MGI
  4. collagen binding Source: MGI
  5. core promoter proximal region sequence-specific DNA binding Source: MGI
  6. co-SMAD binding Source: MGI
  7. double-stranded DNA binding Source: MGI
  8. identical protein binding Source: MGI
  9. phosphatase binding Source: MGI
  10. protein binding transcription factor activity Source: Ensembl
  11. protein heterodimerization activity Source: MGI
  12. protein homodimerization activity Source: MGI
  13. protein kinase binding Source: MGI
  14. RNA polymerase II activating transcription factor binding Source: MGI
  15. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  16. RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Source: MGI
  17. R-SMAD binding Source: MGI
  18. sequence-specific DNA binding Source: MGI
  19. sequence-specific DNA binding transcription factor activity Source: MGI
  20. transcription factor binding Source: MGI
  21. transcription regulatory region DNA binding Source: MGI
  22. transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity Source: MGI
  23. transforming growth factor beta receptor binding Source: MGI
  24. ubiquitin binding Source: MGI
  25. ubiquitin protein ligase binding Source: MGI
  26. zinc ion binding Source: MGI

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  2. activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
  3. activin receptor signaling pathway Source: MGI
  4. cell-cell junction organization Source: MGI
  5. cell cycle arrest Source: MGI
  6. developmental growth Source: MGI
  7. embryonic cranial skeleton morphogenesis Source: MGI
  8. embryonic foregut morphogenesis Source: MGI
  9. embryonic pattern specification Source: MGI
  10. endoderm development Source: MGI
  11. evasion or tolerance of host defenses by virus Source: MGI
  12. extrinsic apoptotic signaling pathway Source: MGI
  13. gastrulation Source: MGI
  14. heart looping Source: MGI
  15. immune response Source: MGI
  16. immune system development Source: MGI
  17. intracellular signal transduction Source: MGI
  18. in utero embryonic development Source: MGI
  19. lens fiber cell differentiation Source: MGI
  20. liver development Source: MGI
  21. mesoderm formation Source: MGI
  22. negative regulation of apoptotic process Source: Ensembl
  23. negative regulation of cell growth Source: MGI
  24. negative regulation of cell proliferation Source: Ensembl
  25. negative regulation of mitotic cell cycle Source: MGI
  26. negative regulation of osteoblast differentiation Source: MGI
  27. negative regulation of protein catabolic process Source: MGI
  28. negative regulation of protein phosphorylation Source: MGI
  29. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  30. nodal signaling pathway Source: MGI
  31. osteoblast development Source: MGI
  32. paraxial mesoderm morphogenesis Source: MGI
  33. pericardium development Source: MGI
  34. positive regulation of alkaline phosphatase activity Source: Ensembl
  35. positive regulation of bone mineralization Source: Ensembl
  36. positive regulation of canonical Wnt signaling pathway Source: MGI
  37. positive regulation of catenin import into nucleus Source: MGI
  38. positive regulation of cell migration Source: Ensembl
  39. positive regulation of epithelial to mesenchymal transition Source: MGI
  40. positive regulation of focal adhesion assembly Source: Ensembl
  41. positive regulation of gene expression Source: MGI
  42. positive regulation of interleukin-1 beta production Source: Ensembl
  43. positive regulation of positive chemotaxis Source: Ensembl
  44. positive regulation of stress fiber assembly Source: Ensembl
  45. positive regulation of transcription, DNA-templated Source: MGI
  46. positive regulation of transcription factor import into nucleus Source: MGI
  47. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  48. positive regulation of transforming growth factor beta3 production Source: Ensembl
  49. protein stabilization Source: MGI
  50. regulation of binding Source: MGI
  51. regulation of epithelial cell proliferation Source: MGI
  52. regulation of striated muscle tissue development Source: MGI
  53. regulation of transcription from RNA polymerase II promoter Source: MGI
  54. regulation of transforming growth factor beta2 production Source: MGI
  55. regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  56. response to hypoxia Source: MGI
  57. signal transduction involved in regulation of gene expression Source: Ensembl
  58. skeletal system development Source: MGI
  59. SMAD protein complex assembly Source: MGI
  60. SMAD protein signal transduction Source: MGI
  61. somitogenesis Source: MGI
  62. thyroid gland development Source: MGI
  63. transcription from RNA polymerase II promoter Source: GOC
  64. transdifferentiation Source: Ensembl
  65. transforming growth factor beta receptor signaling pathway Source: MGI
  66. transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mothers against decapentaplegic homologUniRule annotation
Short name:
MAD homologUniRule annotation
Short name:
Mothers against DPP homologUniRule annotation
Alternative name(s):
SMAD family memberUniRule annotation
Gene namesi
Name:Smad3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1201674. Smad3.

Subcellular locationi

Cytoplasm UniRule annotation. Nucleus UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nuclear chromatin Source: MGI
  3. nuclear inner membrane Source: MGI
  4. nucleoplasm Source: MGI
  5. nucleus Source: MGI
  6. plasma membrane Source: MGI
  7. receptor complex Source: MGI
  8. SMAD2-SMAD3 protein complex Source: MGI
  9. SMAD protein complex Source: MGI
  10. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiQ3V3E0.
ExpressionAtlasiQ3V3E0. baseline and differential.
GenevestigatoriQ3V3E0.

Interactioni

Family & Domainsi

Sequence similaritiesi

Belongs to the dwarfin/SMAD family.UniRule annotation
Contains 1 MH1 (MAD homology 1) domain.UniRule annotation
Contains 1 MH2 (MAD homology 2) domain.UniRule annotation

Phylogenomic databases

HOVERGENiHBG053353.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
3.90.520.10. 1 hit.
InterProiIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiPF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF56366. SSF56366. 1 hit.
PROSITEiPS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3V3E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ITTQNVNTKC ITIPRSLDGR LQVSHRKGLP HVIYCRLWRW PDLHSHHELR
60 70 80 90 100
AMELCEFAFN MKKDEVCVNP YHYQRVETPV LPPVLVPRHT EIPAEFPPLD
110 120 130 140 150
DYSHSIPENT NFPAGIEPQS NIPETPPPGY LSEDGETSDH QMNHSMDAGS
160 170 180 190 200
PNLSPNPMSP AHNNLDLQPV TYCEPAFWCS ISYYELNQRV GETFHASQPS
210 220 230 240 250
MTVDGFTDPS NSERFCLGLL SNVNRNAAVE LTRRHIGRGV RLYYIGGEVF
260 270 280 290 300
AECLSDSAIF VQSPNCNQRY GWHPATVCKI PPGCNLKIFN NQEFAALLAQ
310 320 330 340 350
SVNQGFEAVY QLTRMCTIRM SFVKGWGAEY RRQTVTSTPC WIELHLNGPL
360 370
QWLDKVLTQM GSPSIRCSSV S
Length:371
Mass (Da):41,931
Last modified:October 11, 2005 - v1
Checksum:iBFDB5CCCE440FB1E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041743 mRNA. Translation: BAE20601.1.
UniGeneiMm.7320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041743 mRNA. Translation: BAE20601.1.
UniGeneiMm.7320.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ3V3E0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1201674. Smad3.

Phylogenomic databases

HOVERGENiHBG053353.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ3V3E0.
ExpressionAtlasiQ3V3E0. baseline and differential.
GenevestigatoriQ3V3E0.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
3.90.520.10. 1 hit.
InterProiIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiPF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF56366. SSF56366. 1 hit.
PROSITEiPS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.

Entry informationi

Entry nameiQ3V3E0_MOUSE
AccessioniPrimary (citable) accession number: Q3V3E0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: March 4, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.