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Q3V3E0

- Q3V3E0_MOUSE

UniProt

Q3V3E0 - Q3V3E0_MOUSE

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Protein
Submitted name: Putative uncharacterized protein
Gene
Smad3
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. collagen binding Source: MGI
  3. core promoter proximal region sequence-specific DNA binding Source: Ensembl
  4. double-stranded DNA binding Source: MGI
  5. protein binding Source: MGI
  6. protein binding transcription factor activity Source: Ensembl
  7. sequence-specific DNA binding transcription factor activity Source: MGI
  8. transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity Source: Ensembl
  9. zinc ion binding Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. SMAD protein complex assembly Source: Ensembl
  2. activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
  3. cell cycle arrest Source: Ensembl
  4. cell-cell junction organization Source: Ensembl
  5. developmental growth Source: MGI
  6. embryonic cranial skeleton morphogenesis Source: MGI
  7. embryonic foregut morphogenesis Source: MGI
  8. embryonic pattern specification Source: MGI
  9. endoderm development Source: MGI
  10. evasion or tolerance of host defenses by virus Source: Ensembl
  11. extrinsic apoptotic signaling pathway Source: Ensembl
  12. gastrulation Source: MGI
  13. heart looping Source: MGI
  14. immune response Source: Ensembl
  15. immune system development Source: MGI
  16. in utero embryonic development Source: MGI
  17. lens fiber cell differentiation Source: MGI
  18. liver development Source: MGI
  19. mesoderm formation Source: MGI
  20. negative regulation of apoptotic process Source: Ensembl
  21. negative regulation of cell growth Source: Ensembl
  22. negative regulation of cell proliferation Source: Ensembl
  23. negative regulation of mitotic cell cycle Source: Ensembl
  24. negative regulation of osteoblast differentiation Source: MGI
  25. negative regulation of protein catabolic process Source: Ensembl
  26. negative regulation of protein phosphorylation Source: Ensembl
  27. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  28. nodal signaling pathway Source: Ensembl
  29. osteoblast development Source: MGI
  30. paraxial mesoderm morphogenesis Source: MGI
  31. pericardium development Source: MGI
  32. positive regulation of alkaline phosphatase activity Source: Ensembl
  33. positive regulation of bone mineralization Source: Ensembl
  34. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  35. positive regulation of catenin import into nucleus Source: Ensembl
  36. positive regulation of cell migration Source: Ensembl
  37. positive regulation of epithelial to mesenchymal transition Source: Ensembl
  38. positive regulation of focal adhesion assembly Source: Ensembl
  39. positive regulation of gene expression involved in extracellular matrix organization Source: Ensembl
  40. positive regulation of interleukin-1 beta production Source: Ensembl
  41. positive regulation of positive chemotaxis Source: Ensembl
  42. positive regulation of stress fiber assembly Source: Ensembl
  43. positive regulation of transcription factor import into nucleus Source: Ensembl
  44. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  45. positive regulation of transcription, DNA-templated Source: MGI
  46. positive regulation of transforming growth factor beta3 production Source: Ensembl
  47. protein stabilization Source: Ensembl
  48. regulation of binding Source: MGI
  49. regulation of epithelial cell proliferation Source: MGI
  50. regulation of striated muscle tissue development Source: MGI
  51. regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  52. regulation of transforming growth factor beta2 production Source: Ensembl
  53. response to hypoxia Source: Ensembl
  54. signal transduction involved in regulation of gene expression Source: Ensembl
  55. skeletal system development Source: MGI
  56. somitogenesis Source: MGI
  57. thyroid gland development Source: MGI
  58. transcription, DNA-templated Source: UniProtKB-KW
  59. transdifferentiation Source: Ensembl
  60. transforming growth factor beta receptor signaling pathway Source: MGI
  61. transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Smad3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1201674. Smad3.

Subcellular locationi

GO - Cellular componenti

  1. SMAD protein complex Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. nuclear inner membrane Source: Ensembl
  4. nucleus Source: MGI
  5. plasma membrane Source: MGI
  6. receptor complex Source: Ensembl
  7. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiQ3V3E0.
BgeeiQ3V3E0.
GenevestigatoriQ3V3E0.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG053353.
InParanoidiQ3V3E0.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
3.90.520.10. 1 hit.
InterProiIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiPF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF56366. SSF56366. 1 hit.
PROSITEiPS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3V3E0-1 [UniParc]FASTAAdd to Basket

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ITTQNVNTKC ITIPRSLDGR LQVSHRKGLP HVIYCRLWRW PDLHSHHELR    50
AMELCEFAFN MKKDEVCVNP YHYQRVETPV LPPVLVPRHT EIPAEFPPLD 100
DYSHSIPENT NFPAGIEPQS NIPETPPPGY LSEDGETSDH QMNHSMDAGS 150
PNLSPNPMSP AHNNLDLQPV TYCEPAFWCS ISYYELNQRV GETFHASQPS 200
MTVDGFTDPS NSERFCLGLL SNVNRNAAVE LTRRHIGRGV RLYYIGGEVF 250
AECLSDSAIF VQSPNCNQRY GWHPATVCKI PPGCNLKIFN NQEFAALLAQ 300
SVNQGFEAVY QLTRMCTIRM SFVKGWGAEY RRQTVTSTPC WIELHLNGPL 350
QWLDKVLTQM GSPSIRCSSV S 371
Length:371
Mass (Da):41,931
Last modified:October 11, 2005 - v1
Checksum:iBFDB5CCCE440FB1E
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK041743 mRNA. Translation: BAE20601.1.
UniGeneiMm.7320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK041743 mRNA. Translation: BAE20601.1 .
UniGenei Mm.7320.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1201674. Smad3.

Phylogenomic databases

HOVERGENi HBG053353.
InParanoidi Q3V3E0.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

ArrayExpressi Q3V3E0.
Bgeei Q3V3E0.
Genevestigatori Q3V3E0.

Family and domain databases

Gene3Di 2.60.200.10. 1 hit.
3.90.520.10. 1 hit.
InterProi IPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
[Graphical view ]
PANTHERi PTHR13703. PTHR13703. 1 hit.
Pfami PF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view ]
SMARTi SM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view ]
SUPFAMi SSF49879. SSF49879. 1 hit.
SSF56366. SSF56366. 1 hit.
PROSITEi PS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.

Entry informationi

Entry nameiQ3V3E0_MOUSE
AccessioniPrimary (citable) accession number: Q3V3E0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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