Q3V3E0 (Q3V3E0_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAE20601.1

Gene names

Name:

Smad3 MGI 1201674

Organism

Mus musculus (Mouse) EMBL BAE20601.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	371 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Biological process	Transcription Transcription regulation SAAS SAAS003619
Cellular component	Nucleus SAAS SAAS003619
Gene Ontology (GO)
Biological_process	SMAD protein complex assembly Inferred from electronic annotation. Source: Compara activation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from electronic annotation. Source: Compara cell cycle arrest Inferred from electronic annotation. Source: Compara cell-cell junction organization Inferred from electronic annotation. Source: Compara developmental growth Inferred from genetic interaction PubMed 15183723. Source: MGI embryonic cranial skeleton morphogenesis Inferred from genetic interaction PubMed 15183723. Source: MGI embryonic foregut morphogenesis Inferred from genetic interaction PubMed 15183723. Source: MGI embryonic pattern specification Inferred from genetic interaction PubMed 15183723. Source: MGI endoderm development Inferred from genetic interaction PubMed 15183723. Source: MGI evasion or tolerance of host defenses by virus Inferred from electronic annotation. Source: Compara heart looping Inferred from genetic interaction PubMed 15183723. Source: MGI immune response Inferred from electronic annotation. Source: Compara immune system development Inferred from genetic interaction PubMed 15183723. Source: MGI in utero embryonic development Inferred from genetic interaction PubMed 15183723. Source: MGI induction of apoptosis Inferred from electronic annotation. Source: Compara lens fiber cell differentiation Inferred from mutant phenotype PubMed 17215516. Source: MGI liver development Inferred from genetic interaction PubMed 15183723. Source: MGI mesoderm formation Inferred from mutant phenotype PubMed 15084457. Source: MGI negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of cell growth Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of mitotic cell cycle Inferred from electronic annotation. Source: Compara negative regulation of osteoblast differentiation Inferred from genetic interaction PubMed 15150273. Source: MGI negative regulation of protein catabolic process Inferred from electronic annotation. Source: Compara negative regulation of protein phosphorylation Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 11711431PubMed 9702197. Source: MGI nodal signaling pathway Inferred from electronic annotation. Source: Compara osteoblast development Inferred from genetic interaction PubMed 15150273. Source: MGI paraxial mesoderm morphogenesis Inferred from mutant phenotype PubMed 15084457. Source: MGI pericardium development Inferred from genetic interaction PubMed 15183723. Source: MGI positive regulation of alkaline phosphatase activity Inferred from electronic annotation. Source: Compara positive regulation of bone mineralization Inferred from electronic annotation. Source: Compara positive regulation of canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of catenin import into nucleus Inferred from electronic annotation. Source: Compara positive regulation of cell migration Inferred from electronic annotation. Source: Compara positive regulation of epithelial to mesenchymal transition Inferred from electronic annotation. Source: Compara positive regulation of focal adhesion assembly Inferred from electronic annotation. Source: Compara positive regulation of gene expression involved in extracellular matrix organization Inferred from electronic annotation. Source: Compara positive regulation of interleukin-1 beta production Inferred from electronic annotation. Source: Compara positive regulation of positive chemotaxis Inferred from electronic annotation. Source: Compara positive regulation of stress fiber assembly Inferred from electronic annotation. Source: Compara positive regulation of transcription factor import into nucleus Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 12943993PubMed 15150273PubMed 16619037. Source: MGI positive regulation of transforming growth factor beta3 production Inferred from electronic annotation. Source: Compara protein stabilization Inferred from electronic annotation. Source: Compara regulation of binding Inferred from direct assay PubMed 15282343. Source: MGI regulation of epithelial cell proliferation Inferred from mutant phenotype PubMed 12845704. Source: MGI regulation of striated muscle tissue development Inferred from direct assay PubMed 11711431. Source: MGI regulation of transforming growth factor beta receptor signaling pathway Inferred from direct assay PubMed 11711431. Source: MGI regulation of transforming growth factor beta2 production Inferred from electronic annotation. Source: Compara release of cytochrome c from mitochondria Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara somitogenesis Inferred from mutant phenotype PubMed 15183723. Source: MGI thyroid gland development Inferred from genetic interaction PubMed 15183723. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transdifferentiation Inferred from electronic annotation. Source: Compara transforming growth factor beta receptor signaling pathway Inferred from direct assay PubMed 16619037PubMed 21937600. Source: MGI transport Inferred from electronic annotation. Source: Compara
Cellular_component	SMAD protein complex Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: Compara nuclear inner membrane Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay PubMed 12943993PubMed 15282343. Source: MGI plasma membrane Inferred from direct assay PubMed 12543979. Source: MGI receptor complex Inferred from electronic annotation. Source: Compara transcription factor complex Inferred from electronic annotation. Source: Compara
Molecular_function	chromatin binding Inferred from direct assay PubMed 16619037. Source: MGI core promoter proximal region sequence-specific DNA binding Inferred from electronic annotation. Source: Compara double-stranded DNA binding Inferred from direct assay PubMed 15282343. Source: MGI protein binding transcription factor activity Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 12943993. Source: MGI transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAE20601.1

Sequences

	Sequence		Length	Mass (Da)
	Q3V3E0 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: BFDB5CCCE440FB1E	FASTA	371	41,931
	10 20 30 40 50 60 ITTQNVNTKC ITIPRSLDGR LQVSHRKGLP HVIYCRLWRW PDLHSHHELR AMELCEFAFN 70 80 90 100 110 120 MKKDEVCVNP YHYQRVETPV LPPVLVPRHT EIPAEFPPLD DYSHSIPENT NFPAGIEPQS 130 140 150 160 170 180 NIPETPPPGY LSEDGETSDH QMNHSMDAGS PNLSPNPMSP AHNNLDLQPV TYCEPAFWCS 190 200 210 220 230 240 ISYYELNQRV GETFHASQPS MTVDGFTDPS NSERFCLGLL SNVNRNAAVE LTRRHIGRGV 250 260 270 280 290 300 RLYYIGGEVF AECLSDSAIF VQSPNCNQRY GWHPATVCKI PPGCNLKIFN NQEFAALLAQ 310 320 330 340 350 360 SVNQGFEAVY QLTRMCTIRM SFVKGWGAEY RRQTVTSTPC WIELHLNGPL QWLDKVLTQM 370 GSPSIRCSSV S

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE20601.1. Tissue: Thymus EMBL BAE20601.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE20601.1. Tissue: Thymus EMBL BAE20601.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE20601.1. Tissue: Thymus EMBL BAE20601.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE20601.1. Tissue: Thymus EMBL BAE20601.1.
[5]	Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE20601.1. Tissue: Thymus EMBL BAE20601.1.
[6]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE20601.1. Tissue: Thymus EMBL BAE20601.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE20601.1. Tissue: Thymus EMBL BAE20601.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE20601.1. Tissue: Thymus EMBL BAE20601.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK041743 mRNA. Translation: BAE20601.1.
IPI	IPI00314870.
UniGene	Mm.7320.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3V3E0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc008fqn.1. mouse.
Organism-specific databases
MGI	MGI:1201674. Smad3.
Phylogenomic databases
HOVERGEN	HBG053353.
InParanoid	Q3V3E0.
Gene expression databases
ArrayExpress	Q3V3E0.
Bgee	Q3V3E0.
Genevestigator	Q3V3E0.
Family and domain databases
Gene3D	2.60.200.10. 1 hit. 3.90.520.10. 1 hit.
InterPro	IPR013790. Dwarfin. IPR003619. MAD_homology1_Dwarfin-type. IPR013019. MAD_homology_MH1. IPR017855. SMAD_dom-like. IPR001132. SMAD_dom_Dwarfin-type. IPR008984. SMAD_FHA_domain. [Graphical view]
PANTHER	PTHR13703. PTHR13703. 1 hit.
Pfam	PF03165. MH1. 1 hit. PF03166. MH2. 1 hit. [Graphical view]
SMART	SM00523. DWA. 1 hit. SM00524. DWB. 1 hit. [Graphical view]
SUPFAM	SSF56366. MAD_MH1. 1 hit. SSF49879. SMAD_FHA. 1 hit.
PROSITE	PS51075. MH1. 1 hit. PS51076. MH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Q3V3E0_MOUSE

Accession

Primary (citable) accession number: Q3V3E0

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)