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Q3V3E0

- Q3V3E0_MOUSE

UniProt

Q3V3E0 - Q3V3E0_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Smad3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. collagen binding Source: MGI
    3. core promoter proximal region sequence-specific DNA binding Source: Ensembl
    4. double-stranded DNA binding Source: MGI
    5. protein binding Source: MGI
    6. protein binding transcription factor activity Source: Ensembl
    7. sequence-specific DNA binding transcription factor activity Source: MGI
    8. transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity Source: Ensembl
    9. zinc ion binding Source: Ensembl

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
    2. cell-cell junction organization Source: Ensembl
    3. cell cycle arrest Source: Ensembl
    4. developmental growth Source: MGI
    5. embryonic cranial skeleton morphogenesis Source: MGI
    6. embryonic foregut morphogenesis Source: MGI
    7. embryonic pattern specification Source: MGI
    8. endoderm development Source: MGI
    9. evasion or tolerance of host defenses by virus Source: Ensembl
    10. extrinsic apoptotic signaling pathway Source: Ensembl
    11. gastrulation Source: MGI
    12. heart looping Source: MGI
    13. immune response Source: Ensembl
    14. immune system development Source: MGI
    15. in utero embryonic development Source: MGI
    16. lens fiber cell differentiation Source: MGI
    17. liver development Source: MGI
    18. mesoderm formation Source: MGI
    19. negative regulation of apoptotic process Source: Ensembl
    20. negative regulation of cell growth Source: Ensembl
    21. negative regulation of cell proliferation Source: Ensembl
    22. negative regulation of mitotic cell cycle Source: Ensembl
    23. negative regulation of osteoblast differentiation Source: MGI
    24. negative regulation of protein catabolic process Source: Ensembl
    25. negative regulation of protein phosphorylation Source: Ensembl
    26. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    27. nodal signaling pathway Source: Ensembl
    28. osteoblast development Source: MGI
    29. paraxial mesoderm morphogenesis Source: MGI
    30. pericardium development Source: MGI
    31. positive regulation of alkaline phosphatase activity Source: Ensembl
    32. positive regulation of bone mineralization Source: Ensembl
    33. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    34. positive regulation of catenin import into nucleus Source: Ensembl
    35. positive regulation of cell migration Source: Ensembl
    36. positive regulation of epithelial to mesenchymal transition Source: Ensembl
    37. positive regulation of focal adhesion assembly Source: Ensembl
    38. positive regulation of gene expression involved in extracellular matrix organization Source: Ensembl
    39. positive regulation of interleukin-1 beta production Source: Ensembl
    40. positive regulation of positive chemotaxis Source: Ensembl
    41. positive regulation of stress fiber assembly Source: Ensembl
    42. positive regulation of transcription, DNA-templated Source: MGI
    43. positive regulation of transcription factor import into nucleus Source: Ensembl
    44. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    45. positive regulation of transforming growth factor beta3 production Source: Ensembl
    46. protein stabilization Source: Ensembl
    47. regulation of binding Source: MGI
    48. regulation of epithelial cell proliferation Source: MGI
    49. regulation of striated muscle tissue development Source: MGI
    50. regulation of transforming growth factor beta2 production Source: Ensembl
    51. regulation of transforming growth factor beta receptor signaling pathway Source: MGI
    52. response to hypoxia Source: Ensembl
    53. signal transduction involved in regulation of gene expression Source: Ensembl
    54. skeletal system development Source: MGI
    55. SMAD protein complex assembly Source: Ensembl
    56. somitogenesis Source: MGI
    57. thyroid gland development Source: MGI
    58. transcription, DNA-templated Source: UniProtKB-KW
    59. transdifferentiation Source: Ensembl
    60. transforming growth factor beta receptor signaling pathway Source: MGI
    61. transport Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:Smad3Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1201674. Smad3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nuclear inner membrane Source: Ensembl
    3. nucleus Source: MGI
    4. plasma membrane Source: MGI
    5. receptor complex Source: Ensembl
    6. SMAD protein complex Source: Ensembl
    7. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiQ3V3E0.
    BgeeiQ3V3E0.
    GenevestigatoriQ3V3E0.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG053353.
    InParanoidiQ3V3E0.

    Family and domain databases

    Gene3Di2.60.200.10. 1 hit.
    3.90.520.10. 1 hit.
    InterProiIPR013790. Dwarfin.
    IPR003619. MAD_homology1_Dwarfin-type.
    IPR013019. MAD_homology_MH1.
    IPR017855. SMAD_dom-like.
    IPR001132. SMAD_dom_Dwarfin-type.
    IPR008984. SMAD_FHA_domain.
    [Graphical view]
    PANTHERiPTHR13703. PTHR13703. 1 hit.
    PfamiPF03165. MH1. 1 hit.
    PF03166. MH2. 1 hit.
    [Graphical view]
    SMARTiSM00523. DWA. 1 hit.
    SM00524. DWB. 1 hit.
    [Graphical view]
    SUPFAMiSSF49879. SSF49879. 1 hit.
    SSF56366. SSF56366. 1 hit.
    PROSITEiPS51075. MH1. 1 hit.
    PS51076. MH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q3V3E0-1 [UniParc]FASTAAdd to Basket

    « Hide

    ITTQNVNTKC ITIPRSLDGR LQVSHRKGLP HVIYCRLWRW PDLHSHHELR    50
    AMELCEFAFN MKKDEVCVNP YHYQRVETPV LPPVLVPRHT EIPAEFPPLD 100
    DYSHSIPENT NFPAGIEPQS NIPETPPPGY LSEDGETSDH QMNHSMDAGS 150
    PNLSPNPMSP AHNNLDLQPV TYCEPAFWCS ISYYELNQRV GETFHASQPS 200
    MTVDGFTDPS NSERFCLGLL SNVNRNAAVE LTRRHIGRGV RLYYIGGEVF 250
    AECLSDSAIF VQSPNCNQRY GWHPATVCKI PPGCNLKIFN NQEFAALLAQ 300
    SVNQGFEAVY QLTRMCTIRM SFVKGWGAEY RRQTVTSTPC WIELHLNGPL 350
    QWLDKVLTQM GSPSIRCSSV S 371
    Length:371
    Mass (Da):41,931
    Last modified:October 11, 2005 - v1
    Checksum:iBFDB5CCCE440FB1E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK041743 mRNA. Translation: BAE20601.1.
    UniGeneiMm.7320.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK041743 mRNA. Translation: BAE20601.1 .
    UniGenei Mm.7320.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1201674. Smad3.

    Phylogenomic databases

    HOVERGENi HBG053353.
    InParanoidi Q3V3E0.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3V3E0.
    Bgeei Q3V3E0.
    Genevestigatori Q3V3E0.

    Family and domain databases

    Gene3Di 2.60.200.10. 1 hit.
    3.90.520.10. 1 hit.
    InterProi IPR013790. Dwarfin.
    IPR003619. MAD_homology1_Dwarfin-type.
    IPR013019. MAD_homology_MH1.
    IPR017855. SMAD_dom-like.
    IPR001132. SMAD_dom_Dwarfin-type.
    IPR008984. SMAD_FHA_domain.
    [Graphical view ]
    PANTHERi PTHR13703. PTHR13703. 1 hit.
    Pfami PF03165. MH1. 1 hit.
    PF03166. MH2. 1 hit.
    [Graphical view ]
    SMARTi SM00523. DWA. 1 hit.
    SM00524. DWB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49879. SSF49879. 1 hit.
    SSF56366. SSF56366. 1 hit.
    PROSITEi PS51075. MH1. 1 hit.
    PS51076. MH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.

    Entry informationi

    Entry nameiQ3V3E0_MOUSE
    AccessioniPrimary (citable) accession number: Q3V3E0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)