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Q3V3E0 (Q3V3E0_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Smad3 MGI 1201674
OrganismMus musculus (Mouse) EMBL BAE20601.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length371 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Biological processTranscription
Transcription regulation SAAS SAAS003619
   Cellular componentNucleus SAAS SAAS003619
Gene Ontology (GO)
   Biological_processSMAD protein complex assembly

Inferred from electronic annotation. Source: Ensembl

activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

cell cycle arrest

Inferred from electronic annotation. Source: Ensembl

cell-cell junction organization

Inferred from electronic annotation. Source: Ensembl

developmental growth

Inferred from genetic interaction PubMed 15183723. Source: MGI

embryonic cranial skeleton morphogenesis

Inferred from genetic interaction PubMed 15183723. Source: MGI

embryonic foregut morphogenesis

Inferred from genetic interaction PubMed 15183723. Source: MGI

embryonic pattern specification

Inferred from genetic interaction PubMed 15183723. Source: MGI

endoderm development

Inferred from genetic interaction PubMed 15183723. Source: MGI

evasion or tolerance of host defenses by virus

Inferred from electronic annotation. Source: Ensembl

extrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

gastrulation

Inferred from genetic interaction PubMed 15183723. Source: MGI

heart looping

Inferred from genetic interaction PubMed 15183723. Source: MGI

immune response

Inferred from electronic annotation. Source: Ensembl

immune system development

Inferred from genetic interaction PubMed 15183723. Source: MGI

in utero embryonic development

Inferred from genetic interaction PubMed 15183723. Source: MGI

lens fiber cell differentiation

Inferred from mutant phenotype PubMed 17215516. Source: MGI

liver development

Inferred from genetic interaction PubMed 15183723. Source: MGI

mesoderm formation

Inferred from mutant phenotype PubMed 15084457. Source: MGI

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of mitotic cell cycle

Inferred from electronic annotation. Source: Ensembl

negative regulation of osteoblast differentiation

Inferred from genetic interaction PubMed 15150273. Source: MGI

negative regulation of protein catabolic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 11711431PubMed 9702197. Source: MGI

nodal signaling pathway

Inferred from electronic annotation. Source: Ensembl

osteoblast development

Inferred from genetic interaction PubMed 15150273. Source: MGI

paraxial mesoderm morphogenesis

Inferred from mutant phenotype PubMed 15084457. Source: MGI

pericardium development

Inferred from genetic interaction PubMed 15183723. Source: MGI

positive regulation of alkaline phosphatase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of bone mineralization

Inferred from electronic annotation. Source: Ensembl

positive regulation of canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of catenin import into nucleus

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial to mesenchymal transition

Inferred from electronic annotation. Source: Ensembl

positive regulation of focal adhesion assembly

Inferred from electronic annotation. Source: Ensembl

positive regulation of gene expression involved in extracellular matrix organization

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-1 beta production

Inferred from electronic annotation. Source: Ensembl

positive regulation of positive chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of stress fiber assembly

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription factor import into nucleus

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 12943993PubMed 15150273PubMed 16619037. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 15282343PubMed 15464984. Source: MGI

positive regulation of transforming growth factor beta3 production

Inferred from electronic annotation. Source: Ensembl

protein stabilization

Inferred from electronic annotation. Source: Ensembl

regulation of binding

Inferred from direct assay PubMed 15282343. Source: MGI

regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 12845704. Source: MGI

regulation of striated muscle tissue development

Inferred from direct assay PubMed 11711431. Source: MGI

regulation of transforming growth factor beta receptor signaling pathway

Inferred from direct assay PubMed 11711431. Source: MGI

regulation of transforming growth factor beta2 production

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

signal transduction involved in regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

skeletal system development

Inferred from genetic interaction PubMed 15183723. Source: MGI

somitogenesis

Inferred from mutant phenotype PubMed 15183723. Source: MGI

thyroid gland development

Inferred from genetic interaction PubMed 15183723. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transdifferentiation

Inferred from electronic annotation. Source: Ensembl

transforming growth factor beta receptor signaling pathway

Inferred from direct assay PubMed 16619037PubMed 21937600. Source: MGI

transport

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentSMAD protein complex

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: Ensembl

nuclear inner membrane

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay PubMed 12943993PubMed 15282343. Source: MGI

plasma membrane

Inferred from direct assay PubMed 12543979. Source: MGI

receptor complex

Inferred from electronic annotation. Source: Ensembl

transcription factor complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionchromatin binding

Inferred from direct assay PubMed 16619037. Source: MGI

collagen binding

Inferred from physical interaction PubMed 14559231. Source: MGI

core promoter proximal region sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

double-stranded DNA binding

Inferred from direct assay PubMed 15282343. Source: MGI

protein binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 12943993. Source: MGI

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

Inferred from electronic annotation. Source: Ensembl

zinc ion binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL BAE20601.1

Sequences

Sequence LengthMass (Da)Tools
Q3V3E0 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: BFDB5CCCE440FB1E

FASTA37141,931
        10         20         30         40         50         60 
ITTQNVNTKC ITIPRSLDGR LQVSHRKGLP HVIYCRLWRW PDLHSHHELR AMELCEFAFN 

        70         80         90        100        110        120 
MKKDEVCVNP YHYQRVETPV LPPVLVPRHT EIPAEFPPLD DYSHSIPENT NFPAGIEPQS 

       130        140        150        160        170        180 
NIPETPPPGY LSEDGETSDH QMNHSMDAGS PNLSPNPMSP AHNNLDLQPV TYCEPAFWCS 

       190        200        210        220        230        240 
ISYYELNQRV GETFHASQPS MTVDGFTDPS NSERFCLGLL SNVNRNAAVE LTRRHIGRGV 

       250        260        270        280        290        300 
RLYYIGGEVF AECLSDSAIF VQSPNCNQRY GWHPATVCKI PPGCNLKIFN NQEFAALLAQ 

       310        320        330        340        350        360 
SVNQGFEAVY QLTRMCTIRM SFVKGWGAEY RRQTVTSTPC WIELHLNGPL QWLDKVLTQM 

       370 
GSPSIRCSSV S 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE20601.1.
Tissue: Thymus EMBL BAE20601.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE20601.1.
Tissue: Thymus EMBL BAE20601.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE20601.1.
Tissue: Thymus EMBL BAE20601.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE20601.1.
Tissue: Thymus EMBL BAE20601.1.
[5]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE20601.1.
Tissue: Thymus EMBL BAE20601.1.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE20601.1.
Tissue: Thymus EMBL BAE20601.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE20601.1.
Tissue: Thymus EMBL BAE20601.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE20601.1.
Tissue: Thymus EMBL BAE20601.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK041743 mRNA. Translation: BAE20601.1.
UniGeneMm.7320.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1201674. Smad3.

Phylogenomic databases

HOVERGENHBG053353.
InParanoidQ3V3E0.

Gene expression databases

ArrayExpressQ3V3E0.
BgeeQ3V3E0.
GenevestigatorQ3V3E0.

Family and domain databases

Gene3D2.60.200.10. 1 hit.
3.90.520.10. 1 hit.
InterProIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERPTHR13703. PTHR13703. 1 hit.
PfamPF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view]
SMARTSM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view]
SUPFAMSSF49879. SSF49879. 1 hit.
SSF56366. SSF56366. 1 hit.
PROSITEPS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ3V3E0_MOUSE
AccessionPrimary (citable) accession number: Q3V3E0
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)