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Q3V3A1 (CDK15_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 15

EC=2.7.11.22
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein homolog
Cell division protein kinase 15
Serine/threonine-protein kinase ALS2CR7
Serine/threonine-protein kinase PFTAIRE-2
Gene names
Name:Cdk15
Synonyms:Als2cr7, Pftk2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. UniProtKB O35495

Cofactor

Magnesium By similarity. UniProtKB P28523

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q3V3A1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.1 (identifier: Q3V3A1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-290: Missing.
     336-398: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q3V3A1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     90-90: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Cyclin-dependent kinase 15
PRO_0000283822

Regions

Domain52 – 336285Protein kinase
Nucleotide binding58 – 669ATP By similarity UniProtKB P28523

Sites

Active site1731Proton acceptor By similarity UniProtKB P28523
Binding site811ATP By similarity UniProtKB P28523

Natural variations

Alternative sequence1 – 290290Missing in isoform 2. Ref.1
VSP_052350
Alternative sequence901Missing in isoform 3.
VSP_038766
Alternative sequence336 – 39863Missing in isoform 2. Ref.1
VSP_052351

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 17, 2007. Version 2.
Checksum: 9584802B36C2224F

FASTA43348,457
        10         20         30         40         50         60 
MGQELCAKRL QPGCSCYHRS EGGEAHSCQR SQPGSTEPAV FELTEASSST ASFHPRGLEA 

        70         80         90        100        110        120 
ASAQKLKSKR PRSNSDSFQE ENLRQGLPWK KSLPFGAASS YLNLEKLGEG SYAKVYKGIS 

       130        140        150        160        170        180 
RINGQLVALK VISMNAEEGV PFTAIREASL LKGLKHANIV LLHDIVHTKE TLTFVFEYMH 

       190        200        210        220        230        240 
TDLAQYMSQH PGGLHPHNVR LFMFQLLRGL AYIHHQRVLH RDLKPQNLLL SHLGELKLAD 

       250        260        270        280        290        300 
FGLARAKSIP SQTYSSEVVT LWYRPPDALL GATEYSSELD IWGAGCIFIE MFQGQPLFPG 

       310        320        330        340        350        360 
VSNILEQLEK IWEVLGVPTE DTWPGVSKLP NYNPEWFPPP KPQSLQIVWD RLGGVPEAED 

       370        380        390        400        410        420 
LASQMLKGFP RDRVSAQEAL VHDYFSVLPS QLYQLPDEES LFAVSGVKLK PEMCDLSASY 

       430 
RKRHHLVGVN KCW 

« Hide

Isoform 2 [UniParc].

Checksum: 2BB27714BA6271ED
Show »

FASTA809,070
Isoform 3 [UniParc].

Checksum: 097287D60D4915F6
Show »

FASTA43248,329

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Cerebellum.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK042881 mRNA. Translation: BAE20636.1.
AC116995 Genomic DNA. No translation available.
BC147314 mRNA. Translation: AAI47315.1.
BC147315 mRNA. Translation: AAI47316.1.
BC147758 mRNA. Translation: AAI47759.1.
BC147763 mRNA. Translation: AAI47764.1.
BC172036 mRNA. Translation: AAI72036.1.
CCDSCCDS48273.1. [Q3V3A1-1]
RefSeqNP_001028545.2. NM_001033373.2. [Q3V3A1-1]
XP_006496113.1. XM_006496050.1. [Q3V3A1-3]
UniGeneMm.297713.

3D structure databases

ProteinModelPortalQ3V3A1.
SMRQ3V3A1. Positions 47-424.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000109886.

PTM databases

PhosphoSiteQ3V3A1.

Proteomic databases

PRIDEQ3V3A1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000114248; ENSMUSP00000109886; ENSMUSG00000026023. [Q3V3A1-1]
GeneID271697.
KEGGmmu:271697.
UCSCuc007bdq.2. mouse. [Q3V3A1-3]
uc007bdr.2. mouse. [Q3V3A1-1]
uc007bds.2. mouse. [Q3V3A1-2]

Organism-specific databases

CTD65061.
MGIMGI:3583944. Cdk15.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00600000083998.
HOGENOMHOG000233024.
HOVERGENHBG014652.
InParanoidB2RVR3.
KOK15594.
PhylomeDBQ3V3A1.

Gene expression databases

BgeeQ3V3A1.
CleanExMM_PFTK2.
GenevestigatorQ3V3A1.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio393485.
PROQ3V3A1.
SOURCESearch...

Entry information

Entry nameCDK15_MOUSE
AccessionPrimary (citable) accession number: Q3V3A1
Secondary accession number(s): B2RVR3, B7ZWG3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: July 9, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot