Q3V3A1 (CDK15_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinase 15
EC=2.7.11.22

Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein homolog
Cell division protein kinase 15
Serine/threonine-protein kinase ALS2CR7
Serine/threonine-protein kinase PFTAIRE-2

Gene names

Name:	Cdk15
Synonyms:	Als2cr7, Pftk2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. UniProtKB O35495
Cofactor	Magnesium By similarity. UniProtKB P28523
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q3V3A1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.1 (identifier: Q3V3A1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-290: Missing.
     336-398: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q3V3A1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     90-90: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	Cyclin-dependent kinase 15		PRO_0000283822
Regions
	Domain	52 – 336	285	Protein kinase
	Nucleotide binding	58 – 66	9	ATP By similarity UniProtKB P28523
Sites
	Active site	173	1	Proton acceptor By similarity UniProtKB P28523
	Binding site	81	1	ATP By similarity UniProtKB P28523
Natural variations
	Alternative sequence	1 – 290	290	Missing in isoform 2. Ref.1		VSP_052350
	Alternative sequence	90	1	Missing in isoform 3.		VSP_038766
	Alternative sequence	336 – 398	63	Missing in isoform 2. Ref.1		VSP_052351

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 17, 2007. Version 2. Checksum: 9584802B36C2224F	FASTA	433	48,457
	10 20 30 40 50 60 MGQELCAKRL QPGCSCYHRS EGGEAHSCQR SQPGSTEPAV FELTEASSST ASFHPRGLEA 70 80 90 100 110 120 ASAQKLKSKR PRSNSDSFQE ENLRQGLPWK KSLPFGAASS YLNLEKLGEG SYAKVYKGIS 130 140 150 160 170 180 RINGQLVALK VISMNAEEGV PFTAIREASL LKGLKHANIV LLHDIVHTKE TLTFVFEYMH 190 200 210 220 230 240 TDLAQYMSQH PGGLHPHNVR LFMFQLLRGL AYIHHQRVLH RDLKPQNLLL SHLGELKLAD 250 260 270 280 290 300 FGLARAKSIP SQTYSSEVVT LWYRPPDALL GATEYSSELD IWGAGCIFIE MFQGQPLFPG 310 320 330 340 350 360 VSNILEQLEK IWEVLGVPTE DTWPGVSKLP NYNPEWFPPP KPQSLQIVWD RLGGVPEAED 370 380 390 400 410 420 LASQMLKGFP RDRVSAQEAL VHDYFSVLPS QLYQLPDEES LFAVSGVKLK PEMCDLSASY 430 RKRHHLVGVN KCW
	Isoform 2 [UniParc]. Checksum: 2BB27714BA6271ED	FASTA	80	9,070
	10 20 30 40 50 60 MFQGQPLFPG VSNILEQLEK IWEVLGVPTE DTWPGVSKLP NYNPEESLFA VSGVKLKPEM 70 80 CDLSASYRKR HHLVGVNKCW
	Isoform 3 [UniParc]. Checksum: 097287D60D4915F6	FASTA	432	48,329
	10 20 30 40 50 60 MGQELCAKRL QPGCSCYHRS EGGEAHSCQR SQPGSTEPAV FELTEASSST ASFHPRGLEA 70 80 90 100 110 120 ASAQKLKSKR PRSNSDSFQE ENLRQGLPWK SLPFGAASSY LNLEKLGEGS YAKVYKGISR 130 140 150 160 170 180 INGQLVALKV ISMNAEEGVP FTAIREASLL KGLKHANIVL LHDIVHTKET LTFVFEYMHT 190 200 210 220 230 240 DLAQYMSQHP GGLHPHNVRL FMFQLLRGLA YIHHQRVLHR DLKPQNLLLS HLGELKLADF 250 260 270 280 290 300 GLARAKSIPS QTYSSEVVTL WYRPPDALLG ATEYSSELDI WGAGCIFIEM FQGQPLFPGV 310 320 330 340 350 360 SNILEQLEKI WEVLGVPTED TWPGVSKLPN YNPEWFPPPK PQSLQIVWDR LGGVPEAEDL 370 380 390 400 410 420 ASQMLKGFPR DRVSAQEALV HDYFSVLPSQ LYQLPDEESL FAVSGVKLKP EMCDLSASYR 430 KRHHLVGVNK CW

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J. Tissue: Cerebellum.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK042881 mRNA. Translation: BAE20636.1. AC116995 Genomic DNA. No translation available. BC147314 mRNA. Translation: AAI47315.1. BC147315 mRNA. Translation: AAI47316.1. BC147758 mRNA. Translation: AAI47759.1. BC147763 mRNA. Translation: AAI47764.1. BC172036 mRNA. Translation: AAI72036.1.
IPI	IPI00112066. IPI00844771. IPI00955363.
RefSeq	NP_001028545.2. NM_001033373.2.
UniGene	Mm.297713.
3D structure databases
ProteinModelPortal	Q3V3A1.
SMR	Q3V3A1. Positions 47-386.
ModBase	Search...
PTM databases
PhosphoSite	Q3V3A1.
Proteomic databases
PRIDE	Q3V3A1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000114248; ENSMUSP00000109886; ENSMUSG00000026023.
GeneID	271697.
KEGG	mmu:271697.
UCSC	uc007bdq.2. mouse. uc007bdr.2. mouse. uc007bds.2. mouse.
Organism-specific databases
CTD	65061.
MGI	MGI:3583944. Cdk15.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00600000083998.
HOGENOM	HOG000233024.
HOVERGEN	HBG014652.
InParanoid	B2RVR3.
KO	K15594.
OrthoDB	EOG4J3WH1.
Gene expression databases
ArrayExpress	Q3V3A1.
Bgee	Q3V3A1.
CleanEx	MM_PFTK2.
Genevestigator	Q3V3A1.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	393485.
SOURCE	Search...

Entry information

Entry name

CDK15_MOUSE

Accession

Primary (citable) accession number: Q3V3A1
Secondary accession number(s): B2RVR3, B7ZWG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	April 17, 2007
Last modified:	May 29, 2013
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program