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Protein

Cyclin-dependent kinase 15

Gene

Cdk15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei81 – 811ATPBy similarityPROSITE-ProRule annotation
Active sitei173 – 1731Proton acceptorBy similarityPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi58 – 669ATPBy similarityPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 15 (EC:2.7.11.22)
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein homolog
Cell division protein kinase 15
Serine/threonine-protein kinase ALS2CR7
Serine/threonine-protein kinase PFTAIRE-2
Gene namesi
Name:Cdk15
Synonyms:Als2cr7, Pftk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:3583944. Cdk15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Cyclin-dependent kinase 15PRO_0000283822Add
BLAST

Proteomic databases

PRIDEiQ3V3A1.

PTM databases

PhosphoSiteiQ3V3A1.

Expressioni

Gene expression databases

BgeeiQ3V3A1.
CleanExiMM_PFTK2.
ExpressionAtlasiQ3V3A1. baseline.
GenevestigatoriQ3V3A1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109886.

Structurei

3D structure databases

ProteinModelPortaliQ3V3A1.
SMRiQ3V3A1. Positions 47-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 336285Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121869.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ3V3A1.
KOiK15594.
PhylomeDBiQ3V3A1.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1Curated (identifier: Q3V3A1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQELCAKRL QPGCSCYHRS EGGEAHSCQR SQPGSTEPAV FELTEASSST
60 70 80 90 100
ASFHPRGLEA ASAQKLKSKR PRSNSDSFQE ENLRQGLPWK KSLPFGAASS
110 120 130 140 150
YLNLEKLGEG SYAKVYKGIS RINGQLVALK VISMNAEEGV PFTAIREASL
160 170 180 190 200
LKGLKHANIV LLHDIVHTKE TLTFVFEYMH TDLAQYMSQH PGGLHPHNVR
210 220 230 240 250
LFMFQLLRGL AYIHHQRVLH RDLKPQNLLL SHLGELKLAD FGLARAKSIP
260 270 280 290 300
SQTYSSEVVT LWYRPPDALL GATEYSSELD IWGAGCIFIE MFQGQPLFPG
310 320 330 340 350
VSNILEQLEK IWEVLGVPTE DTWPGVSKLP NYNPEWFPPP KPQSLQIVWD
360 370 380 390 400
RLGGVPEAED LASQMLKGFP RDRVSAQEAL VHDYFSVLPS QLYQLPDEES
410 420 430
LFAVSGVKLK PEMCDLSASY RKRHHLVGVN KCW
Length:433
Mass (Da):48,457
Last modified:April 17, 2007 - v2
Checksum:i9584802B36C2224F
GO
Isoform 21 Publication (identifier: Q3V3A1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-290: Missing.
     336-398: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:80
Mass (Da):9,070
Checksum:i2BB27714BA6271ED
GO
Isoform 3 (identifier: Q3V3A1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-90: Missing.

Note: No experimental confirmation available.

Show »
Length:432
Mass (Da):48,329
Checksum:i097287D60D4915F6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 290290Missing in isoform 2. 1 PublicationVSP_052350Add
BLAST
Alternative sequencei90 – 901Missing in isoform 3. 1 PublicationVSP_038766
Alternative sequencei336 – 39863Missing in isoform 2. 1 PublicationVSP_052351Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042881 mRNA. Translation: BAE20636.1.
AC116995 Genomic DNA. No translation available.
BC147314 mRNA. Translation: AAI47315.1.
BC147315 mRNA. Translation: AAI47316.1.
BC147758 mRNA. Translation: AAI47759.1.
BC147763 mRNA. Translation: AAI47764.1.
BC172036 mRNA. Translation: AAI72036.1.
CCDSiCCDS48273.1. [Q3V3A1-1]
RefSeqiNP_001028545.2. NM_001033373.2. [Q3V3A1-1]
XP_006496113.1. XM_006496050.1. [Q3V3A1-3]
UniGeneiMm.297713.

Genome annotation databases

EnsembliENSMUST00000114248; ENSMUSP00000109886; ENSMUSG00000026023. [Q3V3A1-1]
GeneIDi271697.
KEGGimmu:271697.
UCSCiuc007bdq.2. mouse. [Q3V3A1-3]
uc007bdr.2. mouse. [Q3V3A1-1]
uc007bds.2. mouse. [Q3V3A1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042881 mRNA. Translation: BAE20636.1.
AC116995 Genomic DNA. No translation available.
BC147314 mRNA. Translation: AAI47315.1.
BC147315 mRNA. Translation: AAI47316.1.
BC147758 mRNA. Translation: AAI47759.1.
BC147763 mRNA. Translation: AAI47764.1.
BC172036 mRNA. Translation: AAI72036.1.
CCDSiCCDS48273.1. [Q3V3A1-1]
RefSeqiNP_001028545.2. NM_001033373.2. [Q3V3A1-1]
XP_006496113.1. XM_006496050.1. [Q3V3A1-3]
UniGeneiMm.297713.

3D structure databases

ProteinModelPortaliQ3V3A1.
SMRiQ3V3A1. Positions 47-424.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109886.

PTM databases

PhosphoSiteiQ3V3A1.

Proteomic databases

PRIDEiQ3V3A1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114248; ENSMUSP00000109886; ENSMUSG00000026023. [Q3V3A1-1]
GeneIDi271697.
KEGGimmu:271697.
UCSCiuc007bdq.2. mouse. [Q3V3A1-3]
uc007bdr.2. mouse. [Q3V3A1-1]
uc007bds.2. mouse. [Q3V3A1-2]

Organism-specific databases

CTDi65061.
MGIiMGI:3583944. Cdk15.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121869.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ3V3A1.
KOiK15594.
PhylomeDBiQ3V3A1.

Miscellaneous databases

NextBioi393485.
PROiQ3V3A1.
SOURCEiSearch...

Gene expression databases

BgeeiQ3V3A1.
CleanExiMM_PFTK2.
ExpressionAtlasiQ3V3A1. baseline.
GenevestigatoriQ3V3A1.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain.

Entry informationi

Entry nameiCDK15_MOUSE
AccessioniPrimary (citable) accession number: Q3V3A1
Secondary accession number(s): B2RVR3, B7ZWG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: February 4, 2015
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.