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Q3V3A1

- CDK15_MOUSE

UniProt

Q3V3A1 - CDK15_MOUSE

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Protein
Cyclin-dependent kinase 15
Gene
Cdk15, Als2cr7, Pftk2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Magnesium By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei81 – 811ATP By similarityBy similarity
Active sitei173 – 1731Proton acceptor By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi58 – 669ATP By similarityBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 15 (EC:2.7.11.22)
    Alternative name(s):
    Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein homolog
    Cell division protein kinase 15
    Serine/threonine-protein kinase ALS2CR7
    Serine/threonine-protein kinase PFTAIRE-2
    Gene namesi
    Name:Cdk15
    Synonyms:Als2cr7, Pftk2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:3583944. Cdk15.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Cyclin-dependent kinase 15
    PRO_0000283822Add
    BLAST

    Proteomic databases

    PRIDEiQ3V3A1.

    PTM databases

    PhosphoSiteiQ3V3A1.

    Expressioni

    Gene expression databases

    BgeeiQ3V3A1.
    CleanExiMM_PFTK2.
    GenevestigatoriQ3V3A1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000109886.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3V3A1.
    SMRiQ3V3A1. Positions 47-424.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini52 – 336285Protein kinase
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00600000083998.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    InParanoidiB2RVR3.
    KOiK15594.
    PhylomeDBiQ3V3A1.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3V3A1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGQELCAKRL QPGCSCYHRS EGGEAHSCQR SQPGSTEPAV FELTEASSST    50
    ASFHPRGLEA ASAQKLKSKR PRSNSDSFQE ENLRQGLPWK KSLPFGAASS 100
    YLNLEKLGEG SYAKVYKGIS RINGQLVALK VISMNAEEGV PFTAIREASL 150
    LKGLKHANIV LLHDIVHTKE TLTFVFEYMH TDLAQYMSQH PGGLHPHNVR 200
    LFMFQLLRGL AYIHHQRVLH RDLKPQNLLL SHLGELKLAD FGLARAKSIP 250
    SQTYSSEVVT LWYRPPDALL GATEYSSELD IWGAGCIFIE MFQGQPLFPG 300
    VSNILEQLEK IWEVLGVPTE DTWPGVSKLP NYNPEWFPPP KPQSLQIVWD 350
    RLGGVPEAED LASQMLKGFP RDRVSAQEAL VHDYFSVLPS QLYQLPDEES 400
    LFAVSGVKLK PEMCDLSASY RKRHHLVGVN KCW 433
    Length:433
    Mass (Da):48,457
    Last modified:April 17, 2007 - v2
    Checksum:i9584802B36C2224F
    GO
    Isoform 21 Publication (identifier: Q3V3A1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-290: Missing.
         336-398: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:80
    Mass (Da):9,070
    Checksum:i2BB27714BA6271ED
    GO
    Isoform 3 (identifier: Q3V3A1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         90-90: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:432
    Mass (Da):48,329
    Checksum:i097287D60D4915F6
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 290290Missing in isoform 2. 1 Publication
    VSP_052350Add
    BLAST
    Alternative sequencei90 – 901Missing in isoform 3.
    VSP_038766
    Alternative sequencei336 – 39863Missing in isoform 2. 1 Publication
    VSP_052351Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK042881 mRNA. Translation: BAE20636.1.
    AC116995 Genomic DNA. No translation available.
    BC147314 mRNA. Translation: AAI47315.1.
    BC147315 mRNA. Translation: AAI47316.1.
    BC147758 mRNA. Translation: AAI47759.1.
    BC147763 mRNA. Translation: AAI47764.1.
    BC172036 mRNA. Translation: AAI72036.1.
    CCDSiCCDS48273.1. [Q3V3A1-1]
    RefSeqiNP_001028545.2. NM_001033373.2. [Q3V3A1-1]
    XP_006496113.1. XM_006496050.1. [Q3V3A1-3]
    UniGeneiMm.297713.

    Genome annotation databases

    EnsembliENSMUST00000114248; ENSMUSP00000109886; ENSMUSG00000026023. [Q3V3A1-1]
    GeneIDi271697.
    KEGGimmu:271697.
    UCSCiuc007bdq.2. mouse. [Q3V3A1-3]
    uc007bdr.2. mouse. [Q3V3A1-1]
    uc007bds.2. mouse. [Q3V3A1-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK042881 mRNA. Translation: BAE20636.1 .
    AC116995 Genomic DNA. No translation available.
    BC147314 mRNA. Translation: AAI47315.1 .
    BC147315 mRNA. Translation: AAI47316.1 .
    BC147758 mRNA. Translation: AAI47759.1 .
    BC147763 mRNA. Translation: AAI47764.1 .
    BC172036 mRNA. Translation: AAI72036.1 .
    CCDSi CCDS48273.1. [Q3V3A1-1 ]
    RefSeqi NP_001028545.2. NM_001033373.2. [Q3V3A1-1 ]
    XP_006496113.1. XM_006496050.1. [Q3V3A1-3 ]
    UniGenei Mm.297713.

    3D structure databases

    ProteinModelPortali Q3V3A1.
    SMRi Q3V3A1. Positions 47-424.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000109886.

    PTM databases

    PhosphoSitei Q3V3A1.

    Proteomic databases

    PRIDEi Q3V3A1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000114248 ; ENSMUSP00000109886 ; ENSMUSG00000026023 . [Q3V3A1-1 ]
    GeneIDi 271697.
    KEGGi mmu:271697.
    UCSCi uc007bdq.2. mouse. [Q3V3A1-3 ]
    uc007bdr.2. mouse. [Q3V3A1-1 ]
    uc007bds.2. mouse. [Q3V3A1-2 ]

    Organism-specific databases

    CTDi 65061.
    MGIi MGI:3583944. Cdk15.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00600000083998.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    InParanoidi B2RVR3.
    KOi K15594.
    PhylomeDBi Q3V3A1.

    Miscellaneous databases

    NextBioi 393485.
    PROi Q3V3A1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3V3A1.
    CleanExi MM_PFTK2.
    Genevestigatori Q3V3A1.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Cerebellum.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain.

    Entry informationi

    Entry nameiCDK15_MOUSE
    AccessioniPrimary (citable) accession number: Q3V3A1
    Secondary accession number(s): B2RVR3, B7ZWG3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: April 17, 2007
    Last modified: July 9, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi