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Protein
Submitted name:

Putative uncharacterized protein

Gene

Trpv1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • calcium channel activity Source: MGI
  • cation channel activity Source: MGI
  • cation transmembrane transporter activity Source: MGI
  • ion channel activity Source: MGI
  • phosphoprotein binding Source: MGI
  • temperature-gated ion channel activity Source: MGI

GO - Biological processi

  • behavioral response to pain Source: MGI
  • calcium ion transmembrane transport Source: GOC
  • calcium ion transport Source: MGI
  • cation transmembrane transport Source: GOC
  • cation transport Source: MGI
  • detection of chemical stimulus involved in sensory perception of pain Source: MGI
  • detection of temperature stimulus involved in thermoception Source: MGI
  • diet induced thermogenesis Source: MGI
  • fever generation Source: MGI
  • ion transmembrane transport Source: GOC
  • lipid metabolic process Source: MGI
  • peptide secretion Source: MGI
  • response to heat Source: MGI
  • response to organonitrogen compound Source: MGI
  • response to pain Source: MGI
  • response to pH Source: MGI
  • sensory perception of mechanical stimulus Source: MGI
  • sensory perception of pain Source: MGI
  • smooth muscle contraction involved in micturition Source: MGI
  • temperature homeostasis Source: MGI
  • urinary bladder smooth muscle contraction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Trpv1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1341787. Trpv1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei434 – 45320HelicalSequence analysisAdd
BLAST
Transmembranei473 – 49119HelicalSequence analysisAdd
BLAST
Transmembranei512 – 53221HelicalSequence analysisAdd
BLAST
Transmembranei538 – 55720HelicalSequence analysisAdd
BLAST
Transmembranei578 – 60023HelicalSequence analysisAdd
BLAST
Transmembranei658 – 68225HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: MGI
  • membrane Source: MGI
  • neuron projection Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ3V318.

PTM databases

iPTMnetiQ3V318.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099585.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini201 – 356156ANK_REP_REGIONInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili127 – 14721Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotationSAAS annotation, Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4110DG4. LUCA.
KOG3676. Eukaryota.
HOVERGENiHBG054085.
KOiK05222.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR008347. TRPV1-4_channel.
IPR024863. TRPV1_channel.
[Graphical view]
PANTHERiPTHR10582:SF17. PTHR10582:SF17. 2 hits.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01768. TRPVRECEPTOR.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3V318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKWASLDSD ESEPPAQENS CPDPPDRDPN SKPPPAKPHI FATRSRTRLF
60 70 80 90 100
GKGDSEEASP MDCPYEEGGL ASCPIITVSS VVTLQRSVDG PTCLRQTSQD
110 120 130 140 150
SVSTGVETPP RLYDRRSIFD AVAQSNCQEL ESLLSFLQKS KKRLTDSEFK
160 170 180 190 200
DPETGKTCLL KAMLNLHNGQ NDTIALLLDI ARKTDSLKQF VNASYTDSYY
210 220 230 240 250
KGQTALHIAI ERRNMALVTL LVENGADVQA AANGDFFKKT KGRPGFYFGE
260 270 280 290 300
LPLSLAACTN QLAIVKFLLQ NSWQPADISA RDSVGNTVLH ALVEVADNTA
310 320 330 340 350
DNTKFVTNMY NEILILGAKL HPTLKLEELT NKKGLTPLAL AASSGKIGVL
360 370 380 390 400
AYILQREIHE PECRHLSRKF TEWAYGPVHS SLYDLSCIDT CEKNSVLEVI
410 420 430 440 450
AYSSSETPNR HDMLLVEPLN RLLQDKWDRF VKRIFYFNFF VYCLYMIVFT
460 470 480 490 500
TAAYYRPVEG LPPYKLNNTV GDYFRVTGEI LSVSGGVYFF FRGIQYFLQR
510 520 530 540 550
RPSLKSLFVD SYSEILFFVQ SLFMLVSVVL YFSHRKEYVA SMVFSLAMGW
560 570 580 590 600
TNMLYYTRGF QQMGIYAVMI EKMILRDLCR FMFVYLVFLF GFSTAVVTLI
610 620 630 640 650
EDGKNNSLPV ESPPHKCRGS ACRPGNSYNS LYSTCLELFK FTIGMGDLEF
660 670 680 690 700
TENYDFKAVF IILLLAYVIL TYILLLNMLI ALMGETVNKI AQESKNIWKL
710 720 730 740 750
QRAITILDTE KSFLKCMRKA FRSGKLLQVG FTPDGKDDFR WCFRVDEVNW
760 770 780 790 800
TTWNTNVGII NEDPGNCEGV KRTLSFSLRS GRVSGRNWKN FALVPLLRDA
810 820 830
STRDRHSTQP EEVQLKHYTG SLKPEDAEVF KDSMAPGEK
Length:839
Mass (Da):94,962
Last modified:October 11, 2005 - v1
Checksum:i0D5A27D8C0665F8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK051315 mRNA. Translation: BAE20689.1.
RefSeqiNP_001001445.1. NM_001001445.2.
UniGeneiMm.447485.

Genome annotation databases

GeneIDi193034.
KEGGimmu:193034.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK051315 mRNA. Translation: BAE20689.1.
RefSeqiNP_001001445.1. NM_001001445.2.
UniGeneiMm.447485.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099585.

PTM databases

iPTMnetiQ3V318.

Proteomic databases

PaxDbiQ3V318.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi193034.
KEGGimmu:193034.

Organism-specific databases

CTDi7442.
MGIiMGI:1341787. Trpv1.

Phylogenomic databases

eggNOGiENOG4110DG4. LUCA.
KOG3676. Eukaryota.
HOVERGENiHBG054085.
KOiK05222.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR008347. TRPV1-4_channel.
IPR024863. TRPV1_channel.
[Graphical view]
PANTHERiPTHR10582:SF17. PTHR10582:SF17. 2 hits.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01768. TRPVRECEPTOR.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal ganglionImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal ganglionImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal ganglionImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal ganglionImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal ganglionImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal ganglionImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal ganglionImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal ganglionImported.

Entry informationi

Entry nameiQ3V318_MOUSE
AccessioniPrimary (citable) accession number: Q3V318
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: January 20, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.