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Protein

Kinesin-like protein KIF22

Gene

Kif22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi122 – 129ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Motor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-MMU-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF22
Gene namesi
Name:Kif22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:109233. Kif22.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002629211 – 660Kinesin-like protein KIF22Add BLAST660

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei407PhosphoserineBy similarity1
Modified residuei422PhosphoserineBy similarity1
Modified residuei447PhosphoserineBy similarity1
Cross-linki460Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei540PhosphoserineBy similarity1
Modified residuei576PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ3V300.
MaxQBiQ3V300.
PaxDbiQ3V300.
PeptideAtlasiQ3V300.
PRIDEiQ3V300.

PTM databases

iPTMnetiQ3V300.
PhosphoSitePlusiQ3V300.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030677.
CleanExiMM_KIF22.
ExpressionAtlasiQ3V300. baseline and differential.
GenevisibleiQ3V300. MM.

Interactioni

Subunit structurei

Interacts with FAM83D and SIAH1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi225240. 5 interactors.
IntActiQ3V300. 7 interactors.
STRINGi10090.ENSMUSP00000032915.

Structurei

3D structure databases

ProteinModelPortaliQ3V300.
SMRiQ3V300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 363Kinesin motorPROSITE-ProRule annotationAdd BLAST326

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili460 – 505Sequence analysisAdd BLAST46

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0242. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00900000140824.
HOGENOMiHOG000007569.
HOVERGENiHBG052252.
InParanoidiQ3V300.
KOiK10403.
OMAiAGQRCGP.
OrthoDBiEOG091G0FFB.
PhylomeDBiQ3V300.
TreeFamiTF105233.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiView protein in InterPro
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR026986. KIF22.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR036961. Kinesin_motor_dom_sf.
IPR027417. P-loop_NTPase.
IPR010994. RuvA_2-like.
PANTHERiPTHR24115. PTHR24115. 1 hit.
PTHR24115:SF462. PTHR24115:SF462. 1 hit.
PfamiView protein in Pfam
PF00225. Kinesin. 1 hit.
PRINTSiPR00380. KINESINHEAVY.
SMARTiView protein in SMART
SM00278. HhH1. 2 hits.
SM00129. KISc. 1 hit.
SUPFAMiSSF47781. SSF47781. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3V300-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRAKTCPQ RREMASATSG PGRCVSKGGL GRRPPLARVR VAVRLRPFMD
60 70 80 90 100
GETEAKELPC VRAIDSCSLE VANWKKYQET LKYQFDAFYG EKSTQQEVYV
110 120 130 140 150
GSVQPILRHL LEGQNASVLA YGPTGAGKTH TMLGSPEQPG VIPRALMDLL
160 170 180 190 200
QLAREESAEG RPWDVSVAMS YLEIYQEKVL DLLDPASGDL VIREDCRGNI
210 220 230 240 250
LIPGLTQKPI TSFSDFEQHF LPASRNRAVG ATRLNQRSSR SHAVLLVKVD
260 270 280 290 300
QRERLTPFRQ REGKLYLIDL AGSEDNRRTG NQGIRLKESG AINTSLFVLG
310 320 330 340 350
KVVDALNQGL PRIPYRDSKL TRLLQDSLGG SAHSILIANI APERRFYQDT
360 370 380 390 400
ISALNFTARS KEVINRPFTN ESLQPHALAP VKLSQKELLG PSEAKKAKGP
410 420 430 440 450
EEESTGSPES TAAPASASQK LSLLQKLSNM DPAMLENLLS MERLLGSQGS
460 470 480 490 500
QGTPLLNTPK RERMVLMKTV EEKNLEIERL KMKQKELEAK VLAQEAPDPR
510 520 530 540 550
EKENTPTILQ PPASYSGTVA KPLKKAVVMP LQRIQKQRES SNQIQLLKKG
560 570 580 590 600
PKRKLEPSPE SEAVEKDEDY WEVQISPELL AHGRKKLLDL LNEGSARELR
610 620 630 640 650
SLQRIGQKKA QLIVGWRELH GPFSEVEDLE QVEGISGKQV ESFLKANLLS
660
LAASQHSGPS
Length:660
Mass (Da):73,190
Last modified:November 28, 2006 - v2
Checksum:iAA8B99477BC49B3C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60C → R in BAE43356 (PubMed:15489334).Curated1
Sequence conflicti267L → I in BAE43356 (PubMed:15489334).Curated1
Sequence conflicti528V → E in BAE43356 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075922 mRNA. Translation: BAE43356.1.
BC003427 mRNA. Translation: AAH03427.1.
AF013119 mRNA. Translation: AAC39968.1.
CCDSiCCDS21855.1.
RefSeqiNP_663563.1. NM_145588.1.
UniGeneiMm.286488.

Genome annotation databases

EnsembliENSMUST00000032915; ENSMUSP00000032915; ENSMUSG00000030677.
GeneIDi110033.
KEGGimmu:110033.
UCSCiuc009jud.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiKIF22_MOUSE
AccessioniPrimary (citable) accession number: Q3V300
Secondary accession number(s): O35232, Q99LC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: October 25, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families