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Q3V300

- KIF22_MOUSE

UniProt

Q3V300 - KIF22_MOUSE

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Protein

Kinesin-like protein KIF22

Gene

Kif22

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi122 – 1298ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: RefGenome
  2. ATP binding Source: UniProtKB-KW
  3. DNA binding Source: UniProtKB-KW
  4. microtubule motor activity Source: RefGenome

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. DNA repair Source: InterPro
  3. microtubule-based movement Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.
REACT_199117. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF22
Gene namesi
Name:Kif22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:109233. Kif22.

Subcellular locationi

Nucleus By similarity. Cytoplasmcytoskeleton Curated

GO - Cellular componenti

  1. chromatin Source: MGI
  2. cytoplasm Source: UniProtKB-KW
  3. focal adhesion Source: Ensembl
  4. kinesin complex Source: RefGenome
  5. microtubule Source: UniProtKB-KW
  6. nucleus Source: UniProtKB-KW
  7. spindle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 660660Kinesin-like protein KIF22PRO_0000262921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei407 – 4071PhosphoserineBy similarity
Modified residuei422 – 4221PhosphoserineBy similarity
Modified residuei447 – 4471PhosphoserineBy similarity
Modified residuei540 – 5401PhosphoserineBy similarity
Modified residuei576 – 5761PhosphoserineBy similarity

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ3V300.
PRIDEiQ3V300.

Expressioni

Gene expression databases

BgeeiQ3V300.
CleanExiMM_KIF22.
GenevestigatoriQ3V300.

Interactioni

Subunit structurei

Interacts with FAM83D.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032915.

Structurei

3D structure databases

ProteinModelPortaliQ3V300.
SMRiQ3V300. Positions 35-403, 565-655.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 363326Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili460 – 50546Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00770000120451.
HOGENOMiHOG000007569.
HOVERGENiHBG052252.
InParanoidiQ3V300.
KOiK10403.
OMAiAGQRCGP.
OrthoDBiEOG7Z69BZ.
PhylomeDBiQ3V300.
TreeFamiTF105233.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR026986. KIF22.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR010994. RuvA_2-like.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PTHR24115:SF171. PTHR24115:SF171. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00278. HhH1. 2 hits.
SM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3V300-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLRAKTCPQ RREMASATSG PGRCVSKGGL GRRPPLARVR VAVRLRPFMD
60 70 80 90 100
GETEAKELPC VRAIDSCSLE VANWKKYQET LKYQFDAFYG EKSTQQEVYV
110 120 130 140 150
GSVQPILRHL LEGQNASVLA YGPTGAGKTH TMLGSPEQPG VIPRALMDLL
160 170 180 190 200
QLAREESAEG RPWDVSVAMS YLEIYQEKVL DLLDPASGDL VIREDCRGNI
210 220 230 240 250
LIPGLTQKPI TSFSDFEQHF LPASRNRAVG ATRLNQRSSR SHAVLLVKVD
260 270 280 290 300
QRERLTPFRQ REGKLYLIDL AGSEDNRRTG NQGIRLKESG AINTSLFVLG
310 320 330 340 350
KVVDALNQGL PRIPYRDSKL TRLLQDSLGG SAHSILIANI APERRFYQDT
360 370 380 390 400
ISALNFTARS KEVINRPFTN ESLQPHALAP VKLSQKELLG PSEAKKAKGP
410 420 430 440 450
EEESTGSPES TAAPASASQK LSLLQKLSNM DPAMLENLLS MERLLGSQGS
460 470 480 490 500
QGTPLLNTPK RERMVLMKTV EEKNLEIERL KMKQKELEAK VLAQEAPDPR
510 520 530 540 550
EKENTPTILQ PPASYSGTVA KPLKKAVVMP LQRIQKQRES SNQIQLLKKG
560 570 580 590 600
PKRKLEPSPE SEAVEKDEDY WEVQISPELL AHGRKKLLDL LNEGSARELR
610 620 630 640 650
SLQRIGQKKA QLIVGWRELH GPFSEVEDLE QVEGISGKQV ESFLKANLLS
660
LAASQHSGPS
Length:660
Mass (Da):73,190
Last modified:November 28, 2006 - v2
Checksum:iAA8B99477BC49B3C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601C → R in BAE43356. (PubMed:15489334)Curated
Sequence conflicti267 – 2671L → I in BAE43356. (PubMed:15489334)Curated
Sequence conflicti528 – 5281V → E in BAE43356. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075922 mRNA. Translation: BAE43356.1.
BC003427 mRNA. Translation: AAH03427.1.
AF013119 mRNA. Translation: AAC39968.1.
CCDSiCCDS21855.1.
RefSeqiNP_663563.1. NM_145588.1.
UniGeneiMm.286488.

Genome annotation databases

EnsembliENSMUST00000032915; ENSMUSP00000032915; ENSMUSG00000030677.
GeneIDi110033.
KEGGimmu:110033.
UCSCiuc009jud.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075922 mRNA. Translation: BAE43356.1 .
BC003427 mRNA. Translation: AAH03427.1 .
AF013119 mRNA. Translation: AAC39968.1 .
CCDSi CCDS21855.1.
RefSeqi NP_663563.1. NM_145588.1.
UniGenei Mm.286488.

3D structure databases

ProteinModelPortali Q3V300.
SMRi Q3V300. Positions 35-403, 565-655.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000032915.

Proteomic databases

MaxQBi Q3V300.
PRIDEi Q3V300.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032915 ; ENSMUSP00000032915 ; ENSMUSG00000030677 .
GeneIDi 110033.
KEGGi mmu:110033.
UCSCi uc009jud.1. mouse.

Organism-specific databases

CTDi 3835.
MGIi MGI:109233. Kif22.

Phylogenomic databases

eggNOGi COG5059.
GeneTreei ENSGT00770000120451.
HOGENOMi HOG000007569.
HOVERGENi HBG052252.
InParanoidi Q3V300.
KOi K10403.
OMAi AGQRCGP.
OrthoDBi EOG7Z69BZ.
PhylomeDBi Q3V300.
TreeFami TF105233.

Enzyme and pathway databases

Reactomei REACT_196550. MHC class II antigen presentation.
REACT_199117. Kinesins.

Miscellaneous databases

NextBioi 363193.
PROi Q3V300.
SOURCEi Search...

Gene expression databases

Bgeei Q3V300.
CleanExi MM_KIF22.
Genevestigatori Q3V300.

Family and domain databases

Gene3Di 3.40.850.10. 1 hit.
InterProi IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR026986. KIF22.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR010994. RuvA_2-like.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
PTHR24115:SF171. PTHR24115:SF171. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00278. HhH1. 2 hits.
SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF47781. SSF47781. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "Identification, partial characterization, and genetic mapping of kinesin-like protein genes in mouse."
    Yang Z., Hanlon D.W., Marszalek J.R., Goldstein L.S.
    Genomics 45:123-131(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 127-274.

Entry informationi

Entry nameiKIF22_MOUSE
AccessioniPrimary (citable) accession number: Q3V300
Secondary accession number(s): O35232, Q99LC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: November 26, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3