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Q3V300

- KIF22_MOUSE

UniProt

Q3V300 - KIF22_MOUSE

Protein

Kinesin-like protein KIF22

Gene

Kif22

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi122 – 1298ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. microtubule motor activity Source: InterPro

    GO - Biological processi

    1. DNA repair Source: InterPro
    2. microtubule-based movement Source: InterPro

    Keywords - Molecular functioni

    Motor protein

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_196550. MHC class II antigen presentation.
    REACT_199117. Kinesins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIF22
    Gene namesi
    Name:Kif22
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:109233. Kif22.

    Subcellular locationi

    Nucleus By similarity. Cytoplasmcytoskeleton Curated

    GO - Cellular componenti

    1. chromatin Source: MGI
    2. cytoplasm Source: UniProtKB-KW
    3. focal adhesion Source: Ensembl
    4. kinesin complex Source: InterPro
    5. microtubule Source: UniProtKB-KW
    6. nucleus Source: UniProtKB-SubCell
    7. spindle Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 660660Kinesin-like protein KIF22PRO_0000262921Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei407 – 4071PhosphoserineBy similarity
    Modified residuei422 – 4221PhosphoserineBy similarity
    Modified residuei447 – 4471PhosphoserineBy similarity
    Modified residuei540 – 5401PhosphoserineBy similarity
    Modified residuei576 – 5761PhosphoserineBy similarity

    Post-translational modificationi

    Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ3V300.

    Expressioni

    Gene expression databases

    BgeeiQ3V300.
    CleanExiMM_KIF22.
    GenevestigatoriQ3V300.

    Interactioni

    Subunit structurei

    Interacts with FAM83D.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032915.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3V300.
    SMRiQ3V300. Positions 35-403, 565-655.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 363326Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili460 – 50546Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5059.
    GeneTreeiENSGT00750000117497.
    HOGENOMiHOG000007569.
    HOVERGENiHBG052252.
    InParanoidiQ3V300.
    KOiK10403.
    OMAiAGQRCGP.
    OrthoDBiEOG7Z69BZ.
    PhylomeDBiQ3V300.
    TreeFamiTF105233.

    Family and domain databases

    Gene3Di3.40.850.10. 1 hit.
    InterProiIPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR026986. KIF22.
    IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    IPR010994. RuvA_2-like.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PTHR24115:SF171. PTHR24115:SF171. 1 hit.
    PfamiPF00225. Kinesin. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00278. HhH1. 2 hits.
    SM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47781. SSF47781. 1 hit.
    SSF52540. SSF52540. 2 hits.
    PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3V300-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLRAKTCPQ RREMASATSG PGRCVSKGGL GRRPPLARVR VAVRLRPFMD    50
    GETEAKELPC VRAIDSCSLE VANWKKYQET LKYQFDAFYG EKSTQQEVYV 100
    GSVQPILRHL LEGQNASVLA YGPTGAGKTH TMLGSPEQPG VIPRALMDLL 150
    QLAREESAEG RPWDVSVAMS YLEIYQEKVL DLLDPASGDL VIREDCRGNI 200
    LIPGLTQKPI TSFSDFEQHF LPASRNRAVG ATRLNQRSSR SHAVLLVKVD 250
    QRERLTPFRQ REGKLYLIDL AGSEDNRRTG NQGIRLKESG AINTSLFVLG 300
    KVVDALNQGL PRIPYRDSKL TRLLQDSLGG SAHSILIANI APERRFYQDT 350
    ISALNFTARS KEVINRPFTN ESLQPHALAP VKLSQKELLG PSEAKKAKGP 400
    EEESTGSPES TAAPASASQK LSLLQKLSNM DPAMLENLLS MERLLGSQGS 450
    QGTPLLNTPK RERMVLMKTV EEKNLEIERL KMKQKELEAK VLAQEAPDPR 500
    EKENTPTILQ PPASYSGTVA KPLKKAVVMP LQRIQKQRES SNQIQLLKKG 550
    PKRKLEPSPE SEAVEKDEDY WEVQISPELL AHGRKKLLDL LNEGSARELR 600
    SLQRIGQKKA QLIVGWRELH GPFSEVEDLE QVEGISGKQV ESFLKANLLS 650
    LAASQHSGPS 660
    Length:660
    Mass (Da):73,190
    Last modified:November 28, 2006 - v2
    Checksum:iAA8B99477BC49B3C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti60 – 601C → R in BAE43356. (PubMed:15489334)Curated
    Sequence conflicti267 – 2671L → I in BAE43356. (PubMed:15489334)Curated
    Sequence conflicti528 – 5281V → E in BAE43356. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK075922 mRNA. Translation: BAE43356.1.
    BC003427 mRNA. Translation: AAH03427.1.
    AF013119 mRNA. Translation: AAC39968.1.
    CCDSiCCDS21855.1.
    RefSeqiNP_663563.1. NM_145588.1.
    UniGeneiMm.286488.

    Genome annotation databases

    EnsembliENSMUST00000032915; ENSMUSP00000032915; ENSMUSG00000030677.
    GeneIDi110033.
    KEGGimmu:110033.
    UCSCiuc009jud.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK075922 mRNA. Translation: BAE43356.1 .
    BC003427 mRNA. Translation: AAH03427.1 .
    AF013119 mRNA. Translation: AAC39968.1 .
    CCDSi CCDS21855.1.
    RefSeqi NP_663563.1. NM_145588.1.
    UniGenei Mm.286488.

    3D structure databases

    ProteinModelPortali Q3V300.
    SMRi Q3V300. Positions 35-403, 565-655.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000032915.

    Proteomic databases

    PRIDEi Q3V300.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032915 ; ENSMUSP00000032915 ; ENSMUSG00000030677 .
    GeneIDi 110033.
    KEGGi mmu:110033.
    UCSCi uc009jud.1. mouse.

    Organism-specific databases

    CTDi 3835.
    MGIi MGI:109233. Kif22.

    Phylogenomic databases

    eggNOGi COG5059.
    GeneTreei ENSGT00750000117497.
    HOGENOMi HOG000007569.
    HOVERGENi HBG052252.
    InParanoidi Q3V300.
    KOi K10403.
    OMAi AGQRCGP.
    OrthoDBi EOG7Z69BZ.
    PhylomeDBi Q3V300.
    TreeFami TF105233.

    Enzyme and pathway databases

    Reactomei REACT_196550. MHC class II antigen presentation.
    REACT_199117. Kinesins.

    Miscellaneous databases

    NextBioi 363193.
    PROi Q3V300.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3V300.
    CleanExi MM_KIF22.
    Genevestigatori Q3V300.

    Family and domain databases

    Gene3Di 3.40.850.10. 1 hit.
    InterProi IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR026986. KIF22.
    IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    IPR010994. RuvA_2-like.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    PTHR24115:SF171. PTHR24115:SF171. 1 hit.
    Pfami PF00225. Kinesin. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00278. HhH1. 2 hits.
    SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47781. SSF47781. 1 hit.
    SSF52540. SSF52540. 2 hits.
    PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. "Identification, partial characterization, and genetic mapping of kinesin-like protein genes in mouse."
      Yang Z., Hanlon D.W., Marszalek J.R., Goldstein L.S.
      Genomics 45:123-131(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 127-274.

    Entry informationi

    Entry nameiKIF22_MOUSE
    AccessioniPrimary (citable) accession number: Q3V300
    Secondary accession number(s): O35232, Q99LC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3