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Q3V300 (KIF22_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin-like protein KIF22
Gene names
Name:Kif22
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length660 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA By similarity.

Subunit structure

Interacts with FAM83D By similarity.

Subcellular location

Nucleus By similarity. Cytoplasmcytoskeleton Probable.

Post-translational modification

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation By similarity.

Sequence similarities

Belongs to the kinesin-like protein family.

Contains 1 kinesin-motor domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 660660Kinesin-like protein KIF22
PRO_0000262921

Regions

Domain35 – 294260Kinesin-motor
Nucleotide binding122 – 1298ATP By similarity
Coiled coil460 – 50546 Potential

Amino acid modifications

Modified residue4071Phosphoserine By similarity
Modified residue4221Phosphoserine By similarity
Modified residue4471Phosphoserine By similarity
Modified residue5401Phosphoserine By similarity
Modified residue5761Phosphoserine By similarity

Experimental info

Sequence conflict601C → R in BAE43356. Ref.1
Sequence conflict2671L → I in BAE43356. Ref.1
Sequence conflict5281V → E in BAE43356. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q3V300 [UniParc].

Last modified November 28, 2006. Version 2.
Checksum: AA8B99477BC49B3C

FASTA66073,190
        10         20         30         40         50         60 
MSLRAKTCPQ RREMASATSG PGRCVSKGGL GRRPPLARVR VAVRLRPFMD GETEAKELPC 

        70         80         90        100        110        120 
VRAIDSCSLE VANWKKYQET LKYQFDAFYG EKSTQQEVYV GSVQPILRHL LEGQNASVLA 

       130        140        150        160        170        180 
YGPTGAGKTH TMLGSPEQPG VIPRALMDLL QLAREESAEG RPWDVSVAMS YLEIYQEKVL 

       190        200        210        220        230        240 
DLLDPASGDL VIREDCRGNI LIPGLTQKPI TSFSDFEQHF LPASRNRAVG ATRLNQRSSR 

       250        260        270        280        290        300 
SHAVLLVKVD QRERLTPFRQ REGKLYLIDL AGSEDNRRTG NQGIRLKESG AINTSLFVLG 

       310        320        330        340        350        360 
KVVDALNQGL PRIPYRDSKL TRLLQDSLGG SAHSILIANI APERRFYQDT ISALNFTARS 

       370        380        390        400        410        420 
KEVINRPFTN ESLQPHALAP VKLSQKELLG PSEAKKAKGP EEESTGSPES TAAPASASQK 

       430        440        450        460        470        480 
LSLLQKLSNM DPAMLENLLS MERLLGSQGS QGTPLLNTPK RERMVLMKTV EEKNLEIERL 

       490        500        510        520        530        540 
KMKQKELEAK VLAQEAPDPR EKENTPTILQ PPASYSGTVA KPLKKAVVMP LQRIQKQRES 

       550        560        570        580        590        600 
SNQIQLLKKG PKRKLEPSPE SEAVEKDEDY WEVQISPELL AHGRKKLLDL LNEGSARELR 

       610        620        630        640        650        660 
SLQRIGQKKA QLIVGWRELH GPFSEVEDLE QVEGISGKQV ESFLKANLLS LAASQHSGPS 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
[3]"Identification, partial characterization, and genetic mapping of kinesin-like protein genes in mouse."
Yang Z., Hanlon D.W., Marszalek J.R., Goldstein L.S.
Genomics 45:123-131(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 127-274.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK075922 mRNA. Translation: BAE43356.1.
BC003427 mRNA. Translation: AAH03427.1.
AF013119 mRNA. Translation: AAC39968.1.
RefSeqNP_663563.1. NM_145588.1.
UniGeneMm.286488.

3D structure databases

ProteinModelPortalQ3V300.
SMRQ3V300. Positions 35-403, 565-655.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000032915.

Proteomic databases

PRIDEQ3V300.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032915; ENSMUSP00000032915; ENSMUSG00000030677.
GeneID110033.
KEGGmmu:110033.
UCSCuc009jud.1. mouse.

Organism-specific databases

CTD3835.
MGIMGI:109233. Kif22.

Phylogenomic databases

eggNOGCOG5059.
GeneTreeENSGT00750000117497.
HOGENOMHOG000007569.
HOVERGENHBG052252.
InParanoidQ3V300.
KOK10403.
OMAAGQRCGP.
OrthoDBEOG7Z69BZ.
PhylomeDBQ3V300.
TreeFamTF105233.

Gene expression databases

BgeeQ3V300.
CleanExMM_KIF22.
GenevestigatorQ3V300.

Family and domain databases

Gene3D3.40.850.10. 1 hit.
InterProIPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR026986. KIF22.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR010994. RuvA_2-like.
[Graphical view]
PANTHERPTHR24115. PTHR24115. 1 hit.
PTHR24115:SF171. PTHR24115:SF171. 1 hit.
PfamPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00278. HhH1. 2 hits.
SM00129. KISc. 1 hit.
[Graphical view]
SUPFAMSSF47781. SSF47781. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEPS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio363193.
PROQ3V300.
SOURCESearch...

Entry information

Entry nameKIF22_MOUSE
AccessionPrimary (citable) accession number: Q3V300
Secondary accession number(s): O35232, Q99LC7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: April 16, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot