Q3V300 (KIF22_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF22

Gene names

Name:

Kif22

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	660 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA By similarity.
Subunit structure	Interacts with FAM83D By similarity.
Subcellular location	Nucleus By similarity. Cytoplasm › cytoskeleton Probable.
Post-translational modification	Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation By similarity.
Sequence similarities	Belongs to the kinesin-like protein family. Contains 1 kinesin-motor domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule Nucleus
Domain	Coiled coil
Ligand	ATP-binding DNA-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from electronic annotation. Source: InterPro microtubule-based movement Inferred from electronic annotation. Source: InterPro
Cellular_component	chromatin Inferred from direct assay PubMed 11884614. Source: MGI cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW focal adhesion Inferred from electronic annotation. Source: Compara microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule associated complex Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell spindle Inferred from direct assay PubMed 11884614. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 660	660	Kinesin-like protein KIF22		PRO_0000262921
Regions
	Domain	35 – 294	260	Kinesin-motor
	Nucleotide binding	122 – 129	8	ATP By similarity
	Coiled coil	460 – 505	46	Potential
Amino acid modifications
	Modified residue	407	1	Phosphoserine By similarity
	Modified residue	422	1	Phosphoserine By similarity
	Modified residue	447	1	Phosphoserine By similarity
	Modified residue	540	1	Phosphoserine By similarity
	Modified residue	576	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	60	1	C → R in BAE43356. Ref.1
	Sequence conflict	267	1	L → I in BAE43356. Ref.1
	Sequence conflict	528	1	V → E in BAE43356. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q3V300 [UniParc]. Last modified November 28, 2006. Version 2. Checksum: AA8B99477BC49B3C	FASTA	660	73,190
	10 20 30 40 50 60 MSLRAKTCPQ RREMASATSG PGRCVSKGGL GRRPPLARVR VAVRLRPFMD GETEAKELPC 70 80 90 100 110 120 VRAIDSCSLE VANWKKYQET LKYQFDAFYG EKSTQQEVYV GSVQPILRHL LEGQNASVLA 130 140 150 160 170 180 YGPTGAGKTH TMLGSPEQPG VIPRALMDLL QLAREESAEG RPWDVSVAMS YLEIYQEKVL 190 200 210 220 230 240 DLLDPASGDL VIREDCRGNI LIPGLTQKPI TSFSDFEQHF LPASRNRAVG ATRLNQRSSR 250 260 270 280 290 300 SHAVLLVKVD QRERLTPFRQ REGKLYLIDL AGSEDNRRTG NQGIRLKESG AINTSLFVLG 310 320 330 340 350 360 KVVDALNQGL PRIPYRDSKL TRLLQDSLGG SAHSILIANI APERRFYQDT ISALNFTARS 370 380 390 400 410 420 KEVINRPFTN ESLQPHALAP VKLSQKELLG PSEAKKAKGP EEESTGSPES TAAPASASQK 430 440 450 460 470 480 LSLLQKLSNM DPAMLENLLS MERLLGSQGS QGTPLLNTPK RERMVLMKTV EEKNLEIERL 490 500 510 520 530 540 KMKQKELEAK VLAQEAPDPR EKENTPTILQ PPASYSGTVA KPLKKAVVMP LQRIQKQRES 550 560 570 580 590 600 SNQIQLLKKG PKRKLEPSPE SEAVEKDEDY WEVQISPELL AHGRKKLLDL LNEGSARELR 610 620 630 640 650 660 SLQRIGQKKA QLIVGWRELH GPFSEVEDLE QVEGISGKQV ESFLKANLLS LAASQHSGPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J.
[3]	"Identification, partial characterization, and genetic mapping of kinesin-like protein genes in mouse." Yang Z., Hanlon D.W., Marszalek J.R., Goldstein L.S. Genomics 45:123-131(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 127-274.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK075922 mRNA. Translation: BAE43356.1. BC003427 mRNA. Translation: AAH03427.1. AF013119 mRNA. Translation: AAC39968.1.
IPI	IPI00116757.
RefSeq	NP_663563.1. NM_145588.1.
UniGene	Mm.286488.
3D structure databases
HSSP	HSSP built from PDB template 1II6 based on UniProtKB P52732.
ProteinModelPortal	Q3V300.
SMR	Q3V300. Positions 35-403, 565-655.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000032915.
Proteomic databases
PRIDE	Q3V300.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000032915; ENSMUSP00000032915; ENSMUSG00000030677.
GeneID	110033.
KEGG	mmu:110033.
UCSC	uc009jud.1. mouse.
Organism-specific databases
CTD	3835.
MGI	MGI:109233. Kif22.
Phylogenomic databases
eggNOG	COG5059.
GeneTree	ENSGT00690000101722.
HOGENOM	HOG000007569.
HOVERGEN	HBG052252.
InParanoid	Q3V300.
KO	K10403.
OMA	DCWELQI.
OrthoDB	EOG4548ZH.
Gene expression databases
Bgee	Q3V300.
CleanEx	MM_KIF22.
Genevestigator	Q3V300.
GermOnline	ENSMUSG00000030677. Mus musculus.
Family and domain databases
Gene3D	3.40.850.10. 1 hit.
InterPro	IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif. IPR026986. KIF22. IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. [Graphical view]
PANTHER	PTHR24115:SF171. PTHR24115:SF171. 1 hit.
Pfam	PF00225. Kinesin. 1 hit. [Graphical view]
PRINTS	PR00380. KINESINHEAVY.
SMART	SM00278. HhH1. 2 hits. SM00129. KISc. 1 hit. [Graphical view]
PROSITE	PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	363193.
SOURCE	Search...

Entry information

Entry name

KIF22_MOUSE

Accession

Primary (citable) accession number: Q3V300
Secondary accession number(s): O35232, Q99LC7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	November 28, 2006
Last modified:	May 1, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program