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Q3V2T4

- KTDAP_MOUSE

UniProt

Q3V2T4 - KTDAP_MOUSE

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Protein

Keratinocyte differentiation-associated protein

Gene

Krtdap

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis (By similarity).By similarity

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Keratinocyte differentiation-associated protein
Gene namesi
Name:KrtdapImported
Synonyms:Kdap1 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1928282. Krtdap.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 10280Keratinocyte differentiation-associated proteinSequence AnalysisPRO_0000317056Add
BLAST

Proteomic databases

MaxQBiQ3V2T4.
PaxDbiQ3V2T4.
PRIDEiQ3V2T4.

Expressioni

Tissue specificityi

Expression restricted to suprabasal keratinocytes of the epidermis.1 Publication

Gene expression databases

BgeeiQ3V2T4.
CleanExiMM_KRTDAP.
ExpressionAtlasiQ3V2T4. baseline and differential.
GenevestigatoriQ3V2T4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096159.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG87660.
GeneTreeiENSGT00390000009097.
HOGENOMiHOG000113266.
HOVERGENiHBG108078.
InParanoidiQ3V2T4.
OMAiEEFLNWH.
OrthoDBiEOG7N0C7M.
PhylomeDBiQ3V2T4.
TreeFamiTF341267.

Family and domain databases

InterProiIPR028196. KRTDAP.
[Graphical view]
PfamiPF15200. KRTDAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 13 Publications (identifier: Q3V2T4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIPILPVVA LLSLLALHAV QGAALGHPTI YPEDSSYNNY PTATEGLNNE
60 70 80 90 100
FLNFKRLQSA FQSENFLNWH VITDMFKNAF PFINWDFFPK VKGLRSAAPD

SQ
Length:102
Mass (Da):11,497
Last modified:October 11, 2005 - v1
Checksum:i5EDF30256BA0CD79
GO
Isoform 21 Publication (identifier: Q3V2T4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-102: VKGLRSAAPDSQ → T

Show »
Length:91
Mass (Da):10,388
Checksum:i0D5C2C7F79016E19
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21K → R in BAE20716. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei91 – 10212VKGLR…APDSQ → T in isoform 2. 2 PublicationsVSP_052660Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131603 mRNA. Translation: BAE20713.1.
AK131606 mRNA. Translation: BAE20716.1.
BC132510 mRNA. Translation: AAI32511.1.
BC132512 mRNA. Translation: AAI32513.1.
BC145438 mRNA. Translation: AAI45439.1.
CCDSiCCDS21110.1. [Q3V2T4-1]
RefSeqiNP_001028303.1. NM_001033131.3. [Q3V2T4-1]
UniGeneiMm.268157.

Genome annotation databases

EnsembliENSMUST00000098559; ENSMUSP00000096159; ENSMUSG00000074199. [Q3V2T4-1]
ENSMUST00000190990; ENSMUSP00000139461; ENSMUSG00000074199. [Q3V2T4-2]
GeneIDi64661.
KEGGimmu:64661.
UCSCiuc009ggl.1. mouse. [Q3V2T4-2]
uc009ggm.1. mouse. [Q3V2T4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131603 mRNA. Translation: BAE20713.1 .
AK131606 mRNA. Translation: BAE20716.1 .
BC132510 mRNA. Translation: AAI32511.1 .
BC132512 mRNA. Translation: AAI32513.1 .
BC145438 mRNA. Translation: AAI45439.1 .
CCDSi CCDS21110.1. [Q3V2T4-1 ]
RefSeqi NP_001028303.1. NM_001033131.3. [Q3V2T4-1 ]
UniGenei Mm.268157.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000096159.

Proteomic databases

MaxQBi Q3V2T4.
PaxDbi Q3V2T4.
PRIDEi Q3V2T4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000098559 ; ENSMUSP00000096159 ; ENSMUSG00000074199 . [Q3V2T4-1 ]
ENSMUST00000190990 ; ENSMUSP00000139461 ; ENSMUSG00000074199 . [Q3V2T4-2 ]
GeneIDi 64661.
KEGGi mmu:64661.
UCSCi uc009ggl.1. mouse. [Q3V2T4-2 ]
uc009ggm.1. mouse. [Q3V2T4-1 ]

Organism-specific databases

CTDi 388533.
MGIi MGI:1928282. Krtdap.

Phylogenomic databases

eggNOGi NOG87660.
GeneTreei ENSGT00390000009097.
HOGENOMi HOG000113266.
HOVERGENi HBG108078.
InParanoidi Q3V2T4.
OMAi EEFLNWH.
OrthoDBi EOG7N0C7M.
PhylomeDBi Q3V2T4.
TreeFami TF341267.

Miscellaneous databases

ChiTaRSi Krtdap. mouse.
NextBioi 320159.
PROi Q3V2T4.
SOURCEi Search...

Gene expression databases

Bgeei Q3V2T4.
CleanExi MM_KRTDAP.
ExpressionAtlasi Q3V2T4. baseline and differential.
Genevestigatori Q3V2T4.

Family and domain databases

InterProi IPR028196. KRTDAP.
[Graphical view ]
Pfami PF15200. KRTDAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a conserved cluster of skin-specific genes encoding secreted proteins."
    Moffatt P., Salois P., St Amant N., Gaumond M.-H., Lanctot C.
    Gene 334:123-131(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6JImported.
    Tissue: EmbryoImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: EmbryoImported.

Entry informationi

Entry nameiKTDAP_MOUSE
AccessioniPrimary (citable) accession number: Q3V2T4
Secondary accession number(s): B7ZNU7, Q3V2T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 11, 2005
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3