Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q3V2T4 (KTDAP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratinocyte differentiation-associated protein
Gene names
Name:Krtdap
Synonyms:Kdap
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length102 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis By similarity. UniProtKB P60985 UniProtKB P85411

Subcellular location

Secreted Ref.1.

Tissue specificity

Expression restricted to suprabasal keratinocytes of the epidermis. Ref.1

Ontologies

Keywords
   Biological processDifferentiation
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 Ref.2 Ref.3 (identifier: Q3V2T4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.2 (identifier: Q3V2T4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     91-102: VKGLRSAAPDSQ → T

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 10280Keratinocyte differentiation-associated protein
PRO_0000317056

Natural variations

Alternative sequence91 – 10212VKGLR…APDSQ → T in isoform 2. Ref.2
VSP_052660

Experimental info

Sequence conflict21K → R in BAE20716. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 5EDF30256BA0CD79

FASTA10211,497
        10         20         30         40         50         60 
MKIPILPVVA LLSLLALHAV QGAALGHPTI YPEDSSYNNY PTATEGLNNE FLNFKRLQSA 

        70         80         90        100 
FQSENFLNWH VITDMFKNAF PFINWDFFPK VKGLRSAAPD SQ 

« Hide

Isoform 2 [UniParc].

Checksum: 0D5C2C7F79016E19
Show »

FASTA9110,388

References

« Hide 'large scale' references
[1]"Identification of a conserved cluster of skin-specific genes encoding secreted proteins."
Moffatt P., Salois P., St Amant N., Gaumond M.-H., Lanctot C.
Gene 334:123-131(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Embryo.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK131603 mRNA. Translation: BAE20713.1.
AK131606 mRNA. Translation: BAE20716.1.
BC132510 mRNA. Translation: AAI32511.1.
BC132512 mRNA. Translation: AAI32513.1.
BC145438 mRNA. Translation: AAI45439.1.
RefSeqNP_001028303.1. NM_001033131.3.
UniGeneMm.268157.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000096159.

Proteomic databases

PaxDbQ3V2T4.
PRIDEQ3V2T4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000098559; ENSMUSP00000096159; ENSMUSG00000074199. [Q3V2T4-1]
GeneID64661.
KEGGmmu:64661.
UCSCuc009ggl.1. mouse. [Q3V2T4-2]
uc009ggm.1. mouse. [Q3V2T4-1]

Organism-specific databases

CTD388533.
MGIMGI:1928282. Krtdap.

Phylogenomic databases

eggNOGNOG87660.
GeneTreeENSGT00390000009097.
HOGENOMHOG000113266.
HOVERGENHBG108078.
InParanoidQ3V2T4.
OMAAGPEAFN.
OrthoDBEOG7N0C7M.
PhylomeDBQ3V2T4.
TreeFamTF341267.

Gene expression databases

BgeeQ3V2T4.
CleanExMM_KRTDAP.
GenevestigatorQ3V2T4.

Family and domain databases

InterProIPR028196. KRTDAP.
[Graphical view]
PfamPF15200. KRTDAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio320159.
PROQ3V2T4.
SOURCESearch...

Entry information

Entry nameKTDAP_MOUSE
AccessionPrimary (citable) accession number: Q3V2T4
Secondary accession number(s): B7ZNU7, Q3V2T1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot