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Q3V2T4

- KTDAP_MOUSE

UniProt

Q3V2T4 - KTDAP_MOUSE

Protein

Keratinocyte differentiation-associated protein

Gene

Krtdap

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis By similarity.By similarity

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW

    Keywords - Biological processi

    Differentiation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratinocyte differentiation-associated protein
    Gene namesi
    Name:KrtdapImported
    Synonyms:Kdap1 Publication
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1928282. Krtdap.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 10280Keratinocyte differentiation-associated proteinSequence AnalysisPRO_0000317056Add
    BLAST

    Proteomic databases

    MaxQBiQ3V2T4.
    PaxDbiQ3V2T4.
    PRIDEiQ3V2T4.

    Expressioni

    Tissue specificityi

    Expression restricted to suprabasal keratinocytes of the epidermis.1 Publication

    Gene expression databases

    BgeeiQ3V2T4.
    CleanExiMM_KRTDAP.
    GenevestigatoriQ3V2T4.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000096159.

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG87660.
    GeneTreeiENSGT00390000009097.
    HOGENOMiHOG000113266.
    HOVERGENiHBG108078.
    InParanoidiQ3V2T4.
    OMAiEEFLNWH.
    OrthoDBiEOG7N0C7M.
    PhylomeDBiQ3V2T4.
    TreeFamiTF341267.

    Family and domain databases

    InterProiIPR028196. KRTDAP.
    [Graphical view]
    PfamiPF15200. KRTDAP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 13 Publications (identifier: Q3V2T4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKIPILPVVA LLSLLALHAV QGAALGHPTI YPEDSSYNNY PTATEGLNNE    50
    FLNFKRLQSA FQSENFLNWH VITDMFKNAF PFINWDFFPK VKGLRSAAPD 100
    SQ 102
    Length:102
    Mass (Da):11,497
    Last modified:October 11, 2005 - v1
    Checksum:i5EDF30256BA0CD79
    GO
    Isoform 21 Publication (identifier: Q3V2T4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         91-102: VKGLRSAAPDSQ → T

    Show »
    Length:91
    Mass (Da):10,388
    Checksum:i0D5C2C7F79016E19
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21K → R in BAE20716. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei91 – 10212VKGLR…APDSQ → T in isoform 2. 2 PublicationsVSP_052660Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK131603 mRNA. Translation: BAE20713.1.
    AK131606 mRNA. Translation: BAE20716.1.
    BC132510 mRNA. Translation: AAI32511.1.
    BC132512 mRNA. Translation: AAI32513.1.
    BC145438 mRNA. Translation: AAI45439.1.
    CCDSiCCDS21110.1. [Q3V2T4-1]
    RefSeqiNP_001028303.1. NM_001033131.3. [Q3V2T4-1]
    UniGeneiMm.268157.

    Genome annotation databases

    EnsembliENSMUST00000098559; ENSMUSP00000096159; ENSMUSG00000074199. [Q3V2T4-1]
    GeneIDi64661.
    KEGGimmu:64661.
    UCSCiuc009ggl.1. mouse. [Q3V2T4-2]
    uc009ggm.1. mouse. [Q3V2T4-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK131603 mRNA. Translation: BAE20713.1 .
    AK131606 mRNA. Translation: BAE20716.1 .
    BC132510 mRNA. Translation: AAI32511.1 .
    BC132512 mRNA. Translation: AAI32513.1 .
    BC145438 mRNA. Translation: AAI45439.1 .
    CCDSi CCDS21110.1. [Q3V2T4-1 ]
    RefSeqi NP_001028303.1. NM_001033131.3. [Q3V2T4-1 ]
    UniGenei Mm.268157.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000096159.

    Proteomic databases

    MaxQBi Q3V2T4.
    PaxDbi Q3V2T4.
    PRIDEi Q3V2T4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000098559 ; ENSMUSP00000096159 ; ENSMUSG00000074199 . [Q3V2T4-1 ]
    GeneIDi 64661.
    KEGGi mmu:64661.
    UCSCi uc009ggl.1. mouse. [Q3V2T4-2 ]
    uc009ggm.1. mouse. [Q3V2T4-1 ]

    Organism-specific databases

    CTDi 388533.
    MGIi MGI:1928282. Krtdap.

    Phylogenomic databases

    eggNOGi NOG87660.
    GeneTreei ENSGT00390000009097.
    HOGENOMi HOG000113266.
    HOVERGENi HBG108078.
    InParanoidi Q3V2T4.
    OMAi EEFLNWH.
    OrthoDBi EOG7N0C7M.
    PhylomeDBi Q3V2T4.
    TreeFami TF341267.

    Miscellaneous databases

    NextBioi 320159.
    PROi Q3V2T4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3V2T4.
    CleanExi MM_KRTDAP.
    Genevestigatori Q3V2T4.

    Family and domain databases

    InterProi IPR028196. KRTDAP.
    [Graphical view ]
    Pfami PF15200. KRTDAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a conserved cluster of skin-specific genes encoding secreted proteins."
      Moffatt P., Salois P., St Amant N., Gaumond M.-H., Lanctot C.
      Gene 334:123-131(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6JImported.
      Tissue: EmbryoImported.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: EmbryoImported.

    Entry informationi

    Entry nameiKTDAP_MOUSE
    AccessioniPrimary (citable) accession number: Q3V2T4
    Secondary accession number(s): B7ZNU7, Q3V2T1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3