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Protein
Submitted name:

Putative uncharacterized protein

Gene

Clu

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. misfolded protein binding Source: MGI
  2. ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  1. cell morphogenesis Source: MGI
  2. central nervous system myelin maintenance Source: MGI
  3. chaperone-mediated protein complex assembly Source: MGI
  4. chaperone-mediated protein folding Source: MGI
  5. intrinsic apoptotic signaling pathway Source: MGI
  6. microglial cell activation Source: MGI
  7. microglial cell proliferation Source: MGI
  8. negative regulation of beta-amyloid formation Source: MGI
  9. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  10. negative regulation of protein homooligomerization Source: MGI
  11. positive regulation of apoptotic process Source: MGI
  12. positive regulation of intrinsic apoptotic signaling pathway Source: MGI
  13. positive regulation of neurofibrillary tangle assembly Source: MGI
  14. positive regulation of neuron death Source: MGI
  15. positive regulation of NF-kappaB transcription factor activity Source: MGI
  16. positive regulation of nitric oxide biosynthetic process Source: MGI
  17. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
  18. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: MGI
  19. positive regulation of tau-protein kinase activity Source: MGI
  20. positive regulation of tumor necrosis factor production Source: MGI
  21. protein import Source: MGI
  22. protein stabilization Source: MGI
  23. regulation of beta-amyloid clearance Source: MGI
  24. regulation of neuronal signal transduction Source: MGI
  25. regulation of neuron death Source: MGI
  26. response to misfolded protein Source: MGI
  27. response to virus Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:CluImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88423. Clu.

Subcellular locationi

GO - Cellular componenti

  1. apical dendrite Source: MGI
  2. blood microparticle Source: MGI
  3. cytoplasm Source: MGI
  4. extracellular matrix Source: MGI
  5. extracellular space Source: MGI
  6. extracellular vesicular exosome Source: MGI
  7. mitochondrion Source: MGI
  8. neurofibrillary tangle Source: MGI
  9. perinuclear region of cytoplasm Source: MGI
  10. spherical high-density lipoprotein particle Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ3V245.
ExpressionAtlasiQ3V245. baseline and differential.
GenevestigatoriQ3V245.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022616.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000111799.

Family and domain databases

InterProiIPR016016. Clusterin.
IPR000753. Clusterin-like.
[Graphical view]
PANTHERiPTHR10970:SF1. PTHR10970:SF1. 1 hit.
PfamiPF01093. Clusterin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3V245-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILLLCVAL LLIWDNGMVL GEQEVSDNEL QELSTQGSRY INKEIQNAVQ
60 70
GVKHIKTLIE KTNAERKSLL NSLEEA
Length:76
Mass (Da):8,566
Last modified:October 10, 2005 - v1
Checksum:iC719C9DB39D82A99
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei76 – 761Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132030 mRNA. Translation: BAE20954.1.
UniGeneiMm.200608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132030 mRNA. Translation: BAE20954.1.
UniGeneiMm.200608.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022616.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:88423. Clu.

Phylogenomic databases

HOGENOMiHOG000111799.

Miscellaneous databases

ChiTaRSiClu. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ3V245.
ExpressionAtlasiQ3V245. baseline and differential.
GenevestigatoriQ3V245.

Family and domain databases

InterProiIPR016016. Clusterin.
IPR000753. Clusterin-like.
[Graphical view]
PANTHERiPTHR10970:SF1. PTHR10970:SF1. 1 hit.
PfamiPF01093. Clusterin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HippocampusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HippocampusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HippocampusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2000)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HippocampusImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HippocampusImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HippocampusImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HippocampusImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HippocampusImported.

Entry informationi

Entry nameiQ3V245_MOUSE
AccessioniPrimary (citable) accession number: Q3V245
Entry historyi
Integrated into UniProtKB/TrEMBL: October 10, 2005
Last sequence update: October 10, 2005
Last modified: February 3, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.