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Protein
Submitted name:

Adenylate cyclase type 2

Gene

Adcy2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Ligandi

Nucleotide-bindingSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-163615. PKA activation.
R-MMU-164378. PKA activation in glucagon signalling.
R-MMU-170660. Adenylate cyclase activating pathway.
R-MMU-170670. Adenylate cyclase inhibitory pathway.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-418597. G alpha (z) signalling events.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-5610787. Hedgehog 'off' state.

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylate cyclase type 2Imported
Gene namesi
Name:Adcy2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:99676. Adcy2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei50 – 7425HelicalSequence analysisAdd
BLAST
Transmembranei80 – 10223HelicalSequence analysisAdd
BLAST
Transmembranei109 – 12921HelicalSequence analysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence analysisAdd
BLAST
Transmembranei162 – 18019HelicalSequence analysisAdd
BLAST
Transmembranei192 – 21120HelicalSequence analysisAdd
BLAST
Transmembranei604 – 62522HelicalSequence analysisAdd
BLAST
Transmembranei631 – 65626HelicalSequence analysisAdd
BLAST
Transmembranei684 – 70522HelicalSequence analysisAdd
BLAST
Transmembranei743 – 76119HelicalSequence analysisAdd
BLAST
Transmembranei768 – 78619HelicalSequence analysisAdd
BLAST
Transmembranei806 – 82419HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiQ3V1Q3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022013.

Structurei

3D structure databases

SMRiQ3V1Q3. Positions 282-468, 882-1063.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini294 – 421128Guanylate cyclaseInterPro annotationAdd
BLAST
Domaini891 – 1036146Guanylate cyclaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3619. Eukaryota.
COG2114. LUCA.
GeneTreeiENSGT00760000119042.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
KOiK08042.
OMAiQEHSQEP.
OrthoDBiEOG76X5ZC.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR032628. AC_N.
IPR030672. Adcy.
IPR009398. Adcy_conserved_dom.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF16214. AC_N. 1 hit.
PF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
PIRSFiPIRSF039050. Ade_cyc. 1 hit.
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3V1Q3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWQEAMRRRR YLRDRAEAAA AAAAGGGEGL QRSRDWLYES YYCMSQQHPL
60 70 80 90 100
IVFLLLIVMG ACLALLAVFF ALGLEVEDHV AFLITVPTAL AIFFAIFILV
110 120 130 140 150
CIESVFKKLL RVFSLVIWIC LVAMGYLFMC FGGTVSAWDQ VSFFLFIIFV
160 170 180 190 200
VYTMLPFNMR DAIIASVLTS SSHTIVLSVY LSATPGAKEH LFWQILANVI
210 220 230 240 250
IFICGNLAGA YHKHLMELAL QQTYRDTCNC IKSRIKLEFE KRQQERLLLS
260 270 280 290 300
LLPAHIAMEM KAEIIQRLQG PKAGQMENTN NFHNLYVKRH TNVSILYADI
310 320 330 340 350
VGFTRLASDC SPGELVHMLN ELFGKFDQIA KENECMRIKI LGDCYYCVSG
360 370 380 390 400
LPISLPNHAK NCVKMGLDMC EAIKKVRDAT GVDINMRVGV HSGNVLCGVI
410 420 430 440 450
GLQKWQYDVW SHDVTLANHM EAGGVPGRVH ISSVTLEHLN GAYKVEEGDG
460 470 480 490 500
EIRDPYLKQH LVKTYFVINP KGERRSPQHL FRPRHTLDGA KMRASVRMTR
510 520 530 540 550
YLESWGAAKP FAHLHHRDSM TTENGKISTT DVPMGQHNFQ NRTLRTKSQK
560 570 580 590 600
KRFEEELNER MIQAIDGINA QKQWLKSEDI QRISLFFYNK NIEKEYRATA
610 620 630 640 650
LPAFKYYVTC ACLIFLCIFI VQILVLPKTS ILGFSFGAAF LSLIFILFVC
660 670 680 690 700
FAGQLLQCSK KASASLLWLL KSSGIIANRP WPRISLTIVT TAIILTMAVF
710 720 730 740 750
NMFFLSNSEE TTLPTANASN ANVSVPDNQT AILHARNLFF LPYFIYSCIL
760 770 780 790 800
GLISCSVFLR VNYELKMLIM MVALVGYNII LLHTHAHVLD AYSQVLFQRP
810 820 830 840 850
GIWKDLKTMG SVSLSIFFIT LLVLGRQSEY YCRLDFLWKN KFKKEREEIE
860 870 880 890 900
TMENLNRVLL ENVLPAHVAE HFLARSLKNE ELYHQSYDCV CVMFASIPDF
910 920 930 940 950
KEFYTESDVN KEGLECLRLL NEIIADFDDL LSKPKFSGVE KIKTIGSTYM
960 970 980 990 1000
AATGLSAVPS QEHAQEPERQ YMHIGTMVEF AYALVGKLDA INKHSFNDFK
1010 1020 1030 1040 1050
LRVGINHGPV IAGVIGAQKP QYDIWGNTVN VASRMDSTGV LDKIQVTEET
1060 1070 1080 1090
SLILQTLGYT CTCRGIINVK GKGDLKTYFV NTEMSRSLSQ SNLAS
Length:1,095
Mass (Da):123,916
Last modified:October 11, 2005 - v1
Checksum:iA900EE479D3CC7DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154389 Genomic DNA. No translation available.
AC154482 Genomic DNA. No translation available.
AC239879 Genomic DNA. No translation available.
CT033781 Genomic DNA. No translation available.
AK132312 mRNA. Translation: BAE21097.1.
RefSeqiNP_705762.2. NM_153534.2.
UniGeneiMm.390617.

Genome annotation databases

EnsembliENSMUST00000022013; ENSMUSP00000022013; ENSMUSG00000021536.
GeneIDi210044.
KEGGimmu:210044.
UCSCiuc007rcf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154389 Genomic DNA. No translation available.
AC154482 Genomic DNA. No translation available.
AC239879 Genomic DNA. No translation available.
CT033781 Genomic DNA. No translation available.
AK132312 mRNA. Translation: BAE21097.1.
RefSeqiNP_705762.2. NM_153534.2.
UniGeneiMm.390617.

3D structure databases

SMRiQ3V1Q3. Positions 282-468, 882-1063.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022013.

Proteomic databases

MaxQBiQ3V1Q3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022013; ENSMUSP00000022013; ENSMUSG00000021536.
GeneIDi210044.
KEGGimmu:210044.
UCSCiuc007rcf.1. mouse.

Organism-specific databases

CTDi108.
MGIiMGI:99676. Adcy2.

Phylogenomic databases

eggNOGiKOG3619. Eukaryota.
COG2114. LUCA.
GeneTreeiENSGT00760000119042.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
KOiK08042.
OMAiQEHSQEP.
OrthoDBiEOG76X5ZC.
TreeFamiTF313845.

Enzyme and pathway databases

ReactomeiR-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-163615. PKA activation.
R-MMU-164378. PKA activation in glucagon signalling.
R-MMU-170660. Adenylate cyclase activating pathway.
R-MMU-170670. Adenylate cyclase inhibitory pathway.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-418597. G alpha (z) signalling events.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-5610787. Hedgehog 'off' state.

Miscellaneous databases

NextBioi372842.
SOURCEiSearch...

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR032628. AC_N.
IPR030672. Adcy.
IPR009398. Adcy_conserved_dom.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF16214. AC_N. 1 hit.
PF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
PIRSFiPIRSF039050. Ade_cyc. 1 hit.
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3V1Q3_MOUSE
AccessioniPrimary (citable) accession number: Q3V1Q3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 13, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.