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Q3V1Q3 (Q3V1Q3_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Adcy2 Ensembl ENSMUSP00000022013 MGI 99676
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1095 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS018297
   LigandNucleotide-binding SAAS SAAS018297
   Molecular functionLyase SAAS SAAS018297 RuleBase RU000405
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of adenylate cyclase activity

Traceable author statement PubMed 7766992. Source: MGI

adenylate cyclase-modulating G-protein coupled receptor signaling pathway

Traceable author statement PubMed 9870949. Source: MGI

cAMP biosynthetic process

Traceable author statement PubMed 7766992. Source: MGI

intracellular signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

dendrite

Inferred from direct assay PubMed 9870949. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from direct assay PubMed 9870949. Source: MGI

membrane raft

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement PubMed 7766992. Source: MGI

protein complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionadenylate cyclase activity

Traceable author statement PubMed 7766992. Source: MGI

calcium- and calmodulin-responsive adenylate cyclase activity

Inferred from electronic annotation. Source: Ensembl

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q3V1Q3 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: A900EE479D3CC7DB

FASTA1,095123,916
        10         20         30         40         50         60 
MWQEAMRRRR YLRDRAEAAA AAAAGGGEGL QRSRDWLYES YYCMSQQHPL IVFLLLIVMG 

        70         80         90        100        110        120 
ACLALLAVFF ALGLEVEDHV AFLITVPTAL AIFFAIFILV CIESVFKKLL RVFSLVIWIC 

       130        140        150        160        170        180 
LVAMGYLFMC FGGTVSAWDQ VSFFLFIIFV VYTMLPFNMR DAIIASVLTS SSHTIVLSVY 

       190        200        210        220        230        240 
LSATPGAKEH LFWQILANVI IFICGNLAGA YHKHLMELAL QQTYRDTCNC IKSRIKLEFE 

       250        260        270        280        290        300 
KRQQERLLLS LLPAHIAMEM KAEIIQRLQG PKAGQMENTN NFHNLYVKRH TNVSILYADI 

       310        320        330        340        350        360 
VGFTRLASDC SPGELVHMLN ELFGKFDQIA KENECMRIKI LGDCYYCVSG LPISLPNHAK 

       370        380        390        400        410        420 
NCVKMGLDMC EAIKKVRDAT GVDINMRVGV HSGNVLCGVI GLQKWQYDVW SHDVTLANHM 

       430        440        450        460        470        480 
EAGGVPGRVH ISSVTLEHLN GAYKVEEGDG EIRDPYLKQH LVKTYFVINP KGERRSPQHL 

       490        500        510        520        530        540 
FRPRHTLDGA KMRASVRMTR YLESWGAAKP FAHLHHRDSM TTENGKISTT DVPMGQHNFQ 

       550        560        570        580        590        600 
NRTLRTKSQK KRFEEELNER MIQAIDGINA QKQWLKSEDI QRISLFFYNK NIEKEYRATA 

       610        620        630        640        650        660 
LPAFKYYVTC ACLIFLCIFI VQILVLPKTS ILGFSFGAAF LSLIFILFVC FAGQLLQCSK 

       670        680        690        700        710        720 
KASASLLWLL KSSGIIANRP WPRISLTIVT TAIILTMAVF NMFFLSNSEE TTLPTANASN 

       730        740        750        760        770        780 
ANVSVPDNQT AILHARNLFF LPYFIYSCIL GLISCSVFLR VNYELKMLIM MVALVGYNII 

       790        800        810        820        830        840 
LLHTHAHVLD AYSQVLFQRP GIWKDLKTMG SVSLSIFFIT LLVLGRQSEY YCRLDFLWKN 

       850        860        870        880        890        900 
KFKKEREEIE TMENLNRVLL ENVLPAHVAE HFLARSLKNE ELYHQSYDCV CVMFASIPDF 

       910        920        930        940        950        960 
KEFYTESDVN KEGLECLRLL NEIIADFDDL LSKPKFSGVE KIKTIGSTYM AATGLSAVPS 

       970        980        990       1000       1010       1020 
QEHAQEPERQ YMHIGTMVEF AYALVGKLDA INKHSFNDFK LRVGINHGPV IAGVIGAQKP 

      1030       1040       1050       1060       1070       1080 
QYDIWGNTVN VASRMDSTGV LDKIQVTEET SLILQTLGYT CTCRGIINVK GKGDLKTYFV 

      1090 
NTEMSRSLSQ SNLAS 

« Hide

References

« Hide 'large scale' references
[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE21097.1.
Tissue: Head EMBL BAE21097.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE21097.1.
Tissue: Head EMBL BAE21097.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE21097.1.
Tissue: Head EMBL BAE21097.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE21097.1.
Tissue: Head EMBL BAE21097.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE21097.1.
Tissue: Head EMBL BAE21097.1.
[6]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE21097.1.
Tissue: Head EMBL BAE21097.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE21097.1.
Tissue: Head EMBL BAE21097.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE21097.1.
Tissue: Head EMBL BAE21097.1.
[9]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000022013.
[10]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000022013.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC154389 Genomic DNA. No translation available.
AC154482 Genomic DNA. No translation available.
AC239879 Genomic DNA. No translation available.
CT033781 Genomic DNA. No translation available.
AK132312 mRNA. Translation: BAE21097.1.
RefSeqNP_705762.2. NM_153534.2.
UniGeneMm.390617.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000022013.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022013; ENSMUSP00000022013; ENSMUSG00000021536.
GeneID210044.
KEGGmmu:210044.
UCSCuc007rcf.1. mouse.

Organism-specific databases

CTD108.
MGIMGI:99676. Adcy2.

Phylogenomic databases

GeneTreeENSGT00750000117304.
HOGENOMHOG000006941.
HOVERGENHBG050458.
InParanoidQ3V1Q3.
KOK08042.
OMAFLPYFIY.
OrthoDBEOG76X5ZC.
TreeFamTF313845.

Gene expression databases

GenevestigatorQ3V1Q3.

Family and domain databases

Gene3D3.30.70.1230. 2 hits.
InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
[Graphical view]
PfamPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMSSF55073. SSF55073. 2 hits.
PROSITEPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio372842.
SOURCESearch...

Entry information

Entry nameQ3V1Q3_MOUSE
AccessionPrimary (citable) accession number: Q3V1Q3
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)