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Protein
Submitted name:

Adenylate cyclase type 2

Gene

Adcy2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium- and calmodulin-responsive adenylate cyclase activity Source: Ensembl
  2. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: Ensembl
  2. intracellular signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Ligandi

Nucleotide-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylate cyclase type 2Imported
Gene namesi
Name:Adcy2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:99676. Adcy2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane raft Source: Ensembl
  4. plasma membrane Source: Ensembl
  5. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

GenevestigatoriQ3V1Q3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022013.

Family & Domainsi

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119042.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
KOiK08042.
OMAiQEHSQEP.
OrthoDBiEOG76X5ZC.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR030672. Adcy.
IPR009398. Adcy_conserved_dom.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
PIRSFiPIRSF039050. Ade_cyc. 1 hit.
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3V1Q3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWQEAMRRRR YLRDRAEAAA AAAAGGGEGL QRSRDWLYES YYCMSQQHPL
60 70 80 90 100
IVFLLLIVMG ACLALLAVFF ALGLEVEDHV AFLITVPTAL AIFFAIFILV
110 120 130 140 150
CIESVFKKLL RVFSLVIWIC LVAMGYLFMC FGGTVSAWDQ VSFFLFIIFV
160 170 180 190 200
VYTMLPFNMR DAIIASVLTS SSHTIVLSVY LSATPGAKEH LFWQILANVI
210 220 230 240 250
IFICGNLAGA YHKHLMELAL QQTYRDTCNC IKSRIKLEFE KRQQERLLLS
260 270 280 290 300
LLPAHIAMEM KAEIIQRLQG PKAGQMENTN NFHNLYVKRH TNVSILYADI
310 320 330 340 350
VGFTRLASDC SPGELVHMLN ELFGKFDQIA KENECMRIKI LGDCYYCVSG
360 370 380 390 400
LPISLPNHAK NCVKMGLDMC EAIKKVRDAT GVDINMRVGV HSGNVLCGVI
410 420 430 440 450
GLQKWQYDVW SHDVTLANHM EAGGVPGRVH ISSVTLEHLN GAYKVEEGDG
460 470 480 490 500
EIRDPYLKQH LVKTYFVINP KGERRSPQHL FRPRHTLDGA KMRASVRMTR
510 520 530 540 550
YLESWGAAKP FAHLHHRDSM TTENGKISTT DVPMGQHNFQ NRTLRTKSQK
560 570 580 590 600
KRFEEELNER MIQAIDGINA QKQWLKSEDI QRISLFFYNK NIEKEYRATA
610 620 630 640 650
LPAFKYYVTC ACLIFLCIFI VQILVLPKTS ILGFSFGAAF LSLIFILFVC
660 670 680 690 700
FAGQLLQCSK KASASLLWLL KSSGIIANRP WPRISLTIVT TAIILTMAVF
710 720 730 740 750
NMFFLSNSEE TTLPTANASN ANVSVPDNQT AILHARNLFF LPYFIYSCIL
760 770 780 790 800
GLISCSVFLR VNYELKMLIM MVALVGYNII LLHTHAHVLD AYSQVLFQRP
810 820 830 840 850
GIWKDLKTMG SVSLSIFFIT LLVLGRQSEY YCRLDFLWKN KFKKEREEIE
860 870 880 890 900
TMENLNRVLL ENVLPAHVAE HFLARSLKNE ELYHQSYDCV CVMFASIPDF
910 920 930 940 950
KEFYTESDVN KEGLECLRLL NEIIADFDDL LSKPKFSGVE KIKTIGSTYM
960 970 980 990 1000
AATGLSAVPS QEHAQEPERQ YMHIGTMVEF AYALVGKLDA INKHSFNDFK
1010 1020 1030 1040 1050
LRVGINHGPV IAGVIGAQKP QYDIWGNTVN VASRMDSTGV LDKIQVTEET
1060 1070 1080 1090
SLILQTLGYT CTCRGIINVK GKGDLKTYFV NTEMSRSLSQ SNLAS
Length:1,095
Mass (Da):123,916
Last modified:October 11, 2005 - v1
Checksum:iA900EE479D3CC7DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154389 Genomic DNA. No translation available.
AC154482 Genomic DNA. No translation available.
AC239879 Genomic DNA. No translation available.
CT033781 Genomic DNA. No translation available.
AK132312 mRNA. Translation: BAE21097.1.
RefSeqiNP_705762.2. NM_153534.2.
UniGeneiMm.390617.

Genome annotation databases

EnsembliENSMUST00000022013; ENSMUSP00000022013; ENSMUSG00000021536.
GeneIDi210044.
KEGGimmu:210044.
UCSCiuc007rcf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154389 Genomic DNA. No translation available.
AC154482 Genomic DNA. No translation available.
AC239879 Genomic DNA. No translation available.
CT033781 Genomic DNA. No translation available.
AK132312 mRNA. Translation: BAE21097.1.
RefSeqiNP_705762.2. NM_153534.2.
UniGeneiMm.390617.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022013.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022013; ENSMUSP00000022013; ENSMUSG00000021536.
GeneIDi210044.
KEGGimmu:210044.
UCSCiuc007rcf.1. mouse.

Organism-specific databases

CTDi108.
MGIiMGI:99676. Adcy2.

Phylogenomic databases

GeneTreeiENSGT00760000119042.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
KOiK08042.
OMAiQEHSQEP.
OrthoDBiEOG76X5ZC.
TreeFamiTF313845.

Miscellaneous databases

NextBioi372842.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ3V1Q3.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR030672. Adcy.
IPR009398. Adcy_conserved_dom.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
PIRSFiPIRSF039050. Ade_cyc. 1 hit.
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3V1Q3_MOUSE
AccessioniPrimary (citable) accession number: Q3V1Q3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 29, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.