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Protein

Immunoglobulin superfamily member 10

Gene

Igsf10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the maintenance of osteochondroprogenitor cells pool.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 10
Short name:
IgSF10
Gene namesi
Name:Igsf10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1923481. Igsf10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000028681826 – 2594Immunoglobulin superfamily member 10Add BLAST2569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi439N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi497 ↔ 551PROSITE-ProRule annotation
Disulfide bondi595 ↔ 645PROSITE-ProRule annotation
Glycosylationi627N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1044N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1641 ↔ 1694PROSITE-ProRule annotation
Glycosylationi1676N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1738 ↔ 1791PROSITE-ProRule annotation
Glycosylationi1780N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1835 ↔ 1888PROSITE-ProRule annotation
Glycosylationi1870N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1933N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1934 ↔ 1987PROSITE-ProRule annotation
Disulfide bondi2031 ↔ 2090PROSITE-ProRule annotation
Glycosylationi2072N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2134 ↔ 2184PROSITE-ProRule annotation
Disulfide bondi2232 ↔ 2284PROSITE-ProRule annotation
Disulfide bondi2330 ↔ 2382PROSITE-ProRule annotation
Glycosylationi2364N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2425 ↔ 2477PROSITE-ProRule annotation
Disulfide bondi2521 ↔ 2576PROSITE-ProRule annotation
Modified residuei2574PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ3V1M1.
PaxDbiQ3V1M1.
PeptideAtlasiQ3V1M1.
PRIDEiQ3V1M1.

PTM databases

iPTMnetiQ3V1M1.
PhosphoSitePlusiQ3V1M1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036334.
CleanExiMM_IGSF10.
ExpressionAtlasiQ3V1M1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037246.

Structurei

3D structure databases

ProteinModelPortaliQ3V1M1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 56LRRNTAdd BLAST28
Repeati58 – 79LRR 1Add BLAST22
Repeati82 – 103LRR 2Add BLAST22
Repeati106 – 127LRR 3Add BLAST22
Repeati130 – 151LRR 4Add BLAST22
Repeati154 – 175LRR 5Add BLAST22
Repeati186 – 207LRR 6Add BLAST22
Domaini219 – 281LRRCTAdd BLAST63
Domaini461 – 567Ig-like C2-type 1Add BLAST107
Domaini571 – 661Ig-like C2-type 2Add BLAST91
Domaini1619 – 1710Ig-like C2-type 3Add BLAST92
Repeati1658 – 1681LRR 11Add BLAST24
Domaini1715 – 1807Ig-like C2-type 4Add BLAST93
Domaini1812 – 1901Ig-like C2-type 5Add BLAST90
Domaini1912 – 2005Ig-like C2-type 6Add BLAST94
Domaini2008 – 2106Ig-like C2-type 7Add BLAST99
Domaini2112 – 2200Ig-like C2-type 8Add BLAST89
Domaini2205 – 2302Ig-like C2-type 9Add BLAST98
Domaini2308 – 2398Ig-like C2-type 10Add BLAST91
Domaini2403 – 2493Ig-like C2-type 11Add BLAST91
Domaini2499 – 2592Ig-like C2-type 12Add BLAST94

Sequence similaritiesi

Contains 6 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
ENOG410YEVU. LUCA.
GeneTreeiENSGT00860000133679.
HOVERGENiHBG107995.
InParanoidiQ3V1M1.
OMAiWILANQT.
OrthoDBiEOG091G008G.
PhylomeDBiQ3V1M1.
TreeFamiTF326318.

Family and domain databases

Gene3Di2.60.40.10. 12 hits.
3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 7 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 12 hits.
SM00408. IGc2. 12 hits.
SM00406. IGv. 6 hits.
SM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 12 hits.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 12 hits.
PS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3V1M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKRGREVSC LLISLTAICL VVTPGSRVCP RRCACYVPTE VHCTFRYLTS
60 70 80 90 100
IPDGIPANVE RVNLGYNSLT RLTENDFSGL SRLELLMLHS NGIHRVSDKT
110 120 130 140 150
FSGLQSLQVL KMSYNKVQII EKDTLYGLRS LTRLHLDHNN IEFINPEAFY
160 170 180 190 200
GLTLLRLVHL EGNRLTKLHP DTFVSLSYLQ IFKTSFIKYL YLSDNFLTSL
210 220 230 240 250
PKEMVSSMPN LESLYLHGNP WTCDCHLKWL SEWMQGNPDI IKCKKERIPS
260 270 280 290 300
SPQQCPLCMN PRISKGRSIA MVPSGSFLCT KPTIDPSLKS KSLGIQEDNG
310 320 330 340 350
SASVSPQDFI EPFGSLSLNM TDLSGNKANV ICSIQKPSRT LPIAFTEEND
360 370 380 390 400
YIMLNMSFST NLVCSVNYNH IQPVWQLLAL YSDSPLILER KPQHTETPLL
410 420 430 440 450
SPKYQQVALR PEDTFTNIEA DFKADPFWFQ QEKISLQLNR TATTLSTLQI
460 470 480 490 500
QFSTDAQITL PKAEMRPVKR KWTMILMMNN TRLEHTVLVG GTIALDCPGK
510 520 530 540 550
GDPSPHLEWV LADGSKVRAP YVSEDGRILI DKKGKLELQM ADTFDAGLYH
560 570 580 590 600
CISTNDADAD ILTYRITVVE PYVENKHENG ALHTVIMGEI LDLPCLSTGI
610 620 630 640 650
PDASISWILP RNTVFSQSSR DMQILNNGTL RILQATPKDQ GHYRCVAANP
660 670 680 690 700
SGADFSSFQV SVQMKGQRTI EHDRDIDGSG LEEPKPSVLL KQPPSLKLPA
710 720 730 740 750
SSLTGTEAGK QVSGIHKKNK HRDLTHRRRG DSTLRRFREH RRQLPLSARR
760 770 780 790 800
IDPQHWAALL EKAKKNSVLR KQENTTVKPT PLAIPLVELA GEEKDASGLT
810 820 830 840 850
PPDEEFTVLK TKAFGVPERS PTADSRPVNH GFVTSSASGT EVSSTVNPQT
860 870 880 890 900
LLPTHLPDFK LFNVVDSAAV SKSMNRPVTS KIEDTTHQNP IIIFPSVAEI
910 920 930 940 950
QDSAQVGRTS SQSAHPATGG AMATYGYTTM LSSFTNKANT VLQSANPTES
960 970 980 990 1000
YGPQIPLTEV SRVSSNNSLA HTTKDPGFSK RPSDSHTTAP SLFQTPRNNS
1010 1020 1030 1040 1050
TGNVGRERTI WSRGRAISPY RTPVLRRHRH RIVRPALKGP ANRNISQVSA
1060 1070 1080 1090 1100
TEPPGMCRTC SSTERLTMAT AALSVTGSSH TTLPKANNVG IISEESTTVV
1110 1120 1130 1140 1150
KKPSLLLKNK QDVDIETITT TINYFRSEST HMTPTEASMI SAPTSISLGK
1160 1170 1180 1190 1200
TPIDTSGHLS MPRTIQAGTD LVVTPPLSSP LSQPSIPTKA TSTKLSRRKI
1210 1220 1230 1240 1250
PWHPIFANNH NKEGMLKNLH QFGLQKNTAT KPPEKAPLLP TDHGSSSPST
1260 1270 1280 1290 1300
TLLASLTPAQ SATMAATRRN GTEVQGARSL SAGKEQPFIN SFLVLPSTTR
1310 1320 1330 1340 1350
KRSSTLSFLS VETPTVTTPP VIASAIISET QEVRSKKAKD QTKGSLKNRK
1360 1370 1380 1390 1400
GPTITPRQIS GYSTYSVPTT TDTPLAFSHS PGKVTGRTVS TAAPHSAASL
1410 1420 1430 1440 1450
LGITELPQKC THTSGNITAS ETTLLSKSQE STAMKRASAT PPLLSSGAPR
1460 1470 1480 1490 1500
MPTPSPPPFT KVVVTDSEVP AVFKMMSNRM VTIYESSRHD IDLQQPSAEA
1510 1520 1530 1540 1550
SPNPEILTGS TDFPLSSLLT STPMPAPRVD KPQDSQWKPS PWPENKFQLR
1560 1570 1580 1590 1600
SYSETIEKGK RPEISLSPHL SFPEASTHAL HWNAQRHAEK SVFDKKPAQN
1610 1620 1630 1640 1650
PTSKHLPYDS LPKTILKKPR IIGGKAASFT VPTNSDVLLP CEAVGDPKPT
1660 1670 1680 1690 1700
IHWTRVSSGR EISRGIQKTR FHVLPNGTLS IQRVSIQDRG QYLCAASNPL
1710 1720 1730 1740 1750
GVDHLHVTLS VVSYPARILE SHVKEITAHS GSTVKLKCRV EGMPRPTISW
1760 1770 1780 1790 1800
ILANQTVVSE TPEGSRKVWV TPDGTLIIHN LSLYDRGFYK CVANNPSGQD
1810 1820 1830 1840 1850
SLLVKIQVIT APPVIIEQKR QAIVGVLGES LKLPCTAKGT PQPSVHWVLY
1860 1870 1880 1890 1900
DGTELKPLQL THSRFFLYPN GTLYIRNIVS SVRGTYECIA TSSSGSERRV
1910 1920 1930 1940 1950
VILRVEEQET VPRIETASQK WTEVNLGEKL LLNCSATGDP KPTIIWKLPS
1960 1970 1980 1990 2000
KVVIDQWHRM GSRIHVYPNG SLVIGSVTEK DGGDYLCVAR NKMGDDLVLM
2010 2020 2030 2040 2050
HVRLRLTPAK IEHKQHFKKQ VLHGKDFQVD CKASGSPVPE VSWSLPDGTV
2060 2070 2080 2090 2100
VNNVAQADDS GYRTKRYTLF HNGTLYFNKV GMAEEGDYIC SAQNTLGKDE
2110 2120 2130 2140 2150
MKVHLTVLTA IPRIRQNYRS NVRIKAGDTA VLDCEVTGEP KPNVFWLLPS
2160 2170 2180 2190 2200
NNVISFSNDR FIFHANGTLS INKVKPLDSG KYVCVAQNPS GDDTKTYKLD
2210 2220 2230 2240 2250
IVSRPPLING LYANKTVIKA TAIQHSKKHL DCRADGVPPP QITWIMPDNI
2260 2270 2280 2290 2300
FLTAPYYGGR ITVHQNGTLE IRNIRLSDSA DFTCVVRSEG GESVLVVQLK
2310 2320 2330 2340 2350
VLEMLRRPTF RNPFNEKVVA QVGKPVAMNC SVDGNPTPEI IWILPDGTQF
2360 2370 2380 2390 2400
ANGPQNSPYL MASNGSLIVY KATRNKSGKY RCTARNKVGY IEKLILLEIG
2410 2420 2430 2440 2450
QKPVILTYEP GMIKSAGGES LSLHCVSDGI PKPNVKWTTP GGLVIDRPQV
2460 2470 2480 2490 2500
GGKYILHENG TLVIKETTAH DRGNYICKAQ NSVGQAVISV PVTIVAYPPR
2510 2520 2530 2540 2550
IINYLPRSML RRTGEAMQLH CVALGVPKPQ ITWETPGYSL LSTATERRPH
2560 2570 2580 2590
RSEMLPLQGT LVIQNLRASD SGVYKCRAQN VLGADYATTY IQVL
Length:2,594
Mass (Da):285,598
Last modified:May 15, 2007 - v2
Checksum:iA37D90B7FD255DB6
GO

Sequence cautioni

The sequence AK081990 differs from that shown. Reason: Frameshift at position 1873.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150Y → C in BAE25371 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122038 Genomic DNA. No translation available.
AK143421 mRNA. Translation: BAE25371.1.
AC135238 Genomic DNA. No translation available.
AK132367 mRNA. Translation: BAE21129.1.
AK081990 mRNA. No translation available.
CCDSiCCDS50915.1.
RefSeqiNP_001156356.1. NM_001162884.1.
XP_006501528.1. XM_006501465.3.
XP_006501529.1. XM_006501466.3.
XP_006501530.1. XM_006501467.3.
XP_011238419.1. XM_011240117.2.
UniGeneiMm.228086.
Mm.444186.

Genome annotation databases

EnsembliENSMUST00000039419; ENSMUSP00000037246; ENSMUSG00000036334.
ENSMUST00000193455; ENSMUSP00000141971; ENSMUSG00000036334.
ENSMUST00000194546; ENSMUSP00000141391; ENSMUSG00000036334.
GeneIDi242050.
KEGGimmu:242050.
UCSCiuc008piu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122038 Genomic DNA. No translation available.
AK143421 mRNA. Translation: BAE25371.1.
AC135238 Genomic DNA. No translation available.
AK132367 mRNA. Translation: BAE21129.1.
AK081990 mRNA. No translation available.
CCDSiCCDS50915.1.
RefSeqiNP_001156356.1. NM_001162884.1.
XP_006501528.1. XM_006501465.3.
XP_006501529.1. XM_006501466.3.
XP_006501530.1. XM_006501467.3.
XP_011238419.1. XM_011240117.2.
UniGeneiMm.228086.
Mm.444186.

3D structure databases

ProteinModelPortaliQ3V1M1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037246.

PTM databases

iPTMnetiQ3V1M1.
PhosphoSitePlusiQ3V1M1.

Proteomic databases

MaxQBiQ3V1M1.
PaxDbiQ3V1M1.
PeptideAtlasiQ3V1M1.
PRIDEiQ3V1M1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039419; ENSMUSP00000037246; ENSMUSG00000036334.
ENSMUST00000193455; ENSMUSP00000141971; ENSMUSG00000036334.
ENSMUST00000194546; ENSMUSP00000141391; ENSMUSG00000036334.
GeneIDi242050.
KEGGimmu:242050.
UCSCiuc008piu.2. mouse.

Organism-specific databases

CTDi285313.
MGIiMGI:1923481. Igsf10.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
ENOG410YEVU. LUCA.
GeneTreeiENSGT00860000133679.
HOVERGENiHBG107995.
InParanoidiQ3V1M1.
OMAiWILANQT.
OrthoDBiEOG091G008G.
PhylomeDBiQ3V1M1.
TreeFamiTF326318.

Miscellaneous databases

PROiQ3V1M1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036334.
CleanExiMM_IGSF10.
ExpressionAtlasiQ3V1M1. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 12 hits.
3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 7 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 12 hits.
SM00408. IGc2. 12 hits.
SM00406. IGv. 6 hits.
SM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 12 hits.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 12 hits.
PS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGS10_MOUSE
AccessioniPrimary (citable) accession number: Q3V1M1
Secondary accession number(s): Q3UPM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 30, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.