Q3V1M1 (IGS10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Immunoglobulin superfamily member 10
Short name=IgSF10

Gene names

Name:

Igsf10

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2594 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in the maintenance of osteochondroprogenitor cells pool By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Contains 12 Ig-like C2-type (immunoglobulin-like) domains. Contains 6 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain.
Sequence caution	The sequence AK081990 differs from that shown. Reason: Frameshift at position 1873.

Ontologies

Keywords
Cellular component	Secreted
Domain	Immunoglobulin domain Leucine-rich repeat Repeat Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ossification Inferred from sequence alignment PubMed 14962803. Source: MGI vascular endothelial growth factor receptor signaling pathway Inferred from electronic annotation. Source: InterPro vascular endothelial growth factor signaling pathway Inferred from electronic annotation. Source: GOC
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro vascular endothelial growth factor-activated receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 2594	2569	Immunoglobulin superfamily member 10		PRO_0000286818
Regions
	Domain	29 – 56	28	LRRNT
	Repeat	58 – 79	22	LRR 1
	Repeat	82 – 103	22	LRR 2
	Repeat	106 – 127	22	LRR 3
	Repeat	130 – 151	22	LRR 4
	Repeat	154 – 175	22	LRR 5
	Repeat	186 – 207	22	LRR 6
	Domain	219 – 281	63	LRRCT
	Domain	461 – 567	107	Ig-like C2-type 1
	Domain	571 – 661	91	Ig-like C2-type 2
	Domain	1619 – 1710	92	Ig-like C2-type 3
	Repeat	1658 – 1681	24	LRR 11
	Domain	1715 – 1807	93	Ig-like C2-type 4
	Domain	1812 – 1901	90	Ig-like C2-type 5
	Domain	1912 – 2005	94	Ig-like C2-type 6
	Domain	2008 – 2106	99	Ig-like C2-type 7
	Domain	2112 – 2200	89	Ig-like C2-type 8
	Domain	2205 – 2302	98	Ig-like C2-type 9
	Domain	2308 – 2398	91	Ig-like C2-type 10
	Domain	2403 – 2493	91	Ig-like C2-type 11
	Domain	2499 – 2592	94	Ig-like C2-type 12
Amino acid modifications
	Glycosylation	439	1	N-linked (GlcNAc...) Potential
	Glycosylation	627	1	N-linked (GlcNAc...) Potential
	Glycosylation	1044	1	N-linked (GlcNAc...) Potential
	Glycosylation	1676	1	N-linked (GlcNAc...) Potential
	Glycosylation	1780	1	N-linked (GlcNAc...) Potential
	Glycosylation	1870	1	N-linked (GlcNAc...) Potential
	Glycosylation	1933	1	N-linked (GlcNAc...) Potential
	Glycosylation	2072	1	N-linked (GlcNAc...) Potential
	Glycosylation	2364	1	N-linked (GlcNAc...) Potential
	Disulfide bond	497 ↔ 551		By similarity
	Disulfide bond	595 ↔ 645		By similarity
	Disulfide bond	1641 ↔ 1694		By similarity
	Disulfide bond	1738 ↔ 1791		By similarity
	Disulfide bond	1835 ↔ 1888		By similarity
	Disulfide bond	1934 ↔ 1987		By similarity
	Disulfide bond	2031 ↔ 2090		By similarity
	Disulfide bond	2134 ↔ 2184		By similarity
	Disulfide bond	2232 ↔ 2284		By similarity
	Disulfide bond	2330 ↔ 2382		By similarity
	Disulfide bond	2425 ↔ 2477		By similarity
	Disulfide bond	2521 ↔ 2576		By similarity
Experimental info
	Sequence conflict	150	1	Y → C in BAE25371. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q3V1M1 [UniParc]. Last modified May 15, 2007. Version 2. Checksum: A37D90B7FD255DB6	FASTA	2,594	285,598
	10 20 30 40 50 60 MQKRGREVSC LLISLTAICL VVTPGSRVCP RRCACYVPTE VHCTFRYLTS IPDGIPANVE 70 80 90 100 110 120 RVNLGYNSLT RLTENDFSGL SRLELLMLHS NGIHRVSDKT FSGLQSLQVL KMSYNKVQII 130 140 150 160 170 180 EKDTLYGLRS LTRLHLDHNN IEFINPEAFY GLTLLRLVHL EGNRLTKLHP DTFVSLSYLQ 190 200 210 220 230 240 IFKTSFIKYL YLSDNFLTSL PKEMVSSMPN LESLYLHGNP WTCDCHLKWL SEWMQGNPDI 250 260 270 280 290 300 IKCKKERIPS SPQQCPLCMN PRISKGRSIA MVPSGSFLCT KPTIDPSLKS KSLGIQEDNG 310 320 330 340 350 360 SASVSPQDFI EPFGSLSLNM TDLSGNKANV ICSIQKPSRT LPIAFTEEND YIMLNMSFST 370 380 390 400 410 420 NLVCSVNYNH IQPVWQLLAL YSDSPLILER KPQHTETPLL SPKYQQVALR PEDTFTNIEA 430 440 450 460 470 480 DFKADPFWFQ QEKISLQLNR TATTLSTLQI QFSTDAQITL PKAEMRPVKR KWTMILMMNN 490 500 510 520 530 540 TRLEHTVLVG GTIALDCPGK GDPSPHLEWV LADGSKVRAP YVSEDGRILI DKKGKLELQM 550 560 570 580 590 600 ADTFDAGLYH CISTNDADAD ILTYRITVVE PYVENKHENG ALHTVIMGEI LDLPCLSTGI 610 620 630 640 650 660 PDASISWILP RNTVFSQSSR DMQILNNGTL RILQATPKDQ GHYRCVAANP SGADFSSFQV 670 680 690 700 710 720 SVQMKGQRTI EHDRDIDGSG LEEPKPSVLL KQPPSLKLPA SSLTGTEAGK QVSGIHKKNK 730 740 750 760 770 780 HRDLTHRRRG DSTLRRFREH RRQLPLSARR IDPQHWAALL EKAKKNSVLR KQENTTVKPT 790 800 810 820 830 840 PLAIPLVELA GEEKDASGLT PPDEEFTVLK TKAFGVPERS PTADSRPVNH GFVTSSASGT 850 860 870 880 890 900 EVSSTVNPQT LLPTHLPDFK LFNVVDSAAV SKSMNRPVTS KIEDTTHQNP IIIFPSVAEI 910 920 930 940 950 960 QDSAQVGRTS SQSAHPATGG AMATYGYTTM LSSFTNKANT VLQSANPTES YGPQIPLTEV 970 980 990 1000 1010 1020 SRVSSNNSLA HTTKDPGFSK RPSDSHTTAP SLFQTPRNNS TGNVGRERTI WSRGRAISPY 1030 1040 1050 1060 1070 1080 RTPVLRRHRH RIVRPALKGP ANRNISQVSA TEPPGMCRTC SSTERLTMAT AALSVTGSSH 1090 1100 1110 1120 1130 1140 TTLPKANNVG IISEESTTVV KKPSLLLKNK QDVDIETITT TINYFRSEST HMTPTEASMI 1150 1160 1170 1180 1190 1200 SAPTSISLGK TPIDTSGHLS MPRTIQAGTD LVVTPPLSSP LSQPSIPTKA TSTKLSRRKI 1210 1220 1230 1240 1250 1260 PWHPIFANNH NKEGMLKNLH QFGLQKNTAT KPPEKAPLLP TDHGSSSPST TLLASLTPAQ 1270 1280 1290 1300 1310 1320 SATMAATRRN GTEVQGARSL SAGKEQPFIN SFLVLPSTTR KRSSTLSFLS VETPTVTTPP 1330 1340 1350 1360 1370 1380 VIASAIISET QEVRSKKAKD QTKGSLKNRK GPTITPRQIS GYSTYSVPTT TDTPLAFSHS 1390 1400 1410 1420 1430 1440 PGKVTGRTVS TAAPHSAASL LGITELPQKC THTSGNITAS ETTLLSKSQE STAMKRASAT 1450 1460 1470 1480 1490 1500 PPLLSSGAPR MPTPSPPPFT KVVVTDSEVP AVFKMMSNRM VTIYESSRHD IDLQQPSAEA 1510 1520 1530 1540 1550 1560 SPNPEILTGS TDFPLSSLLT STPMPAPRVD KPQDSQWKPS PWPENKFQLR SYSETIEKGK 1570 1580 1590 1600 1610 1620 RPEISLSPHL SFPEASTHAL HWNAQRHAEK SVFDKKPAQN PTSKHLPYDS LPKTILKKPR 1630 1640 1650 1660 1670 1680 IIGGKAASFT VPTNSDVLLP CEAVGDPKPT IHWTRVSSGR EISRGIQKTR FHVLPNGTLS 1690 1700 1710 1720 1730 1740 IQRVSIQDRG QYLCAASNPL GVDHLHVTLS VVSYPARILE SHVKEITAHS GSTVKLKCRV 1750 1760 1770 1780 1790 1800 EGMPRPTISW ILANQTVVSE TPEGSRKVWV TPDGTLIIHN LSLYDRGFYK CVANNPSGQD 1810 1820 1830 1840 1850 1860 SLLVKIQVIT APPVIIEQKR QAIVGVLGES LKLPCTAKGT PQPSVHWVLY DGTELKPLQL 1870 1880 1890 1900 1910 1920 THSRFFLYPN GTLYIRNIVS SVRGTYECIA TSSSGSERRV VILRVEEQET VPRIETASQK 1930 1940 1950 1960 1970 1980 WTEVNLGEKL LLNCSATGDP KPTIIWKLPS KVVIDQWHRM GSRIHVYPNG SLVIGSVTEK 1990 2000 2010 2020 2030 2040 DGGDYLCVAR NKMGDDLVLM HVRLRLTPAK IEHKQHFKKQ VLHGKDFQVD CKASGSPVPE 2050 2060 2070 2080 2090 2100 VSWSLPDGTV VNNVAQADDS GYRTKRYTLF HNGTLYFNKV GMAEEGDYIC SAQNTLGKDE 2110 2120 2130 2140 2150 2160 MKVHLTVLTA IPRIRQNYRS NVRIKAGDTA VLDCEVTGEP KPNVFWLLPS NNVISFSNDR 2170 2180 2190 2200 2210 2220 FIFHANGTLS INKVKPLDSG KYVCVAQNPS GDDTKTYKLD IVSRPPLING LYANKTVIKA 2230 2240 2250 2260 2270 2280 TAIQHSKKHL DCRADGVPPP QITWIMPDNI FLTAPYYGGR ITVHQNGTLE IRNIRLSDSA 2290 2300 2310 2320 2330 2340 DFTCVVRSEG GESVLVVQLK VLEMLRRPTF RNPFNEKVVA QVGKPVAMNC SVDGNPTPEI 2350 2360 2370 2380 2390 2400 IWILPDGTQF ANGPQNSPYL MASNGSLIVY KATRNKSGKY RCTARNKVGY IEKLILLEIG 2410 2420 2430 2440 2450 2460 QKPVILTYEP GMIKSAGGES LSLHCVSDGI PKPNVKWTTP GGLVIDRPQV GGKYILHENG 2470 2480 2490 2500 2510 2520 TLVIKETTAH DRGNYICKAQ NSVGQAVISV PVTIVAYPPR IINYLPRSML RRTGEAMQLH 2530 2540 2550 2560 2570 2580 CVALGVPKPQ ITWETPGYSL LSTATERRPH RSEMLPLQGT LVIQNLRASD SGVYKCRAQN 2590 VLGADYATTY IQVL

References

[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1196 AND 1297-2594. Strain: C57BL/6J. Tissue: Head and Ovary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC122038 Genomic DNA. No translation available. AK143421 mRNA. Translation: BAE25371.1. AC135238 Genomic DNA. No translation available. AK132367 mRNA. Translation: BAE21129.1. AK081990 mRNA. No translation available.
IPI	IPI00405810.
RefSeq	NP_001156356.1. NM_001162884.1.
UniGene	Mm.228086. Mm.444186.
3D structure databases
HSSP	HSSP built from PDB template 1GWB based on UniProtKB P07359.
ProteinModelPortal	Q3V1M1.
SMR	Q3V1M1. Positions 27-316, 492-691, 1612-2594.
ModBase	Search...
Protein family/group databases
MEROPS	I43.001.
PTM databases
PhosphoSite	Q3V1M1.
Proteomic databases
PRIDE	Q3V1M1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000039419; ENSMUSP00000037246; ENSMUSG00000036334.
GeneID	242050.
KEGG	mmu:242050.
UCSC	uc008piu.2. mouse.
Organism-specific databases
CTD	285313.
MGI	MGI:1923481. Igsf10.
Phylogenomic databases
eggNOG	NOG239806.
GeneTree	ENSGT00700000104014.
HOVERGEN	HBG107995.
InParanoid	Q3V1M1.
OMA	PYVSEDG.
OrthoDB	EOG45MN4F.
Gene expression databases
Bgee	Q3V1M1.
CleanEx	MM_IGSF10.
Genevestigator	Q3V1M1.
Family and domain databases
Gene3D	2.60.40.10. 12 hits.
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003598. Ig_sub2. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000372. LRR-contain_N. IPR009134. Tyr_kinase_VEGFR_rcpt_N. [Graphical view]
Pfam	PF07679. I-set. 12 hits. [Graphical view]
PRINTS	PR01832. VEGFRECEPTOR.
SMART	SM00408. IGc2. 12 hits. SM00369. LRR_TYP. 1 hit. SM00082. LRRCT. 1 hit. SM00013. LRRNT. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 12 hits. PS51450. LRR. 7 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	385215.
SOURCE	Search...

Entry information

Entry name

IGS10_MOUSE

Accession

Primary (citable) accession number: Q3V1M1
Secondary accession number(s): Q3UPM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 15, 2007
Last modified:	May 1, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program