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Q3V1D3

- AMPD1_MOUSE

UniProt

Q3V1D3 - AMPD1_MOUSE

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Protein

AMP deaminase 1

Gene
Ampd1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

AMP deaminase plays a critical role in energy metabolism.

Catalytic activityi

AMP + H2O = IMP + NH3.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi301 – 3011Zinc; catalytic By similarity
Metal bindingi303 – 3031Zinc; catalytic By similarity
Binding sitei303 – 3031Substrate By similarity
Metal bindingi570 – 5701Zinc; catalytic By similarity
Binding sitei573 – 5731Substrate By similarity
Active sitei592 – 5921Proton acceptor By similarity
Metal bindingi647 – 6471Zinc; catalytic By similarity

GO - Molecular functioni

  1. AMP deaminase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
  2. response to organic substance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00591; UER00663.

Names & Taxonomyi

Protein namesi
Recommended name:
AMP deaminase 1 (EC:3.5.4.6)
Alternative name(s):
AMP deaminase isoform M
Myoadenylate deaminase
Gene namesi
Name:Ampd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:88015. Ampd1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 745745AMP deaminase 1PRO_0000269718Add
BLAST

Proteomic databases

MaxQBiQ3V1D3.
PaxDbiQ3V1D3.
PRIDEiQ3V1D3.

PTM databases

PhosphoSiteiQ3V1D3.

Expressioni

Gene expression databases

CleanExiMM_AMPD1.
GenevestigatoriQ3V1D3.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

IntActiQ3V1D3. 1 interaction.
STRINGi10090.ENSMUSP00000088217.

Structurei

3D structure databases

ProteinModelPortaliQ3V1D3.
SMRiQ3V1D3. Positions 565-652.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni372 – 3776Substrate binding By similarity
Regioni648 – 6514Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1816.
GeneTreeiENSGT00390000008190.
HOGENOMiHOG000092200.
HOVERGENiHBG050494.
InParanoidiQ3V1D3.
KOiK01490.
OMAiNMTWMIQ.
OrthoDBiEOG70ZZMQ.
TreeFamiTF300439.

Family and domain databases

InterProiIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR006329. AMPD.
[Graphical view]
PANTHERiPTHR11359. PTHR11359. 1 hit.
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
PIRSFiPIRSF001251. AMP_deaminase_met. 1 hit.
TIGRFAMsiTIGR01429. AMP_deaminase. 1 hit.
PROSITEiPS00485. A_DEAMINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3V1D3-1 [UniParc]FASTAAdd to Basket

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MPLFKLTGQG KQIDDAMRSF AEKVFASEVK DEGGRHEISP FDVDEICPIS    50
LHEMQAHIFH MENLSMDGRR KRRFQGRKTV NLSIPQSETS STKLSHIEEF 100
ISSSPTYESV PDFQRVQITG DYASGVTVED FEVVCKGLYR ALCIREKYMQ 150
KSFQRFPKTP SKYLRNIDGE ALVGNESFYP VFTPPPKKGE DPFRTEDLPA 200
NLGYHLKMKA GVIYIYPDEA AANRDEPKPY PYPNLDDFLD DMNFLLALIA 250
QGPVKTYAHR RLKFLSSKFQ VHQMLNEMDE LKELKNNPHR DFYNCRKVDT 300
HIHAAACMNQ KHLLRFIKKS YHIDADRVVY STKEKSLTLK ELFAKLNMHP 350
YDLTVDSLDV HAGRQTFQRF DKFNDKYNPV GASELRDLYL KTDNYINGEY 400
FATIIKEVGA DLVEAKYQHA EPRLSIYGRS PDEWNKLSSW FVCNRIYCPN 450
MTWMIQVPRI YDVFRSKNFL PHFGKMLENI FLPVFEATIN PQAHPDLSVF 500
LKHITGFDSV DDESKHSGHM FSSKSPKPEE WTMENNPSYT YYAYYMYANI 550
TVLNSLRKER GMNTFLFRPH CGEAGALTHL MTAFMIADNI SHGLNLKKSP 600
VLQYLFFLAQ IPIAMSPLSN NSLFLEYAKN PFLDFLQKGL MISLSTDDPM 650
QFHFTKEPLM EEYAIAAQVF KLSTCDMCEV ARNSVLQCGI SHEEKAKFLG 700
NNYLEEGPVG NDIRRTNVAQ IRMAYRYETW CYELNLIAEG LKATE 745
Length:745
Mass (Da):86,105
Last modified:September 18, 2013 - v2
Checksum:i4595A57908A13239
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti226 – 2261E → D in BAE21218. 1 Publication
Sequence conflicti534 – 5341E → G in BAE21218. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK132524 mRNA. Translation: BAE21218.1.
AC150894 Genomic DNA. No translation available.
AC163297 Genomic DNA. No translation available.
CCDSiCCDS38571.1.
RefSeqiNP_001028475.2. NM_001033303.2.
UniGeneiMm.331272.

Genome annotation databases

EnsembliENSMUST00000090715; ENSMUSP00000088217; ENSMUSG00000070385.
GeneIDi229665.
KEGGimmu:229665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK132524 mRNA. Translation: BAE21218.1 .
AC150894 Genomic DNA. No translation available.
AC163297 Genomic DNA. No translation available.
CCDSi CCDS38571.1.
RefSeqi NP_001028475.2. NM_001033303.2.
UniGenei Mm.331272.

3D structure databases

ProteinModelPortali Q3V1D3.
SMRi Q3V1D3. Positions 565-652.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q3V1D3. 1 interaction.
STRINGi 10090.ENSMUSP00000088217.

PTM databases

PhosphoSitei Q3V1D3.

Proteomic databases

MaxQBi Q3V1D3.
PaxDbi Q3V1D3.
PRIDEi Q3V1D3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000090715 ; ENSMUSP00000088217 ; ENSMUSG00000070385 .
GeneIDi 229665.
KEGGi mmu:229665.

Organism-specific databases

CTDi 270.
MGIi MGI:88015. Ampd1.

Phylogenomic databases

eggNOGi COG1816.
GeneTreei ENSGT00390000008190.
HOGENOMi HOG000092200.
HOVERGENi HBG050494.
InParanoidi Q3V1D3.
KOi K01490.
OMAi NMTWMIQ.
OrthoDBi EOG70ZZMQ.
TreeFami TF300439.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00663 .

Miscellaneous databases

NextBioi 379583.
PROi Q3V1D3.
SOURCEi Search...

Gene expression databases

CleanExi MM_AMPD1.
Genevestigatori Q3V1D3.

Family and domain databases

InterProi IPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR006329. AMPD.
[Graphical view ]
PANTHERi PTHR11359. PTHR11359. 1 hit.
Pfami PF00962. A_deaminase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001251. AMP_deaminase_met. 1 hit.
TIGRFAMsi TIGR01429. AMP_deaminase. 1 hit.
PROSITEi PS00485. A_DEAMINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Skin.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiAMPD1_MOUSE
AccessioniPrimary (citable) accession number: Q3V1D3
Secondary accession number(s): F8VPY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: September 18, 2013
Last modified: September 3, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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