Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acrosin-binding protein

Gene

Acrbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Acrosin-binding protein
Alternative name(s):
Proacrosin-binding protein sp32
Gene namesi
Name:AcrbpImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1859515. Acrbp.

Subcellular locationi

GO - Cellular componenti

  • acrosomal membrane Source: UniProtKB
  • acrosomal vesicle Source: UniProtKB
  • cytoplasmic vesicle Source: MGI
  • extracellular region Source: UniProtKB
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000022751726 – 540Acrosin-binding proteinAdd BLAST515

Post-translational modificationi

The N-terminus is blocked.By similarity
Phosphorylated on Tyr residues in capacitated sperm.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3V140.
PeptideAtlasiQ3V140.
PRIDEiQ3V140.

PTM databases

PhosphoSitePlusiQ3V140.

Expressioni

Tissue specificityi

Expressed by testicular and epididymal spermatozoa (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000072770.
ExpressionAtlasiQ3V140. baseline and differential.
GenevisibleiQ3V140. MM.

Interactioni

Subunit structurei

Binds proacrosin.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085632.

Structurei

3D structure databases

ProteinModelPortaliQ3V140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH17. Eukaryota.
ENOG410YFR0. LUCA.
GeneTreeiENSGT00390000000826.
HOGENOMiHOG000033789.
HOVERGENiHBG080819.
InParanoidiQ3V140.
OMAiEQCHSEA.
OrthoDBiEOG091G0961.
PhylomeDBiQ3V140.
TreeFamiTF336597.

Family and domain databases

InterProiIPR009865. Proacrosin-bd.
[Graphical view]
PANTHERiPTHR21362. PTHR21362. 1 hit.
PfamiPF07222. PBP_sp32. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q3V140-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMNLAAGFLL MLLEVLLLPG TPLSAEESPA STPGSPLSST EYERFFALLT
60 70 80 90 100
PTWKAETTCR LRATHGCRNP TLVQLDQYEN HGLVPDGAVC SDLPYASWFE
110 120 130 140 150
SFCQFAQYRC SNHVYYAKRV RCSQPVSILS PNTLKEVESS AEVPPTSMTT
160 170 180 190 200
PIVSHATATE HQAFQPWPER LNNNVEELLQ SSLSLGGKDQ QSSRRPGQEQ
210 220 230 240 250
RKQEQIQEHK LEEAQEQEEQ EEEEEEEEAK QEEGQGTEAG LESVSRLQSD
260 270 280 290 300
SEPKFQSQSL SSNPSFFTPR VREVESAPLM MKNIQELIRS AQEMDEMNEL
310 320 330 340 350
YDDSWRSQST GSLQQLPHME TLMVLCYSIM ENTCTMTPTA KAWSYMEEEI
360 370 380 390 400
LGFGDSVCDN LGRRHTAACP LCAFCSLKLE QCHSEASVLR QKCDASHKIP
410 420 430 440 450
FISPLLSAQS ISTGNQARIP DKGRFAGLEM YGGLSSEFWC NRLAMKGCED
460 470 480 490 500
DRVSNWLKAE FLSFQEGDFP TKICDTNYIQ YPNYCSFKSQ QCLLRNQNRK
510 520 530 540
MSRMRCMLNE RYNVLSLAKS EEVILRWSQE FSTLAIGQFG
Length:540
Mass (Da):61,141
Last modified:October 11, 2005 - v1
Checksum:i14483661FF5884C4
GO
Isoform 21 Publication (identifier: Q3V140-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-316: SLQQL → RYRKL
     317-540: Missing.

Show »
Length:316
Mass (Da):35,787
Checksum:iD91FABB7DBF40DBD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195R → I in BAC36445 (PubMed:16141072).Curated1
Sequence conflicti201R → H in BAA04498 (Ref. 1) Curated1
Sequence conflicti201R → H in BAA04499 (Ref. 1) Curated1
Sequence conflicti389L → V in BAA04498 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051965312 – 316SLQQL → RYRKL in isoform 2. 3 Publications5
Alternative sequenceiVSP_051966317 – 540Missing in isoform 2. 3 PublicationsAdd BLAST224

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17573 mRNA. Translation: BAA04498.1.
D17574 mRNA. Translation: BAA04499.1.
AK076691 mRNA. Translation: BAC36445.1.
AK132705 mRNA. Translation: BAE21313.1.
BC011079 mRNA. Translation: AAH11079.1.
CCDSiCCDS20542.1. [Q3V140-1]
CCDS51910.1. [Q3V140-2]
RefSeqiNP_001120812.1. NM_001127340.1. [Q3V140-2]
NP_058541.2. NM_016845.2. [Q3V140-1]
UniGeneiMm.347910.

Genome annotation databases

EnsembliENSMUST00000088294; ENSMUSP00000085632; ENSMUSG00000072770. [Q3V140-1]
ENSMUST00000112414; ENSMUSP00000108033; ENSMUSG00000072770. [Q3V140-2]
GeneIDi54137.
KEGGimmu:54137.
UCSCiuc009dth.1. mouse. [Q3V140-2]
uc009dti.2. mouse. [Q3V140-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17573 mRNA. Translation: BAA04498.1.
D17574 mRNA. Translation: BAA04499.1.
AK076691 mRNA. Translation: BAC36445.1.
AK132705 mRNA. Translation: BAE21313.1.
BC011079 mRNA. Translation: AAH11079.1.
CCDSiCCDS20542.1. [Q3V140-1]
CCDS51910.1. [Q3V140-2]
RefSeqiNP_001120812.1. NM_001127340.1. [Q3V140-2]
NP_058541.2. NM_016845.2. [Q3V140-1]
UniGeneiMm.347910.

3D structure databases

ProteinModelPortaliQ3V140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085632.

PTM databases

PhosphoSitePlusiQ3V140.

Proteomic databases

PaxDbiQ3V140.
PeptideAtlasiQ3V140.
PRIDEiQ3V140.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088294; ENSMUSP00000085632; ENSMUSG00000072770. [Q3V140-1]
ENSMUST00000112414; ENSMUSP00000108033; ENSMUSG00000072770. [Q3V140-2]
GeneIDi54137.
KEGGimmu:54137.
UCSCiuc009dth.1. mouse. [Q3V140-2]
uc009dti.2. mouse. [Q3V140-1]

Organism-specific databases

CTDi84519.
MGIiMGI:1859515. Acrbp.

Phylogenomic databases

eggNOGiENOG410IH17. Eukaryota.
ENOG410YFR0. LUCA.
GeneTreeiENSGT00390000000826.
HOGENOMiHOG000033789.
HOVERGENiHBG080819.
InParanoidiQ3V140.
OMAiEQCHSEA.
OrthoDBiEOG091G0961.
PhylomeDBiQ3V140.
TreeFamiTF336597.

Miscellaneous databases

PROiQ3V140.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000072770.
ExpressionAtlasiQ3V140. baseline and differential.
GenevisibleiQ3V140. MM.

Family and domain databases

InterProiIPR009865. Proacrosin-bd.
[Graphical view]
PANTHERiPTHR21362. PTHR21362. 1 hit.
PfamiPF07222. PBP_sp32. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACRBP_MOUSE
AccessioniPrimary (citable) accession number: Q3V140
Secondary accession number(s): Q62253
, Q62254, Q8C621, Q91VQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.