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Protein

ADP/ATP translocase 4

Gene

Slc25a31

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 4
Alternative name(s):
ADP,ATP carrier protein 4
Adenine nucleotide translocator 4
Short name:
ANT 4
Solute carrier family 25 member 31
Sperm flagellar energy carrier protein
Gene namesi
Name:Slc25a31
Synonyms:Aac4, Ant4, Sfec
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1920583. Slc25a31.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei91 – 111Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei125 – 145Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei180 – 200Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei222 – 242Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei286 – 306Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
  • motile cilium Source: UniProtKB-KW
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum, Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002976261 – 320ADP/ATP translocase 4Add BLAST320

Proteomic databases

MaxQBiQ3V132.
PaxDbiQ3V132.
PRIDEiQ3V132.

PTM databases

iPTMnetiQ3V132.
PhosphoSitePlusiQ3V132.

Expressioni

Gene expression databases

BgeeiENSMUSG00000069041.
ExpressionAtlasiQ3V132. baseline and differential.
GenevisibleiQ3V132. MM.

Interactioni

Protein-protein interaction databases

BioGridi215933. 2 interactors.
IntActiQ3V132. 1 interactor.
STRINGi10090.ENSMUSP00000088723.

Structurei

3D structure databases

ProteinModelPortaliQ3V132.
SMRiQ3V132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati19 – 111Solcar 1Add BLAST93
Repeati124 – 214Solcar 2Add BLAST91
Repeati221 – 308Solcar 3Add BLAST88

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
HOVERGENiHBG108348.
InParanoidiQ3V132.
KOiK05863.
OMAiQHEGINA.
OrthoDBiEOG091G0ULB.
PhylomeDBiQ3V132.
TreeFamiTF300743.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3V132-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNESSKKQS SKKALFDPVS FSKDLLAGGV AAAVSKTAVA PIERVKLLLQ
60 70 80 90 100
VQASSKQISP EARYKGMLDC LVRIPREQGF LSYWRGNLAN VIRYFPTQAL
110 120 130 140 150
NFAFKDKYKE LFMSGVNKEK QFWRWFLANL ASGGAAGATS LCVVYPLDFA
160 170 180 190 200
RTRLGVDIGK GPEQRQFTGL GDCIMKIAKS DGLIGLYQGF GVSVQGIIVY
210 220 230 240 250
RASYFGAYDT VKGLLPKPKE TPFLVSFIIA QIVTTCSGIL SYPFDTVRRR
260 270 280 290 300
MMMQSGESDR QYKGTIDCFL KIYRHEGVPA FFRGAFSNIL RGTGGALVLV
310 320
LYDKIKEFLN IDVGGSSSGD
Length:320
Mass (Da):35,258
Last modified:October 11, 2005 - v1
Checksum:iB718DB4AE6C6B2AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38A → T in AAT42264 (PubMed:17137571).Curated1
Sequence conflicti38A → T in AAH50810 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY550241 mRNA. Translation: AAT42264.1.
AK132722 mRNA. Translation: BAE21321.1.
BC050810 mRNA. Translation: AAH50810.1.
CCDSiCCDS17326.1.
RefSeqiNP_848473.2. NM_178386.3.
UniGeneiMm.78691.

Genome annotation databases

EnsembliENSMUST00000091184; ENSMUSP00000088723; ENSMUSG00000069041.
GeneIDi73333.
KEGGimmu:73333.
UCSCiuc008pbi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY550241 mRNA. Translation: AAT42264.1.
AK132722 mRNA. Translation: BAE21321.1.
BC050810 mRNA. Translation: AAH50810.1.
CCDSiCCDS17326.1.
RefSeqiNP_848473.2. NM_178386.3.
UniGeneiMm.78691.

3D structure databases

ProteinModelPortaliQ3V132.
SMRiQ3V132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215933. 2 interactors.
IntActiQ3V132. 1 interactor.
STRINGi10090.ENSMUSP00000088723.

PTM databases

iPTMnetiQ3V132.
PhosphoSitePlusiQ3V132.

Proteomic databases

MaxQBiQ3V132.
PaxDbiQ3V132.
PRIDEiQ3V132.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091184; ENSMUSP00000088723; ENSMUSG00000069041.
GeneIDi73333.
KEGGimmu:73333.
UCSCiuc008pbi.2. mouse.

Organism-specific databases

CTDi83447.
MGIiMGI:1920583. Slc25a31.

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
HOVERGENiHBG108348.
InParanoidiQ3V132.
KOiK05863.
OMAiQHEGINA.
OrthoDBiEOG091G0ULB.
PhylomeDBiQ3V132.
TreeFamiTF300743.

Miscellaneous databases

PROiQ3V132.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069041.
ExpressionAtlasiQ3V132. baseline and differential.
GenevisibleiQ3V132. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADT4_MOUSE
AccessioniPrimary (citable) accession number: Q3V132
Secondary accession number(s): Q80W28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.