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Protein

ADP/ATP translocase 4

Gene

Slc25a31

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93ADPBy similarity1
Binding sitei105ADPBy similarity1
Binding sitei248ADPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 4
Alternative name(s):
ADP,ATP carrier protein 4
Adenine nucleotide translocator 4
Short name:
ANT 4
Solute carrier family 25 member 31
Sperm flagellar energy carrier protein
Gene namesi
Name:Slc25a31
Synonyms:Aac4, Ant4, Sfec
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1920583 Slc25a31

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 50Helical; Name=1By similarityAdd BLAST30
Transmembranei88 – 112Helical; Name=2By similarityAdd BLAST25
Transmembranei123 – 143Helical; Name=3By similarityAdd BLAST21
Transmembranei192 – 212Helical; Name=4By similarityAdd BLAST21
Transmembranei224 – 244Helical; Name=5By similarityAdd BLAST21
Transmembranei285 – 302Helical; Name=6By similarityAdd BLAST18

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum, Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002976261 – 320ADP/ATP translocase 4Add BLAST320

Proteomic databases

MaxQBiQ3V132
PaxDbiQ3V132
PRIDEiQ3V132

PTM databases

iPTMnetiQ3V132
PhosphoSitePlusiQ3V132

Expressioni

Gene expression databases

BgeeiENSMUSG00000069041
ExpressionAtlasiQ3V132 baseline and differential
GenevisibleiQ3V132 MM

Interactioni

Protein-protein interaction databases

BioGridi215933, 2 interactors
IntActiQ3V132, 1 interactor
STRINGi10090.ENSMUSP00000088723

Structurei

3D structure databases

ProteinModelPortaliQ3V132
SMRiQ3V132
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati19 – 111Solcar 1Add BLAST93
Repeati124 – 214Solcar 2Add BLAST91
Repeati221 – 308Solcar 3Add BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni248 – 253Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi248 – 253Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
GeneTreeiENSGT00390000011543
HOGENOMiHOG000165727
HOVERGENiHBG108348
InParanoidiQ3V132
KOiK05863
OMAiGFFSYWR
OrthoDBiEOG091G0ULB
PhylomeDBiQ3V132
TreeFamiTF300743

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q3V132-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNESSKKQS SKKALFDPVS FSKDLLAGGV AAAVSKTAVA PIERVKLLLQ
60 70 80 90 100
VQASSKQISP EARYKGMLDC LVRIPREQGF LSYWRGNLAN VIRYFPTQAL
110 120 130 140 150
NFAFKDKYKE LFMSGVNKEK QFWRWFLANL ASGGAAGATS LCVVYPLDFA
160 170 180 190 200
RTRLGVDIGK GPEQRQFTGL GDCIMKIAKS DGLIGLYQGF GVSVQGIIVY
210 220 230 240 250
RASYFGAYDT VKGLLPKPKE TPFLVSFIIA QIVTTCSGIL SYPFDTVRRR
260 270 280 290 300
MMMQSGESDR QYKGTIDCFL KIYRHEGVPA FFRGAFSNIL RGTGGALVLV
310 320
LYDKIKEFLN IDVGGSSSGD
Length:320
Mass (Da):35,258
Last modified:October 11, 2005 - v1
Checksum:iB718DB4AE6C6B2AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38A → T in AAT42264 (PubMed:17137571).Curated1
Sequence conflicti38A → T in AAH50810 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY550241 mRNA Translation: AAT42264.1
AK132722 mRNA Translation: BAE21321.1
BC050810 mRNA Translation: AAH50810.1
CCDSiCCDS17326.1
RefSeqiNP_848473.2, NM_178386.3
UniGeneiMm.78691

Genome annotation databases

EnsembliENSMUST00000091184; ENSMUSP00000088723; ENSMUSG00000069041
GeneIDi73333
KEGGimmu:73333
UCSCiuc008pbi.2 mouse

Similar proteinsi

Entry informationi

Entry nameiADT4_MOUSE
AccessioniPrimary (citable) accession number: Q3V132
Secondary accession number(s): Q80W28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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