Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Integrin alpha-D

Gene

Itgad

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi474 – 4829Sequence analysis
Calcium bindingi538 – 5469Sequence analysis
Calcium bindingi601 – 6099Sequence analysis

GO - Molecular functioni

GO - Biological processi

  • activated T cell proliferation Source: MGI
  • heterotypic cell-cell adhesion Source: MGI
  • integrin-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-216083. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-D
Alternative name(s):
CD_antigen: CD11d
Gene namesi
Name:Itgad
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3578624. Itgad.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 11071081ExtracellularSequence analysisAdd
BLAST
Transmembranei1108 – 112821HelicalSequence analysisAdd
BLAST
Topological domaini1129 – 116840CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 11681142Integrin alpha-DPRO_0000045902Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis
Disulfide bondi76 ↔ 83By similarity
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence analysis
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence analysis
Disulfide bondi115 ↔ 133By similarity
Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence analysis
Disulfide bondi663 ↔ 718By similarity
Glycosylationi703 – 7031N-linked (GlcNAc...)Sequence analysis
Glycosylationi741 – 7411N-linked (GlcNAc...)Sequence analysis
Disulfide bondi776 ↔ 782By similarity
Glycosylationi791 – 7911N-linked (GlcNAc...)Sequence analysis
Disulfide bondi852 ↔ 867By similarity
Glycosylationi943 – 9431N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1000 ↔ 1024By similarity
Disulfide bondi1029 ↔ 1034By similarity
Glycosylationi1052 – 10521N-linked (GlcNAc...)Sequence analysis
Glycosylationi1077 – 10771N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ3V0T4.
PaxDbiQ3V0T4.
PRIDEiQ3V0T4.

PTM databases

iPTMnetiQ3V0T4.
PhosphoSiteiQ3V0T4.

Expressioni

Gene expression databases

BgeeiQ3V0T4.
CleanExiMM_ITGAD.
ExpressionAtlasiQ3V0T4. baseline and differential.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-D associates with beta-2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033051.

Structurei

3D structure databases

ProteinModelPortaliQ3V0T4.
SMRiQ3V0T4. Positions 159-346, 353-1102.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati28 – 8558FG-GAP 1Add
BLAST
Repeati86 – 14560FG-GAP 2Add
BLAST
Domaini159 – 341183VWFAPROSITE-ProRule annotationAdd
BLAST
Repeati348 – 39952FG-GAP 3Add
BLAST
Repeati400 – 45354FG-GAP 4Add
BLAST
Repeati454 – 51259FG-GAP 5Add
BLAST
Repeati515 – 57359FG-GAP 6Add
BLAST
Repeati578 – 63861FG-GAP 7Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1133 – 11375GFFKR motif

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000113114.
HOVERGENiHBG100530.
InParanoidiQ3V0T4.
OrthoDBiEOG7353W1.
PhylomeDBiQ3V0T4.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3V0T4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFKTIWIER YRKLINLFRA LASCHGSNLD VEKPVVFKED AASFGQTVVQ
60 70 80 90 100
FGGSRLVVGA PLEAVAVNQT GQLYDCAPAT GVCQPILLHI PLEAVNMSLG
110 120 130 140 150
LSLVADTNNS QLLACGPTAQ RACAKNMYAK GSCLLLGSSL QFIQAIPATM
160 170 180 190 200
PECPGQEMDI AFLIDGSGSI DQSDFTQMKD FVKALMGQLA STSTSFSLMQ
210 220 230 240 250
YSNILKTHFT FTEFKSSLSP QSLVDAIVQL QGLTYTASGI QKVVKELFHS
260 270 280 290 300
KNGARKSAKK ILIVITDGQK FRDPLEYRHV IPEAEKAGII RYAIGVGDAF
310 320 330 340 350
REPTALQELN TIGSAPSQDH VFKVGNFVAL RSIQRQIQEK IFAIEGTESR
360 370 380 390 400
SSSSFQHEMS QEGFSSALSM DGPVLGAVGS FSWSGGAFLY PSNMRSTFIN
410 420 430 440 450
MSQENEDMRD AYLGYSTALA FWKGVHSLIL GAPRHQHTGK VVIFTQESRH
460 470 480 490 500
WRPKSEVRGT QIGSYFGASL CSVDMDRDGS TDLVLIGVPH YYEHTRGGQV
510 520 530 540 550
SVCPMPGVRS RWHCGTTLHG EQGHPWGRFG AALTVLGDVN GDSLADVAIG
560 570 580 590 600
APGEEENRGA VYIFHGASRQ DIAPSPSQRV TGSQLFLRLQ YFGQSLSGGQ
610 620 630 640 650
DLTQDGLVDL AVGAQGHVLL LRSLPLLKVG ISIRFAPSEV AKTVYQCWGR
660 670 680 690 700
TPTVLEAGEA TVCLTVRKGS PDLLGDVQSS VRYDLALDPG RLISRAIFDE
710 720 730 740 750
TKNCTLTRRK TLGLGDHCET MKLLLPDCVE DAVTPIILRL NLSLAGDSAP
760 770 780 790 800
SRNLRPVLAV GSQDHVTASF PFEKNCKQEL LCEGNLGVSF NFSGLQVLEV
810 820 830 840 850
GSSPELTVTV TVWNEGEDSY GTLIKFYYPA ELSYRRVTRA QQPHPYPLRL
860 870 880 890 900
ACEAEPTGQE SLRSSSCSIN HPIFREGAKA TFMITFDVSY KAFLGDRLLL
910 920 930 940 950
RASASSENNK PETSKTAFQL ELPVKYTVYT VISRQEDSTK HFNFSSSHGE
960 970 980 990 1000
RQKEAEHRYR VNNLSPLTLA ISVNFWVPIL LNGVAVWDVT LRSPAQGVSC
1010 1020 1030 1040 1050
VSQREPPQHS DLLTQIQGRS VLDCAIADCL HLRCDIPSLG TLDELDFILK
1060 1070 1080 1090 1100
GNLSFGWISQ TLQKKVLLLS EAEITFNTSV YSQLPGQEAF LRAQVSTMLE
1110 1120 1130 1140 1150
EYVVYEPVFL MVFSSVGGLL LLALITVALY KLGFFKRQYK EMLDLPSADP
1160
DPAGQADSNH ETPPHLTS
Length:1,168
Mass (Da):127,829
Last modified:October 11, 2005 - v1
Checksum:i15FCDF2618AD05C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132915 mRNA. Translation: BAE21419.1.
UniGeneiMm.334257.

Genome annotation databases

EnsembliENSMUST00000106237; ENSMUSP00000101844; ENSMUSG00000070369.
UCSCiuc009jyd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132915 mRNA. Translation: BAE21419.1.
UniGeneiMm.334257.

3D structure databases

ProteinModelPortaliQ3V0T4.
SMRiQ3V0T4. Positions 159-346, 353-1102.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033051.

PTM databases

iPTMnetiQ3V0T4.
PhosphoSiteiQ3V0T4.

Proteomic databases

MaxQBiQ3V0T4.
PaxDbiQ3V0T4.
PRIDEiQ3V0T4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106237; ENSMUSP00000101844; ENSMUSG00000070369.
UCSCiuc009jyd.2. mouse.

Organism-specific databases

MGIiMGI:3578624. Itgad.

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000113114.
HOVERGENiHBG100530.
InParanoidiQ3V0T4.
OrthoDBiEOG7353W1.
PhylomeDBiQ3V0T4.

Enzyme and pathway databases

ReactomeiR-MMU-216083. Integrin cell surface interactions.

Miscellaneous databases

PROiQ3V0T4.
SOURCEiSearch...

Gene expression databases

BgeeiQ3V0T4.
CleanExiMM_ITGAD.
ExpressionAtlasiQ3V0T4. baseline and differential.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiITAD_MOUSE
AccessioniPrimary (citable) accession number: Q3V0T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 11, 2005
Last modified: January 20, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.