Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Integrin alpha-D

Gene

Itgad

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi474 – 482Sequence analysis9
Calcium bindingi538 – 546Sequence analysis9
Calcium bindingi601 – 609Sequence analysis9

GO - Molecular functioni

GO - Biological processi

  • activated T cell proliferation Source: MGI
  • heterotypic cell-cell adhesion Source: MGI
  • integrin-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-216083. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-D
Alternative name(s):
CD_antigen: CD11d
Gene namesi
Name:Itgad
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3578624. Itgad.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 1107ExtracellularSequence analysisAdd BLAST1081
Transmembranei1108 – 1128HelicalSequence analysisAdd BLAST21
Topological domaini1129 – 1168CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000004590227 – 1168Integrin alpha-DAdd BLAST1142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi68N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi76 ↔ 83By similarity
Glycosylationi96N-linked (GlcNAc...)Sequence analysis1
Glycosylationi108N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi115 ↔ 133By similarity
Glycosylationi400N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi663 ↔ 718By similarity
Glycosylationi703N-linked (GlcNAc...)Sequence analysis1
Glycosylationi741N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi776 ↔ 782By similarity
Glycosylationi791N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi852 ↔ 867By similarity
Glycosylationi943N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1000 ↔ 1024By similarity
Disulfide bondi1029 ↔ 1034By similarity
Glycosylationi1052N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1077N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ3V0T4.
PaxDbiQ3V0T4.
PRIDEiQ3V0T4.

PTM databases

iPTMnetiQ3V0T4.
PhosphoSitePlusiQ3V0T4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000070369.
CleanExiMM_ITGAD.
ExpressionAtlasiQ3V0T4. baseline and differential.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-D associates with beta-2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033051.

Structurei

3D structure databases

ProteinModelPortaliQ3V0T4.
SMRiQ3V0T4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati28 – 85FG-GAP 1PROSITE-ProRule annotationAdd BLAST58
Repeati86 – 145FG-GAP 2PROSITE-ProRule annotationAdd BLAST60
Domaini159 – 341VWFAPROSITE-ProRule annotationAdd BLAST183
Repeati348 – 399FG-GAP 3PROSITE-ProRule annotationAdd BLAST52
Repeati400 – 451FG-GAP 4PROSITE-ProRule annotationAdd BLAST52
Repeati452 – 512FG-GAP 5PROSITE-ProRule annotationAdd BLAST61
Repeati515 – 573FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati578 – 638FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1133 – 1137GFFKR motif5

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000113114.
HOVERGENiHBG100530.
InParanoidiQ3V0T4.
PhylomeDBiQ3V0T4.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3V0T4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFKTIWIER YRKLINLFRA LASCHGSNLD VEKPVVFKED AASFGQTVVQ
60 70 80 90 100
FGGSRLVVGA PLEAVAVNQT GQLYDCAPAT GVCQPILLHI PLEAVNMSLG
110 120 130 140 150
LSLVADTNNS QLLACGPTAQ RACAKNMYAK GSCLLLGSSL QFIQAIPATM
160 170 180 190 200
PECPGQEMDI AFLIDGSGSI DQSDFTQMKD FVKALMGQLA STSTSFSLMQ
210 220 230 240 250
YSNILKTHFT FTEFKSSLSP QSLVDAIVQL QGLTYTASGI QKVVKELFHS
260 270 280 290 300
KNGARKSAKK ILIVITDGQK FRDPLEYRHV IPEAEKAGII RYAIGVGDAF
310 320 330 340 350
REPTALQELN TIGSAPSQDH VFKVGNFVAL RSIQRQIQEK IFAIEGTESR
360 370 380 390 400
SSSSFQHEMS QEGFSSALSM DGPVLGAVGS FSWSGGAFLY PSNMRSTFIN
410 420 430 440 450
MSQENEDMRD AYLGYSTALA FWKGVHSLIL GAPRHQHTGK VVIFTQESRH
460 470 480 490 500
WRPKSEVRGT QIGSYFGASL CSVDMDRDGS TDLVLIGVPH YYEHTRGGQV
510 520 530 540 550
SVCPMPGVRS RWHCGTTLHG EQGHPWGRFG AALTVLGDVN GDSLADVAIG
560 570 580 590 600
APGEEENRGA VYIFHGASRQ DIAPSPSQRV TGSQLFLRLQ YFGQSLSGGQ
610 620 630 640 650
DLTQDGLVDL AVGAQGHVLL LRSLPLLKVG ISIRFAPSEV AKTVYQCWGR
660 670 680 690 700
TPTVLEAGEA TVCLTVRKGS PDLLGDVQSS VRYDLALDPG RLISRAIFDE
710 720 730 740 750
TKNCTLTRRK TLGLGDHCET MKLLLPDCVE DAVTPIILRL NLSLAGDSAP
760 770 780 790 800
SRNLRPVLAV GSQDHVTASF PFEKNCKQEL LCEGNLGVSF NFSGLQVLEV
810 820 830 840 850
GSSPELTVTV TVWNEGEDSY GTLIKFYYPA ELSYRRVTRA QQPHPYPLRL
860 870 880 890 900
ACEAEPTGQE SLRSSSCSIN HPIFREGAKA TFMITFDVSY KAFLGDRLLL
910 920 930 940 950
RASASSENNK PETSKTAFQL ELPVKYTVYT VISRQEDSTK HFNFSSSHGE
960 970 980 990 1000
RQKEAEHRYR VNNLSPLTLA ISVNFWVPIL LNGVAVWDVT LRSPAQGVSC
1010 1020 1030 1040 1050
VSQREPPQHS DLLTQIQGRS VLDCAIADCL HLRCDIPSLG TLDELDFILK
1060 1070 1080 1090 1100
GNLSFGWISQ TLQKKVLLLS EAEITFNTSV YSQLPGQEAF LRAQVSTMLE
1110 1120 1130 1140 1150
EYVVYEPVFL MVFSSVGGLL LLALITVALY KLGFFKRQYK EMLDLPSADP
1160
DPAGQADSNH ETPPHLTS
Length:1,168
Mass (Da):127,829
Last modified:October 11, 2005 - v1
Checksum:i15FCDF2618AD05C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132915 mRNA. Translation: BAE21419.1.
UniGeneiMm.334257.

Genome annotation databases

EnsembliENSMUST00000106237; ENSMUSP00000101844; ENSMUSG00000070369.
UCSCiuc009jyd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132915 mRNA. Translation: BAE21419.1.
UniGeneiMm.334257.

3D structure databases

ProteinModelPortaliQ3V0T4.
SMRiQ3V0T4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033051.

PTM databases

iPTMnetiQ3V0T4.
PhosphoSitePlusiQ3V0T4.

Proteomic databases

MaxQBiQ3V0T4.
PaxDbiQ3V0T4.
PRIDEiQ3V0T4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106237; ENSMUSP00000101844; ENSMUSG00000070369.
UCSCiuc009jyd.2. mouse.

Organism-specific databases

MGIiMGI:3578624. Itgad.

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000113114.
HOVERGENiHBG100530.
InParanoidiQ3V0T4.
PhylomeDBiQ3V0T4.

Enzyme and pathway databases

ReactomeiR-MMU-216083. Integrin cell surface interactions.

Miscellaneous databases

PROiQ3V0T4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070369.
CleanExiMM_ITGAD.
ExpressionAtlasiQ3V0T4. baseline and differential.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITAD_MOUSE
AccessioniPrimary (citable) accession number: Q3V0T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.