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Q3V0N8

- Q3V0N8_MOUSE

UniProt

Q3V0N8 - Q3V0N8_MOUSE

Protein
Submitted name:

Solute carrier family 12 member 6

Gene

Slc12a6

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. potassium:chloride symporter activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Solute carrier family 12 member 6Imported
    Gene namesi
    Name:Slc12a6Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2135960. Slc12a6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: InterPro

    Expressioni

    Gene expression databases

    GenevestigatoriQ3V0N8.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00560000076892.
    HOGENOMiHOG000092644.
    HOVERGENiHBG052852.
    KOiK14427.
    OrthoDBiEOG78M01J.

    Family and domain databases

    InterProiIPR004841. AA-permease/SLC12A_dom.
    IPR018491. K/Cl_cotranspt_1/3.
    IPR000076. KCL_cotranspt.
    IPR004842. Na/K/Cl_cotransptS.
    [Graphical view]
    PfamiPF00324. AA_permease. 2 hits.
    PF03522. KCl_Cotrans_1. 1 hit.
    [Graphical view]
    PRINTSiPR01081. KCLTRNSPORT.
    TIGRFAMsiTIGR00930. 2a30. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3V0N8-1 [UniParc]FASTAAdd to Basket

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    MHPPEATTKM SSVRFMVTPT KIDDIPGLSD TSPDLSSRSS SRVRFSSRES     50
    VPETSRSEPM SELSGATTSL ATVALDPSSD RTSNPQDVTE DPSQNSITGE 100
    HSQLLDDGHK KARNAYLNNS NYEEGDEYFD KNLALFEEEM DTRPKVSSLL 150
    NRMANYTNLT QGAKEHEEAE NITEGKKKPT KSPQMGTFMG VYLPCLQNIF 200
    GVILFLRLTW VVGTAGILQA FAIVLICCCC TMLTAISMSA IATNGVVPAG 250
    GSYFMISRAL GPEFGGAVGL CFYLGTTFAA AMYILGAIEI FLVYIVPRAA 300
    IFRSDDALKE SAAMLNNMRV YGTAFLVLMV LVVFIGVRYV NKFASLFLAC 350
    VIVSILAIYA GAIKSSFAPP HFPVCMLGNR TLSSRHLDIC SKTKEVDNMT 400
    VPSKLWGFFC NSSQFFNATC DEYFVHNNVI SIQGIPGLAS GIITENLWSN 450
    YLPKGEIIEK PSAKSSDVLG NLNHEYVLAD ITTSFTLLVG IFFPSVTGIM 500
    AGSNRSGDLK DAQKSIPIGT ILAILTTSFV YLSNVVLFGA CIEGVVLRDK 550
    FGDAVKGNLV VGTLSWPSPW VIVIGSFFST CGAGLQSLTG APRLLQAIAK 600
    DNIIPFLRVF GHSKANGEPT WALLLTAAIA ELGILIASLD LVAPILSMFF 650
    LMCYLFVNLA CALQTLLRTP NWRPRFRYYH WALSFMGMSI CLALMFISSW 700
    YYAIVAMVIA GMIYKYIEYQ GAEKEWGDGI RGLSLSAARF ALLRLEEGPP 750
    HTKNWRPQLL VLLKLDEDLH VKHPRLLTFA SQLKAGKGLT IVGSVIVGNF 800
    LENYGDALAA EQTIKHLMEA EKVKGFCQLV VAAKLKEGIS HLIQSCGLGG 850
    MKHNTVVMGW PNGWRQSEDA RAWKTFIGTV RVTTAAHLAL LVAKNVSFFP 900
    SNVEQFSEGN IDVWWIVHDG GMLMLLPFLL KQHKVWRKCS IRIFTVAQLE 950
    DNSIQMKKDL ATFLYHLRIE AEVEVVEMHD SDISAYTYER TLMMEQRSQM 1000
    LRHMRLSKTE RDREAQLVKD RNSMLRLTSI GSDEDEETET YQEKVHMTWT 1050
    KDKYMASRGQ KVKSMEGFQD LLNMRPDQSN VRRMHTAVKL NEVIVNKSHE 1100
    AKLVLLNMPG PPRNPEGSSL CKAAFGWS 1128
    Length:1,128
    Mass (Da):124,951
    Last modified:October 11, 2005 - v1
    Checksum:i12A6BEB4445B5D39
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL683897 Genomic DNA. No translation available.
    AL713853 Genomic DNA. No translation available.
    AK133006 mRNA. Translation: BAE21466.1.
    RefSeqiNP_598409.2. NM_133648.2.
    NP_598410.2. NM_133649.2.
    UniGeneiMm.491155.

    Genome annotation databases

    EnsembliENSMUST00000110991; ENSMUSP00000106619; ENSMUSG00000027130.
    GeneIDi107723.
    KEGGimmu:107723.
    UCSCiuc008lot.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL683897 Genomic DNA. No translation available.
    AL713853 Genomic DNA. No translation available.
    AK133006 mRNA. Translation: BAE21466.1 .
    RefSeqi NP_598409.2. NM_133648.2.
    NP_598410.2. NM_133649.2.
    UniGenei Mm.491155.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000110991 ; ENSMUSP00000106619 ; ENSMUSG00000027130 .
    GeneIDi 107723.
    KEGGi mmu:107723.
    UCSCi uc008lot.2. mouse.

    Organism-specific databases

    CTDi 9990.
    MGIi MGI:2135960. Slc12a6.

    Phylogenomic databases

    GeneTreei ENSGT00560000076892.
    HOGENOMi HOG000092644.
    HOVERGENi HBG052852.
    KOi K14427.
    OrthoDBi EOG78M01J.

    Miscellaneous databases

    NextBioi 359318.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3V0N8.

    Family and domain databases

    InterProi IPR004841. AA-permease/SLC12A_dom.
    IPR018491. K/Cl_cotranspt_1/3.
    IPR000076. KCL_cotranspt.
    IPR004842. Na/K/Cl_cotransptS.
    [Graphical view ]
    Pfami PF00324. AA_permease. 2 hits.
    PF03522. KCl_Cotrans_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01081. KCLTRNSPORT.
    TIGRFAMsi TIGR00930. 2a30. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    9. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    11. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ3V0N8_MOUSE
    AccessioniPrimary (citable) accession number: Q3V0N8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3