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Protein
Submitted name:

Solute carrier family 12 member 6

Gene

Slc12a6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Solute carrier family 12 member 6Imported
Gene namesi
Name:Slc12a6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2135960. Slc12a6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Transmembranei212 – 234HelicalSequence analysisAdd BLAST23
Transmembranei272 – 297HelicalSequence analysisAdd BLAST26
Transmembranei318 – 337HelicalSequence analysisAdd BLAST20
Transmembranei343 – 362HelicalSequence analysisAdd BLAST20
Transmembranei476 – 496HelicalSequence analysisAdd BLAST21
Transmembranei516 – 542HelicalSequence analysisAdd BLAST27
Transmembranei621 – 639HelicalSequence analysisAdd BLAST19
Transmembranei645 – 666HelicalSequence analysisAdd BLAST22
Transmembranei678 – 695HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000027130.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028549.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini190 – 363AA_permeaseInterPro annotationAdd BLAST174
Domaini482 – 760AA_permeaseInterPro annotationAdd BLAST279
Domaini774 – 892SLC12InterPro annotationAdd BLAST119
Domaini905 – 1114SLC12InterPro annotationAdd BLAST210

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2082. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119053.
HOGENOMiHOG000092644.
HOVERGENiHBG052852.
KOiK14427.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR030364. KCC3.
IPR000076. KCL_cotranspt.
IPR018491. SLC12_C.
IPR004842. SLC12A_fam.
[Graphical view]
PANTHERiPTHR11827:SF66. PTHR11827:SF66. 4 hits.
PfamiPF00324. AA_permease. 2 hits.
PF03522. SLC12. 2 hits.
[Graphical view]
PRINTSiPR01081. KCLTRNSPORT.
TIGRFAMsiTIGR00930. 2a30. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3V0N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPPEATTKM SSVRFMVTPT KIDDIPGLSD TSPDLSSRSS SRVRFSSRES
60 70 80 90 100
VPETSRSEPM SELSGATTSL ATVALDPSSD RTSNPQDVTE DPSQNSITGE
110 120 130 140 150
HSQLLDDGHK KARNAYLNNS NYEEGDEYFD KNLALFEEEM DTRPKVSSLL
160 170 180 190 200
NRMANYTNLT QGAKEHEEAE NITEGKKKPT KSPQMGTFMG VYLPCLQNIF
210 220 230 240 250
GVILFLRLTW VVGTAGILQA FAIVLICCCC TMLTAISMSA IATNGVVPAG
260 270 280 290 300
GSYFMISRAL GPEFGGAVGL CFYLGTTFAA AMYILGAIEI FLVYIVPRAA
310 320 330 340 350
IFRSDDALKE SAAMLNNMRV YGTAFLVLMV LVVFIGVRYV NKFASLFLAC
360 370 380 390 400
VIVSILAIYA GAIKSSFAPP HFPVCMLGNR TLSSRHLDIC SKTKEVDNMT
410 420 430 440 450
VPSKLWGFFC NSSQFFNATC DEYFVHNNVI SIQGIPGLAS GIITENLWSN
460 470 480 490 500
YLPKGEIIEK PSAKSSDVLG NLNHEYVLAD ITTSFTLLVG IFFPSVTGIM
510 520 530 540 550
AGSNRSGDLK DAQKSIPIGT ILAILTTSFV YLSNVVLFGA CIEGVVLRDK
560 570 580 590 600
FGDAVKGNLV VGTLSWPSPW VIVIGSFFST CGAGLQSLTG APRLLQAIAK
610 620 630 640 650
DNIIPFLRVF GHSKANGEPT WALLLTAAIA ELGILIASLD LVAPILSMFF
660 670 680 690 700
LMCYLFVNLA CALQTLLRTP NWRPRFRYYH WALSFMGMSI CLALMFISSW
710 720 730 740 750
YYAIVAMVIA GMIYKYIEYQ GAEKEWGDGI RGLSLSAARF ALLRLEEGPP
760 770 780 790 800
HTKNWRPQLL VLLKLDEDLH VKHPRLLTFA SQLKAGKGLT IVGSVIVGNF
810 820 830 840 850
LENYGDALAA EQTIKHLMEA EKVKGFCQLV VAAKLKEGIS HLIQSCGLGG
860 870 880 890 900
MKHNTVVMGW PNGWRQSEDA RAWKTFIGTV RVTTAAHLAL LVAKNVSFFP
910 920 930 940 950
SNVEQFSEGN IDVWWIVHDG GMLMLLPFLL KQHKVWRKCS IRIFTVAQLE
960 970 980 990 1000
DNSIQMKKDL ATFLYHLRIE AEVEVVEMHD SDISAYTYER TLMMEQRSQM
1010 1020 1030 1040 1050
LRHMRLSKTE RDREAQLVKD RNSMLRLTSI GSDEDEETET YQEKVHMTWT
1060 1070 1080 1090 1100
KDKYMASRGQ KVKSMEGFQD LLNMRPDQSN VRRMHTAVKL NEVIVNKSHE
1110 1120
AKLVLLNMPG PPRNPEGSSL CKAAFGWS
Length:1,128
Mass (Da):124,951
Last modified:October 11, 2005 - v1
Checksum:i12A6BEB4445B5D39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL683897 Genomic DNA. No translation available.
AL713853 Genomic DNA. No translation available.
AK133006 mRNA. Translation: BAE21466.1.
RefSeqiNP_598409.2. NM_133648.2.
NP_598410.2. NM_133649.2.
UniGeneiMm.491155.

Genome annotation databases

EnsembliENSMUST00000110991; ENSMUSP00000106619; ENSMUSG00000027130.
GeneIDi107723.
KEGGimmu:107723.
UCSCiuc008lot.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL683897 Genomic DNA. No translation available.
AL713853 Genomic DNA. No translation available.
AK133006 mRNA. Translation: BAE21466.1.
RefSeqiNP_598409.2. NM_133648.2.
NP_598410.2. NM_133649.2.
UniGeneiMm.491155.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028549.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110991; ENSMUSP00000106619; ENSMUSG00000027130.
GeneIDi107723.
KEGGimmu:107723.
UCSCiuc008lot.2. mouse.

Organism-specific databases

CTDi9990.
MGIiMGI:2135960. Slc12a6.

Phylogenomic databases

eggNOGiKOG2082. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119053.
HOGENOMiHOG000092644.
HOVERGENiHBG052852.
KOiK14427.

Miscellaneous databases

ChiTaRSiSlc12a6. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027130.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR030364. KCC3.
IPR000076. KCL_cotranspt.
IPR018491. SLC12_C.
IPR004842. SLC12A_fam.
[Graphical view]
PANTHERiPTHR11827:SF66. PTHR11827:SF66. 4 hits.
PfamiPF00324. AA_permease. 2 hits.
PF03522. SLC12. 2 hits.
[Graphical view]
PRINTSiPR01081. KCLTRNSPORT.
TIGRFAMsiTIGR00930. 2a30. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ3V0N8_MOUSE
AccessioniPrimary (citable) accession number: Q3V0N8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.