Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Plastin-1

Gene

Pls1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Actin-bundling protein in the absence of calcium.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi24 – 35121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi64 – 75122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • intestinal D-glucose absorption Source: UniProtKB
  • positive regulation of establishment of protein localization to plasma membrane Source: UniProtKB
  • positive regulation of multicellular organism growth Source: UniProtKB
  • regulation of microvillus length Source: UniProtKB
  • terminal web assembly Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plastin-1
Gene namesi
Name:Pls1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:104809. Pls1.

Subcellular locationi

GO - Cellular componenti

  • brush border Source: UniProtKB
  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • terminal web Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 630630Plastin-1PRO_0000364188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei9 – 91PhosphoserineBy similarity
Modified residuei30 – 301PhosphotyrosineBy similarity
Modified residuei32 – 321PhosphoserineBy similarity
Modified residuei90 – 901N6-acetyllysineBy similarity
Cross-linki167 – 167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei267 – 2671PhosphoserineBy similarity
Modified residuei292 – 2921PhosphoserineBy similarity
Modified residuei296 – 2961N6-acetyllysineBy similarity
Modified residuei299 – 2991N6-acetyllysineBy similarity
Modified residuei325 – 3251PhosphoserineBy similarity
Modified residuei363 – 3631N6-acetyllysineBy similarity
Modified residuei408 – 4081PhosphoserineBy similarity
Modified residuei474 – 4741N6-acetyllysineBy similarity
Modified residuei476 – 4761PhosphoserineBy similarity
Modified residuei544 – 5441N6-acetyllysineBy similarity
Modified residuei581 – 5811N6-acetyllysineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ3V0K9.
PaxDbiQ3V0K9.
PeptideAtlasiQ3V0K9.
PRIDEiQ3V0K9.

PTM databases

iPTMnetiQ3V0K9.
PhosphoSiteiQ3V0K9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049493.
ExpressionAtlasiQ3V0K9. baseline and differential.
GenevisibleiQ3V0K9. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiQ3V0K9. 1 interaction.
STRINGi10090.ENSMUSP00000091317.

Structurei

3D structure databases

ProteinModelPortaliQ3V0K9.
SMRiQ3V0K9. Positions 15-83, 120-629.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 4636EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini51 – 8636EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini108 – 381274Actin-binding 1Add
BLAST
Domaini122 – 238117CH 1PROSITE-ProRule annotationAdd
BLAST
Domaini266 – 377112CH 2PROSITE-ProRule annotationAdd
BLAST
Domaini382 – 626245Actin-binding 2Add
BLAST
Domaini396 – 505110CH 3PROSITE-ProRule annotationAdd
BLAST
Domaini517 – 626110CH 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 actin-binding domains.Curated
Contains 4 CH (calponin-homology) domains.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0046. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00390000005691.
HOGENOMiHOG000213447.
HOVERGENiHBG003082.
InParanoidiQ3V0K9.
KOiK17275.
OMAiSKMARIK.
OrthoDBiEOG091G03YP.
PhylomeDBiQ3V0K9.
TreeFamiTF300680.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.418.10. 4 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR030235. PLS1.
[Graphical view]
PANTHERiPTHR19961:SF27. PTHR19961:SF27. 1 hit.
PfamiPF00307. CH. 4 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 4 hits.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 2 hits.
PS00020. ACTININ_2. 2 hits.
PS50021. CH. 4 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3V0K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENSTTTISR EELEELQEAF NKIDIDNSGY VSDYELQDLF KEASLPLPGY
60 70 80 90 100
KVREIVEKIL VVADNNKDGK ISFEEFVSLM QELKSKDISK TFRKIINKRE
110 120 130 140 150
GITAIGGTSS ISSEGTQHSY SEEEKVAFVN WINKALENDA DCSHLLPMNP
160 170 180 190 200
NDGSLFKSLA DGILLCKMIN LSEPDTIDER AINKKKLTPF TVSENLNLAL
210 220 230 240 250
NSASAIGCTV VNIGAQDLKE GKPHLVLGLL WQIIKVGLFA DIEISRNEAL
260 270 280 290 300
IALLKDGEDL EELMKLSPEE LLLRWVNYHL TNAGWRTINN FSQDIKDSKA
310 320 330 340 350
YFHLLNQIAP KGDRDDGPAV AIDLSGFNEK NDLKRAGFML QEADKLGCRQ
360 370 380 390 400
FVTPADVVSG NPKLNLAFVA NLFNTYPCLH KPDNNDIDLN LLEGESKEER
410 420 430 440 450
TFRNWMNSLG VNPYINHLYS DLADALVIFQ LYEMIRVPVN WSQVNKPPYP
460 470 480 490 500
ALGGNMKKIE NCNYAVELGK NEAKFSLVGI AGQDLNEGNA TLTLALVWQL
510 520 530 540 550
MRRYTLKVLS DLGEGEKVTD DIIIKWVNQT LKSANKSTSI SSFKDKSIST
560 570 580 590 600
SLPVLDLIDA IAPNAVRQEM IKREHLTDED KLNNAKYAIS VARKIGARIY
610 620 630
ALPDDLVEVK PKMVMTVFAC LMGKGLNRLK
Length:630
Mass (Da):70,408
Last modified:October 11, 2005 - v1
Checksum:i1F7254CB97780742
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133070 mRNA. Translation: BAE21495.1.
CH466560 Genomic DNA. Translation: EDL20943.1.
BC139068 mRNA. Translation: AAI39069.1.
BC139069 mRNA. Translation: AAI39070.1.
CCDSiCCDS23412.1.
RefSeqiNP_001028382.1. NM_001033210.3.
XP_006510809.1. XM_006510746.2.
XP_006510810.1. XM_006510747.1.
UniGeneiMm.11869.

Genome annotation databases

EnsembliENSMUST00000093800; ENSMUSP00000091317; ENSMUSG00000049493.
GeneIDi102502.
KEGGimmu:102502.
UCSCiuc009rbk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133070 mRNA. Translation: BAE21495.1.
CH466560 Genomic DNA. Translation: EDL20943.1.
BC139068 mRNA. Translation: AAI39069.1.
BC139069 mRNA. Translation: AAI39070.1.
CCDSiCCDS23412.1.
RefSeqiNP_001028382.1. NM_001033210.3.
XP_006510809.1. XM_006510746.2.
XP_006510810.1. XM_006510747.1.
UniGeneiMm.11869.

3D structure databases

ProteinModelPortaliQ3V0K9.
SMRiQ3V0K9. Positions 15-83, 120-629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3V0K9. 1 interaction.
STRINGi10090.ENSMUSP00000091317.

PTM databases

iPTMnetiQ3V0K9.
PhosphoSiteiQ3V0K9.

Proteomic databases

MaxQBiQ3V0K9.
PaxDbiQ3V0K9.
PeptideAtlasiQ3V0K9.
PRIDEiQ3V0K9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093800; ENSMUSP00000091317; ENSMUSG00000049493.
GeneIDi102502.
KEGGimmu:102502.
UCSCiuc009rbk.2. mouse.

Organism-specific databases

CTDi5357.
MGIiMGI:104809. Pls1.

Phylogenomic databases

eggNOGiKOG0046. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00390000005691.
HOGENOMiHOG000213447.
HOVERGENiHBG003082.
InParanoidiQ3V0K9.
KOiK17275.
OMAiSKMARIK.
OrthoDBiEOG091G03YP.
PhylomeDBiQ3V0K9.
TreeFamiTF300680.

Miscellaneous databases

PROiQ3V0K9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049493.
ExpressionAtlasiQ3V0K9. baseline and differential.
GenevisibleiQ3V0K9. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.418.10. 4 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR030235. PLS1.
[Graphical view]
PANTHERiPTHR19961:SF27. PTHR19961:SF27. 1 hit.
PfamiPF00307. CH. 4 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 4 hits.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 2 hits.
PS00020. ACTININ_2. 2 hits.
PS50021. CH. 4 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLSI_MOUSE
AccessioniPrimary (citable) accession number: Q3V0K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.