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Protein

Plastin-1

Gene

Pls1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Actin-bundling protein in the absence of calcium.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi24 – 351PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi64 – 752PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • actin crosslink formation Source: GO_Central
  • actin filament bundle assembly Source: GO_Central
  • actin filament network formation Source: GO_Central
  • intestinal D-glucose absorption Source: UniProtKB
  • positive regulation of establishment of protein localization to plasma membrane Source: UniProtKB
  • positive regulation of multicellular organism growth Source: UniProtKB
  • regulation of microvillus length Source: UniProtKB
  • terminal web assembly Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plastin-1
Gene namesi
Name:Pls1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:104809. Pls1.

Subcellular locationi

GO - Cellular componenti

  • actin filament Source: GO_Central
  • actin filament bundle Source: GO_Central
  • brush border Source: UniProtKB
  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • terminal web Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003641881 – 630Plastin-1Add BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei30PhosphotyrosineBy similarity1
Modified residuei32PhosphoserineBy similarity1
Modified residuei90N6-acetyllysineBy similarity1
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei267PhosphoserineBy similarity1
Modified residuei292PhosphoserineBy similarity1
Modified residuei296N6-acetyllysineBy similarity1
Modified residuei299N6-acetyllysineBy similarity1
Modified residuei325PhosphoserineBy similarity1
Modified residuei363N6-acetyllysineBy similarity1
Modified residuei408PhosphoserineBy similarity1
Modified residuei474N6-acetyllysineBy similarity1
Modified residuei476PhosphoserineBy similarity1
Modified residuei544N6-acetyllysineBy similarity1
Modified residuei581N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ3V0K9.
PaxDbiQ3V0K9.
PeptideAtlasiQ3V0K9.
PRIDEiQ3V0K9.

PTM databases

iPTMnetiQ3V0K9.
PhosphoSitePlusiQ3V0K9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049493.
ExpressionAtlasiQ3V0K9. baseline and differential.
GenevisibleiQ3V0K9. MM.

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ3V0K9. 1 interactor.
STRINGi10090.ENSMUSP00000091317.

Structurei

3D structure databases

ProteinModelPortaliQ3V0K9.
SMRiQ3V0K9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 46EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini51 – 86EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini108 – 381Actin-binding 1Add BLAST274
Domaini122 – 238CH 1PROSITE-ProRule annotationAdd BLAST117
Domaini266 – 377CH 2PROSITE-ProRule annotationAdd BLAST112
Domaini382 – 626Actin-binding 2Add BLAST245
Domaini396 – 505CH 3PROSITE-ProRule annotationAdd BLAST110
Domaini517 – 626CH 4PROSITE-ProRule annotationAdd BLAST110

Sequence similaritiesi

Contains 2 actin-binding domains.Curated
Contains 4 CH (calponin-homology) domains.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0046. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00390000005691.
HOGENOMiHOG000213447.
HOVERGENiHBG003082.
InParanoidiQ3V0K9.
KOiK17275.
OMAiSKMARIK.
OrthoDBiEOG091G03YP.
PhylomeDBiQ3V0K9.
TreeFamiTF300680.

Family and domain databases

CDDicd00014. CH. 2 hits.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
1.10.418.10. 4 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR030235. PLS1.
[Graphical view]
PANTHERiPTHR19961:SF27. PTHR19961:SF27. 1 hit.
PfamiPF00307. CH. 4 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 4 hits.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 2 hits.
PS00020. ACTININ_2. 2 hits.
PS50021. CH. 4 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3V0K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENSTTTISR EELEELQEAF NKIDIDNSGY VSDYELQDLF KEASLPLPGY
60 70 80 90 100
KVREIVEKIL VVADNNKDGK ISFEEFVSLM QELKSKDISK TFRKIINKRE
110 120 130 140 150
GITAIGGTSS ISSEGTQHSY SEEEKVAFVN WINKALENDA DCSHLLPMNP
160 170 180 190 200
NDGSLFKSLA DGILLCKMIN LSEPDTIDER AINKKKLTPF TVSENLNLAL
210 220 230 240 250
NSASAIGCTV VNIGAQDLKE GKPHLVLGLL WQIIKVGLFA DIEISRNEAL
260 270 280 290 300
IALLKDGEDL EELMKLSPEE LLLRWVNYHL TNAGWRTINN FSQDIKDSKA
310 320 330 340 350
YFHLLNQIAP KGDRDDGPAV AIDLSGFNEK NDLKRAGFML QEADKLGCRQ
360 370 380 390 400
FVTPADVVSG NPKLNLAFVA NLFNTYPCLH KPDNNDIDLN LLEGESKEER
410 420 430 440 450
TFRNWMNSLG VNPYINHLYS DLADALVIFQ LYEMIRVPVN WSQVNKPPYP
460 470 480 490 500
ALGGNMKKIE NCNYAVELGK NEAKFSLVGI AGQDLNEGNA TLTLALVWQL
510 520 530 540 550
MRRYTLKVLS DLGEGEKVTD DIIIKWVNQT LKSANKSTSI SSFKDKSIST
560 570 580 590 600
SLPVLDLIDA IAPNAVRQEM IKREHLTDED KLNNAKYAIS VARKIGARIY
610 620 630
ALPDDLVEVK PKMVMTVFAC LMGKGLNRLK
Length:630
Mass (Da):70,408
Last modified:October 11, 2005 - v1
Checksum:i1F7254CB97780742
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133070 mRNA. Translation: BAE21495.1.
CH466560 Genomic DNA. Translation: EDL20943.1.
BC139068 mRNA. Translation: AAI39069.1.
BC139069 mRNA. Translation: AAI39070.1.
CCDSiCCDS23412.1.
RefSeqiNP_001028382.1. NM_001033210.3.
XP_006510809.1. XM_006510746.3.
XP_006510810.1. XM_006510747.2.
UniGeneiMm.11869.

Genome annotation databases

EnsembliENSMUST00000093800; ENSMUSP00000091317; ENSMUSG00000049493.
GeneIDi102502.
KEGGimmu:102502.
UCSCiuc009rbk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133070 mRNA. Translation: BAE21495.1.
CH466560 Genomic DNA. Translation: EDL20943.1.
BC139068 mRNA. Translation: AAI39069.1.
BC139069 mRNA. Translation: AAI39070.1.
CCDSiCCDS23412.1.
RefSeqiNP_001028382.1. NM_001033210.3.
XP_006510809.1. XM_006510746.3.
XP_006510810.1. XM_006510747.2.
UniGeneiMm.11869.

3D structure databases

ProteinModelPortaliQ3V0K9.
SMRiQ3V0K9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3V0K9. 1 interactor.
STRINGi10090.ENSMUSP00000091317.

PTM databases

iPTMnetiQ3V0K9.
PhosphoSitePlusiQ3V0K9.

Proteomic databases

MaxQBiQ3V0K9.
PaxDbiQ3V0K9.
PeptideAtlasiQ3V0K9.
PRIDEiQ3V0K9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093800; ENSMUSP00000091317; ENSMUSG00000049493.
GeneIDi102502.
KEGGimmu:102502.
UCSCiuc009rbk.2. mouse.

Organism-specific databases

CTDi5357.
MGIiMGI:104809. Pls1.

Phylogenomic databases

eggNOGiKOG0046. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00390000005691.
HOGENOMiHOG000213447.
HOVERGENiHBG003082.
InParanoidiQ3V0K9.
KOiK17275.
OMAiSKMARIK.
OrthoDBiEOG091G03YP.
PhylomeDBiQ3V0K9.
TreeFamiTF300680.

Miscellaneous databases

PROiQ3V0K9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049493.
ExpressionAtlasiQ3V0K9. baseline and differential.
GenevisibleiQ3V0K9. MM.

Family and domain databases

CDDicd00014. CH. 2 hits.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
1.10.418.10. 4 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR030235. PLS1.
[Graphical view]
PANTHERiPTHR19961:SF27. PTHR19961:SF27. 1 hit.
PfamiPF00307. CH. 4 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 4 hits.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 2 hits.
PS00020. ACTININ_2. 2 hits.
PS50021. CH. 4 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLSI_MOUSE
AccessioniPrimary (citable) accession number: Q3V0K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.