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Q3V0C5

- UBP48_MOUSE

UniProt

Q3V0C5 - UBP48_MOUSE

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Protein

Ubiquitin carboxyl-terminal hydrolase 48

Gene

Usp48

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei98 – 981NucleophilePROSITE-ProRule annotation
Active sitei353 – 3531Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.068.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 48 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 48
Ubiquitin thioesterase 48
Ubiquitin-specific-processing protease 48
Gene namesi
Name:Usp48
Synonyms:Kiaa4202
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2158502. Usp48.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10521052Ubiquitin carboxyl-terminal hydrolase 48PRO_0000249524Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei903 – 9031PhosphoserineBy similarity
Modified residuei904 – 9041PhosphoserineBy similarity
Modified residuei905 – 9051PhosphoserineBy similarity
Modified residuei973 – 9731N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ3V0C5.
PaxDbiQ3V0C5.
PRIDEiQ3V0C5.

PTM databases

PhosphoSiteiQ3V0C5.

Expressioni

Gene expression databases

BgeeiQ3V0C5.
CleanExiMM_USP48.
ExpressionAtlasiQ3V0C5. baseline and differential.
GenevestigatoriQ3V0C5.

Interactioni

Subunit structurei

Interacts with TRAF2 and RELA.By similarity

Protein-protein interaction databases

BioGridi228386. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ3V0C5.
SMRiQ3V0C5. Positions 84-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 420332USPAdd
BLAST
Domaini459 – 55395DUSP 1PROSITE-ProRule annotationAdd
BLAST
Domaini568 – 691124DUSP 2PROSITE-ProRule annotationAdd
BLAST
Domaini710 – 841132DUSP 3PROSITE-ProRule annotationAdd
BLAST
Domaini946 – 102681Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 3 DUSP domains.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5077.
GeneTreeiENSGT00760000119158.
HOGENOMiHOG000231639.
HOVERGENiHBG080368.
InParanoidiQ3V0C5.
KOiK11858.
OMAiLSNWPED.
PhylomeDBiQ3V0C5.
TreeFamiTF106280.

Family and domain databases

Gene3Di3.30.2230.10. 1 hit.
InterProiIPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
SUPFAMiSSF143791. SSF143791. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3V0C5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPRLQLEKA AWRWAETVRP EEVSQEHIET AYRIWLEPCI RGVCRRNCRG
60 70 80 90 100
NPNCLVGIGE HIWLGEIDEN SFHSIDDPNC ERRKKNSFVG LTNLGATCYV
110 120 130 140 150
NTFLQVWFLN LELRQALYLC PSTCSDYTKG DGIHGGKDYE PQTICEHLQY
160 170 180 190 200
LFALLQNSNR RYIDPSGFVK ALGLDTGQQQ DAQEFSKLFM SLLEDTLSKQ
210 220 230 240 250
KNPDVRNVVQ QQFCGEYAYV TVCNQCGRES KLVSKFYELE LNIQGHKQLT
260 270 280 290 300
DCISEFLKEE RLEGDNRYFC ENCQSKQNAT RKIRLLSLPC TLNLQLMRFV
310 320 330 340 350
FDRQTGHKKK LNAYIGFSES LDMEPYVEHK GGSFVYELSA VLIHRGVSAY
360 370 380 390 400
SGHYIAHVKD PQSGEWYKFN DEDIEKMEGK KLQLGIEEDL EPSKSQTRKP
410 420 430 440 450
KCGKGTHCSR NAYMLVYRLQ AQEKNHTMVQ VPAFLQELVD RDNSKFEEWC
460 470 480 490 500
VEMAEMRKQS VDKGKAKHEE VKELYQRLPA GAEPYEFVSL EWLQKWLDES
510 520 530 540 550
TPTKPIDNNA CLCSHDKLHP DKISIMKRIS EYAANIFYSR YGGGPRLTVK
560 570 580 590 600
ALCKDCVVER CRVLRLKNQL NEDYKAVNNL LKSTMKGDGF WVGKSSLRSW
610 620 630 640 650
RQLALEQLDE QDGEAEQSNG KINGSTFNKD ESKEEKKEEE EELNFNEDIL
660 670 680 690 700
CPHGELSISE NERRLVSQEA WSKLQQYFPK APEFPSYREC CSQCKILERE
710 720 730 740 750
GEENEALHKM IANEQKTSLP NLFQDKNRPC LSNWPEDTDA LYIVSHFFLD
760 770 780 790 800
EWRKFVRKPA RSAPVSSIGN AALLCPHGGL MFTFPSLTKE DSKLCQPLER
810 820 830 840 850
REGGWPTAAH NNIALIWPSE WQMIQKLFVV DKVIKITRIE VGDVNPSQTQ
860 870 880 890 900
YISEPSLCPD CREGLLCQQQ RDLREYTQAT IYVHKVVDNK KVMKDSAPEL
910 920 930 940 950
NVSSSETEED KEEAKPDGEK DPDFNQSNGS TKRQKTSQQG YVAYQKQVIR
960 970 980 990 1000
RSTRHRKVRG EKALLVSANQ TLKELKIQIM HAFSVAPFDQ NLSIDGKILN
1010 1020 1030 1040 1050
DDCATLGTLG VIPESVILLK ADEPIADYAA MDDVMQVCMP EEGFKGTGLL

GH
Length:1,052
Mass (Da):120,631
Last modified:September 19, 2006 - v2
Checksum:i347520CB80F34303
GO
Isoform 2 (identifier: Q3V0C5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVGPCPFGRRRRRRRRPPGSASATSVKAM

Note: No experimental confirmation available.

Show »
Length:1,080
Mass (Da):123,723
Checksum:i0449068D6093A9CD
GO
Isoform 3 (identifier: Q3V0C5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-390: L → LA
     483-484: EP → GL
     485-1052: Missing.

Show »
Length:485
Mass (Da):55,956
Checksum:i558437C9A7A809FE
GO
Isoform 4 (identifier: Q3V0C5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     483-484: EP → GL
     485-1052: Missing.

Show »
Length:484
Mass (Da):55,884
Checksum:i8ACBDF6704499F90
GO
Isoform 5 (identifier: Q3V0C5-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-390: L → LA

Show »
Length:1,053
Mass (Da):120,702
Checksum:i503A45728DEE622D
GO

Sequence cautioni

The sequence AAH21769.1 differs from that shown. Reason: Frameshift at position 377.
The sequence BAD90375.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MVGPCPFGRRRRRRRRPPGS ASATSVKAM in isoform 2. 1 PublicationVSP_020482
Alternative sequencei390 – 3901L → LA in isoform 3 and isoform 5. 2 PublicationsVSP_020483
Alternative sequencei483 – 4842EP → GL in isoform 3 and isoform 4. 2 PublicationsVSP_020484
Alternative sequencei485 – 1052568Missing in isoform 3 and isoform 4. 2 PublicationsVSP_020485Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK220190 mRNA. Translation: BAD90375.1. Different initiation.
AK133251 mRNA. Translation: BAE21579.1.
AK166158 mRNA. Translation: BAE38603.1.
BC021769 mRNA. Translation: AAH21769.1. Frameshift.
CCDSiCCDS38924.1. [Q3V0C5-1]
RefSeqiNP_570949.2. NM_130879.2. [Q3V0C5-1]
XP_006538662.1. XM_006538599.1. [Q3V0C5-5]
UniGeneiMm.218478.

Genome annotation databases

EnsembliENSMUST00000055131; ENSMUSP00000055016; ENSMUSG00000043411. [Q3V0C5-1]
GeneIDi170707.
KEGGimmu:170707.
UCSCiuc008vjh.1. mouse. [Q3V0C5-2]
uc008vji.1. mouse. [Q3V0C5-3]
uc008vjj.1. mouse. [Q3V0C5-4]
uc008vjl.1. mouse. [Q3V0C5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK220190 mRNA. Translation: BAD90375.1 . Different initiation.
AK133251 mRNA. Translation: BAE21579.1 .
AK166158 mRNA. Translation: BAE38603.1 .
BC021769 mRNA. Translation: AAH21769.1 . Frameshift.
CCDSi CCDS38924.1. [Q3V0C5-1 ]
RefSeqi NP_570949.2. NM_130879.2. [Q3V0C5-1 ]
XP_006538662.1. XM_006538599.1. [Q3V0C5-5 ]
UniGenei Mm.218478.

3D structure databases

ProteinModelPortali Q3V0C5.
SMRi Q3V0C5. Positions 84-417.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 228386. 1 interaction.

Protein family/group databases

MEROPSi C19.068.

PTM databases

PhosphoSitei Q3V0C5.

Proteomic databases

MaxQBi Q3V0C5.
PaxDbi Q3V0C5.
PRIDEi Q3V0C5.

Protocols and materials databases

DNASUi 170707.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055131 ; ENSMUSP00000055016 ; ENSMUSG00000043411 . [Q3V0C5-1 ]
GeneIDi 170707.
KEGGi mmu:170707.
UCSCi uc008vjh.1. mouse. [Q3V0C5-2 ]
uc008vji.1. mouse. [Q3V0C5-3 ]
uc008vjj.1. mouse. [Q3V0C5-4 ]
uc008vjl.1. mouse. [Q3V0C5-1 ]

Organism-specific databases

CTDi 84196.
MGIi MGI:2158502. Usp48.
Rougei Search...

Phylogenomic databases

eggNOGi COG5077.
GeneTreei ENSGT00760000119158.
HOGENOMi HOG000231639.
HOVERGENi HBG080368.
InParanoidi Q3V0C5.
KOi K11858.
OMAi LSNWPED.
PhylomeDBi Q3V0C5.
TreeFami TF106280.

Miscellaneous databases

ChiTaRSi USP48. mouse.
NextBioi 370218.
PROi Q3V0C5.
SOURCEi Search...

Gene expression databases

Bgeei Q3V0C5.
CleanExi MM_USP48.
ExpressionAtlasi Q3V0C5. baseline and differential.
Genevestigatori Q3V0C5.

Family and domain databases

Gene3Di 3.30.2230.10. 1 hit.
InterProi IPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
SUPFAMi SSF143791. SSF143791. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Embryonic tail.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Lung and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-633 (ISOFORM 5).
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiUBP48_MOUSE
AccessioniPrimary (citable) accession number: Q3V0C5
Secondary accession number(s): Q3TM39, Q571J9, Q8VDJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: October 29, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3