Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q3V0C5

- UBP48_MOUSE

UniProt

Q3V0C5 - UBP48_MOUSE

Protein

Ubiquitin carboxyl-terminal hydrolase 48

Gene

Usp48

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 2 (19 Sep 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei98 – 981NucleophilePROSITE-ProRule annotation
    Active sitei353 – 3531Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.068.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 48 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 48
    Ubiquitin thioesterase 48
    Ubiquitin-specific-processing protease 48
    Gene namesi
    Name:Usp48
    Synonyms:Kiaa4202
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:2158502. Usp48.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10521052Ubiquitin carboxyl-terminal hydrolase 48PRO_0000249524Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei903 – 9031PhosphoserineBy similarity
    Modified residuei904 – 9041PhosphoserineBy similarity
    Modified residuei905 – 9051PhosphoserineBy similarity
    Modified residuei973 – 9731N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ3V0C5.
    PaxDbiQ3V0C5.
    PRIDEiQ3V0C5.

    PTM databases

    PhosphoSiteiQ3V0C5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3V0C5.
    BgeeiQ3V0C5.
    CleanExiMM_USP48.
    GenevestigatoriQ3V0C5.

    Interactioni

    Subunit structurei

    Interacts with TRAF2 and RELA.By similarity

    Protein-protein interaction databases

    BioGridi228386. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3V0C5.
    SMRiQ3V0C5. Positions 84-417, 962-1013.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini89 – 420332USPAdd
    BLAST
    Domaini459 – 55395DUSP 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini568 – 691124DUSP 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini710 – 841132DUSP 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini946 – 102681Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 3 DUSP domains.PROSITE-ProRule annotation
    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5077.
    GeneTreeiENSGT00740000115066.
    HOGENOMiHOG000231639.
    HOVERGENiHBG080368.
    KOiK11858.
    OMAiLSNWPED.
    PhylomeDBiQ3V0C5.
    TreeFamiTF106280.

    Family and domain databases

    Gene3Di3.30.2230.10. 1 hit.
    InterProiIPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    SUPFAMiSSF143791. SSF143791. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS51283. DUSP. 3 hits.
    PS50053. UBIQUITIN_2. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3V0C5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPRLQLEKA AWRWAETVRP EEVSQEHIET AYRIWLEPCI RGVCRRNCRG     50
    NPNCLVGIGE HIWLGEIDEN SFHSIDDPNC ERRKKNSFVG LTNLGATCYV 100
    NTFLQVWFLN LELRQALYLC PSTCSDYTKG DGIHGGKDYE PQTICEHLQY 150
    LFALLQNSNR RYIDPSGFVK ALGLDTGQQQ DAQEFSKLFM SLLEDTLSKQ 200
    KNPDVRNVVQ QQFCGEYAYV TVCNQCGRES KLVSKFYELE LNIQGHKQLT 250
    DCISEFLKEE RLEGDNRYFC ENCQSKQNAT RKIRLLSLPC TLNLQLMRFV 300
    FDRQTGHKKK LNAYIGFSES LDMEPYVEHK GGSFVYELSA VLIHRGVSAY 350
    SGHYIAHVKD PQSGEWYKFN DEDIEKMEGK KLQLGIEEDL EPSKSQTRKP 400
    KCGKGTHCSR NAYMLVYRLQ AQEKNHTMVQ VPAFLQELVD RDNSKFEEWC 450
    VEMAEMRKQS VDKGKAKHEE VKELYQRLPA GAEPYEFVSL EWLQKWLDES 500
    TPTKPIDNNA CLCSHDKLHP DKISIMKRIS EYAANIFYSR YGGGPRLTVK 550
    ALCKDCVVER CRVLRLKNQL NEDYKAVNNL LKSTMKGDGF WVGKSSLRSW 600
    RQLALEQLDE QDGEAEQSNG KINGSTFNKD ESKEEKKEEE EELNFNEDIL 650
    CPHGELSISE NERRLVSQEA WSKLQQYFPK APEFPSYREC CSQCKILERE 700
    GEENEALHKM IANEQKTSLP NLFQDKNRPC LSNWPEDTDA LYIVSHFFLD 750
    EWRKFVRKPA RSAPVSSIGN AALLCPHGGL MFTFPSLTKE DSKLCQPLER 800
    REGGWPTAAH NNIALIWPSE WQMIQKLFVV DKVIKITRIE VGDVNPSQTQ 850
    YISEPSLCPD CREGLLCQQQ RDLREYTQAT IYVHKVVDNK KVMKDSAPEL 900
    NVSSSETEED KEEAKPDGEK DPDFNQSNGS TKRQKTSQQG YVAYQKQVIR 950
    RSTRHRKVRG EKALLVSANQ TLKELKIQIM HAFSVAPFDQ NLSIDGKILN 1000
    DDCATLGTLG VIPESVILLK ADEPIADYAA MDDVMQVCMP EEGFKGTGLL 1050
    GH 1052
    Length:1,052
    Mass (Da):120,631
    Last modified:September 19, 2006 - v2
    Checksum:i347520CB80F34303
    GO
    Isoform 2 (identifier: Q3V0C5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MVGPCPFGRRRRRRRRPPGSASATSVKAM

    Note: No experimental confirmation available.

    Show »
    Length:1,080
    Mass (Da):123,723
    Checksum:i0449068D6093A9CD
    GO
    Isoform 3 (identifier: Q3V0C5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         390-390: L → LA
         483-484: EP → GL
         485-1052: Missing.

    Show »
    Length:485
    Mass (Da):55,956
    Checksum:i558437C9A7A809FE
    GO
    Isoform 4 (identifier: Q3V0C5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         483-484: EP → GL
         485-1052: Missing.

    Show »
    Length:484
    Mass (Da):55,884
    Checksum:i8ACBDF6704499F90
    GO
    Isoform 5 (identifier: Q3V0C5-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         390-390: L → LA

    Show »
    Length:1,053
    Mass (Da):120,702
    Checksum:i503A45728DEE622D
    GO

    Sequence cautioni

    The sequence AAH21769.1 differs from that shown. Reason: Frameshift at position 377.
    The sequence BAD90375.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MVGPCPFGRRRRRRRRPPGS ASATSVKAM in isoform 2. 1 PublicationVSP_020482
    Alternative sequencei390 – 3901L → LA in isoform 3 and isoform 5. 2 PublicationsVSP_020483
    Alternative sequencei483 – 4842EP → GL in isoform 3 and isoform 4. 2 PublicationsVSP_020484
    Alternative sequencei485 – 1052568Missing in isoform 3 and isoform 4. 2 PublicationsVSP_020485Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK220190 mRNA. Translation: BAD90375.1. Different initiation.
    AK133251 mRNA. Translation: BAE21579.1.
    AK166158 mRNA. Translation: BAE38603.1.
    BC021769 mRNA. Translation: AAH21769.1. Frameshift.
    CCDSiCCDS38924.1. [Q3V0C5-1]
    RefSeqiNP_570949.2. NM_130879.2. [Q3V0C5-1]
    XP_006538662.1. XM_006538599.1. [Q3V0C5-5]
    UniGeneiMm.218478.

    Genome annotation databases

    EnsembliENSMUST00000055131; ENSMUSP00000055016; ENSMUSG00000043411. [Q3V0C5-1]
    GeneIDi170707.
    KEGGimmu:170707.
    UCSCiuc008vjh.1. mouse. [Q3V0C5-2]
    uc008vji.1. mouse. [Q3V0C5-3]
    uc008vjj.1. mouse. [Q3V0C5-4]
    uc008vjl.1. mouse. [Q3V0C5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK220190 mRNA. Translation: BAD90375.1 . Different initiation.
    AK133251 mRNA. Translation: BAE21579.1 .
    AK166158 mRNA. Translation: BAE38603.1 .
    BC021769 mRNA. Translation: AAH21769.1 . Frameshift.
    CCDSi CCDS38924.1. [Q3V0C5-1 ]
    RefSeqi NP_570949.2. NM_130879.2. [Q3V0C5-1 ]
    XP_006538662.1. XM_006538599.1. [Q3V0C5-5 ]
    UniGenei Mm.218478.

    3D structure databases

    ProteinModelPortali Q3V0C5.
    SMRi Q3V0C5. Positions 84-417, 962-1013.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 228386. 1 interaction.

    Protein family/group databases

    MEROPSi C19.068.

    PTM databases

    PhosphoSitei Q3V0C5.

    Proteomic databases

    MaxQBi Q3V0C5.
    PaxDbi Q3V0C5.
    PRIDEi Q3V0C5.

    Protocols and materials databases

    DNASUi 170707.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055131 ; ENSMUSP00000055016 ; ENSMUSG00000043411 . [Q3V0C5-1 ]
    GeneIDi 170707.
    KEGGi mmu:170707.
    UCSCi uc008vjh.1. mouse. [Q3V0C5-2 ]
    uc008vji.1. mouse. [Q3V0C5-3 ]
    uc008vjj.1. mouse. [Q3V0C5-4 ]
    uc008vjl.1. mouse. [Q3V0C5-1 ]

    Organism-specific databases

    CTDi 84196.
    MGIi MGI:2158502. Usp48.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG5077.
    GeneTreei ENSGT00740000115066.
    HOGENOMi HOG000231639.
    HOVERGENi HBG080368.
    KOi K11858.
    OMAi LSNWPED.
    PhylomeDBi Q3V0C5.
    TreeFami TF106280.

    Miscellaneous databases

    ChiTaRSi USP48. mouse.
    NextBioi 370218.
    PROi Q3V0C5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3V0C5.
    Bgeei Q3V0C5.
    CleanExi MM_USP48.
    Genevestigatori Q3V0C5.

    Family and domain databases

    Gene3Di 3.30.2230.10. 1 hit.
    InterProi IPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF143791. SSF143791. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS51283. DUSP. 3 hits.
    PS50053. UBIQUITIN_2. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Embryonic tail.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Strain: C57BL/6J.
      Tissue: Lung and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-633 (ISOFORM 5).
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiUBP48_MOUSE
    AccessioniPrimary (citable) accession number: Q3V0C5
    Secondary accession number(s): Q3TM39, Q571J9, Q8VDJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: September 19, 2006
    Last modified: October 1, 2014
    This is version 82 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3