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Q3V0C5

- UBP48_MOUSE

UniProt

Q3V0C5 - UBP48_MOUSE

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Protein
Ubiquitin carboxyl-terminal hydrolase 48
Gene
Usp48, Kiaa4202
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei98 – 981Nucleophile By similarity
Active sitei353 – 3531Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.068.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 48 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 48
Ubiquitin thioesterase 48
Ubiquitin-specific-processing protease 48
Gene namesi
Name:Usp48
Synonyms:Kiaa4202
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2158502. Usp48.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10521052Ubiquitin carboxyl-terminal hydrolase 48
PRO_0000249524Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei903 – 9031Phosphoserine By similarity
Modified residuei904 – 9041Phosphoserine By similarity
Modified residuei905 – 9051Phosphoserine By similarity
Modified residuei973 – 9731N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ3V0C5.
PaxDbiQ3V0C5.
PRIDEiQ3V0C5.

PTM databases

PhosphoSiteiQ3V0C5.

Expressioni

Gene expression databases

ArrayExpressiQ3V0C5.
BgeeiQ3V0C5.
CleanExiMM_USP48.
GenevestigatoriQ3V0C5.

Interactioni

Subunit structurei

Interacts with TRAF2 and RELA By similarity.

Protein-protein interaction databases

BioGridi228386. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ3V0C5.
SMRiQ3V0C5. Positions 84-417, 962-1013.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 420332USP
Add
BLAST
Domaini459 – 55395DUSP 1
Add
BLAST
Domaini568 – 691124DUSP 2
Add
BLAST
Domaini710 – 841132DUSP 3
Add
BLAST
Domaini946 – 102681Ubiquitin-like
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 3 DUSP domains.
Contains 1 USP domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5077.
GeneTreeiENSGT00740000115066.
HOGENOMiHOG000231639.
HOVERGENiHBG080368.
KOiK11858.
OMAiLSNWPED.
PhylomeDBiQ3V0C5.
TreeFamiTF106280.

Family and domain databases

Gene3Di3.30.2230.10. 1 hit.
InterProiIPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
SUPFAMiSSF143791. SSF143791. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3V0C5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAPRLQLEKA AWRWAETVRP EEVSQEHIET AYRIWLEPCI RGVCRRNCRG     50
NPNCLVGIGE HIWLGEIDEN SFHSIDDPNC ERRKKNSFVG LTNLGATCYV 100
NTFLQVWFLN LELRQALYLC PSTCSDYTKG DGIHGGKDYE PQTICEHLQY 150
LFALLQNSNR RYIDPSGFVK ALGLDTGQQQ DAQEFSKLFM SLLEDTLSKQ 200
KNPDVRNVVQ QQFCGEYAYV TVCNQCGRES KLVSKFYELE LNIQGHKQLT 250
DCISEFLKEE RLEGDNRYFC ENCQSKQNAT RKIRLLSLPC TLNLQLMRFV 300
FDRQTGHKKK LNAYIGFSES LDMEPYVEHK GGSFVYELSA VLIHRGVSAY 350
SGHYIAHVKD PQSGEWYKFN DEDIEKMEGK KLQLGIEEDL EPSKSQTRKP 400
KCGKGTHCSR NAYMLVYRLQ AQEKNHTMVQ VPAFLQELVD RDNSKFEEWC 450
VEMAEMRKQS VDKGKAKHEE VKELYQRLPA GAEPYEFVSL EWLQKWLDES 500
TPTKPIDNNA CLCSHDKLHP DKISIMKRIS EYAANIFYSR YGGGPRLTVK 550
ALCKDCVVER CRVLRLKNQL NEDYKAVNNL LKSTMKGDGF WVGKSSLRSW 600
RQLALEQLDE QDGEAEQSNG KINGSTFNKD ESKEEKKEEE EELNFNEDIL 650
CPHGELSISE NERRLVSQEA WSKLQQYFPK APEFPSYREC CSQCKILERE 700
GEENEALHKM IANEQKTSLP NLFQDKNRPC LSNWPEDTDA LYIVSHFFLD 750
EWRKFVRKPA RSAPVSSIGN AALLCPHGGL MFTFPSLTKE DSKLCQPLER 800
REGGWPTAAH NNIALIWPSE WQMIQKLFVV DKVIKITRIE VGDVNPSQTQ 850
YISEPSLCPD CREGLLCQQQ RDLREYTQAT IYVHKVVDNK KVMKDSAPEL 900
NVSSSETEED KEEAKPDGEK DPDFNQSNGS TKRQKTSQQG YVAYQKQVIR 950
RSTRHRKVRG EKALLVSANQ TLKELKIQIM HAFSVAPFDQ NLSIDGKILN 1000
DDCATLGTLG VIPESVILLK ADEPIADYAA MDDVMQVCMP EEGFKGTGLL 1050
GH 1052
Length:1,052
Mass (Da):120,631
Last modified:September 19, 2006 - v2
Checksum:i347520CB80F34303
GO
Isoform 2 (identifier: Q3V0C5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVGPCPFGRRRRRRRRPPGSASATSVKAM

Note: No experimental confirmation available.

Show »
Length:1,080
Mass (Da):123,723
Checksum:i0449068D6093A9CD
GO
Isoform 3 (identifier: Q3V0C5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-390: L → LA
     483-484: EP → GL
     485-1052: Missing.

Show »
Length:485
Mass (Da):55,956
Checksum:i558437C9A7A809FE
GO
Isoform 4 (identifier: Q3V0C5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     483-484: EP → GL
     485-1052: Missing.

Show »
Length:484
Mass (Da):55,884
Checksum:i8ACBDF6704499F90
GO
Isoform 5 (identifier: Q3V0C5-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-390: L → LA

Show »
Length:1,053
Mass (Da):120,702
Checksum:i503A45728DEE622D
GO

Sequence cautioni

The sequence AAH21769.1 differs from that shown. Reason: Frameshift at position 377.
The sequence BAD90375.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MVGPCPFGRRRRRRRRPPGS ASATSVKAM in isoform 2.
VSP_020482
Alternative sequencei390 – 3901L → LA in isoform 3 and isoform 5.
VSP_020483
Alternative sequencei483 – 4842EP → GL in isoform 3 and isoform 4.
VSP_020484
Alternative sequencei485 – 1052568Missing in isoform 3 and isoform 4.
VSP_020485Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK220190 mRNA. Translation: BAD90375.1. Different initiation.
AK133251 mRNA. Translation: BAE21579.1.
AK166158 mRNA. Translation: BAE38603.1.
BC021769 mRNA. Translation: AAH21769.1. Frameshift.
CCDSiCCDS38924.1. [Q3V0C5-1]
RefSeqiNP_570949.2. NM_130879.2. [Q3V0C5-1]
XP_006538662.1. XM_006538599.1. [Q3V0C5-5]
UniGeneiMm.218478.

Genome annotation databases

EnsembliENSMUST00000055131; ENSMUSP00000055016; ENSMUSG00000043411. [Q3V0C5-1]
GeneIDi170707.
KEGGimmu:170707.
UCSCiuc008vjh.1. mouse. [Q3V0C5-2]
uc008vji.1. mouse. [Q3V0C5-3]
uc008vjj.1. mouse. [Q3V0C5-4]
uc008vjl.1. mouse. [Q3V0C5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK220190 mRNA. Translation: BAD90375.1 . Different initiation.
AK133251 mRNA. Translation: BAE21579.1 .
AK166158 mRNA. Translation: BAE38603.1 .
BC021769 mRNA. Translation: AAH21769.1 . Frameshift.
CCDSi CCDS38924.1. [Q3V0C5-1 ]
RefSeqi NP_570949.2. NM_130879.2. [Q3V0C5-1 ]
XP_006538662.1. XM_006538599.1. [Q3V0C5-5 ]
UniGenei Mm.218478.

3D structure databases

ProteinModelPortali Q3V0C5.
SMRi Q3V0C5. Positions 84-417, 962-1013.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 228386. 1 interaction.

Protein family/group databases

MEROPSi C19.068.

PTM databases

PhosphoSitei Q3V0C5.

Proteomic databases

MaxQBi Q3V0C5.
PaxDbi Q3V0C5.
PRIDEi Q3V0C5.

Protocols and materials databases

DNASUi 170707.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055131 ; ENSMUSP00000055016 ; ENSMUSG00000043411 . [Q3V0C5-1 ]
GeneIDi 170707.
KEGGi mmu:170707.
UCSCi uc008vjh.1. mouse. [Q3V0C5-2 ]
uc008vji.1. mouse. [Q3V0C5-3 ]
uc008vjj.1. mouse. [Q3V0C5-4 ]
uc008vjl.1. mouse. [Q3V0C5-1 ]

Organism-specific databases

CTDi 84196.
MGIi MGI:2158502. Usp48.
Rougei Search...

Phylogenomic databases

eggNOGi COG5077.
GeneTreei ENSGT00740000115066.
HOGENOMi HOG000231639.
HOVERGENi HBG080368.
KOi K11858.
OMAi LSNWPED.
PhylomeDBi Q3V0C5.
TreeFami TF106280.

Miscellaneous databases

ChiTaRSi USP48. mouse.
NextBioi 370218.
PROi Q3V0C5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q3V0C5.
Bgeei Q3V0C5.
CleanExi MM_USP48.
Genevestigatori Q3V0C5.

Family and domain databases

Gene3Di 3.30.2230.10. 1 hit.
InterProi IPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
SUPFAMi SSF143791. SSF143791. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Embryonic tail.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Lung and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-633 (ISOFORM 5).
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiUBP48_MOUSE
AccessioniPrimary (citable) accession number: Q3V0C5
Secondary accession number(s): Q3TM39, Q571J9, Q8VDJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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