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Protein

Zinc finger protein 583

Gene

Znf583

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri211 – 233C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri239 – 261C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri267 – 289C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri519 – 541C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 583
Gene namesi
Name:Znf583
Synonyms:Zfp583
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2682297. Zfp583.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476751 – 568Zinc finger protein 583Add BLAST568

Proteomic databases

PaxDbiQ3V080.
PRIDEiQ3V080.

PTM databases

iPTMnetiQ3V080.
PhosphoSitePlusiQ3V080.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030443.
CleanExiMM_ZFP583.
ExpressionAtlasiQ3V080. baseline and differential.
GenevisibleiQ3V080. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053935.

Structurei

3D structure databases

ProteinModelPortaliQ3V080.
SMRiQ3V080.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 77KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri211 – 233C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri239 – 261C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri267 – 289C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri519 – 541C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOVERGENiHBG018163.
InParanoidiQ3V080.
KOiK09228.
OMAiHTMESFL.
OrthoDBiEOG091G02KC.
PhylomeDBiQ3V080.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3V080-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNLLTFED VSVNFTQEEW QWLSDTQRDL YRKVTLENYK SLVSLGIPVY
60 70 80 90 100
KPAVISLLEQ GKDPWMVQKK GARDTCPDWQ YVFKGTEFIS KQDIYKESAK
110 120 130 140 150
VLTMGRSHFS SSLDCPDLKE DHENEDWFKN RLGRQEVHSH QLFITHKEVP
160 170 180 190 200
ESEIRGCNPS CQAVHQNAIL DVPQCSSTKE RIDQSEPQKR SYRKKSVEMK
210 220 230 240 250
HKKVQVEKRI LKCSECEKVF NQTSSLTLHQ RIHTGEKPYA CVECGKAFSQ
260 270 280 290 300
SANLAQHKRI HTGEKPYECK ECRKAFSQNA HLAQHQRVHT GEKPYQCKEC
310 320 330 340 350
KKAFSQIAHL TQHQRIHTGE RPFECIECGK AFSNGSFLAQ HQRIHTGEKP
360 370 380 390 400
YVCHVCGKAF SHRGYLIVHQ RIHTGERPYE CKECRKSFSQ YAHLSQHQRV
410 420 430 440 450
HTGEKPYECK VCRKAFSQVA YLDQHQRVHT GEKPYECAEC RKAFSNSSSL
460 470 480 490 500
AQHQRSHTGE KPYICKECRK TFSQNAGLAQ HQRIHTGEKP YECNICGKAF
510 520 530 540 550
SYSGSLTLHQ RIHTGERPYE CKDCRKSFRQ RAHLAHHEKV HTMESFLSLS
560
SPSPSMSSQL PRTLGLIS
Length:568
Mass (Da):65,709
Last modified:October 11, 2005 - v1
Checksum:i32640CB4CBEDA2E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038614 mRNA. Translation: BAE20539.1.
AK133380 mRNA. Translation: BAE21624.1.
CCDSiCCDS39751.1.
RefSeqiNP_001028421.1. NM_001033249.3.
XP_011248777.1. XM_011250475.2.
UniGeneiMm.333558.

Genome annotation databases

EnsembliENSMUST00000062765; ENSMUSP00000053935; ENSMUSG00000030443.
ENSMUST00000108560; ENSMUSP00000104200; ENSMUSG00000030443.
ENSMUST00000165705; ENSMUSP00000129551; ENSMUSG00000030443.
GeneIDi213011.
KEGGimmu:213011.
UCSCiuc009fbc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038614 mRNA. Translation: BAE20539.1.
AK133380 mRNA. Translation: BAE21624.1.
CCDSiCCDS39751.1.
RefSeqiNP_001028421.1. NM_001033249.3.
XP_011248777.1. XM_011250475.2.
UniGeneiMm.333558.

3D structure databases

ProteinModelPortaliQ3V080.
SMRiQ3V080.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053935.

PTM databases

iPTMnetiQ3V080.
PhosphoSitePlusiQ3V080.

Proteomic databases

PaxDbiQ3V080.
PRIDEiQ3V080.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062765; ENSMUSP00000053935; ENSMUSG00000030443.
ENSMUST00000108560; ENSMUSP00000104200; ENSMUSG00000030443.
ENSMUST00000165705; ENSMUSP00000129551; ENSMUSG00000030443.
GeneIDi213011.
KEGGimmu:213011.
UCSCiuc009fbc.2. mouse.

Organism-specific databases

CTDi213011.
MGIiMGI:2682297. Zfp583.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOVERGENiHBG018163.
InParanoidiQ3V080.
KOiK09228.
OMAiHTMESFL.
OrthoDBiEOG091G02KC.
PhylomeDBiQ3V080.
TreeFamiTF341817.

Miscellaneous databases

PROiQ3V080.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030443.
CleanExiMM_ZFP583.
ExpressionAtlasiQ3V080. baseline and differential.
GenevisibleiQ3V080. MM.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN583_MOUSE
AccessioniPrimary (citable) accession number: Q3V080
Secondary accession number(s): Q3V3L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.