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Protein

Multidrug and toxin extrusion protein 2

Gene

Slc47a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Solute transporter for tetraethylammonium (TEA), cimetidine, choline, procainamide, cimetidine, quinidine, guanidine, N-methylnicotinamide (NMN). Responsible for the secretion of cationic drugs across the brush border membranes.1 Publication

Kineticsi

  1. KM=0.710 mM for TEA1 Publication
  1. Vmax=0.004 nmol/min/mg enzyme toward TEA1 Publication

pH dependencei

Optimum pH is 8.5. Active from pH 6 to 8.5.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.66.1.16. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug and toxin extrusion protein 2
Short name:
MATE-2
Short name:
mMATE-2
Alternative name(s):
H(+)/organic cation antiporter kidney-specific
Solute carrier family 47 member 2
Gene namesi
Name:Slc47a2
Synonyms:Mate2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3588190. Slc47a2.

Subcellular locationi

  • Membrane Curated; Multi-pass membrane protein Curated

  • Note: Localized to the plasma membrane and to the intracellular organelles.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4646CytoplasmicSequence analysisAdd
BLAST
Transmembranei47 – 6721HelicalSequence analysisAdd
BLAST
Topological domaini68 – 8114ExtracellularSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Topological domaini103 – 12220CytoplasmicSequence analysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence analysisAdd
BLAST
Topological domaini144 – 16118ExtracellularSequence analysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence analysisAdd
BLAST
Topological domaini183 – 19614CytoplasmicSequence analysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence analysisAdd
BLAST
Topological domaini218 – 2258ExtracellularSequence analysis
Transmembranei226 – 24621HelicalSequence analysisAdd
BLAST
Topological domaini247 – 26620CytoplasmicSequence analysisAdd
BLAST
Transmembranei267 – 28620HelicalSequence analysisAdd
BLAST
Topological domaini287 – 30418ExtracellularSequence analysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence analysisAdd
BLAST
Topological domaini326 – 34520CytoplasmicSequence analysisAdd
BLAST
Transmembranei346 – 36621HelicalSequence analysisAdd
BLAST
Topological domaini367 – 37913ExtracellularSequence analysisAdd
BLAST
Transmembranei380 – 40021HelicalSequence analysisAdd
BLAST
Topological domaini401 – 41515CytoplasmicSequence analysisAdd
BLAST
Transmembranei416 – 43621HelicalSequence analysisAdd
BLAST
Topological domaini437 – 4437ExtracellularSequence analysis
Transmembranei444 – 46421HelicalSequence analysisAdd
BLAST
Topological domaini465 – 54581CytoplasmicSequence analysisAdd
BLAST
Transmembranei546 – 56621HelicalSequence analysisAdd
BLAST
Topological domaini567 – 5737ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

GuidetoPHARMACOLOGYi1217.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Multidrug and toxin extrusion protein 2PRO_0000312852Add
BLAST

Proteomic databases

PaxDbiQ3V050.
PRIDEiQ3V050.

Expressioni

Tissue specificityi

Expressed in testis; especially in testicular Leydig cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000069855.
CleanExiMM_SLC47A2.
ExpressionAtlasiQ3V050. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090710.

Structurei

3D structure databases

ProteinModelPortaliQ3V050.
SMRiQ3V050. Positions 42-484.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1347. Eukaryota.
COG0534. LUCA.
GeneTreeiENSGT00390000015713.
HOGENOMiHOG000060313.
HOVERGENiHBG056043.
InParanoidiQ3V050.
KOiK03327.
OMAiARCSCTT.
OrthoDBiEOG091G06X2.
PhylomeDBiQ3V050.
TreeFamiTF324441.

Family and domain databases

InterProiIPR002528. MATE_fam.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3V050-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAEDSLGA TIQPPELVRV PRGRSLRILL GLRGALSPDV RREAAALVAL
60 70 80 90 100
AGPVFLAQLM IFLISIVSSI FCGHLGKVEL DAVTLAVSVV NVTGISVGTG
110 120 130 140 150
LASACDTLMS QSFGGKNLKR VGVILQRGIL ILLLCCFPCW AIFLNTERLL
160 170 180 190 200
LLLRQDPDVA RLAQVYVMIC IPALPAAFLF QLQTRYLQSQ GIIMPQVIVG
210 220 230 240 250
IAANVVNVGM NAFLLYALDL GVVGSAWANT TSQFFLSALL FLYVWWKRIH
260 270 280 290 300
IHTWGGWTRE CFQEWSSYTR LAIPSMFMVC IEWWTFEIGT FLAGLVNVTE
310 320 330 340 350
LGAQAVIYEL ASVAYMVPFG FGVAASVRVG NALGAGNADQ ARCSCTTVLL
360 370 380 390 400
CAGVCALLVG ILLAALKDVV AYIFTNDKDI ISLVSQVMPI FAPFHLFDAL
410 420 430 440 450
AGTCGGVLRG TGKQKIGAVL NTIGYYGFGF PIGVSLMFAA KLGIIGLWAG
460 470 480 490 500
LIVCVSFQAF SYLIYILRTN WSRVAEQAQV RAGLKSTKEL IPTPADLPIL
510 520 530 540 550
EREVMDGVIL PDIIRPESQT GQLVVEENSQ CAVPTVGEVL TGRQLVFYRG
560 570
MALTVSVAVL IAGIVVRVFN DRG
Length:573
Mass (Da):61,789
Last modified:October 11, 2005 - v1
Checksum:iB18968B12E84F805
GO

Sequence cautioni

The sequence CAI25733 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133432 mRNA. Translation: BAE21655.1.
AL669884 Genomic DNA. Translation: CAI25733.1. Sequence problems.
BC147619 mRNA. Translation: AAI47620.1.
BC157913 mRNA. Translation: AAI57914.1.
CCDSiCCDS24810.1.
RefSeqiNP_001028714.1. NM_001033542.2.
UniGeneiMm.340166.

Genome annotation databases

EnsembliENSMUST00000093029; ENSMUSP00000090710; ENSMUSG00000069855.
GeneIDi380701.
KEGGimmu:380701.
UCSCiuc007jhg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133432 mRNA. Translation: BAE21655.1.
AL669884 Genomic DNA. Translation: CAI25733.1. Sequence problems.
BC147619 mRNA. Translation: AAI47620.1.
BC157913 mRNA. Translation: AAI57914.1.
CCDSiCCDS24810.1.
RefSeqiNP_001028714.1. NM_001033542.2.
UniGeneiMm.340166.

3D structure databases

ProteinModelPortaliQ3V050.
SMRiQ3V050. Positions 42-484.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090710.

Chemistry

GuidetoPHARMACOLOGYi1217.

Protein family/group databases

TCDBi2.A.66.1.16. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

Proteomic databases

PaxDbiQ3V050.
PRIDEiQ3V050.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093029; ENSMUSP00000090710; ENSMUSG00000069855.
GeneIDi380701.
KEGGimmu:380701.
UCSCiuc007jhg.1. mouse.

Organism-specific databases

CTDi146802.
MGIiMGI:3588190. Slc47a2.

Phylogenomic databases

eggNOGiKOG1347. Eukaryota.
COG0534. LUCA.
GeneTreeiENSGT00390000015713.
HOGENOMiHOG000060313.
HOVERGENiHBG056043.
InParanoidiQ3V050.
KOiK03327.
OMAiARCSCTT.
OrthoDBiEOG091G06X2.
PhylomeDBiQ3V050.
TreeFamiTF324441.

Miscellaneous databases

PROiQ3V050.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069855.
CleanExiMM_SLC47A2.
ExpressionAtlasiQ3V050. baseline and differential.

Family and domain databases

InterProiIPR002528. MATE_fam.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS47A2_MOUSE
AccessioniPrimary (citable) accession number: Q3V050
Secondary accession number(s): B2RXN1, Q5SS46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.