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Protein

Transmembrane emp24 domain-containing protein 1

Gene

Tmed1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane emp24 domain-containing protein 1
Alternative name(s):
Interleukin-1 receptor-like 1 ligand
Putative T1/ST2 receptor-binding protein
p24 family protein gamma-1
Short name:
p24gamma1
Gene namesi
Name:Tmed1
Synonyms:Il1rl1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:106201. Tmed1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 194170ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21521HelicalSequence analysisAdd
BLAST
Topological domaini216 – 22712CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 227203Transmembrane emp24 domain-containing protein 1PRO_0000248020Add
BLAST

Proteomic databases

MaxQBiQ3V009.
PaxDbiQ3V009.
PeptideAtlasiQ3V009.
PRIDEiQ3V009.

PTM databases

PhosphoSiteiQ3V009.
SwissPalmiQ3V009.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000032180.
CleanExiMM_TMED1.
ExpressionAtlasiQ3V009. baseline and differential.
GenevisibleiQ3V009. MM.

Interactioni

Subunit structurei

Homodimer in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. May interact with IL1RL1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ3V009. 1 interaction.
STRINGi10090.ENSMUSP00000034698.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 12583GOLDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili145 – 17026Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi218 – 22710COPI vesicle coat-bindingSequence analysis
Motifi218 – 2192COPII vesicle coat-bindingSequence analysis

Sequence similaritiesi

Belongs to the EMP24/GP25L family.Curated
Contains 1 GOLD domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3287. Eukaryota.
ENOG410Z18S. LUCA.
GeneTreeiENSGT00670000097656.
HOGENOMiHOG000039809.
HOVERGENiHBG000271.
InParanoidiQ3V009.
KOiK20348.
OMAiAGRSECF.
OrthoDBiEOG091G0RNG.
PhylomeDBiQ3V009.
TreeFamiTF313000.

Family and domain databases

InterProiIPR009038. GOLD_dom.
IPR015720. TMP21-related.
[Graphical view]
PANTHERiPTHR22811. PTHR22811. 1 hit.
PfamiPF01105. EMP24_GP25L. 1 hit.
[Graphical view]
SMARTiSM01190. EMP24_GP25L. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
PROSITEiPS50866. GOLD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3V009-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAAGAAVAL ALWLLLPAVG VGEAGPPPIQ DGEFTFLLPA GRKQCFYQSA
60 70 80 90 100
PANASLETEY QVIGGAGLDV DFTLESPQGV LLVSESRKAD GVHTVEPTEA
110 120 130 140 150
GDYRLCFDNS FSTISEKLVF FELIFDSFQD EEEVEGWAEA VEPEEMLDVK
160 170 180 190 200
MEDIKESIET MRTRLERSIQ MLTLLRAFEA RDRNLQEDNL ERVNFWSAAN
210 220
VAVLLLVAVL QVCTLKRFFH DKRPVPT
Length:227
Mass (Da):25,263
Last modified:October 11, 2005 - v1
Checksum:iF37FC38E54AB4495
GO
Isoform 2 (identifier: Q3V009-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.
     86-94: SRKADGVHT → MLVLRPSTR

Show »
Length:142
Mass (Da):16,635
Checksum:i859CA05B4CBEDC4E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8585Missing in isoform 2. 1 PublicationVSP_020135Add
BLAST
Alternative sequencei86 – 949SRKADGVHT → MLVLRPSTR in isoform 2. 1 PublicationVSP_020136

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133513 mRNA. Translation: BAE21696.1.
AK160525 mRNA. Translation: BAE35843.1.
U41805 mRNA. Translation: AAC52472.1.
CCDSiCCDS22904.1. [Q3V009-1]
RefSeqiNP_034874.2. NM_010744.4. [Q3V009-1]
XP_011240714.1. XM_011242412.1. [Q3V009-2]
UniGeneiMm.196618.

Genome annotation databases

EnsembliENSMUST00000034698; ENSMUSP00000034698; ENSMUSG00000032180. [Q3V009-1]
GeneIDi17083.
KEGGimmu:17083.
UCSCiuc009olp.1. mouse. [Q3V009-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133513 mRNA. Translation: BAE21696.1.
AK160525 mRNA. Translation: BAE35843.1.
U41805 mRNA. Translation: AAC52472.1.
CCDSiCCDS22904.1. [Q3V009-1]
RefSeqiNP_034874.2. NM_010744.4. [Q3V009-1]
XP_011240714.1. XM_011242412.1. [Q3V009-2]
UniGeneiMm.196618.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3V009. 1 interaction.
STRINGi10090.ENSMUSP00000034698.

PTM databases

PhosphoSiteiQ3V009.
SwissPalmiQ3V009.

Proteomic databases

MaxQBiQ3V009.
PaxDbiQ3V009.
PeptideAtlasiQ3V009.
PRIDEiQ3V009.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034698; ENSMUSP00000034698; ENSMUSG00000032180. [Q3V009-1]
GeneIDi17083.
KEGGimmu:17083.
UCSCiuc009olp.1. mouse. [Q3V009-1]

Organism-specific databases

CTDi11018.
MGIiMGI:106201. Tmed1.

Phylogenomic databases

eggNOGiKOG3287. Eukaryota.
ENOG410Z18S. LUCA.
GeneTreeiENSGT00670000097656.
HOGENOMiHOG000039809.
HOVERGENiHBG000271.
InParanoidiQ3V009.
KOiK20348.
OMAiAGRSECF.
OrthoDBiEOG091G0RNG.
PhylomeDBiQ3V009.
TreeFamiTF313000.

Miscellaneous databases

PROiQ3V009.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032180.
CleanExiMM_TMED1.
ExpressionAtlasiQ3V009. baseline and differential.
GenevisibleiQ3V009. MM.

Family and domain databases

InterProiIPR009038. GOLD_dom.
IPR015720. TMP21-related.
[Graphical view]
PANTHERiPTHR22811. PTHR22811. 1 hit.
PfamiPF01105. EMP24_GP25L. 1 hit.
[Graphical view]
SMARTiSM01190. EMP24_GP25L. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
PROSITEiPS50866. GOLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMED1_MOUSE
AccessioniPrimary (citable) accession number: Q3V009
Secondary accession number(s): Q3TUX8, Q61073, Q91YK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.