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Protein

Calcium-transporting ATPase

Gene

Atp2c1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processCalcium transportUniRule annotation, Ion transport, Transport
LigandATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:Atp2c1Imported
ORF Names:mCG_4445Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1889008 Atp2c1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei137 – 153HelicalUniRule annotationAdd BLAST17
Transmembranei302 – 321HelicalUniRule annotationAdd BLAST20
Transmembranei327 – 356HelicalUniRule annotationAdd BLAST30
Transmembranei735 – 755HelicalUniRule annotationAdd BLAST21
Transmembranei808 – 828HelicalUniRule annotationAdd BLAST21
Transmembranei877 – 894HelicalUniRule annotationAdd BLAST18
Transmembranei906 – 928HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000032570

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 133Cation_ATPase_NInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0202 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00890000139334
HOGENOMiHOG000265621
HOVERGENiHBG106478
OMAiCRSESKS
OrthoDBiEOG091G0NXU

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR030336 ATP2C1
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006413 P-type_ATPase_IIA_PMR1
IPR001757 P_typ_ATPase
PANTHERiPTHR42861:SF2 PTHR42861:SF2, 1 hit
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01522 ATPase-IIA2_Ca, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UZR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLLPPSGF SYLKKYPLHS IRKYLSTLRS QRAEEQVARF QKIPNVENET
60 70 80 90 100
MIPVLTSKRA SELAVSEVAG LLQADLQNGL NKSEVSHRRA FHGWNEFDIS
110 120 130 140 150
EDEPLWKKYI SQFKNPLIML LLASAVISIL MRQFDDAVSI TVAIVIVVTV
160 170 180 190 200
AFVQEYRSEK SLEELSKLVP PECHCVREGK LEHTLARDLV PGDTVCLSVG
210 220 230 240 250
DRVPADLRLF EAVDLSVDES SLTGETAPCS KVTAPQPAAN GDLASRSNIA
260 270 280 290 300
FMGTLVRCGK AKGIVIGTGE NSEFGEVFKM MQAEEAPKTP LQKSMDLLGK
310 320 330 340 350
QLSFYSFGII GIIMLVGWLL GKDILEMFTI SVSLAVAAIP EGLPIVVTVT
360 370 380 390 400
LALGVMRMVK KRAIVKKLPI VETLGCCNVI CSDKTGTLTK NEMTVTHILT
410 420 430 440 450
SDGLHAEVTG VGYNQFGEVI VDGDVVHGFY NPAVSRIVEA GCVCNDAVIR
460 470 480 490 500
NNTLMGKPTE GALIALAMKM GLDGLQQDYI RKAEYPFSSE QKWMAVKCVH
510 520 530 540 550
RTQQDRPEIC FMKGAYEQVI KYCTTYNSKG QTLALTQQQR DLYQQEKARM
560 570 580 590 600
GSAGLRVLAL ASGPELGQLT FLGLVGIIDP PRTGVKEAVT TLIASGVSIK
610 620 630 640 650
MITGDSQETA IAIASRLGLY SKTSQSVSGE EVDTMEVQHL SQIVPKVAVF
660 670 680 690 700
YRASPRHKMK IIKSLQKNGA VVAMTGDGVN DAVALKAADI GVAMGQTGTD
710 720 730 740 750
VCKEAADMIL VDDDFQTIMS AIEEGKGIYN NIKNFVRFQL STSIAALTLI
760 770 780 790 800
SLATLMNFPN PLNAMQILWI NIIMDGPPAQ SLGVEPVDKD VIRKPPRNWK
810 820 830 840 850
DSILTKNLIL KILVSSIIIV CGTLFVFWRE LRDNVITPRD TTMTFTCFVF
860 870 880 890 900
FDMFNALSSR SQTKSVFEIG LCSNKMFCYA VLGSIMGQLL VIYFPPLQKV
910 920 930 940 950
FQTESLSILD LLFLLGLTSS VCIVSEIIKK VERSREKVQK NAGSASSSFL

EV
Length:952
Mass (Da):104,304
Last modified:October 11, 2005 - v1
Checksum:i19844547C4E17FBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113016 Genomic DNA No translation available.
AC117679 Genomic DNA No translation available.
AK133703 mRNA Translation: BAE21790.1
CH466560 Genomic DNA Translation: EDL21108.1
RefSeqiNP_001240760.1, NM_001253831.1
UniGeneiMm.326247
Mm.489853

Genome annotation databases

EnsembliENSMUST00000085133; ENSMUSP00000082220; ENSMUSG00000032570
GeneIDi235574
UCSCiuc009rih.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ3UZR5_MOUSE
AccessioniPrimary (citable) accession number: Q3UZR5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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