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Protein

Calcium-transporting ATPase

Gene

Atp2c1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processCalcium transportUniRule annotation, Ion transport, Transport
LigandATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:Atp2c1Imported
ORF Names:mCG_4445Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1889008. Atp2c1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei137 – 153HelicalUniRule annotationAdd BLAST17
Transmembranei302 – 321HelicalUniRule annotationAdd BLAST20
Transmembranei327 – 356HelicalUniRule annotationAdd BLAST30
Transmembranei735 – 755HelicalUniRule annotationAdd BLAST21
Transmembranei808 – 828HelicalUniRule annotationAdd BLAST21
Transmembranei877 – 894HelicalUniRule annotationAdd BLAST18
Transmembranei906 – 928HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000032570.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 133Cation_ATPase_NInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00890000139334.
HOGENOMiHOG000265621.
HOVERGENiHBG106478.
OMAiCRSESKS.
OrthoDBiEOG091G0NXU.

Family and domain databases

Gene3Di3.40.1110.10. 1 hit.
3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR030336. ATP2C1.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_dom_N.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom_sf.
IPR008250. ATPase_P-typ_transduc_dom_A_sf.
IPR036412. HAD-like_sf.
IPR023214. HAD_sf.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
PANTHERiPTHR42861:SF2. PTHR42861:SF2. 1 hit.
PfamiView protein in Pfam
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PRINTSiPR00120. HATPASE.
SMARTiView protein in SMART
SM00831. Cation_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81653. SSF81653. 1 hit.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UZR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLLPPSGF SYLKKYPLHS IRKYLSTLRS QRAEEQVARF QKIPNVENET
60 70 80 90 100
MIPVLTSKRA SELAVSEVAG LLQADLQNGL NKSEVSHRRA FHGWNEFDIS
110 120 130 140 150
EDEPLWKKYI SQFKNPLIML LLASAVISIL MRQFDDAVSI TVAIVIVVTV
160 170 180 190 200
AFVQEYRSEK SLEELSKLVP PECHCVREGK LEHTLARDLV PGDTVCLSVG
210 220 230 240 250
DRVPADLRLF EAVDLSVDES SLTGETAPCS KVTAPQPAAN GDLASRSNIA
260 270 280 290 300
FMGTLVRCGK AKGIVIGTGE NSEFGEVFKM MQAEEAPKTP LQKSMDLLGK
310 320 330 340 350
QLSFYSFGII GIIMLVGWLL GKDILEMFTI SVSLAVAAIP EGLPIVVTVT
360 370 380 390 400
LALGVMRMVK KRAIVKKLPI VETLGCCNVI CSDKTGTLTK NEMTVTHILT
410 420 430 440 450
SDGLHAEVTG VGYNQFGEVI VDGDVVHGFY NPAVSRIVEA GCVCNDAVIR
460 470 480 490 500
NNTLMGKPTE GALIALAMKM GLDGLQQDYI RKAEYPFSSE QKWMAVKCVH
510 520 530 540 550
RTQQDRPEIC FMKGAYEQVI KYCTTYNSKG QTLALTQQQR DLYQQEKARM
560 570 580 590 600
GSAGLRVLAL ASGPELGQLT FLGLVGIIDP PRTGVKEAVT TLIASGVSIK
610 620 630 640 650
MITGDSQETA IAIASRLGLY SKTSQSVSGE EVDTMEVQHL SQIVPKVAVF
660 670 680 690 700
YRASPRHKMK IIKSLQKNGA VVAMTGDGVN DAVALKAADI GVAMGQTGTD
710 720 730 740 750
VCKEAADMIL VDDDFQTIMS AIEEGKGIYN NIKNFVRFQL STSIAALTLI
760 770 780 790 800
SLATLMNFPN PLNAMQILWI NIIMDGPPAQ SLGVEPVDKD VIRKPPRNWK
810 820 830 840 850
DSILTKNLIL KILVSSIIIV CGTLFVFWRE LRDNVITPRD TTMTFTCFVF
860 870 880 890 900
FDMFNALSSR SQTKSVFEIG LCSNKMFCYA VLGSIMGQLL VIYFPPLQKV
910 920 930 940 950
FQTESLSILD LLFLLGLTSS VCIVSEIIKK VERSREKVQK NAGSASSSFL

EV
Length:952
Mass (Da):104,304
Last modified:October 11, 2005 - v1
Checksum:i19844547C4E17FBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113016 Genomic DNA. No translation available.
AC117679 Genomic DNA. No translation available.
AK133703 mRNA. Translation: BAE21790.1.
CH466560 Genomic DNA. Translation: EDL21108.1.
RefSeqiNP_001240760.1. NM_001253831.1.
UniGeneiMm.326247.
Mm.489853.

Genome annotation databases

EnsembliENSMUST00000085133; ENSMUSP00000082220; ENSMUSG00000032570.
GeneIDi235574.
UCSCiuc009rih.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ3UZR5_MOUSE
AccessioniPrimary (citable) accession number: Q3UZR5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 22, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported