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Protein

MARVEL domain-containing protein 2

Gene

Marveld2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing.1 Publication

GO - Biological processi

  • bicellular tight junction assembly Source: MGI
  • cell-cell junction organization Source: MGI
  • establishment of endothelial barrier Source: MGI
  • sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Biological processi

Hearing

Names & Taxonomyi

Protein namesi
Recommended name:
MARVEL domain-containing protein 2
Alternative name(s):
Tricellulin
Gene namesi
Name:Marveld2
Synonyms:Mrvldc2, Tric
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2446166. Marveld2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 191191CytoplasmicSequence analysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence analysisAdd
BLAST
Topological domaini213 – 25139ExtracellularSequence analysisAdd
BLAST
Transmembranei252 – 27221HelicalSequence analysisAdd
BLAST
Topological domaini273 – 28816CytoplasmicSequence analysisAdd
BLAST
Transmembranei289 – 30921HelicalSequence analysisAdd
BLAST
Topological domaini310 – 33829ExtracellularSequence analysisAdd
BLAST
Transmembranei339 – 35921HelicalSequence analysisAdd
BLAST
Topological domaini360 – 555196CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • basolateral plasma membrane Source: MGI
  • bicellular tight junction Source: MGI
  • cytoplasm Source: MGI
  • cytoplasmic vesicle Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • paranodal junction Source: MGI
  • Schmidt-Lanterman incisure Source: MGI
  • tricellular tight junction Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555MARVEL domain-containing protein 2PRO_0000271527Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 1171PhosphoserineCombined sources
Modified residuei121 – 1211PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UZP0.
PaxDbiQ3UZP0.
PRIDEiQ3UZP0.

PTM databases

iPTMnetiQ3UZP0.
PhosphoSiteiQ3UZP0.

Expressioni

Tissue specificityi

Predominently localized to small intestine, stomach and kidney, in epithelial cells.1 Publication

Gene expression databases

BgeeiQ3UZP0.
CleanExiMM_MARVELD2.
ExpressionAtlasiQ3UZP0. baseline and differential.
GenevisibleiQ3UZP0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022137.

Structurei

3D structure databases

ProteinModelPortaliQ3UZP0.
SMRiQ3UZP0. Positions 438-545.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini185 – 364180MARVELPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili521 – 54525Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi46 – 538Poly-Pro

Sequence similaritiesi

Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4796. Eukaryota.
ENOG410ZNGU. LUCA.
GeneTreeiENSGT00550000074378.
HOGENOMiHOG000155323.
HOVERGENiHBG079727.
InParanoidiQ3UZP0.
KOiK17291.
OMAiSPPNSCK.
OrthoDBiEOG783MV9.
PhylomeDBiQ3UZP0.
TreeFamiTF326161.

Family and domain databases

InterProiIPR031176. ELL/occludin.
IPR008253. Marvel.
IPR031177. MARVELD2.
IPR010844. Occludin_ELL.
[Graphical view]
PANTHERiPTHR23288. PTHR23288. 1 hit.
PTHR23288:SF3. PTHR23288:SF3. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
PF07303. Occludin_ELL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UZP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSDARSRI RDRGYSEVPR DTSCPDGTIR TFQSLHSSEL AVSADPLPPP
60 70 80 90 100
PLPLQPPFGP SFYSSDTEEP AVAPDLKPVR RFVPDSWKNF FRGKKKDPEW
110 120 130 140 150
DNPVSDIRYI SDGVECSPPA SPARANHHPY KDPSRGSQGT FNSQHEADAM
160 170 180 190 200
FAHDPYASLD RRTQTARTYS EKVEEYNLRY AYMKSWAGLL RILGVVELLL
210 220 230 240 250
GAGVFACVTA YIHKDNEWYN LFGYTQPYGM GGLGSLGNTY GGYYYSGPKT
260 270 280 290 300
PFVLVVAGLA WITTIIILVL GMSMYYRTIL LDSNWWPLTE FGVNVALFIL
310 320 330 340 350
YMAAAIVYVN DTNRGGLCYY PLFNTPMNAM FCRVEGGQIA AMIFLFVTMI
360 370 380 390 400
VYLVSALVCL KLWRHEAARR HREFLEQQEI NDPSLSSKRK MCEAAISDRQ
410 420 430 440 450
RDQEVNVKDL RTTTKMTPEL LSGHIPPGHI PKPIVMPDYV AKYPVIQTDD
460 470 480 490 500
DRERYKAVFQ DQFSEYKELS AEVQAILRKF DELDTVMSRL PHHSENRQEH
510 520 530 540 550
ERISRIHEEF RKKKNDPSFL EKKERCDYLK NKLSHIKQRI QEYDKVMNWD

TQGYP
Length:555
Mass (Da):63,662
Last modified:October 11, 2005 - v1
Checksum:iCF91270F47D4DDD5
GO

Sequence cautioni

The sequence AAH49919.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 13112ASPAR…HHPYK → TRPPTRPPTRP in AAH03296 (PubMed:15489334).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB219935 mRNA. Translation: BAE54512.1.
DQ143929 mRNA. Translation: ABA18656.1.
AK133741 mRNA. Translation: BAE21816.1.
BC003296 mRNA. Translation: AAH03296.1.
BC049919 mRNA. Translation: AAH49919.1. Different initiation.
CCDSiCCDS26732.1.
RefSeqiNP_001033691.1. NM_001038602.4.
XP_006517668.1. XM_006517605.1.
UniGeneiMm.25300.

Genome annotation databases

EnsembliENSMUST00000022137; ENSMUSP00000022137; ENSMUSG00000021636.
ENSMUST00000168772; ENSMUSP00000126438; ENSMUSG00000021636.
GeneIDi218518.
KEGGimmu:218518.
UCSCiuc007rra.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB219935 mRNA. Translation: BAE54512.1.
DQ143929 mRNA. Translation: ABA18656.1.
AK133741 mRNA. Translation: BAE21816.1.
BC003296 mRNA. Translation: AAH03296.1.
BC049919 mRNA. Translation: AAH49919.1. Different initiation.
CCDSiCCDS26732.1.
RefSeqiNP_001033691.1. NM_001038602.4.
XP_006517668.1. XM_006517605.1.
UniGeneiMm.25300.

3D structure databases

ProteinModelPortaliQ3UZP0.
SMRiQ3UZP0. Positions 438-545.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022137.

PTM databases

iPTMnetiQ3UZP0.
PhosphoSiteiQ3UZP0.

Proteomic databases

MaxQBiQ3UZP0.
PaxDbiQ3UZP0.
PRIDEiQ3UZP0.

Protocols and materials databases

DNASUi218518.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022137; ENSMUSP00000022137; ENSMUSG00000021636.
ENSMUST00000168772; ENSMUSP00000126438; ENSMUSG00000021636.
GeneIDi218518.
KEGGimmu:218518.
UCSCiuc007rra.2. mouse.

Organism-specific databases

CTDi153562.
MGIiMGI:2446166. Marveld2.

Phylogenomic databases

eggNOGiKOG4796. Eukaryota.
ENOG410ZNGU. LUCA.
GeneTreeiENSGT00550000074378.
HOGENOMiHOG000155323.
HOVERGENiHBG079727.
InParanoidiQ3UZP0.
KOiK17291.
OMAiSPPNSCK.
OrthoDBiEOG783MV9.
PhylomeDBiQ3UZP0.
TreeFamiTF326161.

Miscellaneous databases

NextBioi376331.
PROiQ3UZP0.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UZP0.
CleanExiMM_MARVELD2.
ExpressionAtlasiQ3UZP0. baseline and differential.
GenevisibleiQ3UZP0. MM.

Family and domain databases

InterProiIPR031176. ELL/occludin.
IPR008253. Marvel.
IPR031177. MARVELD2.
IPR010844. Occludin_ELL.
[Graphical view]
PANTHERiPTHR23288. PTHR23288. 1 hit.
PTHR23288:SF3. PTHR23288:SF3. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
PF07303. Occludin_ELL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells."
    Ikenouchi J., Furuse M., Furuse K., Sasaki H., Tsukita S., Tsukita S.
    J. Cell Biol. 171:939-945(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TOPOLOGY, FUNCTION, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Cochlea.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 120-555.
    Strain: Czech II and FVB/N.
    Tissue: Mammary gland.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117 AND SER-121, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney and Lung.

Entry informationi

Entry nameiMALD2_MOUSE
AccessioniPrimary (citable) accession number: Q3UZP0
Secondary accession number(s): Q80UJ4, Q99LE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 11, 2005
Last modified: January 20, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.