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Protein

MARVEL domain-containing protein 2

Gene

Marveld2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing.1 Publication

GO - Biological processi

  • bicellular tight junction assembly Source: MGI
  • cell-cell junction organization Source: MGI
  • establishment of endothelial barrier Source: MGI
  • sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Biological processi

Hearing

Names & Taxonomyi

Protein namesi
Recommended name:
MARVEL domain-containing protein 2
Alternative name(s):
Tricellulin
Gene namesi
Name:Marveld2
Synonyms:Mrvldc2, Tric
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2446166. Marveld2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 191CytoplasmicSequence analysisAdd BLAST191
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 251ExtracellularSequence analysisAdd BLAST39
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 288CytoplasmicSequence analysisAdd BLAST16
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 338ExtracellularSequence analysisAdd BLAST29
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 555CytoplasmicSequence analysisAdd BLAST196

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • basolateral plasma membrane Source: MGI
  • bicellular tight junction Source: MGI
  • cytoplasm Source: MGI
  • cytoplasmic vesicle Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • paranodal junction Source: MGI
  • Schmidt-Lanterman incisure Source: MGI
  • tricellular tight junction Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002715271 – 555MARVEL domain-containing protein 2Add BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117PhosphoserineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei158PhosphoserineBy similarity1
Modified residuei163PhosphothreonineBy similarity1
Modified residuei384PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UZP0.
PaxDbiQ3UZP0.
PRIDEiQ3UZP0.

PTM databases

iPTMnetiQ3UZP0.
PhosphoSitePlusiQ3UZP0.

Expressioni

Tissue specificityi

Predominently localized to small intestine, stomach and kidney, in epithelial cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000021636.
CleanExiMM_MARVELD2.
ExpressionAtlasiQ3UZP0. baseline and differential.
GenevisibleiQ3UZP0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022137.

Structurei

3D structure databases

ProteinModelPortaliQ3UZP0.
SMRiQ3UZP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 364MARVELPROSITE-ProRule annotationAdd BLAST180

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili521 – 545Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 53Poly-Pro8

Sequence similaritiesi

Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4796. Eukaryota.
ENOG410ZNGU. LUCA.
GeneTreeiENSGT00550000074378.
HOGENOMiHOG000155323.
HOVERGENiHBG079727.
InParanoidiQ3UZP0.
KOiK17291.
OMAiSPPNSCK.
OrthoDBiEOG091G04ZP.
PhylomeDBiQ3UZP0.
TreeFamiTF326161.

Family and domain databases

InterProiIPR031176. ELL/occludin.
IPR008253. Marvel.
IPR031177. MARVELD2.
IPR010844. Occludin_ELL.
[Graphical view]
PANTHERiPTHR23288. PTHR23288. 1 hit.
PTHR23288:SF3. PTHR23288:SF3. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
PF07303. Occludin_ELL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UZP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSDARSRI RDRGYSEVPR DTSCPDGTIR TFQSLHSSEL AVSADPLPPP
60 70 80 90 100
PLPLQPPFGP SFYSSDTEEP AVAPDLKPVR RFVPDSWKNF FRGKKKDPEW
110 120 130 140 150
DNPVSDIRYI SDGVECSPPA SPARANHHPY KDPSRGSQGT FNSQHEADAM
160 170 180 190 200
FAHDPYASLD RRTQTARTYS EKVEEYNLRY AYMKSWAGLL RILGVVELLL
210 220 230 240 250
GAGVFACVTA YIHKDNEWYN LFGYTQPYGM GGLGSLGNTY GGYYYSGPKT
260 270 280 290 300
PFVLVVAGLA WITTIIILVL GMSMYYRTIL LDSNWWPLTE FGVNVALFIL
310 320 330 340 350
YMAAAIVYVN DTNRGGLCYY PLFNTPMNAM FCRVEGGQIA AMIFLFVTMI
360 370 380 390 400
VYLVSALVCL KLWRHEAARR HREFLEQQEI NDPSLSSKRK MCEAAISDRQ
410 420 430 440 450
RDQEVNVKDL RTTTKMTPEL LSGHIPPGHI PKPIVMPDYV AKYPVIQTDD
460 470 480 490 500
DRERYKAVFQ DQFSEYKELS AEVQAILRKF DELDTVMSRL PHHSENRQEH
510 520 530 540 550
ERISRIHEEF RKKKNDPSFL EKKERCDYLK NKLSHIKQRI QEYDKVMNWD

TQGYP
Length:555
Mass (Da):63,662
Last modified:October 11, 2005 - v1
Checksum:iCF91270F47D4DDD5
GO

Sequence cautioni

The sequence AAH49919 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120 – 131ASPAR…HHPYK → TRPPTRPPTRP in AAH03296 (PubMed:15489334).CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB219935 mRNA. Translation: BAE54512.1.
DQ143929 mRNA. Translation: ABA18656.1.
AK133741 mRNA. Translation: BAE21816.1.
BC003296 mRNA. Translation: AAH03296.1.
BC049919 mRNA. Translation: AAH49919.1. Different initiation.
CCDSiCCDS26732.1.
RefSeqiNP_001033691.1. NM_001038602.4.
XP_006517668.1. XM_006517605.1.
UniGeneiMm.25300.

Genome annotation databases

EnsembliENSMUST00000022137; ENSMUSP00000022137; ENSMUSG00000021636.
ENSMUST00000168772; ENSMUSP00000126438; ENSMUSG00000021636.
GeneIDi218518.
KEGGimmu:218518.
UCSCiuc007rra.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB219935 mRNA. Translation: BAE54512.1.
DQ143929 mRNA. Translation: ABA18656.1.
AK133741 mRNA. Translation: BAE21816.1.
BC003296 mRNA. Translation: AAH03296.1.
BC049919 mRNA. Translation: AAH49919.1. Different initiation.
CCDSiCCDS26732.1.
RefSeqiNP_001033691.1. NM_001038602.4.
XP_006517668.1. XM_006517605.1.
UniGeneiMm.25300.

3D structure databases

ProteinModelPortaliQ3UZP0.
SMRiQ3UZP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022137.

PTM databases

iPTMnetiQ3UZP0.
PhosphoSitePlusiQ3UZP0.

Proteomic databases

MaxQBiQ3UZP0.
PaxDbiQ3UZP0.
PRIDEiQ3UZP0.

Protocols and materials databases

DNASUi218518.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022137; ENSMUSP00000022137; ENSMUSG00000021636.
ENSMUST00000168772; ENSMUSP00000126438; ENSMUSG00000021636.
GeneIDi218518.
KEGGimmu:218518.
UCSCiuc007rra.2. mouse.

Organism-specific databases

CTDi153562.
MGIiMGI:2446166. Marveld2.

Phylogenomic databases

eggNOGiKOG4796. Eukaryota.
ENOG410ZNGU. LUCA.
GeneTreeiENSGT00550000074378.
HOGENOMiHOG000155323.
HOVERGENiHBG079727.
InParanoidiQ3UZP0.
KOiK17291.
OMAiSPPNSCK.
OrthoDBiEOG091G04ZP.
PhylomeDBiQ3UZP0.
TreeFamiTF326161.

Miscellaneous databases

PROiQ3UZP0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021636.
CleanExiMM_MARVELD2.
ExpressionAtlasiQ3UZP0. baseline and differential.
GenevisibleiQ3UZP0. MM.

Family and domain databases

InterProiIPR031176. ELL/occludin.
IPR008253. Marvel.
IPR031177. MARVELD2.
IPR010844. Occludin_ELL.
[Graphical view]
PANTHERiPTHR23288. PTHR23288. 1 hit.
PTHR23288:SF3. PTHR23288:SF3. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
PF07303. Occludin_ELL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMALD2_MOUSE
AccessioniPrimary (citable) accession number: Q3UZP0
Secondary accession number(s): Q80UJ4, Q99LE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.