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Protein

Pro-interleukin-16

Gene

Il16

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation
Biological processChemotaxisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-interleukin-16UniRule annotation
Cleaved into the following chain:
Interleukin-16UniRule annotation
Short name:
IL-16UniRule annotation
Alternative name(s):
Lymphocyte chemoattractant factorUniRule annotation
Short name:
LCFUniRule annotation
Gene namesi
Name:Il16Imported
Synonyms:IL16UniRule annotation
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1270855. Il16.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation
  • Secreted UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation, SecretedUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiQ3UZ81.
PRIDEiQ3UZ81.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ3UZ81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini407 – 492PDZ (DHR)InterPro annotationAdd BLAST86
Domaini528 – 611PDZ (DHR)InterPro annotationAdd BLAST84

Phylogenomic databases

eggNOGiKOG3528. Eukaryota.
ENOG4110362. LUCA.
HOVERGENiHBG000100.

Family and domain databases

InterProiView protein in InterPro
IPR020450. IL-16.
IPR001478. PDZ.
PfamiView protein in Pfam
PF00595. PDZ. 1 hit.
PRINTSiPR01931. INTRLEUKIN16.
SMARTiView protein in SMART
SM00228. PDZ. 2 hits.
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiView protein in PROSITE
PS50106. PDZ. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UZ81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYSFDITAE DPWVRISDCI KNLFSPIMSE NHSHTPLQPN TSLGEEDGTQ
60 70 80 90 100
GCPEGGLSKM DAANGAPRVY KSADGSTVKK GPPVAPKPAW FRQSLKGLRN
110 120 130 140 150
RAPDPRRPPE VASAIQPTPV SRDPPGPQPQ ASSSIRQRIS SFENFGSSQL
160 170 180 190 200
PDRGVQRLSL QPSSGETTKF PGKQDGGRFS GLLGQGATVT AKHRQTEVES
210 220 230 240 250
MSTTFPNSSE VRDPGLPESP PPGQRPSTKA LSPDPLLRLL TTQSEDTQGP
260 270 280 290 300
GLKMPSQRAR SFPLTRTQSC ETKLLDEKAS KLYSISSQLS SAVMKSLLCL
310 320 330 340 350
PSSVSCGQIT CIPKERVSPK SPCNNSSAAE GFGEAMASDT GFSLNLSELR
360 370 380 390 400
EYSEGLTEPG ETEDRNHCSS QAGQSVISLL SAEELEKLIE EVRVLDEATL
410 420 430 440 450
KQLDSIHVTI LHKEEGAGLG FSLAGGADLE NKVITVHRVF TNGLASQGGT
460 470 480 490 500
IQKGNEVLSI NGKSLKGATH NDALAILRQA RDPRQAVIVT RRTTVEATHD
510 520 530 540 550
LNSSTDSTAS ASAASDISVE SKEATVCTVT LEKTSAGLGF SLEGGKGSLH
560 570 580 590 600
GDKPLTINRI FKGTEQGEMV QPGDEILQLA GTAVQGLTRF EAWNVIKALP
610 620
DGPVTIVIRR TSLQCKQTTA SADS
Length:624
Mass (Da):66,433
Last modified:October 11, 2005 - v1
Checksum:i01EC116F349B816E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK134007 mRNA. Translation: BAE21977.1.
UniGeneiMm.10137.

Genome annotation databases

UCSCiuc009idt.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ3UZ81_MOUSE
AccessioniPrimary (citable) accession number: Q3UZ81
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: July 5, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)