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Protein
Submitted name:

Putative uncharacterized protein

Gene

Fzd3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinSAAS annotation, ReceptorSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Fzd3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:108476. Fzd3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei204 – 226HelicalSequence analysisAdd BLAST23
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Transmembranei291 – 316HelicalSequence analysisAdd BLAST26
Transmembranei328 – 349HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500423029723 – 357Sequence analysisAdd BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 89PROSITE-ProRule annotation
Disulfide bondi36 ↔ 82PROSITE-ProRule annotation
Disulfide bondi103 ↔ 127PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiQ3UYZ0.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115325.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 136FZ (frizzled)InterPro annotationAdd BLAST114
Domaini199 – 357G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST159

Sequence similaritiesi

Belongs to the G-protein coupled receptor Fz/Smo family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOVERGENiHBG006977.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiView protein in InterPro
IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026553. FZD3_vertebrates.
IPR017981. GPCR_2-like.
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF100. PTHR11309:SF100. 1 hit.
PfamiView protein in Pfam
PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
PRINTSiPR00489. FRIZZLED.
SMARTiView protein in SMART
SM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiView protein in PROSITE
PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q3UYZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVSWIVFDL WLLTVFLGQI GGHSLFSCEP ITLRMCQDLP YNTTFMPNLL
60 70 80 90 100
NHYDQQTAAL AMEPFHPMVN LDCSRDFRPF LCALYAPICM EYGRVTLPCR
110 120 130 140 150
RLCQRAYSEC SKLMEMFGVP WPEDMECSRF PDCDEPYPRL VDLNLVGDPT
160 170 180 190 200
EGAPVAVQRD YGFWCPRELK IDPDLGYSFL HVRDCSPPCP NMYFRREELS
210 220 230 240 250
FARYFIGLIS IICLSATLFT FLTFLIDVTR FRYPERPIIF YAVCYMMVSL
260 270 280 290 300
IFFIGFLLED RVACNASSPA QYKASTVTQG YHNKACTMLF MVLYFFTMAG
310 320 330 340 350
SVWWVILTIT WFLAAVPKWG SEAIEKKALL FHASAWGIPG TLTIILLAMN

KIEGDNI
Length:357
Mass (Da):41,013
Last modified:October 11, 2005 - v1
Checksum:i17698D0E53EE0B2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei357Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK134261 mRNA. Translation: BAE22071.1.
UniGeneiMm.214687.
Mm.404299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK134261 mRNA. Translation: BAE22071.1.
UniGeneiMm.214687.
Mm.404299.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115325.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ3UYZ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:108476. Fzd3.

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOVERGENiHBG006977.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiView protein in InterPro
IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026553. FZD3_vertebrates.
IPR017981. GPCR_2-like.
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF100. PTHR11309:SF100. 1 hit.
PfamiView protein in Pfam
PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
PRINTSiPR00489. FRIZZLED.
SMARTiView protein in SMART
SM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiView protein in PROSITE
PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ3UYZ0_MOUSE
AccessioniPrimary (citable) accession number: Q3UYZ0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: February 15, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.