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Protein

Amino acid transporter

Gene

Slc1a2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

SymportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Amino acid transporterUniRule annotation
Gene namesi
Name:Slc1a2Imported
ORF Names:mCG_9657Imported, RP23-163L4.1-001Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:101931. Slc1a2.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei45 – 67HelicalUniRule annotationAdd BLAST23
Transmembranei88 – 108HelicalUniRule annotationAdd BLAST21
Transmembranei120 – 142HelicalUniRule annotationAdd BLAST23
Transmembranei238 – 255HelicalUniRule annotationAdd BLAST18
Transmembranei275 – 300HelicalUniRule annotationAdd BLAST26
Transmembranei312 – 338HelicalUniRule annotationAdd BLAST27
Transmembranei344 – 367HelicalUniRule annotationAdd BLAST24
Transmembranei432 – 456HelicalUniRule annotationAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000005089.
ExpressionAtlasiQ3UYK6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079100.

Structurei

3D structure databases

SMRiQ3UYK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
HOVERGENiHBG000080.
KOiK05613.
OMAiIEMMTKT.
OrthoDBiEOG091G0UCE.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 2 hits.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UYK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTEGANNM PKQVEVRMHD SHLSSDEPKH RNLGMRMCDK LGKNLLLSLT
60 70 80 90 100
VFGVILGAVC GGLLRLASPI HPDVVMLIAF PGDILMRMLK MLILPLIISS
110 120 130 140 150
LITGLSGLDA KASGRLGTRA MVYYMSTTII AAVLGVILVL AIHPGNPKLK
160 170 180 190 200
KQLGPGKKND EVSSLDAFLD LIRNLFPENL VQACFQQIQT VTKKVLVAPP
210 220 230 240 250
SEEANTTKAV ISMLNETMNE APEETKIVIK KGLEFKDGMN VLGLIGFFIA
260 270 280 290 300
FGIAMGKMGE QAKLMVEFFN ILNEIVMKLV IMIMWYSPLG IACLICGKII
310 320 330 340 350
AIKDLEVVAR QLGMYMITVI VGLIIHGGIF LPLIYFVVTR KNPFSFFAGI
360 370 380 390 400
FQAWITALGT ASSAGTLPVT FRCLEDNLGI DKRVTRFVLP VGATINMDGT
410 420 430 440 450
ALYEAVAAIF IAQMNGVILD GGQIVTVSLT ATLASIGAAS IPSAGLVTML
460 470 480 490 500
LILTAVGLPT EDISLLVAVD WLLDRMRTSV NVVGDSFGAG IVYHLSKSEL
510 520 530 540 550
DTIDSQHRMQ EDIEMTKTQS IYDDKNHRES NSNQCVYAAH NSVVIDECKV
560 570
TLAANGKSAD CSVEEEPWKR EK
Length:572
Mass (Da):62,030
Last modified:October 11, 2005 - v1
Checksum:i13C7C30DED40CA81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK134609 mRNA. Translation: BAE22206.1.
AL844605, AL844155 Genomic DNA. Translation: CAM27623.1.
CH466519 Genomic DNA. Translation: EDL27674.1.
RefSeqiNP_001070982.1. NM_001077514.3.
NP_001070983.1. NM_001077515.2.
UniGeneiMm.267547.
Mm.371582.
Mm.453107.
Mm.453110.

Genome annotation databases

GeneIDi20511.
KEGGimmu:20511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK134609 mRNA. Translation: BAE22206.1.
AL844605, AL844155 Genomic DNA. Translation: CAM27623.1.
CH466519 Genomic DNA. Translation: EDL27674.1.
RefSeqiNP_001070982.1. NM_001077514.3.
NP_001070983.1. NM_001077515.2.
UniGeneiMm.267547.
Mm.371582.
Mm.453107.
Mm.453110.

3D structure databases

SMRiQ3UYK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079100.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20511.
KEGGimmu:20511.

Organism-specific databases

CTDi6506.
MGIiMGI:101931. Slc1a2.

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
HOVERGENiHBG000080.
KOiK05613.
OMAiIEMMTKT.
OrthoDBiEOG091G0UCE.

Miscellaneous databases

ChiTaRSiSlc1a2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005089.
ExpressionAtlasiQ3UYK6. baseline and differential.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 2 hits.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3UYK6_MOUSE
AccessioniPrimary (citable) accession number: Q3UYK6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.