Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TBC1 domain family member 9

Gene

Tbc1d9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a GTPase-activating protein for Rab family protein(s).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei562Arginine fingerBy similarity1
Sitei601Glutamine fingerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 9
Gene namesi
Name:Tbc1d9
Synonyms:Kiaa0882
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1918560 Tbc1d9

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002885001 – 1264TBC1 domain family member 9Add BLAST1264

Proteomic databases

PaxDbiQ3UYK3
PeptideAtlasiQ3UYK3
PRIDEiQ3UYK3

PTM databases

iPTMnetiQ3UYK3
PhosphoSitePlusiQ3UYK3

Expressioni

Gene expression databases

BgeeiENSMUSG00000031709
CleanExiMM_TBC1D9
GenevisibleiQ3UYK3 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi214627, 1 interactor
STRINGi10090.ENSMUSP00000091093

Structurei

3D structure databases

ProteinModelPortaliQ3UYK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 213GRAM 1Add BLAST68
Domaini293 – 361GRAM 2Add BLAST69
Domaini515 – 702Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST188
Domaini886 – 921EF-handPROSITE-ProRule annotationAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 41Poly-GlyAdd BLAST11

Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4347 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00760000119137
HOGENOMiHOG000276905
HOVERGENiHBG054142
InParanoidiQ3UYK3
KOiK19951
OMAiDRGKRAN
OrthoDBiEOG091G00RI
PhylomeDBiQ3UYK3
TreeFamiTF313145

Family and domain databases

CDDicd13351 PH-GRAM1_TCB1D9_TCB1D9B, 1 hit
cd13354 PH-GRAM2_TCB1D9_TCB1D9B, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR036014 TCB1D9/TCB1D9B_PH-GRAM1
IPR036017 TCB1D9/TCB1D9B_PH-GRAM2
PfamiView protein in Pfam
PF02893 GRAM, 2 hits
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 2 hits
SM00164 TBC, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS50086 TBC_RABGAP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UYK3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWVNPEEVLL ANALWITERA NPYFILQRRK GHGGDGGGGG GLAGLLVGTL
60 70 80 90 100
DVVLDSSARV APYRILYQTP DSLVYWTIAC GGSRKEVTEH WEWLEQNLLQ
110 120 130 140 150
TLSIFENEND VTTFVRGKIQ GIIAEYNKIN DVKEDEDTEK FKEAIVKFHR
160 170 180 190 200
LFGMPEEEKL VNYYSCSYWK GRVPRQGWMY LSINHLCFSS FLMGREAKLV
210 220 230 240 250
IRWVDITQLE KNATLLLPDM IKVSTRSSEH FFSVFLNINE TFKLMEQLAN
260 270 280 290 300
IAMRQLLDNE GFEQDRSLPK LKKKSPKKVS ALKRDLDARA KSERYRALFR
310 320 330 340 350
LPKDEKLDGH TDCTLWTPFN KMHILGQMFV STNYICFTSK EENLCSLIIP
360 370 380 390 400
LREVTIVEKA DSCSVLPSPL SISTRNRMTF LFANLKDRDF LVQRISDFLQ
410 420 430 440 450
QTTSRIYSDK EFSGSCNSSD DEVYSRPSSL VSSSPQRSTS SDADGERPFN
460 470 480 490 500
LNGNSVPTAT QTLMTMYRRR SPEEFNPKLA KEFLKEQAWK IHFAEYGQGI
510 520 530 540 550
CMYRTEKTRE LVLKGIPESM RGELWLLLSG AINEKATHPG YYEGLVEKSM
560 570 580 590 600
GKYNLATEEI ERDLHRSLPE HPAFQNEMGI AALRRVLTAY AFRNPNIGYC
610 620 630 640 650
QAMNIVTSVL LLYAKEEEAF WLLVALCERM LPDYYNTRVV GALVDQGVFE
660 670 680 690 700
ELARDYVPQL YDCMQDLGVI STISLSWFLT LFLSVMPFES AVVVVDCFFY
710 720 730 740 750
EGIKVIFQLA LAVLDANVDK LLNCKDDGEA MTVLGRYLDS VTNKDSTLPP
760 770 780 790 800
IPHLHSLLSD DVGPYPAVDI FRLIGTSYEK FGTIRADLIE QMRFKQRLKV
810 820 830 840 850
IQTLEDTTKR NVVRTIVTET SFTIDELEEL YALFKAEHLT SCYWGGSSNA
860 870 880 890 900
LDRHDPSLPY LEQYRIDFEQ FKGMFVLLFP WACGTHSDVL ASRLFQLLDE
910 920 930 940 950
NGDSLINFRE FVSGLSAACH GDLTEKLKLL YKMHVLPEPS CDQDEPDSAF
960 970 980 990 1000
EATQYFFEDI TPECTHVVGL DSRGKQSADD GFVTVSLKQD RGKRANSQEN
1010 1020 1030 1040 1050
RNYLKLWTAE NKSKSKTAKD LPKLNQGQFI ELCKTMYNMF SEDPNEQELY
1060 1070 1080 1090 1100
HATAAVTSLL LEIGEVGKFF ITQPAKEDAV PGPPCGQAIP GMLFPKKGSS
1110 1120 1130 1140 1150
QSYVVESTEP LTASLAVDSE EHSLGGQMED IKLEDSSPRD NGACSSMLIS
1160 1170 1180 1190 1200
DDDTKDDSSM SSYSVLSAGS HEEDKLHCED IGEDTVLVRS SQGRATLPRS
1210 1220 1230 1240 1250
SSLDRDWAIT FEQFLASLLT EPALVRYFDK PVCMMARVTS AKNIRMMGKP
1260
LTSASDYEIS ALSG
Length:1,264
Mass (Da):143,024
Last modified:May 29, 2007 - v2
Checksum:iCBCB4203FD6C48D3
GO
Isoform 2 (identifier: Q3UYK3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-353: Missing.

Note: No experimental confirmation available.
Show »
Length:1,031
Mass (Da):115,610
Checksum:iA3F35CEF3E39D54A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti376N → S in BAE22209 (PubMed:16141072).Curated1
Sequence conflicti465T → N in BAE22209 (PubMed:16141072).Curated1
Sequence conflicti544G → D in BAD32328 (PubMed:15368895).Curated1
Sequence conflicti1261A → R in BAC36601 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025698121 – 353Missing in isoform 2. 1 PublicationAdd BLAST233

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017015 mRNA Translation: BAB30550.1
AK049049 mRNA Translation: BAC33525.1
AK077081 mRNA Translation: BAC36601.1
AK134614 mRNA Translation: BAE22209.1
AK173050 mRNA Translation: BAD32328.1
CCDSiCCDS22448.1 [Q3UYK3-2]
CCDS52607.1 [Q3UYK3-1]
RefSeqiNP_001104774.1, NM_001111304.1 [Q3UYK3-1]
NP_082034.1, NM_027758.4 [Q3UYK3-2]
UniGeneiMm.24031

Genome annotation databases

EnsembliENSMUST00000034145; ENSMUSP00000034145; ENSMUSG00000031709 [Q3UYK3-2]
ENSMUST00000093393; ENSMUSP00000091093; ENSMUSG00000031709 [Q3UYK3-1]
GeneIDi71310
KEGGimmu:71310
UCSCiuc009mju.2 mouse [Q3UYK3-2]
uc009mjv.2 mouse [Q3UYK3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTBCD9_MOUSE
AccessioniPrimary (citable) accession number: Q3UYK3
Secondary accession number(s): Q69ZW8
, Q8BIJ5, Q8BVP3, Q9CUB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: March 28, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health