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Protein

TBC1 domain family member 9

Gene

Tbc1d9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a GTPase-activating protein for Rab family protein(s).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei562Arginine fingerBy similarity1
Sitei601Glutamine fingerBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 9
Gene namesi
Name:Tbc1d9
Synonyms:Kiaa0882
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1918560. Tbc1d9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002885001 – 1264TBC1 domain family member 9Add BLAST1264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei402PhosphothreonineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei441PhosphoserineBy similarity1
Modified residuei471PhosphoserineBy similarity1
Modified residuei1255PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3UYK3.
PeptideAtlasiQ3UYK3.
PRIDEiQ3UYK3.

PTM databases

iPTMnetiQ3UYK3.
PhosphoSitePlusiQ3UYK3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031709.
CleanExiMM_TBC1D9.
GenevisibleiQ3UYK3. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi214627. 1 interactor.
STRINGi10090.ENSMUSP00000091093.

Structurei

3D structure databases

ProteinModelPortaliQ3UYK3.
SMRiQ3UYK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 213GRAM 1Add BLAST68
Domaini293 – 361GRAM 2Add BLAST69
Domaini515 – 702Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST188
Domaini886 – 921EF-handPROSITE-ProRule annotationAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 41Poly-GlyAdd BLAST11

Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Sequence similaritiesi

Contains 1 EF-hand domain.PROSITE-ProRule annotation
Contains 2 GRAM domains.Curated
Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4347. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119137.
HOGENOMiHOG000276905.
HOVERGENiHBG054142.
InParanoidiQ3UYK3.
KOiK19951.
OMAiFQTPIQI.
OrthoDBiEOG091G00RI.
PhylomeDBiQ3UYK3.
TreeFamiTF313145.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR004182. GRAM.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF02893. GRAM. 2 hits.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 2 hits.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47923. SSF47923. 2 hits.
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UYK3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWVNPEEVLL ANALWITERA NPYFILQRRK GHGGDGGGGG GLAGLLVGTL
60 70 80 90 100
DVVLDSSARV APYRILYQTP DSLVYWTIAC GGSRKEVTEH WEWLEQNLLQ
110 120 130 140 150
TLSIFENEND VTTFVRGKIQ GIIAEYNKIN DVKEDEDTEK FKEAIVKFHR
160 170 180 190 200
LFGMPEEEKL VNYYSCSYWK GRVPRQGWMY LSINHLCFSS FLMGREAKLV
210 220 230 240 250
IRWVDITQLE KNATLLLPDM IKVSTRSSEH FFSVFLNINE TFKLMEQLAN
260 270 280 290 300
IAMRQLLDNE GFEQDRSLPK LKKKSPKKVS ALKRDLDARA KSERYRALFR
310 320 330 340 350
LPKDEKLDGH TDCTLWTPFN KMHILGQMFV STNYICFTSK EENLCSLIIP
360 370 380 390 400
LREVTIVEKA DSCSVLPSPL SISTRNRMTF LFANLKDRDF LVQRISDFLQ
410 420 430 440 450
QTTSRIYSDK EFSGSCNSSD DEVYSRPSSL VSSSPQRSTS SDADGERPFN
460 470 480 490 500
LNGNSVPTAT QTLMTMYRRR SPEEFNPKLA KEFLKEQAWK IHFAEYGQGI
510 520 530 540 550
CMYRTEKTRE LVLKGIPESM RGELWLLLSG AINEKATHPG YYEGLVEKSM
560 570 580 590 600
GKYNLATEEI ERDLHRSLPE HPAFQNEMGI AALRRVLTAY AFRNPNIGYC
610 620 630 640 650
QAMNIVTSVL LLYAKEEEAF WLLVALCERM LPDYYNTRVV GALVDQGVFE
660 670 680 690 700
ELARDYVPQL YDCMQDLGVI STISLSWFLT LFLSVMPFES AVVVVDCFFY
710 720 730 740 750
EGIKVIFQLA LAVLDANVDK LLNCKDDGEA MTVLGRYLDS VTNKDSTLPP
760 770 780 790 800
IPHLHSLLSD DVGPYPAVDI FRLIGTSYEK FGTIRADLIE QMRFKQRLKV
810 820 830 840 850
IQTLEDTTKR NVVRTIVTET SFTIDELEEL YALFKAEHLT SCYWGGSSNA
860 870 880 890 900
LDRHDPSLPY LEQYRIDFEQ FKGMFVLLFP WACGTHSDVL ASRLFQLLDE
910 920 930 940 950
NGDSLINFRE FVSGLSAACH GDLTEKLKLL YKMHVLPEPS CDQDEPDSAF
960 970 980 990 1000
EATQYFFEDI TPECTHVVGL DSRGKQSADD GFVTVSLKQD RGKRANSQEN
1010 1020 1030 1040 1050
RNYLKLWTAE NKSKSKTAKD LPKLNQGQFI ELCKTMYNMF SEDPNEQELY
1060 1070 1080 1090 1100
HATAAVTSLL LEIGEVGKFF ITQPAKEDAV PGPPCGQAIP GMLFPKKGSS
1110 1120 1130 1140 1150
QSYVVESTEP LTASLAVDSE EHSLGGQMED IKLEDSSPRD NGACSSMLIS
1160 1170 1180 1190 1200
DDDTKDDSSM SSYSVLSAGS HEEDKLHCED IGEDTVLVRS SQGRATLPRS
1210 1220 1230 1240 1250
SSLDRDWAIT FEQFLASLLT EPALVRYFDK PVCMMARVTS AKNIRMMGKP
1260
LTSASDYEIS ALSG
Length:1,264
Mass (Da):143,024
Last modified:May 29, 2007 - v2
Checksum:iCBCB4203FD6C48D3
GO
Isoform 2 (identifier: Q3UYK3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-353: Missing.

Note: No experimental confirmation available.
Show »
Length:1,031
Mass (Da):115,610
Checksum:iA3F35CEF3E39D54A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti376N → S in BAE22209 (PubMed:16141072).Curated1
Sequence conflicti465T → N in BAE22209 (PubMed:16141072).Curated1
Sequence conflicti544G → D in BAD32328 (PubMed:15368895).Curated1
Sequence conflicti1261A → R in BAC36601 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025698121 – 353Missing in isoform 2. 1 PublicationAdd BLAST233

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017015 mRNA. Translation: BAB30550.1.
AK049049 mRNA. Translation: BAC33525.1.
AK077081 mRNA. Translation: BAC36601.1.
AK134614 mRNA. Translation: BAE22209.1.
AK173050 mRNA. Translation: BAD32328.1.
CCDSiCCDS22448.1. [Q3UYK3-2]
CCDS52607.1. [Q3UYK3-1]
RefSeqiNP_001104774.1. NM_001111304.1. [Q3UYK3-1]
NP_082034.1. NM_027758.4. [Q3UYK3-2]
UniGeneiMm.24031.

Genome annotation databases

EnsembliENSMUST00000034145; ENSMUSP00000034145; ENSMUSG00000031709. [Q3UYK3-2]
ENSMUST00000093393; ENSMUSP00000091093; ENSMUSG00000031709. [Q3UYK3-1]
GeneIDi71310.
KEGGimmu:71310.
UCSCiuc009mju.2. mouse. [Q3UYK3-2]
uc009mjv.2. mouse. [Q3UYK3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017015 mRNA. Translation: BAB30550.1.
AK049049 mRNA. Translation: BAC33525.1.
AK077081 mRNA. Translation: BAC36601.1.
AK134614 mRNA. Translation: BAE22209.1.
AK173050 mRNA. Translation: BAD32328.1.
CCDSiCCDS22448.1. [Q3UYK3-2]
CCDS52607.1. [Q3UYK3-1]
RefSeqiNP_001104774.1. NM_001111304.1. [Q3UYK3-1]
NP_082034.1. NM_027758.4. [Q3UYK3-2]
UniGeneiMm.24031.

3D structure databases

ProteinModelPortaliQ3UYK3.
SMRiQ3UYK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214627. 1 interactor.
STRINGi10090.ENSMUSP00000091093.

PTM databases

iPTMnetiQ3UYK3.
PhosphoSitePlusiQ3UYK3.

Proteomic databases

PaxDbiQ3UYK3.
PeptideAtlasiQ3UYK3.
PRIDEiQ3UYK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034145; ENSMUSP00000034145; ENSMUSG00000031709. [Q3UYK3-2]
ENSMUST00000093393; ENSMUSP00000091093; ENSMUSG00000031709. [Q3UYK3-1]
GeneIDi71310.
KEGGimmu:71310.
UCSCiuc009mju.2. mouse. [Q3UYK3-2]
uc009mjv.2. mouse. [Q3UYK3-1]

Organism-specific databases

CTDi23158.
MGIiMGI:1918560. Tbc1d9.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4347. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119137.
HOGENOMiHOG000276905.
HOVERGENiHBG054142.
InParanoidiQ3UYK3.
KOiK19951.
OMAiFQTPIQI.
OrthoDBiEOG091G00RI.
PhylomeDBiQ3UYK3.
TreeFamiTF313145.

Miscellaneous databases

ChiTaRSiTbc1d9. mouse.
PROiQ3UYK3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031709.
CleanExiMM_TBC1D9.
GenevisibleiQ3UYK3. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR004182. GRAM.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF02893. GRAM. 2 hits.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 2 hits.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47923. SSF47923. 2 hits.
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBCD9_MOUSE
AccessioniPrimary (citable) accession number: Q3UYK3
Secondary accession number(s): Q69ZW8
, Q8BIJ5, Q8BVP3, Q9CUB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 2, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.