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Unreviewed, UniProtKB/TrEMBL Q3UYK2 (Q3UYK2_MOUSE)

Last modified February 9, 2010. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein namesSubmitted name:
    Putative uncharacterized protein EMBL BAE22210.1
Submitted name:
    Presenilin 1, isoform CRA_a EMBL EDL02742.1
Gene names
Name: Psen1 MGI 1202717
ORF Names: mCG_116810 EMBL EDL02742.1
OrganismMus musculus (Mouse) EMBL BAE22210.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

Ontologies

Gene Ontology (GO)
   Biological processCajal-Retzius cell differentiation

Inferred from mutant phenotype. Source: MGI

L-glutamate transport

Inferred from mutant phenotype. Source: MGI

Notch receptor processing

Inferred from mutant phenotype. Source: MGI

T cell activation during immune response

Inferred from genetic interaction. Source: MGI

T cell receptor signaling pathway

Inferred from genetic interaction. Source: MGI

activation of MAPKK activity

Inferred from mutant phenotype. Source: MGI

amyloid precursor protein catabolic process

Inferred from mutant phenotype. Source: MGI

anagen

Inferred from genetic interaction. Source: MGI

anti-apoptosis

Inferred from electronic annotation. Source: Compara

autophagic vacuole assembly

Inferred from mutant phenotype. Source: MGI

beta-amyloid metabolic process

Inferred from mutant phenotype. Source: MGI

blood vessel development

Inferred from mutant phenotype. Source: MGI

brain morphogenesis

Inferred from genetic interaction. Source: MGI

cell fate specification

Inferred from genetic interaction. Source: MGI

cell-cell adhesion

Inferred from electronic annotation. Source: Compara

cerebral cortex cell migration

Inferred from mutant phenotype. Source: MGI

choline transport

Inferred from mutant phenotype. Source: MGI

dorsal/ventral neural tube patterning

Inferred from genetic interaction. Source: MGI

embryonic limb morphogenesis

Inferred from genetic interaction. Source: MGI

epithelial cell proliferation

Inferred from genetic interaction. Source: MGI

heart looping

Inferred from genetic interaction. Source: MGI

hemopoietic progenitor cell differentiation

Inferred from genetic interaction. Source: MGI

membrane protein ectodomain proteolysis

Inferred from electronic annotation. Source: Compara

memory

Inferred from genetic interaction. Source: MGI

mitochondrial transport

Inferred from mutant phenotype. Source: MGI

myeloid leukocyte differentiation

Inferred from genetic interaction. Source: MGI

negative regulation of axonogenesis

Inferred from mutant phenotype. Source: MGI

negative regulation of neuron apoptosis

Inferred from electronic annotation. Source: Compara

negative regulation of protein amino acid phosphorylation

Inferred from genetic interaction. Source: MGI

negative regulation of protein kinase activity

Inferred from mutant phenotype. Source: MGI

neuron apoptosis

Inferred from genetic interaction. Source: MGI

neuron development

Inferred from mutant phenotype. Source: MGI

neuron migration

Inferred from mutant phenotype. Source: MGI

positive regulation of MAP kinase activity

Inferred from mutant phenotype. Source: MGI

positive regulation of apoptosis

Inferred from genetic interaction. Source: MGI

positive regulation of coagulation

Inferred from mutant phenotype. Source: MGI

positive regulation of protein amino acid phosphorylation

Inferred from mutant phenotype. Source: MGI

post-embryonic development

Inferred from mutant phenotype. Source: MGI

protein amino acid glycosylation

Inferred from mutant phenotype. Source: MGI

protein transport

Inferred from genetic interaction. Source: MGI

regulation of epidermal growth factor receptor activity

Inferred from genetic interaction. Source: MGI

regulation of protein binding

Inferred from genetic interaction. Source: MGI

regulation of resting membrane potential

Inferred from mutant phenotype. Source: MGI

regulation of synaptic plasticity

Inferred from genetic interaction. Source: MGI

regulation of synaptic transmission, glutamatergic

Inferred from mutant phenotype. Source: MGI

response to DNA damage stimulus

Inferred from mutant phenotype. Source: MGI

response to oxidative stress

Inferred from genetic interaction. Source: MGI

skeletal system morphogenesis

Inferred from mutant phenotype. Source: MGI

smooth endoplasmic reticulum calcium ion homeostasis

Inferred from genetic interaction. Source: MGI

somitogenesis

Inferred from genetic interaction. Source: MGI

synaptic vesicle targeting

Inferred from mutant phenotype. Source: MGI

thymus development

Inferred from genetic interaction. Source: MGI

   Cellular componentGolgi apparatus

Inferred from direct assay. Source: MGI

axon

Inferred from direct assay. Source: MGI

cell soma

Inferred from direct assay. Source: MGI

ciliary rootlet

Inferred from direct assay. Source: MGI

cytoplasmic vesicle

Inferred from direct assay. Source: MGI

dendritic shaft

Inferred from direct assay. Source: MGI

endoplasmic reticulum

Inferred from direct assay. Source: MGI

growth cone

Inferred from direct assay. Source: MGI

integral to plasma membrane

Inferred from electronic annotation. Source: Compara

lysosomal membrane

Inferred from electronic annotation. Source: Compara

membrane raft

Inferred from electronic annotation. Source: Compara

mitochondrial inner membrane

Inferred from electronic annotation. Source: Compara

neuromuscular junction

Inferred from electronic annotation. Source: Compara

nuclear outer membrane

Inferred from electronic annotation. Source: Compara

protein complex

Inferred from electronic annotation. Source: Compara

synaptosome

Inferred from electronic annotation. Source: Compara

   Molecular functionPDZ domain binding

Inferred from electronic annotation. Source: Compara

beta-catenin binding

Inferred from electronic annotation. Source: Compara

cadherin binding

Inferred from physical interaction. Source: MGI

endopeptidase activity

Inferred from genetic interaction. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q3UYK2-1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: D07215B4BAD2D549

FASTA46752,640
        10         20         30         40         50         60 
MTEIPAPLSY FQNAQMSEDS HSSSAIRSQN DSQERQQQHD RQRLDNPEPI SNGRPQSNSR 

        70         80         90        100        110        120 
QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVSFYTRKD GQLIYTPFTE 

       130        140        150        160        170        180 
DTETVGQRAL HSILNAAIMI SVIVIMTILL VVLYKYRCYK VIHAWLIISS LLLLFFFSFI 

       190        200        210        220        230        240 
YLGEVFKTYN VAVDYVTVAL LIWNFGVVGM IAIHWKGPLR LQQAYLIMIS ALMALVFIKY 

       250        260        270        280        290        300 
LPEWTAWLIL AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE 

       310        320        330        340        350        360 
GDPEAQRRVP KNPKYNTQRA ERETQDSGSG NDDGGFSEEW EAQRDSHLGP HRSTPESRAA 

       370        380        390        400        410        420 
VQELSGSILT SEDPEERGVK LGLGDFIFYS VLVGKASATA SGDWNTTIAC FVAILIGLCL 

       430        440        450        460 
TLLLLAIFKK ALPALPISIT FGLVFYFATD YLVQPFMDQL AFHQFYI 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J EMBL BAE22210.1.
Tissue: Medulla oblongata EMBL BAE22210.1, Lung EMBL BAE38500.1 and Thymus EMBL BAE22058.1.
[2]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed: 12040188] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL02742.1.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL02742.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK134232 mRNA. Translation: BAE22058.1.
AK134615 mRNA. Translation: BAE22210.1.
AK148101 mRNA. Translation: BAE28344.1.
AK165984 mRNA. Translation: BAE38500.1.
CH466590 Genomic DNA. Translation: EDL02742.1.
CH466590 Genomic DNA. Translation: EDL02744.1.
IPIIPI00117124.
RefSeqNP_032969.1.
UniGeneMm.998

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ3UYK2.

Proteomic databases

PRIDEQ3UYK2.

Genome annotation databases

EnsemblENSMUST00000041806; ENSMUSP00000048363; ENSMUSG00000019969; Mus musculus. [Genome view]
ENSMUST00000101225; ENSMUSP00000098786; ENSMUSG00000019969; Mus musculus. [Genome view]
GeneID19164.
KEGGmmu:19164.

Organism-specific databases

CTD19164.
MGIMGI:1202717. Psen1.

Phylogenomic databases

HOVERGENQ3UYK2.
InParanoidQ3UYK2.
OMAFYFATDN.
PhylomeDBQ3UYK2.

Gene expression databases

ArrayExpressQ3UYK2.
BgeeQ3UYK2.
GenevestigatorQ3UYK2.

Family and domain databases

InterProIPR002031. Pept_A22A_PS1.
IPR006639. Peptidase_A22.
IPR001108. Peptidase_A22A.
[Graphical view]
PANTHERPTHR10202:SF7. Pept_A22A_PS1. 1 hit.
PTHR10202. Peptidase_A22A. 1 hit.
PfamPF01080. Presenilin. 1 hit.
[Graphical view]
PRINTSPR01072. PRESENILIN.
PR01073. PRESENILIN1.
SMARTSM00730. PSN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio295822.
SOURCESearch...

Entry information

Entry nameQ3UYK2_MOUSE
AccessionPrimary (citable) accession number: Q3UYK2
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: February 9, 2010
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information