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Protein

Presenilin

Gene

Psen1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, ProteaseUniRule annotation
Biological processNotch signaling pathwayUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
PresenilinUniRule annotation (EC:3.4.23.-UniRule annotation)
Gene namesi
Name:Psen1Imported
ORF Names:mCG_116810Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1202717 Psen1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei82 – 100HelicalUniRule annotationAdd BLAST19
Transmembranei133 – 154HelicalUniRule annotationAdd BLAST22
Transmembranei161 – 183HelicalUniRule annotationAdd BLAST23
Transmembranei195 – 213HelicalUniRule annotationAdd BLAST19
Transmembranei225 – 241HelicalUniRule annotationAdd BLAST17
Transmembranei247 – 263HelicalUniRule annotationAdd BLAST17
Transmembranei408 – 428HelicalUniRule annotationAdd BLAST21
Transmembranei434 – 453HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Golgi apparatusUniRule annotation, Membrane

PTM / Processingi

Proteomic databases

MaxQBiQ3UYK2
PRIDEiQ3UYK2

Expressioni

Gene expression databases

BgeeiENSMUSG00000019969
ExpressionAtlasiQ3UYK2 baseline and differential

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Family & Domainsi

Domaini

The PAL motif is required for normal active site conformation.UniRule annotation

Sequence similaritiesi

Belongs to the peptidase A22A family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2736 Eukaryota
ENOG410XPZD LUCA
HOVERGENiHBG011375
KOiK04505
OMAiIAIHWKG
OrthoDBiEOG091G0C72

Family and domain databases

InterProiView protein in InterPro
IPR002031 Pept_A22A_PS1
IPR001108 Peptidase_A22A
IPR006639 Preselin/SPP
PANTHERiPTHR10202 PTHR10202, 1 hit
PfamiView protein in Pfam
PF01080 Presenilin, 1 hit
PRINTSiPR01072 PRESENILIN
PR01073 PRESENILIN1
SMARTiView protein in SMART
SM00730 PSN, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UYK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEIPAPLSY FQNAQMSEDS HSSSAIRSQN DSQERQQQHD RQRLDNPEPI
60 70 80 90 100
SNGRPQSNSR QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI
110 120 130 140 150
KSVSFYTRKD GQLIYTPFTE DTETVGQRAL HSILNAAIMI SVIVIMTILL
160 170 180 190 200
VVLYKYRCYK VIHAWLIISS LLLLFFFSFI YLGEVFKTYN VAVDYVTVAL
210 220 230 240 250
LIWNFGVVGM IAIHWKGPLR LQQAYLIMIS ALMALVFIKY LPEWTAWLIL
260 270 280 290 300
AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE
310 320 330 340 350
GDPEAQRRVP KNPKYNTQRA ERETQDSGSG NDDGGFSEEW EAQRDSHLGP
360 370 380 390 400
HRSTPESRAA VQELSGSILT SEDPEERGVK LGLGDFIFYS VLVGKASATA
410 420 430 440 450
SGDWNTTIAC FVAILIGLCL TLLLLAIFKK ALPALPISIT FGLVFYFATD
460
YLVQPFMDQL AFHQFYI
Length:467
Mass (Da):52,640
Last modified:October 11, 2005 - v1
Checksum:iD07215B4BAD2D549
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK134232 mRNA Translation: BAE22058.1
AK134615 mRNA Translation: BAE22210.1
AK148101 mRNA Translation: BAE28344.1
AK165984 mRNA Translation: BAE38500.1
CH466590 Genomic DNA Translation: EDL02742.1
CH466590 Genomic DNA Translation: EDL02744.1
RefSeqiNP_032969.1, NM_008943.2
XP_006515668.1, XM_006515605.3
UniGeneiMm.998

Genome annotation databases

GeneIDi19164
KEGGimmu:19164

Similar proteinsi

Entry informationi

Entry nameiQ3UYK2_MOUSE
AccessioniPrimary (citable) accession number: Q3UYK2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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